Filtered By:
Drug: Promethazine
This page shows you your search results in order of date.
Order by Relevance | Date
Total 22 results found since Jan 2013.
Phenothiazines reduced autophagy in ischemic stroke through endoplasmic reticulum (ER) stress-associated PERK-eIF2 α pathway
CONCLUSION: The combined treatment of C + P plays a crucial role in stroke therapy by inhibiting ER stress-mediated autophagy, thereby leading to reduced apoptosis and increased neuroprotection. Our findings highlight the PERK-eIF2α pathway as a central mechanism through which C + P exerts its beneficial effects. The results from this study may pave the way for the development of more targeted and effective treatments for stroke patients.PMID:37673390 | DOI:10.1016/j.expneurol.2023.114524
Source: Experimental Neurology - September 6, 2023 Category: Neurology Authors: Shuyu Lv Xiaokun Geng Ho Jun Yun Yuchuan Ding Source Type: research
Phenothiazine Inhibits Neuroinflammation and Inflammasome Activation Independent of Hypothermia After Ischemic Stroke
In conclusion, C + P treatment conferred neuroprotection in stroke by suppressing neuroinflammation and NLRP3 inflammasome activation. The present study suggests that JAK2/STAT3/p38/HIF-1α/FoxO1 are vital regulators and potential targets for efficacious therapy following ischemic stroke.PMID:34455546 | DOI:10.1007/s12035-021-02542-3
Source: Molecular Medicine - August 29, 2021 Category: Molecular Biology Authors: Sichao Guo Xiaokun Geng Hangil Lee Yuchuan Ding Source Type: research
Chlorpromazine and promethazine reduces Brain injury through RIP1-RIP3 regulated activation of NLRP3 inflammasome following ischemic stroke
Conclusion: These findings suggest that the anti-inflammatory effect of C + P may be dependent on drug-induced hypothermia and regulation of the NLRP3 inflammasome via the RIP1/RIP3 complex. Future investigations are needed regarding C + P as potential treatment of ischemic stroke.PMID:33829970 | DOI:10.1080/01616412.2021.1910904
Source: Neurological Research - April 8, 2021 Category: Neurology Authors: Qian Jiang M élissa Wills Xiaokun Geng Yuchuan Ding Source Type: research
An Inhibitory and Beneficial Effect of Chlorpromazine and Promethazine (C+P) on Hyperglycolysis through HIF-1 α Regulation in Ischemic Stroke
CONCLUSION: C+P, partially depending on hypothermia, attenuates hyperglycolysis and NOX activation through HIF-1α regulation.PMID:33811844 | DOI:10.1016/j.brainres.2021.147463
Source: Brain Research - April 3, 2021 Category: Neurology Authors: Sichao Guo Eric Cosky Fengwu Li Longfei Guan Yu Ji Wenjing Wei Changya Peng Xiaokun Geng Yuchuan Ding Source Type: research
Rapid Intervention of Chlorpromazine and Promethazine for Hibernation-Like Effect in Stroke: Rationale, Design, and Protocol for a Prospective Randomized Controlled Trial
This study on Rapid Intervention of Chlorpromazine and Promethazine for Hibernation-like Effect in Stroke (RICHES) will be the first prospective randomized controlled trial to ascertain the safety, feasibility, and preliminary efficacy of intravenous C+P as a neuroprotection strategy in AIS patients. These results will provide parameters for future studies, provide insights into treatment effects, and neuroprotection with phenothiazine in AIS.Clinical Trial Registration:www.chictr.org.cn, identifier: ChiCTR2000038727.
Source: Frontiers in Neurology - March 17, 2021 Category: Neurology Source Type: research
Neuroprotective Effects of Early Hypothermia Induced by Phenothiazines and DHC in Ischemic Stroke.
Conclusion: Both interischemia and inter-reperfusion pharmacological hypothermia treatments play a role in neuroprotection after stroke. Interischemia hypothermia treatment may be better able to induce stronger neuroprotection after ischemic stroke. This study provides a new avenue and reference for stronger neuroprotective hypothermia before vascular recanalization in stroke patients.
PMID: 33531913 [PubMed]
Source: Evidence-based Complementary and Alternative Medicine - February 4, 2021 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
Phosphoenolpyruvate Carboxykinase (PCK) in the Brain Gluconeogenic Pathway Contributes to Oxidative and Lactic Injury After Stroke
AbstractTo demonstrate the role of the rate-limiting and ATP-dependent gluconeogenic enzyme phosphoenolpyruvate carboxykinase (PCK) in oxidative and lactic stress and the effect of phenothiazine on PCK after stroke, a total of 168 adult male Sprague Dawley rats (3 months old, 280–300 g) underwent 2-h intraluminal middle cerebral artery occlusion (MCAO) and reperfusion for 6, 24, 48 h, or 7 days. Phenothiazine (chlorpromazine and promethazine (C+P)) (8 mg/kg) and 3-mercaptopicolinic acid (3-MPA, a PCK inhibitor, 100 μM) were administered at reperfusi on onset. The effects of phosphoenolpyruvate, 3-MPA, or PCK knoc...
Source: Molecular Neurobiology - January 8, 2021 Category: Neurology Source Type: research
Artificial Hibernation by Phenothiazines: A Potential Neuroprotective Therapy Against Cerebral Inflammation in Stroke.
CONCLUSION: This study showed an inhibitory effect of C+P on brain inflammation, which may be partially dependent on drug-induced hibernation, as well as other mechanisms of action by these drugs. These findings further suggest the great potential of C+P in the clinical treatment of ischemic stroke.
PMID: 31232236 [PubMed - as supplied by publisher]
Source: Current Neurovascular Research - June 23, 2019 Category: Neurology Authors: Guan L, Guo S, Yip J, Elkin KB, Li F, Peng C, Geng X, Ding Y Tags: Curr Neurovasc Res Source Type: research
Low dose concomitant treatment with chlorpromazine and promethazine is safe in acute ischemic stroke.
CONCLUSIONS: While the addition of low dose chlorpromazine and promethazine to standard of care for acute ischemic stroke did not have any significant improvement in functional outcomes, there were no serious adverse effects. Thus, the use of chlorpromazine and promethazine in the acute ischemic stroke setting and future studies using higher doses of C+P are justified.
PMID: 31096724 [PubMed - in process]
Source: Journal of Neurosurgical Sciences - May 19, 2019 Category: Neurosurgery Tags: J Neurosurg Sci Source Type: research
