Association of Muscle Endurance, Fatigability, and Strength With Functional Limitation and Mortality in the Health Aging and Body Composition Study
Conclusions: Muscle endurance, estimated by isokinetic work, is an indicator of muscle health associated with mobility limitation and mortality providing important insight beyond strength testing. (Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - January 12, 2017 Category: Geriatrics Authors: Roshanravan, B., Patel, K. V., Fried, L. F., Robinson-Cohen, C., de Boer, I. H., Harris, T., Murphy, R. A., Satterfield, S., Goodpaster, B. H., Shlipak, M., Newman, A. B., Kestenbaum, B., for the Health ABC study Tags: Research Article Source Type: research

Cross-Sectional and Prospective Associations Between {beta}-Amyloid in the Brain and Chair Rise Performance in Nondementia Older Adults With Spontaneous Memory Complaints
Conclusions: Brain amyloid was not found to be associated to chair rise performance in nondemented older adults with memory complaints. Potential mechanisms on the links, if any, of amyloid load with physical performance are probably not dependent on muscle function. (Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - January 12, 2017 Category: Geriatrics Authors: de Souto Barreto, P., Cesari, M., Rolland, Y., Salabert, A. S., Payoux, P., Andrieu, S., Vellas, B., for the MAPT Study Group Tags: Research Article Source Type: research

Impact of Potentially Inappropriate Prescribing on Adverse Drug Events, Health Related Quality of Life and Emergency Hospital Attendance in Older People Attending General Practice: A Prospective Cohort Study
This study investigates the longitudinal association of PIP with adverse drug events (ADEs), health related quality of life, and accident & emergency visits. Methods: Study design: Two-year (2010–2012) prospective cohort study (n = 904, ≥70 years, community-dwelling) with linked pharmacy dispensing data. Exposure: Baseline PIP: Screening Tool for Older Persons potentially Inappropriate Prescriptions (STOPP) and Beers 2012 applied 12 months prior. Study outcomes: ADEs (patient interview), health related quality of life (EQ-5D-3L: patient questionnaire), and accident & emergency visits (general practice med...
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - January 12, 2017 Category: Geriatrics Authors: Wallace, E., McDowell, R., Bennett, K., Fahey, T., Smith, S. M. Tags: Research Article Source Type: research

Walking Pace and the Risk of Cognitive Decline and Dementia in Elderly Populations: A Meta-analysis of Prospective Cohort Studies
Conclusions: This meta-analysis provides accumulated evidence supporting that slow or decreased walking pace is significantly associated with elevated risk of cognitive decline and dementia in elderly populations. (Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - January 12, 2017 Category: Geriatrics Authors: Quan, M., Xun, P., Chen, C., Wen, J., Wang, Y., Wang, R., Chen, P., He, K. Tags: Research Article Source Type: research

Associations of Guideline Recommended Medications for Acute Coronary Syndromes With Fall-Related Hospitalizations and Cardiovascular Events in Older Women With Ischemic Heart Disease
Conclusions: In older women with ischemic heart disease, the combination of the four recommended medication classes was associated with increased risk of falls, particularly among frail women, with no statistically significant gain in cardiovascular health. The risks of falls and consequential morbidity in women over 75 needs consideration when prescribing medications after myocardial infarction. (Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - January 12, 2017 Category: Geriatrics Authors: Peeters, G., Tett, S. E., Hollingworth, S. A., Gnjidic, D., Hilmer, S. N., Dobson, A. J., Hubbard, R. E. Tags: Research Article Source Type: research

Risk Factors Associated With Cognitive, Functional, and Behavioral Trajectories of Newly Diagnosed Dementia Patients
Conclusions: Sociodemographic characteristics and clinical comorbidities predict cognitive and functional changes. Only cognitive status explains behavioral decline. Results provide an understanding of the characteristics that impact cognitive, functional, and behavioral decline. (Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - January 12, 2017 Category: Geriatrics Authors: Jutkowitz, E., MacLehose, R. F., Gaugler, J. E., Dowd, B., Kuntz, K. M., Kane, R. L. Tags: Research Article Source Type: research

Safety and Effectiveness of Statins for Prevention of Recurrent Myocardial Infarction in 12 156 Typical Older Patients: A Quasi-Experimental Study
Conclusions: Estimates of statin effectiveness for the prevention of recurrent myocardial infarction in patients aged 60–79 years were similar to trial results, but more evidence is needed in the older group. There may be an excess of falls and fractures in very old patients, which deserves further investigation. (Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - January 12, 2017 Category: Geriatrics Authors: Ble, A., Hughes, P. M., Delgado, J., Masoli, J. A., Bowman, K., Zirk-Sadowski, J., Mujica Mota, R. E., Henley, W. E., Melzer, D. Tags: Research Article Source Type: research

Midlife Risk Factors for Impaired Physical and Cognitive Functioning at Older Ages: A Cohort Study
Background: Previous studies examined midlife risk factors separately for old-age impaired physical and cognitive functioning. We determined the overlap of risk factors for both domains of functioning within the same setting. Methods: Biological and behavioral risk factors at age 50 years and cognitive and physical functioning were assessed 18 (SD = 5) years later in the Whitehall II study (N = 6,316). Impaired physical functioning was defined as ≥1 limitation on the activities of daily living scale. Impaired cognitive functioning was defined as Mini-Mental State Examination score
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - January 12, 2017 Category: Geriatrics Authors: Brunner, E. J., Welch, C. A., Shipley, M. J., Ahmadi-Abhari, S., Singh-Manoux, A., Kivimäki, M. Tags: Research Article Source Type: research

Validation of Consumer-Based Hip and Wrist Activity Monitors in Older Adults With Varied Ambulatory Abilities
Background: The accuracy of step detection in consumer-based wearable activity monitors in older adults with varied ambulatory abilities is not known. Methods: We assessed the validity of two hip-worn (Fitbit One and Omron HJ-112) and two wrist-worn (Fitbit Flex and Jawbone UP) activity monitors in 99 older adults of varying ambulatory abilities and also included the validity results from the ankle-worn StepWatch as a comparison device. Nonimpaired, impaired (Short Physical Performance Battery Score 11.5% (ICCs
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - January 12, 2017 Category: Geriatrics Authors: Floegel, T. A., Florez-Pregonero, A., Hekler, E. B., Buman, M. P. Tags: Research Article Source Type: research

Comorbidity Indices Versus Function as Potential Predictors of 30-Day Readmission in Older Patients Following Postacute Rehabilitation
Conclusions: Comorbidity indices were weakly associated with 30-day readmission in older adults discharged from postacute inpatient rehabilitation. Adding patient-level functional status to the comorbidity indices further improved the discriminatory ability to predict readmission in our sample. (Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - January 12, 2017 Category: Geriatrics Authors: Kumar, A., Karmarkar, A. M., Graham, J. E., Resnik, L., Tan, A., Deutsch, A., Ottenbacher, K. J. Tags: Research Article Source Type: research

Incorporating Persistent Pain in Phenotypic Frailty Measurement and Prediction of Adverse Health Outcomes
Conclusions: Findings support consideration of persistent pain as a component of the frailty phenotype. Persistent pain assessment may provide an expedient method to enhance frailty measurement and improve prediction of adverse outcomes. (Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - January 12, 2017 Category: Geriatrics Authors: Lohman, M. C., Whiteman, K. L., Greenberg, R. L., Bruce, M. L. Tags: Research Article Source Type: research

The Longitudinal Study of Aging in Human Young Adults: Knowledge Gaps and Research Agenda
Conclusions: This article articulates research needs to improve longitudinal measurement of the pace of aging in young people, to pinpoint factors that slow or speed the pace of aging, to compare pace of aging against genomic clocks, to explain slow-aging young adults, and to apply pace of aging in preventive clinical trials of antiaging therapies. This article puts forward a research agenda to fill the knowledge gap concerning lifelong causes of aging. (Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - January 12, 2017 Category: Geriatrics Authors: Moffitt, T. E., Belsky, D. W., Danese, A., Poulton, R., Caspi, A. Tags: Special Article Source Type: research

Obesity in Older People With and Without Conditions Associated With Weight Loss: Follow-up of 955,000 Primary Care Patients
Background: Moderate obesity in later life may improve survival, prompting calls to revise obesity control policies. However, this obesity paradox may be due to confounding from smoking, diseases causing weight-loss, plus varying follow-up periods. We aimed to estimate body mass index (BMI) associations with mortality, incident type 2 diabetes, and coronary heart disease in older people with and without the above confounders. Methods: Cohort analysis in Clinical Practice Research Datalink primary care, hospital and death certificate electronic medical records in England for ages 60 to more than 85 years. Models were adjus...
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - January 12, 2017 Category: Geriatrics Authors: Bowman, K., Delgado, J., Henley, W. E., Masoli, J. A., Kos, K., Brayne, C., Thokala, P., Lafortune, L., Kuchel, G. A., Ble, A., Melzer, D., as part of the Ageing Well Programme of the NIHR School for Public Health Research, England Tags: Research Article Source Type: research

Impact of Single or Repeated Dose Intranasal Zinc-free Insulin in Young and Aged F344 Rats on Cognition, Signaling, and Brain Metabolism
Novel therapies have turned to delivering compounds to the brain using nasal sprays, bypassing the blood brain barrier, and enriching treatment options for brain aging and/or Alzheimer’s disease. We conducted a series of in vivo experiments to test the impact of intranasal Apidra, a zinc-free insulin formulation, on the brain of young and aged F344 rats. Both single acute and repeated daily doses were compared to test the hypothesis that insulin could improve memory recall in aged memory-deficient animals. We quantified insulin signaling in different brain regions and at different times following delivery. We measure...
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - January 12, 2017 Category: Geriatrics Authors: Anderson, K. L., Frazier, H. N., Maimaiti, S., Bakshi, V. V., Majeed, Z. R., Brewer, L. D., Porter, N. M., Lin, A.-L., Thibault, O. Tags: Original Article Source Type: research

Cognitive Difficulty Intensifies Age-related Changes in Anterior Frontal Hemodynamics: Novel Evidence from Near-infrared Spectroscopy
Alongside age-related brain deterioration, cognitive functioning declines, particularly for more demanding tasks. Past research indicates that, to offset this decline, older adults exhibit hemodynamic changes consistent with recruitment of more anterior brain regions. However, the nature of the hemodynamic changes remains unclear. To address this knowledge gap, we used near-infrared spectroscopy in 36 young adults (aged 18–30 years) and 36 older adults (aged 60–72 years) to assess anterior frontal hemodynamic responses to engagement in three cognitive tasks of increasing difficulty. Behavioral results for all t...
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - January 12, 2017 Category: Geriatrics Authors: Bierre, K. L., Lucas, S. J. E., Guiney, H., Cotter, J. D., Machado, L. Tags: Original Article Source Type: research

Mifepristone Reduces Food Palatability and Affects Drosophila Feeding and Lifespan
The Drosophila GeneSwitch system facilitates the spatial and temporal control of gene expression through dietary supplementation of mifepristone (RU486). Because experimental and control groups differ only by treatment with RU486, confounding results from using flies of different genetic backgrounds are eliminated, making GeneSwitch especially useful in studies of aging. However, the effect of RU486 itself on longevity has not been well characterized, particularly in relation to nutritional states known to affect lifespan. Here, we show that RU486 has dose- and diet-dependent effects on longevity in both sexes. On low nutr...
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - January 12, 2017 Category: Geriatrics Authors: Yamada, R., Deshpande, S. A., Keebaugh, E. S., Ehrlich, M. R., Soto Obando, A., Ja, W. W. Tags: Original Article Source Type: research

Reduced Oxidative Burst by Primed Neutrophils in the Elderly Individuals Is Associated With Increased Levels of the CD16bright/CD62Ldim Immunosuppressive Subset
The aim of our study was to analyze polymorphonuclear neutrophil (PMN) functions in elderly individuals compared with those in healthy young participants, directly in whole blood to avoid issues with data interpretation related to cell isolation procedures. Despite the presence of increased circulating levels of proinflammatory cytokines, resting PMNs from the elderly individuals were not activated as shown by normal CD62L and CD11b expression at the PMN surface and normal constitutive reactive oxygen species (ROS) production. However, suboptimal stimulation induced modulations of CD62L and CD11b expression, which positive...
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - January 12, 2017 Category: Geriatrics Authors: Sauce, D., Dong, Y., Campillo-Gimenez, L., Casulli, S., Bayard, C., Autran, B., Boddaert, J., Appay, V., Elbim, C. Tags: Original Article Source Type: research

Effect of Age, Estrogen Status, and Late-Life GPER Activation on Cardiac Structure and Function in the Fischer344xBrown Norway Female Rat
Age-associated changes in cardiac structure and function, together with estrogen loss, contribute to the progression of heart failure with preserved ejection fraction in older women. To investigate the effects of aging and estrogen loss on the development of its precursor, asymptomatic left ventricular diastolic dysfunction, echocardiograms were performed in 10 middle-aged (20 months) and 30 old-aged (30 months) female Fischer344xBrown-Norway rats, 4 and 8 weeks after ovariectomy (OVX) and sham procedures (gonads left intact). The cardioprotective potential of administering chronic G1, the selective agonist to the new G-pr...
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - January 12, 2017 Category: Geriatrics Authors: Alencar, A. K., da Silva, J. S., Lin, M., Silva, A. M., Sun, X., Ferrario, C. M., Cheng, C., Sudo, R. T., Zapata-Sudo, G., Wang, H., Groban, L. Tags: Original Article Source Type: research

Aging and SKN-1-dependent Loss of 20S Proteasome Adaptation to Oxidative Stress in C. elegans
Aging is marked by a collapse of protein homeostasis and deterioration of adaptive stress responses that often lead to disease. During aging, the induction of stress responses decline along with protein quality control. Here, we have shown that the ability to mount an adaptive response by pretreatment with minor oxidative stress is abrogated in aged Caenorhabditis elegans. We have identified a defect in SKN-1 signaling sensitivity during aging and have also found an aging-related increase in basal proteasome expression and in vitro activity, however, adaptation of the 20S proteasome in response to stress is lost in old ani...
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - January 12, 2017 Category: Geriatrics Authors: Raynes, R., Juarez, C., Pomatto, L. C. D., Sieburth, D., Davies, K. J. A. Tags: Original Article Source Type: research

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Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - January 12, 2017 Category: Geriatrics Tags: Cover / Standing Material Source Type: research

Medical Sciences Table of Contents
(Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - January 12, 2017 Category: Geriatrics Tags: Cover / Standing Material Source Type: research

Medical
(Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - January 12, 2017 Category: Geriatrics Tags: Cover / Standing Material Source Type: research

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(Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - January 12, 2017 Category: Geriatrics Tags: Cover / Standing Material Source Type: research

Biological Sciences Table of Contents
(Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - January 12, 2017 Category: Geriatrics Tags: Cover / Standing Material Source Type: research

Biological
(Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - January 12, 2017 Category: Geriatrics Tags: Cover / Standing Material Source Type: research

Response to Letter From De Alfieri et al.: Biological Resilience of Elderly Hospitalized Patients
(Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - December 13, 2016 Category: Geriatrics Authors: Whitson, H. E., Duan-Porter, W., Schmader, K., Morey, M., Cohen, H. J., Colon-Emeric, C. Tags: Letter to the Editor Source Type: research

Biologic Resilience of Elderly Hospitalized Patients
(Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - December 13, 2016 Category: Geriatrics Authors: De Alfieri, W., Borgogni, T., Costanzo, S., Nistico, F. Tags: Letter to the Editor Source Type: research

Association Between Sleep Characteristics and Incident Dementia Accounting for Baseline Cognitive Status: A Prospective Population-Based Study
Conclusions: Short and extended TIB and delayed rising among older adults predicted increased dementia incidence in the following 17 years. The pattern of findings suggests that extended TIB and late rising represent prodromal features whereas short TIB appeared to be a risk factor for dementia. (Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - December 13, 2016 Category: Geriatrics Authors: Bokenberger, K., Ström, P., Dahl Aslan, A. K., Johansson, A. L. V., Gatz, M., Pedersen, N. L., Akerstedt, T. Tags: Research Article Source Type: research

Associations Between Arthritis and Change in Physical Function in U.S. Retirees
Conclusions: Arthritis was associated with a greater prevalence of physical function limitations. Preventing limitations caused by arthritis is a key strategy to prevent disability in retirees. (Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - December 13, 2016 Category: Geriatrics Authors: Baker, N. A., Barbour, K. E., Helmick, C. G., Zack, M. M., Al Snih, S. Tags: Research Article Source Type: research

The Relationship Between Cognitive Functioning and the JNC-8 Guidelines for Hypertension in Older Adults
Background: Guidelines for hypertension treatment by the Eighth Joint National Committee (JNC-8) in 2014 recommended a target systolic blood pressure (BP) of
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - December 13, 2016 Category: Geriatrics Authors: Goldstein, F. C., Hajjar, I. M., Dunn, C. B., Levey, A. I., Wharton, W. Tags: Research Article Source Type: research

Assessing Fatigability in the Lab and in Daily Life in Older Adults With Osteoarthritis Using Perceived, Performance, and Ecological Measures
Conclusion: Lab-based fatigability measures are related to physical capacity measured both in the lab and daily life. Lab-based fatigability measures provide important information regarding daily life fatigability useful for future intervention development. (Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - December 13, 2016 Category: Geriatrics Authors: Murphy, S. L., Kratz, A. L., Schepens Niemiec, S. L. Tags: Research Article Source Type: research

The Survival of Spouses Marrying Into Longevity-Enriched Families
Conclusion: The mortality for ages 20–69 years of spouses marrying into longevity-enriched families is substantially lower than the mortality in the background population, although long-lived siblings participation bias may have contributed to the difference. This finding has implications for the use of spouses as controls in healthy aging and longevity studies, as environmental and/or genetic overmatching may occur. (Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - December 13, 2016 Category: Geriatrics Authors: Pedersen, J. K., Elo, I. T., Schupf, N., Perls, T. T., Stallard, E., Yashin, A. I., Christensen, K. Tags: Research Article Source Type: research

The Severity of Acute Illness and Functional Trajectories in Hospitalized Older Medical Patients
Background: Acute diseases and hospitalization are associated with functional deterioration in older persons. Although most of the functional decline occurs before hospitalization in response to the acute diseases, the role played by comorbidity in the functional trajectories around hospitalization is unclear. Methods: Observational prospective study of 696 elderly individuals hospitalized in two Italian general medicine wards. Functional status of the elderly patients at 2 weeks before hospitalization (baseline), at hospital admission, and at discharge was measured by the Barthel Index. Comorbidity was measured at admiss...
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - December 13, 2016 Category: Geriatrics Authors: Fimognari, F. L., Pierantozzi, A., De Alfieri, W., Salani, B., Zuccaro, S. M., Arone, A., Palleschi, G., Palleschi, L. Tags: Research Article Source Type: research

Sarcopenia and Health Care Utilization in Older Women
Conclusion: Estimated effects of sarcopenia on health care utilization were negligible. However, slowness was associated with greater health care utilization. (Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - December 13, 2016 Category: Geriatrics Authors: Cawthon, P. M., Lui, L.-Y., McCulloch, C. E., Cauley, J. A., Paudel, M. L., Taylor, B., Schousboe, J. T., Ensrud, K. E. Tags: Research Article Source Type: research

Effects of Age and Functional Status on the Relationship of Systolic Blood Pressure With Mortality in Mid and Late Life: The ARIC Study
Background. Impaired functional status attenuates the relationship of systolic blood pressure (SBP) with mortality in older adults but has not been studied in middle-aged populations. Method. Among 10,264 stroke-free Atherosclerosis Risk in Communities participants (mean age 62.8 [5.7] years; 6,349 [62%] younger [
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - December 13, 2016 Category: Geriatrics Authors: Windham, B. G., Griswold, M. E., Lirette, S., Kucharska-Newton, A., Foraker, R. E., Rosamond, W., Coresh, J., Kritchevsky, S., Mosley, T. H. Tags: Research Article Source Type: research

Effects of Mobility and Cognition on Hospitalization and Inpatient Days in Women in Late Life
Conclusions: Among women late in life, mobility limitations and cognitive deficits were each independent predictors of higher inpatient health care utilization even after considering each other and conventional predictors. Additive effects of reduced mobility and poorer cognition may be important to consider in medical decision making and health care policy planning for the growing population of adults aged ≥85 years. (Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - December 13, 2016 Category: Geriatrics Authors: Ensrud, K. E., Lui, L.-Y., Paudel, M. L., Schousboe, J. T., Kats, A. M., Cauley, J. A., McCulloch, C. E., Yaffe, K., Cawthon, P. M., Hillier, T. A., Taylor, B. C., for the Study of Osteoporotic Fractures (SOF) Tags: Research Article Source Type: research

Simple Test of Manual Dexterity Can Help to Identify Persons at High Risk for Neurodegenerative Diseases in the Community
Conclusions: A rapid, nonlaboratory test of manual dexterity may help to identify persons at high risk for neurodegenerative diseases. This highlights the importance of motor function in the preclinical phase of both dementia and parkinsonism and may aid in selecting individuals for refined screening and neuroprotective trials. (Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - December 13, 2016 Category: Geriatrics Authors: Darweesh, S. K. L., Wolters, F. J., Hofman, A., Stricker, B. H., Koudstaal, P. J., Ikram, M. A. Tags: Special Issue: Utility of Brief Cognitive and Physical Assessments in Clinical Care: Special Article Source Type: research

Measuring Frailty Can Help Emergency Departments Identify Independent Seniors at Risk of Functional Decline After Minor Injuries
Conclusion. Measuring frailty in community-dwelling seniors with minor injuries in EDs may enhance current risk screening for functional decline. However, before implementation in usual care, feasibility issues such as inter-rater reliability and acceptability of frailty tools in the EDs have to be addressed. (Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - December 13, 2016 Category: Geriatrics Authors: Sirois, M.-J., Griffith, L., Perry, J., Daoust, R., Veillette, N., Lee, J., Pelletier, M., Wilding, L., Emond, M. Tags: Research Article Source Type: research

Cognitive Status at Hospital Admission: Postoperative Trajectory of Functional Recovery for Hip Fracture
The objective was to determine whether baseline cognition was a determinant of the rate of functional recovery over 6 months after hip fracture. Methods. A consecutive cohort of 383 patients 65 years or older who were treated for hip fracture within a Canadian health region were grouped on cognitive status. Participants with Mini-Mental Status Examination scores
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - December 13, 2016 Category: Geriatrics Authors: Jones, C. A., Jhangri, G. S., Feeny, D. H., Beaupre, L. A. Tags: Research Article Source Type: research

Utility of Brief Cognitive and Physical Assessments in Clinical Care
(Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - December 13, 2016 Category: Geriatrics Authors: Studenski, S. Tags: Editorial Source Type: research

Multiple Metazoan Life-span Interventions Exhibit a Sex-specific Strehler-Mildvan Inverse Relationship Between Initial Mortality Rate and Age-dependent Mortality Rate Acceleration
The Gompertz equation describes survival in terms of initial mortality rate (parameter a), indicative of health, and age-dependent acceleration in mortality rate (parameter b), indicative of aging. Gompertz parameters were analyzed for several published studies. In Drosophila females, mating increases egg production and decreases median life span, consistent with a trade-off between reproduction and longevity. Mating increased parameter a, causing decreased median life span, whereas time parameter b was decreased. The inverse correlation between parameters indicates the Strehler–Mildvan (S-M) relationship, where loss...
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - December 13, 2016 Category: Geriatrics Authors: Shen, J., Landis, G. N., Tower, J. Tags: Original Article Source Type: research

Four Cases of Spontaneous Neoplasia in the Naked Mole-Rat (Heterocephalus glaber), A Putative Cancer-Resistant Species
The naked mole-rat (Heterocephalus glaber) is widely acclaimed to be cancer-resistant and of considerable research interest based on a paucity of reports of neoplasia in this species. We have, however, encountered four spontaneous cases of neoplasia and one presumptive case of neoplasia through routine necropsy and biopsy of individuals in a zoo collection of nonhybrid naked mole-rats bred from a single pair. One case each of metastasizing hepatocellular carcinoma, nephroblastoma (Wilms’ tumor), and multicentric lymphosarcoma, as well as presumptive esophageal adenocarcinoma (Barrett’s esophagus-like) was ident...
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - December 13, 2016 Category: Geriatrics Authors: Taylor, K. R., Milone, N. A., Rodriguez, C. E. Tags: Brief Report Source Type: research

A Stress-Resistant Lipidomic Signature Confers Extreme Longevity to Humans
Plasma lipidomic profile is species specific and an optimized feature associated with animal longevity. In the present work, the use of mass spectrometry technologies allowed us to determine the plasma lipidomic profile and the fatty acid pattern of healthy humans with exceptional longevity. Here, we show that it is possible to define a lipidomic signature only using 20 lipid species to discriminate adult, aged and centenarian subjects obtaining an almost perfect accuracy (90%–100%). Furthermore, we propose specific lipid species belonging to ceramides, widely involved in cell-stress response, as biomarkers of extrem...
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - December 13, 2016 Category: Geriatrics Authors: Jove, M., Naudi, A., Gambini, J., Borras, C., Cabre, R., Portero-Otin, M., Vina, J., Pamplona, R. Tags: Original Article Source Type: research

CNS-wide Sexually Dimorphic Induction of the Major Histocompatibility Complex 1 Pathway With Aging
The major histocompatibility complex I (MHCI) pathway, which canonically functions in innate immune viral antigen presentation and detection, is functionally pleiotropic in the central nervous system (CNS). Alternative roles include developmental synapse pruning, regulation of synaptic plasticity, and inhibition of neuronal insulin signaling; all processes altered during brain aging. Upregulation of MHCI components with aging has been reported; however, no systematic examination of MHCI cellular localization, expression, and regulation across CNS regions, life span, and sexes has been reported. In the mouse, MHCI is expres...
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - December 13, 2016 Category: Geriatrics Authors: Mangold, C. A., Masser, D. R., Stanford, D. R., Bixler, G. V., Pisupati, A., Giles, C. B., Wren, J. D., Ford, M. M., Sonntag, W. E., Freeman, W. M. Tags: Original Article Source Type: research

17{alpha}-Estradiol: A Novel Therapeutic Intervention to Target Age-related Chronic Inflammation
(Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - December 13, 2016 Category: Geriatrics Authors: Gonzalez-Freire, M., Diaz-Ruiz, A., de Cabo, R. Tags: Guest Editorial Source Type: research

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Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - December 13, 2016 Category: Geriatrics Tags: Cover / Standing Material Source Type: research

Medical Sciences Table of Contents
(Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - December 13, 2016 Category: Geriatrics Tags: Cover / Standing Material Source Type: research

Medical
(Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - December 13, 2016 Category: Geriatrics Tags: Cover / Standing Material Source Type: research

Cover
(Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - December 13, 2016 Category: Geriatrics Tags: Cover / Standing Material Source Type: research

Biological Sciences Table of Contents
(Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - December 13, 2016 Category: Geriatrics Tags: Cover / Standing Material Source Type: research