• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

Peroxisome proliferator-activated receptor γ (PPARγ): A master gatekeeper in CNS injury and repair
We describe its structure and function and identify the genes that it targets. PPARγ regulation of inflammation, metabolism, cell fate (proliferation/differentiation/maturation/survival), and many other processes also has relevance to other neurological diseases. Therefore, PPARγ is an attractive target for therapies against a number of progressive neurological disorders.
Source: Progress in Neurobiology - July 10, 2018 Category: Neuroscience Source Type: research

Plasma Metal Concentrations and Incident Coronary Heart Disease in Chinese Adults: The Dongfeng-Tongji Cohort
Conclusions: Our study suggested that incident CHD was positively associated with plasma levels of titanium and arsenic, and inversely associated with selenium. Additional research is needed to confirm these findings in other populations. https://doi.org/10.1289/EHP1521 Received: 22 December 2016 Revised: 17 September 2017 Accepted: 19 September 2017 Published: 19 October 2017 Address correspondence to T. Wu, or A. Pan, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hongkong Rd., Wuhan 430030, Hubei, China. Telephone: +86-27-83692347. Email: wut@mails.tjmu.edu.cn or p...
Source: EHP Research - October 20, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Peroxisome proliferator-activated receptor γ (PPARγ): A master gatekeeper in CNS injury and repair
We describe its structure and function and identify the genes that it targets. PPARγ regulation of inflammation, metabolism, cell fate (proliferation/differentiation/maturation/survival), and many other processes also has relevance to other neurological diseases. Therefore, PPARγ is an attractive target for therapies against a number of progressive neurological disorders.
Source: Progress in Neurobiology - October 13, 2017 Category: Neuroscience Source Type: research

Neuronal Cell Sheets of Cortical Motor Neuron Phenotype Derived from Human iPSCs.
Abstract Transplantation of stem cells that differentiate into more mature neural cells brings about functional improvement in preclinical studies of stroke. Previous transplant approaches in the diseased brain utilized injection of the cells in a cell suspension. In addition, neural stem cells were preferentially used for grafting. However, these cells had no specific relationship to the damaged tissue of stroke and brain injury patients. The injection of cells in a suspension destroyed the cell-cell interactions that are suggested to be important for promoting functional integrity of cortical motor neurons. In o...
Source: Cell Transplantation - August 1, 2017 Category: Cytology Authors: Suzuki N, Arimitsu N, Shimizu J, Takai K, Hirotsu C, Ueda Y, Wakisaka S, Fujiwara N, Suzuki T Tags: Cell Transplant Source Type: research

Neuronal cell sheet of cortical motor neuron phenotype derived from human iPS cells.
Abstract <p>Transplantation of stem cells which differentiate into more mature neural cells brings about functional improvement in pre-clinical studies of stroke. Previous transplant approaches in diseased brain have utilized injection of the cells in a cell suspension. In addition, neural stem cells were preferentially used as graft. However, these cells had no specific relationship to the damaged tissue of stroke patients and brain injury. The injection of cells in a suspension destroyed the cell-cell interactions that are suggested to be important for promoting functional integrity as cortical motor neuro...
Source: Cell Transplantation - March 17, 2017 Category: Cytology Authors: Suzuki N, Arimitsu N, Shimizu J, Takai K, Hirotsu C, Takada E, Ueda Y, Wakisaka S, Fujiwara N, Suzuki T Tags: Cell Transplant Source Type: research

Estimated Prestroke Peak VO2 Is Related to Circulating IGF-1 Levels During Acute Stroke
Conclusions. Improving aerobic fitness prior to stroke may be beneficial by increasing baseline IGF-1 levels. These results set the groundwork for future clinical trials to determine whether high IGF-1 and aerobic fitness are beneficial to stroke recovery by providing neuroprotection and improving function.
Source: Neurorehabilitation and Neural Repair - December 10, 2016 Category: Neurology Authors: Mattlage, A. E., Rippee, M. A., Abraham, M. G., Sandt, J., Billinger, S. A. Tags: Original Research Articles Source Type: research

Impact of Intermittent Fasting on Health and Disease Processes.
Abstract Humans in modern societies typically consume food at least three times daily, while laboratory animals are fed ad libitum. Overconsumption of food with such eating patterns often leads to metabolic morbidities (insulin resistance, excessive accumulation of visceral fat, etc.), particularly when associated with a sedentary lifestyle. Because animals, including humans, evolved in environments where food was relatively scarce, they developed numerous adaptations that enabled them to function at a high level, both physically and cognitively, when in a food-deprived/fasted state. Intermittent fasting (IF) enco...
Source: Ageing Research Reviews - October 30, 2016 Category: Genetics & Stem Cells Authors: Mattson MP, Longo VD, Harvie M Tags: Ageing Res Rev Source Type: research

This Vitamin Can Save Your Brain
Your brain has amazing abilities. And it can heal itself. That’s not something you’re likely to hear from mainstream medicine — especially if you or a loved one suffer from the effects of stroke, Alzheimer’s, Parkinson’s or another form of dementia. Here at the Sears Institute for Anti-Aging Medicine, I’ve seen many people with brain damage. And, sadly, most have been deemed “hopeless” by so-called medical experts. But I can tell you there is nothing hopeless about dementia — no matter what its cause. With the right nutrients, there are times when brain damage can be reversed. And now recent research from...
Source: Al Sears, MD Natural Remedies - December 23, 2015 Category: Complementary Medicine Authors: Al Sears Tags: Brain Health Alzheimer's dementia nutrients tocotrienol vitamin E Source Type: news

Contemporary Outcomes of Coronary Artery Bypass Grafting Among Patients With Insulin-Treated and Non–Insulin-Treated Diabetes
Conclusions Patients with diabetes undergoing CABG have substantially increased risk of major adverse events. Patients with ITDM represent an especially high-risk group.
Source: The Annals of Thoracic Surgery - August 25, 2015 Category: Cardiovascular & Thoracic Surgery Source Type: research

Contemporary Outcomes of Coronary Artery Bypass Grafting Among Patients With Insulin-Treated and Non-Insulin-Treated Diabetes.
CONCLUSIONS: Patients with diabetes undergoing CABG have substantially increased risk of major adverse events. Patients with ITDM represent an especially high-risk group. PMID: 26319487 [PubMed - as supplied by publisher]
Source: The Annals of Thoracic Surgery - August 25, 2015 Category: Cardiovascular & Thoracic Surgery Authors: Li Z, Amsterdam EA, Young JN, Hoegh H, Armstrong EJ Tags: Ann Thorac Surg Source Type: research

Mechanistic Evidence in Support of Alpha1-Antitrypsin as a Therapeutic Approach for Type 1 Diabetes
Utilizing endogenous molecules as a therapeutic approach is almost unequivocally superior to engineered or synthetic molecules. However, one rarely encounters an anti-inflammatory, cytoprotective, immunomodulatory and wound-healing molecule that has been available for use for decades. α1-antitrypsin (AAT), a circulating protein that rises more than 4-fold during acute-phase responses, has been administered for a rare genetic deficiency at large doses, for life. Aside from advances in insulin therapy, medical research in type 1 diabetes (T1D) has predominantly focused on autoimmunity—controlling the adaptive imm...
Source: Journal of Diabetes Science and Technology - October 28, 2014 Category: Endocrinology Authors: Fleixo-Lima, G., Ventura, H., Medini, M., Bar, L., Strauss, P., Lewis, E. C. Tags: Review Articles Source Type: research

Endothelin-1-Induced Focal Cerebral Ischemia in the Growth Hormone/IGF-1 Deficient Lewis Dwarf Rat
This study was designed to assess whether GH/IGF-1-deficiency influences the outcome of cerebral ischemia. We found that endothelin-1-induced middle cerebral artery occlusion resulted in a modest but nonsignificant decrease in cerebral infarct size in GH/IGF-1 deficient dw/dw rats compared with control heterozygous littermates and dw/dw rats with early-life GH treatment. Expression of endothelin receptors and endothelin-1-induced constriction of the middle cerebral arteries were similar in the three experimental groups. Interestingly, dw/dw rats exhibited reduced brain edema and less astrocytic infiltration compared with t...
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - October 9, 2014 Category: Geriatrics Authors: Yan, H., Mitschelen, M., Toth, P., Ashpole, N. M., Farley, J. A., Hodges, E. L., Warrington, J. P., Han, S., Fung, K.-M., Csiszar, A., Ungvari, Z., Sonntag, W. E. Tags: Original Article Source Type: research

Estrogen-IGF-1 interactions in neuroprotection: Ischemic Stroke as a case study.
Abstract The steroid hormone 17b-estradiol and the peptide hormone insulin-like growth factor (IGF)-1 independently exert neuroprotective actions in neurologic diseases such as stroke. Only a few studies have directly addressed the interaction between the two hormone systems, however, there is a large literature that indicates potentially greater interactions between the 17b-estradiol and IGF-1 systems. The present review focuses on key issues related to this interaction including IGF-1 and sex differences and common activation of second messenger systems. Using ischemic stroke as a case study, this review also fo...
Source: Frontiers in Neuroendocrinology - May 29, 2014 Category: Endocrinology Authors: Sohrabji F Tags: Front Neuroendocrinol Source Type: research

Deregulation of inflammatory response in the diabetic condition is associated with increased ischemic brain injury
Conclusions: These results showed that diabetic conditions deregulate acute inflammatory response and that the condition is associated with increased stroke-induced injury. The study suggests that interventions aimed at restoring appropriate inflammatory response in peripheral immune cells/macrophages may be beneficial in reducing stroke-induced brain injury in subjects with chronic inflammatory conditions.
Source: Journal of Neuroinflammation - May 1, 2014 Category: Neurology Authors: Eunhee KimAaron TolhurstSunghee Cho Source Type: research

Pages: 1  2  3