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Scientific Landscape of Oxidative Stress in Stroke: From a Bibliometric Analysis to an in-Depth Review
Neurochem Res. 2023 Jul 28. doi: 10.1007/s11064-023-03999-5. Online ahead of print.ABSTRACTStroke is an acute cerebrovascular disease resulting from either obstruction or rupture of a blood vessel in the brain. Oxidative stress (OS), referred to a status where cellular oxidative capacities overwhelm antioxidative defenses, is involved in the pathophysiology of stroke. The bibliometric analysis and in-depth review aim to depict the research trend of OS in stroke. Relevant scientific publications were acquired from the Web of Science Core Collection database. Scientific landscape of OS in stroke was illustrated by general qu...
Source: Neurochemical Research - July 28, 2023 Category: Neuroscience Authors: Minqi Zhou Jiayu Xin Jinyu Chen Caiyun Sun Bingyue Huo Wenting Zhang Xiangqian Liu Source Type: research

Discharge prescription patterns for antiplatelet and statin therapy following carotid endarterectomy: an analysis of the vascular quality initiative
Conclusions Although statin use has substantially improved following CEA, more than half of individuals not on a statin preprocedure remained this way at discharge. In addition, DAPT at discharge was frequent, a quarter of whom were on SAPT preprocedure. Further efforts are needed to improve rates of new statin prescriptions, ensure appropriate APT intensity at discharge and determine how different discharge APT regimens impact outcomes.
Source: BMJ Open - July 25, 2023 Category: General Medicine Authors: Eppler, M., Singh, N., Ding, L., Magee, G., Garg, P. Tags: Open access, Cardiovascular medicine Source Type: research

TeleRehabilitation with Aims to Improve Lower extremity recovery in community-dwelling individuals who have had a stroke: protocol for a multisite, parallel group, assessor-blinded, randomised attention-controlled trial
Introduction Telerehabilitation is an accessible service delivery model that may support innovative lower extremity rehabilitation programmes that extend the stroke recovery continuum into the community. Unfortunately, there is limited evidence on the provision of exercises for lower extremity recovery after stroke delivered using telerehabilitation. In response, we developed the TeleRehabilitation with Aims to Improve Lower extremity recovery poststroke (TRAIL) programme, a 4-week progressive exercise and self-management intervention delivered synchronously using video-conferencing technology. Our primary hypothesis is th...
Source: BMJ Open - July 19, 2023 Category: General Medicine Authors: Sakakibara, B. M., Wiley, E., Barclay, R., Bayley, M., Davis, J. C., Eng, J. J., Harris, A., Inness, E. L., MacKay-Lyons, M., Monaghan, J., Pollock, C., Pooyania, S., Schneeberg, A., Teasell, R., Yao, J., Tang, A. Tags: Open access, Health services research Source Type: research

The contribution of genotype-guided selection of P2Y12 inhibitor on prognosis in ACS /CCS patients undergoing percutaneous coronary intervention: a retrospective cohort study
ConclusionsGenotype-guided selection of P2Y12 inhibitor made a very positive contribution on the prognosis in Chinese ACS/CCS patients undergoing PCI. Instead of intensifying antiplatelet strategies, conventional-dose clopidogrel could be recommended as P2Y12 inhibitor after weighing MACEs and bleeding events in CYP2C19 IM patients.
Source: European Journal of Clinical Pharmacology - July 14, 2023 Category: Drugs & Pharmacology Source Type: research

Usefulness of the PRECISE-DAPT score at differentiating between ticagrelor and prasugrel for dual antiplatelet therapy initiation
AbstractAs a part of dual antiplatelet therapy (DAPT), prasugrel or ticagrelor is prescribed along with aspirin to patients of acute coronary syndrome (ACS) undergoing percutaneous coronary intervention (PCI). We aimed to assess if the PRECISE-DAPT score, which provides prediction of bleeding during DAPT, could be used to choose between prasugrel and ticagrelor for DAPT initiation. 181 patients out of which 71 received prasugrel and 110 received ticagrelor were enrolled in this prospective cohort study. PRECISE-DAPT score was calculated for everyone and was used to dichotomize patients into two subgroups (score<25 and �...
Source: Journal of Thrombosis and Thrombolysis - July 4, 2023 Category: Hematology Source Type: research

Staged use of ordinal and linear disability scales: a practical approach to granular assessment of acute stroke outcome
ConclusionAmong patients enrolled in an acute neuroprotective stroke trial, the ALDS showed strong convergent validity and superior discrimination characteristics compared with the modified Rankin Scale and increased projected trial power to detect clinically meaningful treatment benefits.
Source: Frontiers in Neurology - June 28, 2023 Category: Neurology Source Type: research

The Combinations of the Patterns of Non-Adherence to Anti-Platelet Regimen in Stented Patients (PARIS) and Coronary Revascularization Demonstrating Outcome Study in Kyoto (CREDO-Kyoto) Thrombotic and Bleeding Risk Scores on Clinical Outcomes in Patients with Acute Myocardial Infarction
Conclusion The combinations of the PARIS and CREDO-Kyoto risk scores might be useful for evaluating ischemic and bleeding risks in patients with acute MI undergoing primary PCI.PMID:37344423 | DOI:10.2169/internalmedicine.2117-23
Source: Internal Medicine - June 21, 2023 Category: Internal Medicine Authors: Daichi Yamashita Yuichi Saito Takanori Sato Tadahiro Matsumoto Sakuramaru Suzuki Kan Saito Shinichi Wakabayashi Hideki Kitahara Koichi Sano Yoshio Kobayashi Source Type: research

Effectiveness and Safety of Lacosamide, A Third-generation Anti-seizure Medication, for Poststroke Seizure and Epilepsy: A Literature Review
Curr Neuropharmacol. 2023 Jun 20. doi: 10.2174/1570159X21666230616114255. Online ahead of print.ABSTRACTAdvances in stroke treatment have resulted in a dramatic reduction in stroke mortality. Nevertheless, poststroke seizures and epilepsy are issues of clinical importance affecting survivors. Additionally, stroke is the most common cause of epilepsy in older adults. Although numerous antiseizure medications exist, studies are needed to provide robust evidence of the efficacy and tolerability of these medicines for treating poststroke seizures and epilepsy. Crucially, the newer generations of antiseizure medications require...
Source: Epilepsy Curr - June 21, 2023 Category: Neurology Authors: Yu-Shiue Chen Ming-Chi Lai Tsang-Shan Chen Yung-Hsin Tseng Ya Jhen Li Chin-Wei Huang Source Type: research

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