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Drug: Doxycycline

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Total 18 results found since Jan 2013.

Tetracycline-, Doxycycline-, Minocycline-Induced Pseudotumor Cerebri and Esophageal Perforation
AbstractTetracyclines are a class of broad-spectrum bacteriostatic antibiotics used to treat many infections, including methicillin-resistantStaphylococcus aureus (MRSA), acne, pelvic inflammatory disease, chlamydial infections, and a host of zoonotic infections. These drugs work by inhibiting protein synthesis in bacterial ribosomes, specifically by disallowing aminoacyl-tRNA molecules from binding to the ribosomal acceptor sites. While rare, tetracycline antibiotics, particularly minocycline and doxycycline, are associated with an increased risk of developing esophageal perforation and pseudotumor cerebri (PTC, or idiopa...
Source: Advances in Therapy - February 10, 2023 Category: Drugs & Pharmacology Source Type: research

Randomized, double-blind, placebo-controlled, crossover trial of oral doxycycline for epistaxis in hereditary hemorrhagic telangiectasia
Vascular malformations in hereditary hemorrhagic telangiectasia (HHT) lead to chronic recurrent bleeding, hemorrhage, stroke, heart failure, and liver disease. There is great interest in identifying novel ther...
Source: Orphanet Journal of Rare Diseases - November 7, 2022 Category: Internal Medicine Authors: K. P. Thompson, J. Sykes, P. Chandakkar, P. Marambaud, N. T. Vozoris, D. A. Marchuk and M. E. Faughnan Tags: Research Source Type: research

Dual arterial thrombosis: A diagnostic enigma
Shasthara Paneyala, SC Nemichandra, Harsha Sundaramurthy, K Vimala Christina ColacoAnnals of African Medicine 2022 21(3):291-295 Cold agglutinin disease is a rare cause of arterial thrombosis leading to stroke, commonly encountered against a background of mycoplasma pneumonia infections. A 22-year-old patient presented with acute-onset left hemiplegia preceded by a short history of fever and cough. Magnetic resonance imaging (MRI) showed a right middle cerebral artery infarct. Serially repeated hemoglobin levels showed a progressive drop and peripheral smear showed evidence of hemolysis. Blood drawn for investigations wou...
Source: Annals of African Medicine - September 26, 2022 Category: African Health Authors: Shasthara Paneyala SC Nemichandra Harsha Sundaramurthy K Vimala Christina Colaco Source Type: research

Functional Assessment of Stroke-Induced Regulation of miR-20a-3p and Its Role as a Neuroprotectant
This study identifies and characterizes a specific member of the miR-17 –92 cluster, miR-20a-3p, as a possible stroke therapeutic. A comprehensive microRNA screening showed that miR-20a-3p was significantly upregulated in astrocytes of adult female rats, which typically have better stroke outcomes, while it was profoundly downregulated in astrocytes of middle-aged fem ales and adult and middle-aged males, groups that typically have more severe stroke outcomes. Assays using primary human astrocytes and neurons show that miR-20a-3p treatment alters mitochondrial dynamics in both cell types. To assess whether stroke outcome...
Source: Translational Stroke Research - April 27, 2022 Category: Neurology Source Type: research

Dolichoectasia: a brain arterial disease with an elusive treatment
We report four cases, all men 50 years or older. Of the two patients treated with doxycycline, we noted a slowdown of the basilar artery (BA) growth, but the BA continued to grow in the other patient. Of the two patients who received apixaban, none had a subsequent stroke in 5 and 4 years of follow-up, respectively. One patient was admitted with a fatal BA thrombosis and rupture, and pathological examination of the brain arteries demonstrated advanced arterial wall degeneration but no atherosclerosis.DISCUSSION: These cases exemplify the challenges of treating people with dolichoectasia and highlight the need for better ev...
Source: Atherosclerosis - April 20, 2022 Category: Cardiology Authors: Edgar R Lopez-Navarro Soojin Park Joshua Z Willey Jose Gutierrez Source Type: research

Functional Assessment of Stroke-Induced Regulation of miR-20a-3p and Its Role as a Neuroprotectant
This study identifies and characterizes a specific member of the miR-17-92 cluster, miR-20a-3p, as a possible stroke therapeutic. A comprehensive microRNA screening showed that miR-20a-3p was significantly upregulated in astrocytes of adult female rats, which typically have better stroke outcomes, while it was profoundly downregulated in astrocytes of middle-aged females and adult and middle-aged males, groups that typically have more severe stroke outcomes. Assays using primary human astrocytes and neurons show that miR-20a-3p treatment alters mitochondrial dynamics in both cell types. To assess whether stroke outcomes co...
Source: Cell Research - September 27, 2021 Category: Cytology Authors: Taylor E Branyan Amutha Selvamani Min Jung Park Kriti E Korula Kelby F Kosel Rahul Srinivasan Farida Sohrabji Source Type: research

Doxycycline for community treatment of suspected COVID-19 in people at high risk of adverse outcomes in the UK (PRINCIPLE): a randomised, controlled, open-label, adaptive platform trial
Lancet Respir Med. 2021 Jul 27:S2213-2600(21)00310-6. doi: 10.1016/S2213-2600(21)00310-6. Online ahead of print.ABSTRACTBACKGROUND: Doxycycline is often used for treating COVID-19 respiratory symptoms in the community despite an absence of evidence from clinical trials to support its use. We aimed to assess the efficacy of doxycycline to treat suspected COVID-19 in the community among people at high risk of adverse outcomes.METHODS: We did a national, open-label, multi-arm, adaptive platform randomised trial of interventions against COVID-19 in older people (PRINCIPLE) across primary care centres in the UK. We included peo...
Source: Respiratory Care - July 30, 2021 Category: Respiratory Medicine Authors: Christopher C Butler Ly-Mee Yu Jienchi Dorward Oghenekome Gbinigie Gail Hayward Benjamin R Saville Oliver Van Hecke Nicholas Berry Michelle A Detry Christina Saunders Mark Fitzgerald Victoria Harris Ratko Djukanovic Stephan Gadola John Kirkpatrick Simon d Source Type: research

A case of cerebral vasculitis due to neurobartonellosis
We report a case of a 60-year-old right-handed woman with hypertension, hyperlipidemia, and hypothyroidism who presented with a three-week history of recurrent thunderclap headaches accompanied by photophobia, phonophobia, nausea, and vomiting. She reported one brief episode of slurred speech, expressive aphasia, right facial droop, and right hemiparesis suggestive of a TIA. Family history was remarkable for primary angiitis of the CNS (PACNS) in the mother. Neurologic examination was unremarkable. CT of the head was negative; CT angiography (CTA) of the head and neck suggested fibromuscular dysplasia in bilateral cervical...
Source: Neurology Neuroimmunology and Neuroinflammation - June 3, 2020 Category: Neurology Authors: Poursheykhi, M., Mithani, F., Garg, T., Cajavilca, C., Jaijakul, S., Fung, S., Klucznik, R., Gadhia, R. Tags: All Headache, Vasculitis, All Cerebrovascular disease/Stroke Clinical/Scientific Notes Source Type: research

The bacteria stroke: Leclercia adecarboxylata folliculitis in a healthy swimmer —an emerging aquatic pathogen?
A 12-year-old healthy boy presented with a 2-month painful acneiform eruption. On exam erythematous follicular papules and pustules were scattered over bilateral shoulders and back. These surfaces were moderately tender to light palpation; the patient even complained that clothing in contact with his skin elicited pain. Doxycycline 75 mg po qd × 10 days was prescribed to cover common Staphylococcus aureus folliculitis. Due to the atypical presentation of significant pain, a bacterial culture was collected.
Source: Journal of the American Academy of Dermatology - August 2, 2018 Category: Dermatology Source Type: research

Long-Term Risk of Acute Myocardial Infarction, Stroke, and Death With Outpatient Use of Clarithromycin: A Retrospective Cohort Study
AbstractIn a retrospective cohort study of patients enrolled in the UK Clinical Practice Research Datalink during 2000 –2013, we evaluated long-term risks of death, stroke, and acute myocardial infarction (AMI) in adults prescribed clarithromycin. Patients were outpatients aged 40–85 years, who were prescribed clarithromycin (n = 287,748), doxycycline (n = 267,729), or erythromycin (n = 442,999), orHelicobacter pylori eradication therapy with a proton pump inhibitor, amoxicillin, and either clarithromycin (n = 27,639) or metronidazole (n = 14,863). We analyzed time to death, stroke, or AMI with Cox proportional hazards...
Source: American Journal of Epidemiology - September 20, 2017 Category: Epidemiology Source Type: research

Inhibition of Gelatinases (MMP-2 and MMP-9) by Withania somnifera Phytochemicals Confers Neuroprotection in Stroke: An In Silico Analysis
AbstractA stroke or cerebrovascular accident is a serious, life-threatening medical condition that occurs when the blood supply to part of the brain is severely reduced or cut off, depriving brain tissue of oxygen and nutrients. Studies suggested that level of gelatinases (MMP-2 and MMP-9) usually increases in the brain after stroke. The elevated activity of gelatinases plays the deleterious role in ischemic stroke, hemorrhagic stroke and perinatal hypoxic –ischemic brain injury. Therefore, matrix metalloproteinase (MMP)-2 and MMP-9 inhibition have therapeutic importance in stroke condition. Present in silico study inves...
Source: Interdisciplinary Sciences, Computational Life Sciences - May 9, 2017 Category: Bioinformatics Source Type: research

An unusual case of typhus group rickettsial infection presenting as cerebrovascular stroke
Publication date: Available online 10 November 2015 Source:Pediatric Infectious Disease Author(s): C.L. Srinivasa Murthy, P. Namitha, K. Raghavendra, Naveen Kumar, Rajath Pejaver Rickettsial diseases are a group of infections caused by obligate intracellular Gram-negative bacilli and transmitted to man by arthropod vectors. They are prevalent in many parts in India and are characterized by microvasculitis, causing microinfarcts in various organs. 1 Complications of rickettsial infection include pneumonias, renal failures, and neurological involvement. Neurological complications, such as meningitis and meningoencepha...
Source: Pediatric Infectious Disease - January 15, 2016 Category: Pediatrics Source Type: research

An unusual case of Typhus group rickettsial infection presenting as cerebrovascular stroke.
Publication date: Available online 10 November 2015 Source:Pediatric Infectious Disease Author(s): C L Srinivasa Murthy, P Namitha, K Raghavendra, Naveen Kumar, Rajath Pejaver Rickettsial diseases are a group of infections caused by obligate intracellular gram negative bacilli and transmitted to man by arthropod vectors. They are prevalent in many parts in India and are characterized by microvasculitis, causing microinfarcts in various organs 1). Complications of rickettsial infection include pneumonias, renal failures and neurological involvement. Neurological complications such as meningitis and meningoencephaliti...
Source: Pediatric Infectious Disease - November 10, 2015 Category: Pediatrics Source Type: research

Rethinking of doxycycline therapy in Creutzfeldt-Jakob disease
Compassionate use of doxycycline, a tetracycline antibiotic, in patients with Creutzfeldt-Jakob disease (CJD) revealed an increased survival of 4–7 months as compared with historical controls, a result not confirmed by a randomised, double blind, placebo-controlled trial.1 Is then therapy with doxycycline for patients with CJD over? The report of Assar et al2 on a single patient with variably protease-sensitive prionopathy (VPSPr),3 a rare subtype form of sporadic CJD, who received 4-year treatment with doxycycline at a relatively early stage of disease, suggests it is not and encourages novel studies on the use...
Source: Journal of Neurology, Neurosurgery and Psychiatry - June 12, 2015 Category: Neurosurgery Authors: Pocchiari, M., Ladogana, A. Tags: Dementia, Infection (neurology), Sleep disorders (neurology), Stroke, Variant Creutzfeld-Jakob Disease, Child and adolescent psychiatry, Memory disorders (psychiatry), Sleep disorders Editorial commentaries Source Type: research

Mortality of bullous pemphigoid in Singapore: risk factors and causes of death in 359 patients seen at the National Skin Centre.
CONCLUSION: This study confirmed an increased 3-year mortality rate for BP patients in Singapore. Risk factors for increased mortality include medical co-morbidities, especially neurological, cardiac and renal diseases. Treatment with combination therapy, including the use of low to moderate dose corticosteroid, appeared to decrease mortality risk in BP patients. This article is protected by copyright. All rights reserved. PMID: 24372558 [PubMed - as supplied by publisher]
Source: The British Journal of Dermatology - December 24, 2013 Category: Dermatology Authors: Cai SC, Allen JC, Lim YL, Chua SH, Tan SH, Tang MB Tags: Br J Dermatol Source Type: research