De Novo Cerebrovascular Malformation in the Adult Mouse After Endothelial Alk1 Deletion and Angiogenic Stimulation [Brief Reports]

Conclusions—
Deletion of Alk1 in EC in adult mice leads to an increased local EC proliferation during brain angiogenesis and de novo brain AVM.

Source: Stroke - February 24, 2014 Category: Neurology Authors: Chen, W., Sun, Z., Han, Z., Jun, K., Camus, M., Wankhede, M., Mao, L., Arnold, T., Young, W. L., Su, H. Tags: Cerebrovascular disease/stroke, Animal models of human disease, Genetically altered mice, Aneurysm, AVM, hematoma Brief Reports Source Type: research