Journals of Gerontology Series A: Biological Sciences and Medical Sciences This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Association of Muscle Endurance, Fatigability, and Strength With Functional Limitation and Mortality in the Health Aging and Body Composition Study
Conclusions: Muscle endurance, estimated by isokinetic work, is an indicator of muscle health associated with mobility limitation and mortality providing important insight beyond strength testing. (Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - January 12, 2017 Category: Geriatrics Authors: Roshanravan, B., Patel, K. V., Fried, L. F., Robinson-Cohen, C., de Boer, I. H., Harris, T., Murphy, R. A., Satterfield, S., Goodpaster, B. H., Shlipak, M., Newman, A. B., Kestenbaum, B., for the Health ABC study Tags: Research Article Source Type: research

Cross-Sectional and Prospective Associations Between {beta}-Amyloid in the Brain and Chair Rise Performance in Nondementia Older Adults With Spontaneous Memory Complaints
Conclusions: Brain amyloid was not found to be associated to chair rise performance in nondemented older adults with memory complaints. Potential mechanisms on the links, if any, of amyloid load with physical performance are probably not dependent on muscle function. (Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - January 12, 2017 Category: Geriatrics Authors: de Souto Barreto, P., Cesari, M., Rolland, Y., Salabert, A. S., Payoux, P., Andrieu, S., Vellas, B., for the MAPT Study Group Tags: Research Article Source Type: research

Impact of Potentially Inappropriate Prescribing on Adverse Drug Events, Health Related Quality of Life and Emergency Hospital Attendance in Older People Attending General Practice: A Prospective Cohort Study
Conclusions: Older community-dwelling people, prescribed ≥2 STOPP PIP are more likely to report ADEs, poorer health related quality of life and attend the accident & emergency department over 2-year follow-up. (Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - January 12, 2017 Category: Geriatrics Authors: Wallace, E., McDowell, R., Bennett, K., Fahey, T., Smith, S. M. Tags: Research Article Source Type: research

Walking Pace and the Risk of Cognitive Decline and Dementia in Elderly Populations: A Meta-analysis of Prospective Cohort Studies
Conclusions: This meta-analysis provides accumulated evidence supporting that slow or decreased walking pace is significantly associated with elevated risk of cognitive decline and dementia in elderly populations. (Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - January 12, 2017 Category: Geriatrics Authors: Quan, M., Xun, P., Chen, C., Wen, J., Wang, Y., Wang, R., Chen, P., He, K. Tags: Research Article Source Type: research

Associations of Guideline Recommended Medications for Acute Coronary Syndromes With Fall-Related Hospitalizations and Cardiovascular Events in Older Women With Ischemic Heart Disease
Conclusions: In older women with ischemic heart disease, the combination of the four recommended medication classes was associated with increased risk of falls, particularly among frail women, with no statistically significant gain in cardiovascular health. The risks of falls and consequential morbidity in women over 75 needs consideration when prescribing medications after myocardial infarction. (Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - January 12, 2017 Category: Geriatrics Authors: Peeters, G., Tett, S. E., Hollingworth, S. A., Gnjidic, D., Hilmer, S. N., Dobson, A. J., Hubbard, R. E. Tags: Research Article Source Type: research

Risk Factors Associated With Cognitive, Functional, and Behavioral Trajectories of Newly Diagnosed Dementia Patients
Conclusions: Sociodemographic characteristics and clinical comorbidities predict cognitive and functional changes. Only cognitive status explains behavioral decline. Results provide an understanding of the characteristics that impact cognitive, functional, and behavioral decline. (Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - January 12, 2017 Category: Geriatrics Authors: Jutkowitz, E., MacLehose, R. F., Gaugler, J. E., Dowd, B., Kuntz, K. M., Kane, R. L. Tags: Research Article Source Type: research

Safety and Effectiveness of Statins for Prevention of Recurrent Myocardial Infarction in 12 156 Typical Older Patients: A Quasi-Experimental Study
Conclusions: Estimates of statin effectiveness for the prevention of recurrent myocardial infarction in patients aged 60–79 years were similar to trial results, but more evidence is needed in the older group. There may be an excess of falls and fractures in very old patients, which deserves further investigation. (Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - January 12, 2017 Category: Geriatrics Authors: Ble, A., Hughes, P. M., Delgado, J., Masoli, J. A., Bowman, K., Zirk-Sadowski, J., Mujica Mota, R. E., Henley, W. E., Melzer, D. Tags: Research Article Source Type: research

Midlife Risk Factors for Impaired Physical and Cognitive Functioning at Older Ages: A Cohort Study
Conclusions: Several midlife risk factors are associated with impaired physical and cognitive functioning in old age, supporting a unified prevention policy. Analysis of 12 risk factors at age 50 suggests that strategies targeting physical inactivity, hypertension, and poor lung function will reduce impairments in both cognitive and physical functioning in old age. (Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - January 12, 2017 Category: Geriatrics Authors: Brunner, E. J., Welch, C. A., Shipley, M. J., Ahmadi-Abhari, S., Singh-Manoux, A., Kivimäki, M. Tags: Research Article Source Type: research

Validation of Consumer-Based Hip and Wrist Activity Monitors in Older Adults With Varied Ambulatory Abilities
Conclusions: StepWatch, Omron HJ-112, Fitbit One, and Jawbone UP appeared accurate at measuring steps in older adults with nonimpaired and impaired ambulation during a self-paced walking test. StepWatch also appeared accurate at measuring steps in cane-users. (Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - January 12, 2017 Category: Geriatrics Authors: Floegel, T. A., Florez-Pregonero, A., Hekler, E. B., Buman, M. P. Tags: Research Article Source Type: research

Comorbidity Indices Versus Function as Potential Predictors of 30-Day Readmission in Older Patients Following Postacute Rehabilitation
Conclusions: Comorbidity indices were weakly associated with 30-day readmission in older adults discharged from postacute inpatient rehabilitation. Adding patient-level functional status to the comorbidity indices further improved the discriminatory ability to predict readmission in our sample. (Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - January 12, 2017 Category: Geriatrics Authors: Kumar, A., Karmarkar, A. M., Graham, J. E., Resnik, L., Tan, A., Deutsch, A., Ottenbacher, K. J. Tags: Research Article Source Type: research

Incorporating Persistent Pain in Phenotypic Frailty Measurement and Prediction of Adverse Health Outcomes
Conclusions: Findings support consideration of persistent pain as a component of the frailty phenotype. Persistent pain assessment may provide an expedient method to enhance frailty measurement and improve prediction of adverse outcomes. (Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - January 12, 2017 Category: Geriatrics Authors: Lohman, M. C., Whiteman, K. L., Greenberg, R. L., Bruce, M. L. Tags: Research Article Source Type: research

The Longitudinal Study of Aging in Human Young Adults: Knowledge Gaps and Research Agenda
Conclusions: This article articulates research needs to improve longitudinal measurement of the pace of aging in young people, to pinpoint factors that slow or speed the pace of aging, to compare pace of aging against genomic clocks, to explain slow-aging young adults, and to apply pace of aging in preventive clinical trials of antiaging therapies. This article puts forward a research agenda to fill the knowledge gap concerning lifelong causes of aging. (Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - January 12, 2017 Category: Geriatrics Authors: Moffitt, T. E., Belsky, D. W., Danese, A., Poulton, R., Caspi, A. Tags: Special Article Source Type: research

Obesity in Older People With and Without Conditions Associated With Weight Loss: Follow-up of 955,000 Primary Care Patients
Conclusions: Obesity is associated with shorter survival plus higher incidence of coronary heart disease and type 2 diabetes in older populations after accounting for the studied confounders, at least to age 84. These results cast doubt on calls to revise obesity control policies based on the claimed risk paradox at older ages. (Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - January 12, 2017 Category: Geriatrics Authors: Bowman, K., Delgado, J., Henley, W. E., Masoli, J. A., Kos, K., Brayne, C., Thokala, P., Lafortune, L., Kuchel, G. A., Ble, A., Melzer, D., as part of the Ageing Well Programme of the NIHR School for Public Health Research, England Tags: Research Article Source Type: research

Impact of Single or Repeated Dose Intranasal Zinc-free Insulin in Young and Aged F344 Rats on Cognition, Signaling, and Brain Metabolism
Novel therapies have turned to delivering compounds to the brain using nasal sprays, bypassing the blood brain barrier, and enriching treatment options for brain aging and/or Alzheimer’s disease. We conducted a series of in vivo experiments to test the impact of intranasal Apidra, a zinc-free insulin formulation, on the brain of young and aged F344 rats. Both single acute and repeated daily doses were compared to test the hypothesis that insulin could improve memory recall in aged memory-deficient animals. We quantified insulin signaling in different brain regions and at different times following delivery. We measure...
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - January 12, 2017 Category: Geriatrics Authors: Anderson, K. L., Frazier, H. N., Maimaiti, S., Bakshi, V. V., Majeed, Z. R., Brewer, L. D., Porter, N. M., Lin, A.-L., Thibault, O. Tags: Original Article Source Type: research

Cognitive Difficulty Intensifies Age-related Changes in Anterior Frontal Hemodynamics: Novel Evidence from Near-infrared Spectroscopy
Alongside age-related brain deterioration, cognitive functioning declines, particularly for more demanding tasks. Past research indicates that, to offset this decline, older adults exhibit hemodynamic changes consistent with recruitment of more anterior brain regions. However, the nature of the hemodynamic changes remains unclear. To address this knowledge gap, we used near-infrared spectroscopy in 36 young adults (aged 18–30 years) and 36 older adults (aged 60–72 years) to assess anterior frontal hemodynamic responses to engagement in three cognitive tasks of increasing difficulty. Behavioral results for all t...
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - January 12, 2017 Category: Geriatrics Authors: Bierre, K. L., Lucas, S. J. E., Guiney, H., Cotter, J. D., Machado, L. Tags: Original Article Source Type: research