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Condition: Dementia
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Total 430 results found since Jan 2013.

Cognitive impairment in patients with end-stage renal disease: Accelerated brain aging?
ConclusionsOverall, differences in cognitive functions, cortical volumes/thickness and white matter integrity associated with dialysis are also cognitive domains and brain structure changes associated with normal aging. In other words, non-demented, independently living dialysis patients present an accelerated brain aging phenotype even after taking into account effects of age, diabetes and depression.
Source: Journal of the Formosan Medical Association - February 8, 2019 Category: General Medicine Source Type: research

Structural brain network measures are superior to vascular burden scores in predicting early cognitive impairment in post stroke patients with small vessel disease
ConclusionsBrain network measures, but not the SVD score, are significantly correlated with cognition in post-stroke SVD patients. Mediation analysis showed that the cerebral vascular lesions produce cognitive dysfunction by interfering with the structural brain network in SVD patients. The brain network measures may be regarded as direct and independent surrogate markers of cognitive impairment in SVD.
Source: NeuroImage: Clinical - February 5, 2019 Category: Radiology Source Type: research

The 12-Word Philadelphia Verbal Learning Test Performances in Older Adults: Brain MRI and Cerebrospinal Fluid Correlates and Regression-Based Normative Data
Conclusion: The PVLT appears sensitive to markers of neurodegeneration, including temporal regions affected by AD. Conversely, in cognitively normal older adults, PVLT performance seems to relate to white matter disease and axonal injury, perhaps reflecting non-AD pathways to cognitive change. Enhanced normative data enrich the clinical utility of this tool.Dement Geriatr Cogn Disord Extra 2018;8:476 –491
Source: Dementia and Geriatric Cognitive Disorders Extra - December 6, 2018 Category: Geriatrics Source Type: research

Sex Differences in the Prevalence of and Risk Factors for Cognitive Impairment No Dementia among the Elderly in a Rural Area of Northern China: A Population-Based Cross-Sectional Study
Conclusion: These findings suggest that it is crucial to address the secondary prevention of stroke and to consider the psychological status among the elderly with low educational attainment in order to reduce the burden of CIND in China.Neuroepidemiology 2019;52:25 –31
Source: Neuroepidemiology - November 26, 2018 Category: Epidemiology Source Type: research

Circulating inflammatory biomarkers are related to cerebrovascular disease in older adults
Conclusions Among older adults, increased circulating inflammatory biomarkers were associated with the presence of infarcts and microbleeds, WMH burden, and progression of WMH.
Source: Neurology Neuroimmunology and Neuroinflammation - November 14, 2018 Category: Neurology Authors: Gu, Y., Gutierrez, J., Meier, I. B., Guzman, V. A., Manly, J. J., Schupf, N., Brickman, A. M., Mayeux, R. Tags: All Imaging, All Immunology, All Cerebrovascular disease/Stroke, All Cognitive Disorders/Dementia, All epidemiology Article Source Type: research

Right hippocampus atrophy is independently associated with Alzheimer's disease with psychosis
ConclusionWe found that more severe hippocampal atrophy is associated with AD+P than with AD −P. In addition, atrophy of the right hippocampus remained significant among AD+P after adjustment for frontal volume. These findings suggest that right hippocampal atrophy is independently associated with AD+P.
Source: Psychogeriatrics - November 14, 2018 Category: Geriatrics Authors: Kangyoon Lee, Young Min Lee, Je ‐Min Park, Byung‐Dae Lee, Eunsoo Moon, Hee‐Jeong Jeong, Soo Yeon Kim, Young‐In Chung, Ji‐Hoon Kim Tags: ORIGINAL ARTICLE Source Type: research

The kynurenine pathway and cognitive performance in community-dwelling older adults. The Hordaland Health Study
ConclusionHigher KTR and neopterin levels, biomarkers of cellular immune activation, were associated with reduced cognitive performance, implying an association between the innate immune system, memory, and language.
Source: Brain, Behavior, and Immunity - October 25, 2018 Category: Neurology Source Type: research

The 2017 hormone therapy position statement of The North American Menopause Society
The 2017 Hormone Therapy Position Statement of The North American Menopause Society (NAMS) updates the 2012 Hormone Therapy Position Statement of The North American Menopause Society and identifies future research needs. An Advisory Panel of clinicians and researchers expert in the field of women's health and menopause was recruited by NAMS to review the 2012 Position Statement, evaluate new literature, assess the evidence, and reach consensus on recommendations, using the level of evidence to identify the strength of recommendations and the quality of the evidence. The Panel's recommendations were reviewed and approved by...
Source: Menopause - October 25, 2018 Category: OBGYN Tags: Commemorative Papers Source Type: research

Bone mineral loss and cognitive impairment: The PRESENT project
Low bone mineral density (BMD) is correlated with Alzheimer's disease and its severity, but the association remains unclear in adults (≥50 years) without a history of stroke or dementia. We assessed BMD and cognitive function using the Mini-Mental Status Examination (MMSE) in 650 stroke- and dementia-free subjects (≥50 years) who were recruited for an early health check-up program between January 2009 and December 2010. The mean age was 62.9 ± 8.0 years and mean MMSE score was 27.6 ± 3.6. A total of 361 subjects had reduced BMD: 197 (30.3%) had osteopenia and 154 (23.6%) had osteoporosis, based on criteria ...
Source: Medicine - October 1, 2018 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research

Sex Differences in the Prevalence of and Risk Factors for Nonvascular Cognitive Function in Rural, Low-Income Elderly in Tianjin, China
Conclusion: These findings suggest that it is crucial to manage and control hypertension and improve educational attainment in order to reduce the prevalence and burden of nonvascular cognitive impairment among low-income residents, both men and women, in rural China.Neuroepidemiology 2018;51:138 –148
Source: Neuroepidemiology - August 9, 2018 Category: Epidemiology Source Type: research

Prevalence and Costs of Discharge Diagnoses in Inpatient General Internal Medicine: a Multi-center Cross-sectional Study
ConclusionsGIM services care for a markedly heterogeneous population but the most common conditions were similar across 7 hospitals. The diversity of conditions cared for in GIM may be challenging for healthcare delivery and quality improvement. Initiatives that cut across individual diseases to address processes of care, patient experience, and functional outcomes may be more relevant to a greater proportion of the GIM population than disease-specific efforts.
Source: Journal of General Internal Medicine - July 27, 2018 Category: Internal Medicine Source Type: research

Academy of Laser Dentistry Now Accepting Applications for 2019 Seidner Student Scholarship Program
Coral Springs, FL – July 17, 2018 –The Academy of Laser Dentistry (ALD) the only independent and unbiased non-profit association dedicated to improving patient care with the proper use of laser technology, is now accepting applications for theDr. Eugene M. Seidner Student Scholarship Program. Named in the memory of Dr. Seidner, a laser dentistry pioneer who also served as ALD president 1996-1997, three recipients will be honored during the ALD ’s 26th Anniversary Conference& Exhibition,April 4-6th at the Hilton Anatole in Dallas, Texas.According to ALD executive director Gail Siminovsky, CAE, “The ALD is v...
Source: Dental Technology Blog - July 25, 2018 Category: Dentistry Source Type: news

Higher Aortic Stiffness is Related to Lower Cerebral Blood Flow and Preserved Cerebrovascular Reactivity in Older Adults.
Conclusions -Greater aortic stiffening relates to lower regional CBF and higher CVR in cognitively normal older adults, especially among individuals with increased genetic predisposition for Alzheimer's disease. Central arterial stiffening may contribute to reductions in regional CBF despite preserved cerebrovascular reserve capacity. PMID: 30018169 [PubMed - as supplied by publisher]
Source: Circulation - July 17, 2018 Category: Cardiology Authors: Jefferson AL, Cambronero FE, Liu D, Moore EE, Neal JE, Terry JG, Nair S, Pechman KR, Rane S, Davis LT, Gifford KA, Hohman TJ, Bell SP, Wang TJ, Beckman JA, Carr JJ Tags: Circulation Source Type: research

Racial and Ethnic Disparities in Dementia Risk Among Individuals With Low Education.
We examined differences in dementia risk between low-educated non-Hispanic whites, Hispanics, and African Americans, and the impact of lifetime risk factors using data from the nationally representative Aging, Demographics, and Memory Study (N = 819). RESULTS: As indicated by Cox regression modeling, dementia risk of low-educated individuals was not significantly different between ethnic groups but was related to having an APOE e4 allele (hazard ratio [HR] 1.89), depression (HR 1.67), stroke (HR 1.60), and smoking (HR 1.32). Further, even in people with low education, every additional year of education decreased de...
Source: The American Journal of Geriatric Psychiatry - July 15, 2018 Category: Psychiatry Tags: Am J Geriatr Psychiatry Source Type: research