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Drug: Tamoxifen

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Using Dental Pulp Stem Cells for Stroke Therapy
Conclusion and Future Perspectives Stem cell-based therapy is a promising alternative for stroke treatment. While stem cells from different sources, including induced PSC, ESC, MSC, and NSC, have been investigated, using NSC and enhancing the natural mechanisms is most appropriate for brain repair. In preclinical models of stroke, stem cell transplantation has led to positive outcomes through a variety of cellular and molecular mechanisms, many being mediated by the array of beneficial factors produced by the cells. Recent advances in cellular reprogramming have provided alternative sources of NSC to be investigated, allo...
Source: Frontiers in Neurology - April 28, 2019 Category: Neurology Source Type: research

Activation of neuronal Ras ‐related C3 botulinum toxin substrate 1 (Rac1) improves post‐stroke recovery and axonal plasticity in mice
We propose that activation of neuronal Rac1 mediates the release of BDNF via PAK1 signaling, which further promotes axonal plasticity and alleviates astrogliosis, and eventually contributes to functional recovery after brain ischemia. Targeting neuronal Rac1 may offer a potential therapeutic target for promoting brain remapping and functional recovery after stroke. AbstractLong-term disability after stroke is common but the mechanisms of post-stroke recovery remain unclear. Cerebral Ras-related C3 botulinum toxin substrate (Rac) 1 contributes to functional recovery after ischemic stroke in mice. As Rac1 plays divergent rol...
Source: Journal of Neurochemistry - May 22, 2021 Category: Neuroscience Authors: Fan Bu, Yashasvee Munshi, J Weldon Furr, Jia ‐wei Min, Li Qi, Anthony Patrizz, Zachary R. Spahr, Akihiko Urayama, Julia K. Kofler, Louise D. McCullough, Jun Li Tags: ORIGINAL ARTICLE Source Type: research

Activation of Neuronal Ras ‐Related C3 Botulinum Toxin Substrate 1 (Rac1) Improves Post‐Stroke Recovery and Axonal Plasticity in Mice
AbstractLong ‐term disability after stroke is common but the mechanisms of post‐stroke recovery is unclear. Cerebral Ras‐related C3 botulinum toxin substrate (Rac) 1 contributes to functional recovery after ischemic stroke in mice. As Rac1 plays divergent roles in individual cell types after central neural system injury, we herein examined the specific role of neuronal Rac1 in post‐stroke recovery and axonal regeneration. Young male mice were subjected to 60‐minutes middle cerebral artery occlusion (MCAO). Inducible deletion of neuronal Rac1 by daily intraperitoneal injection of tamoxifen (2 mg/4 0 g) into Thy1...
Source: Journal of Neurochemistry - September 21, 2020 Category: Neuroscience Authors: Fan Bu, Yashasvee Munshi, J Weldon Furr, Jia ‐wei Min, Li Qi, Anthony Patrizz, Zachary R. Spahr, Akihiko Urayama, Julia K. Kofler, Louise D. McCullough, Jun Li Tags: ORIGINAL ARTICLE Source Type: research

Vascular Stat3 Promotes Angiogenesis and Neuroplasticity Long-Term After Stroke.
CONCLUSIONS: -Endothelial Stat3 regulates angiogenesis, axon growth and ECM-remodeling and is essential for long-term recovery after stroke. It might serve as a potent target for stroke treatment after the acute phase by fostering angiogenesis and neuroregeneration. PMID: 25794850 [PubMed - as supplied by publisher]
Source: Circulation - March 20, 2015 Category: Cardiology Authors: Hoffmann CJ, Harms U, Rex A, Szulzewsky F, Wolf SA, Grittner U, Lättig-Tünnemann G, Sendtner M, Kettenmann H, Dirnagl U, Endres M, Harms C Tags: Circulation Source Type: research

The Incident Ocular Diseases Related to Chemotherapy in Cancer Patients are Associated with Increasing Risk of Incident Stroke
CONCLUSIONS: Incident ocular diseases related to chemotherapy were associated with a significantly higher risk of stroke.PMID:37229341 | PMC:PMC10203719 | DOI:10.6515/ACS.202305_39(3).20221005A
Source: Cancer Control - May 25, 2023 Category: Cancer & Oncology Authors: Kai-Chun Cheng Hung-Pin Tu Tsung-Hsien Lin Kai-Hung Cheng Source Type: research

Selective knockout of astrocytic Na+/H+ exchanger isoform 1 reduces astrogliosis, BBB damage, infarction, and improves neurological function after ischemic stroke
In this study, we created a Nhe1flox/flox (Nhe1f/f) mouse line with exon 5 of Nhe1 flanked with two loxP sites and selective ablation of Nhe1 in astrocytes was achieved by crossing Nhe1f/f mice with Gfap‐CreERT2 Cre‐recombinase mice. Gfap‐CreERT2+/−;Nhe1f/f mice at postnatal day 60–90 were treated with either corn oil or tamoxifen (Tam, 75 mg/kg/day, i.p.) for 5 days. After 30 days post‐injection, mice underwent transient middle cerebral artery occlusion (tMCAO) to induce ischemic stroke. Compared with the oil‐vehicle group (control), Tam‐treated Gfap‐CreERT2+/−;Nhe1f/f (Nhe1 KO) mice developed signifi...
Source: Glia - September 19, 2017 Category: Neurology Authors: Gulnaz Begum, Shanshan Song, Shaoxia Wang, Hanshu Zhao, Mohammad Iqbal H. Bhuiyan, Eric Li, Rachel Nepomuceno, Qing Ye, Ming Sun, Michael Joseph Calderon, Donna B. Stolz, Claudette St. Croix, Simon C. Watkins, Yinhuai Chen, Pingnian He, Gary E. Shull, Dan Tags: RESEARCH ARTICLE Source Type: research

AIs Not Tied to Cardiac Ischemia, Stroke in Breast CA PatientsAIs Not Tied to Cardiac Ischemia, Stroke in Breast CA Patients
Breast cancer patients on aromatase inhibitors (AIs) do not seem to be at greater risk for cardiac ischemia or stroke compared with those taking tamoxifen, researchers have found. Reuters Health Information
Source: Medscape Medical News Headlines - May 2, 2016 Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news

GSE103782 Stroke target identification guided by astrocyte transcriptome analysis single animal
Contributors : Cordula Rakers ; Melvin Schleif ; Thomas Ulas ; Kristian H ändler ; Santiago ValleTorres ; Toni Schumacher ; Khalid Tai ; Caroline Dalmoro ; Joachim L Schultze ; Walker Jackson ; Gabor C PetzoldSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Mus musculusWe aimed to investigate the influence of ischemic stroke in mice on their ribosomal mRNA in astrocytes. Therefore, we make use of the conditional Cre/LoxP System in the RiboTag mouse line in order to isolate the ribosomal mRNA of astrocytes. CreERT2 expression under the astrocyte-specific Cx43 promoter is induced by Tamoxif...
Source: GEO: Gene Expression Omnibus - February 22, 2019 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Other Mus musculus Source Type: research

GSE103781 Stroke target identification guided by astrocyte transcriptome analysis pool
Contributors : Cordula Rakers ; Melvin Schleif ; Thomas Ulas ; Kristian H ändler ; Santiago ValleTorres ; Toni Schumacher ; Khalid Tai ; Caroline Dalmoro ; Joachim L Schultze ; Walker Jackson ; Gabor C PetzoldSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Mus musculusWe aimed to investigate the influence of ischemic stroke in mice on their ribosomal mRNA in astrocytes. Therefore, we make use of the conditional Cre/LoxP System in the RiboTag mouse line in order to isolate the ribosomal mRNA of astrocytes. CreERT2 expression under the astrocyte-specific Cx43 promoter is induced by Tamoxif...
Source: GEO: Gene Expression Omnibus - February 22, 2019 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Other Mus musculus Source Type: research

GSE141972 TGF β-activated kinase 1-dependent microglial and macrophage responses aggravate long-term outcomes after ischemic stroke
Contributors : Yejie Shi ; Jun ChenSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusMicroglia/macrophages (Mi/M Φ) can profoundly influence stroke outcomes by acquiring functionally dominant phenotypes (pro-inflammatory or anti-inflammatory; neurotoxic or neuroprotective). Identification of the molecular mechanisms that dictate the functional status of Mi/MΦ after brain ischemia/reperfusion may reveal novel therapeutic targets for stroke. We hypothesized that activation of TGFβ-activated kinase 1 (TAK1), a key MAP3K upstream of multiple inflammation-regulating pathways, drives Mi/M...
Source: GEO: Gene Expression Omnibus - March 10, 2020 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research

De Novo Cerebrovascular Malformation in the Adult Mouse After Endothelial Alk1 Deletion and Angiogenic Stimulation Brief Reports
Conclusions— Deletion of Alk1 in EC in adult mice leads to an increased local EC proliferation during brain angiogenesis and de novo brain AVM.
Source: Stroke - February 24, 2014 Category: Neurology Authors: Chen, W., Sun, Z., Han, Z., Jun, K., Camus, M., Wankhede, M., Mao, L., Arnold, T., Young, W. L., Su, H. Tags: Cerebrovascular disease/stroke, Animal models of human disease, Genetically altered mice, Aneurysm, AVM, hematoma Brief Reports Source Type: research

An Embolic Stroke in a Patient With PROC p.Lys193del
We report a 58-year-old woman who suddenly developed brain infarction with weakness of the left lower extremity and left perioral dysesthesia during postoperative tamoxifen therapy for breast cancer and prednisolone therapy for rheumatoid arthritis. Diffusion-weighted images detected multiple areas of hyperintensity in the posterior circulation system of the brain. Despite extensive examinations, we could not identify any embolic sources except hypoplasia of the right vertebral artery. We found decreased activity of protein C against its antigen level (activity: 59% versus antigen: 122%) with enhanced activity of coagulati...
Source: Journal of Stroke and Cerebrovascular Diseases - February 10, 2020 Category: Neurology Authors: Kana Ueki, Kuniyuki Nakamura, Yoshinobu Wakisaka, Shinichi Wada, Yoji Yoshikawa, Shinya Matsumoto, Taeko Hotta, Dongchong Kang, Takanari Kitazono, Tetsuro Ago Tags: Case Report Source Type: research

Association of Tamoxifen Use and Reduced Cardiovascular Events Among Asian Females With Breast Cancer.
Conclusions: In Asian female breast cancer patients, tamoxifen use was associated with reduced risks of AMI, ischemic, hemorrhagic stroke and total cardiovascular events. PMID: 24107360 [PubMed - as supplied by publisher]
Source: Circulation Journal - October 9, 2013 Category: Cardiology Authors: Yang TL, Wu TC, Huang CC, Huang PH, Chung CM, Lin SJ, Chen JW, Chan WL, Chiang CH, Leu HB Tags: Circ J Source Type: research

1366p * risk-benefit index of tamoxifen and raloxifene for chemoprevention of korean breast cancer
Conclusions: Women under the age 40 had more benefit than risk from tamoxifen chemoprevention. In the postmenopausal women with a uterus, raloxifene has more favorable risk-benefit index than tamoxifen.Disclosure: All authors have declared no conflicts of interest.
Source: Annals of Oncology - September 24, 2014 Category: Cancer & Oncology Authors: Chang, M. Tags: prevention and screening Source Type: research

Abstract PD4-2: Cardiovascular toxicity following aromatase inhibitor use in 13,273 survivors cared for in a HMO
Discussion These results indicate that variation exists in the type of CVD events that occur in breast cancer patients receiving AIs in comparison to tamoxifen users. For example, the risk of ischemic disease or stroke was not elevated in those who used AIs only versus TAM users. However, overall CVD events were greater in women who used AIs only (or sequentially after TAM), especially if they received left-sided breast irradiation. While these observational study results require cautious interpretation, they provide a basis for comparing the benefits and risks of endocrine treatments. Citation Format: Reina Haque, Joanne ...
Source: Cancer Research - April 30, 2015 Category: Cancer & Oncology Authors: Haque, R., Schottinger, J. E., Shi, J., Chung, J., Avila, C., Amundsen, B., Chlebowski, R. T. Tags: Poster Discussion Abstracts Source Type: research