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Total 295 results found since Jan 2013.
Abstract #140: BDNF Genotype and tDCS Interaction in Aphasia Therapy
Introduction: Using a double blinded randomized controlled trial, we evaluated the extent to which brain stimulation (anodal transcranial direct current stimulation [A-tDCS]) applied during speech therapy, was a futile adjunctive intervention to improve speech production (naming) in individuals with chronic post-stroke aphasia. This futility design evaluated a null hypothesis of 'A-tDCS results in better treatment outcome than sham tDCS.'
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - January 22, 2019 Category: Neurology Authors: Julius Fridriksson, Jordan Elm, Brielle C. Stark, Alexandra Basilakos, Chris Rorden, Souvik Sen, Mark George, Leonardo Bonilha Source Type: research
A pragmatic, adaptive clinical trial design for a rare disease: The FOcal Cerebral Arteriopathy Steroid (FOCAS) trial
We present a pragmatic approach to clinical trial design that may inform the approach to other rare disorders.
Source: Contemporary Clinical Trials - October 12, 2019 Category: Radiology Authors: Yeonhee Park, Heather J. Fullerton, Jordan J. Elm Source Type: research
Intensive LDL cholesterol-lowering treatment beyond current recommendations for the prevention of major vascular events: a systematic review and meta-analysis of randomised trials including 327 037 participants
Publication date: January 2020Source: The Lancet Diabetes & Endocrinology, Volume 8, Issue 1Author(s): Nelson Wang, Jordan Fulcher, Nishan Abeysuriya, Laura Park, Shejil Kumar, Gian Luca Di Tanna, Ian Wilcox, Anthony Keech, Anthony Rodgers, Sean LalSummaryBackgroundThe benefits of LDL cholesterol-lowering treatment for the prevention of atherosclerotic cardiovascular disease are well established. However, the extent to which these effects differ by baseline LDL cholesterol, atherosclerotic cardiovascular disease risk, and the presence of comorbidities remains uncertain.MethodsWe did a systematic literature search (MEDLINE,...
Source: The Lancet Diabetes and Endocrinology - December 18, 2019 Category: Endocrinology Source Type: research
Using novel magnetic resonance imaging methods to predict stroke risk in individuals with sickle cell anemia
Publication date: Available online 12 March 2020Source: Hematology/Oncology and Stem Cell TherapyAuthor(s): Lori C. Jordan, Adetola A. Kassim, Karina L. Wilkerson, Chelsea A. Lee, Spencer L. Waddle, Manus J. Donahue
Source: Hematology Oncology and Stem Cell Therapy - March 13, 2020 Category: Cancer & Oncology Source Type: research
COVID-19 Business Updates Provide Some Clarity
The unknowns still outnumber the knowns, but recent business updates provide some clarity around how the medical device industry is fairing during the COVID-19 pandemic. First and foremost, it is clear that companies are hurting in the areas of elective procedures, which are being deferred. But there may be some silver linings hidden amongst the bad news.
Needham & Co. medtech analyst Mike Matson estimates that medical device sales across the industry will continue to drop by an average of 40% to 50% until the economy begins to reopen and hospitals start to resume elective procedures.
Matson's e...
Source: MDDI - April 10, 2020 Category: Medical Devices Authors: Amanda Pedersen Tags: COVID-19 Business Source Type: news
Aspirin and other non-steroidal anti-inflammatory drugs for the prevention of dementia.
CONCLUSIONS: There is no evidence to support the use of low-dose aspirin or other NSAIDs of any class (celecoxib, rofecoxib or naproxen) for the prevention of dementia, but there was evidence of harm. Although there were limitations in the available evidence, it seems unlikely that there is any need for further trials of low-dose aspirin for dementia prevention. If future studies of NSAIDs for dementia prevention are planned, they will need to be cognisant of the safety concerns arising from the existing studies.
PMID: 32352165 [PubMed - in process]
Source: Cochrane Database of Systematic Reviews - April 29, 2020 Category: General Medicine Authors: Jordan F, Quinn TJ, McGuinness B, Passmore P, Kelly JP, Tudur Smith C, Murphy K, Devane D Tags: Cochrane Database Syst Rev Source Type: research
Predicting ambulatory recovery in acute ischemic stroke patients with thrombolytic therapy
Future Neurology, Ahead of Print.
Source: Future Neurology - May 10, 2020 Category: Neurology Authors: Matthew Scalise Leanne Brechtel Zachary Conn Benjamin Bailes Jordan Gainey Thomas I Nathaniel Source Type: research
Priapism in a patient with coronavirus disease 2019 (COVID-19): A case report
Thromboembolic complications related to SARS-CoV-2 have been extensively reported. They include deep vein thrombosis, pulmonary embolism, ischemic stroke, and acute coronary syndrome. Penile thrombosis has not been reported as a thrombotic complication of SARS-CoV-2 infection with hypercoagulability.Here we describe a case of priapism as a thromboembolic complication in a patient with COVID-19 who recovered from acute respiratory distress syndrome (ARDS). We discuss the underlying pathophysiological mechanisms mainly related to an hypercoagulability state.
Source: The American Journal of Emergency Medicine - June 16, 2020 Category: Emergency Medicine Authors: Myriam Lamamri, Ala Chebbi, Jordan Mamane, Sofia Abbad, Milena Munuzzolini, Florence Sarfati, St éphane Legriel Source Type: research
Involvement of the Benzodiazepine Site in the Anticonvulsant Activity of Tapinanthus globiferus against Pentylenetetrazole-induced Seizures in Mice
Planta Med DOI: 10.1055/a-1209-1254
Tapinanthus globiferus is often referred to as an all-purpose herb for the treatment of stroke and epilepsy. The present study investigates the anticonvulsant effect of methanolic leaf extract, active fractions, and lupeol (isolate) of Tapinanthus globiferus in mice as well as the underlying mechanisms. Following phytochemical studies of T. globiferus, preliminary assays were performed to evaluate MLE-induced toxic effect and behavioral changes. The pentylenetetrazol (70 mg/kg, i. p.)-induced seizure was evaluated in mice that were pretreated orally with vehicle 10 mL/kg, MLE (4...
Source: Planta Medica - July 14, 2020 Category: Drugs & Pharmacology Authors: Elusiyan, Christianah A. Faria, Ana Luiza Gon çalves Mendes, Ane Emanuelle Queiroga Silva, Irans é Oliveira Martins, Jos é Luis Rodrigues Rosa, Daniel Alves Pedrino, Gustavo Rodrigues Costa, Elson Alves Ibrahim, Mohamed Ali Zjawiony, Jordan K. Fajemiro Tags: Original Papers Source Type: research
Variation in Fluid and Vasopressor Use in Shock With and Without Physiologic Assessment: A Multicenter Observational Study
Conclusions:
The use of physiologic assessment in the 24 hours after shock onset is associated with increased use of vasopressor but not with fluid administration.
Source: Critical Care Medicine - September 12, 2020 Category: Emergency Medicine Tags: Clinical Investigations Source Type: research
Priapism in a patient with coronavirus disease 2019 (COVID-19)
Thromboembolic complications related to SARS-CoV-2 have been extensively reported. They include deep vein thrombosis, pulmonary embolism, ischemic stroke, and acute coronary syndrome. Penile thrombosis has not been reported as a thrombotic complication of SARS-CoV-2 infection with hypercoagulability.Here we describe a case of priapism as a thromboembolic complication in a patient with COVID-19 who recovered from acute respiratory distress syndrome (ARDS). We discuss the underlying pathophysiological mechanisms mainly related to an hypercoagulability state.
Source: The American Journal of Emergency Medicine - June 17, 2020 Category: Emergency Medicine Authors: Myriam Lamamri, Ala Chebbi, Jordan Mamane, Sofia Abbad, Milena Munuzzolini, Florence Sarfati, St éphane Legriel Tags: Case Report Source Type: research
Pharmacological targeting of coagulation factor XI mitigates the development of experimental atherosclerosis in low-density lipoprotein receptor-deficient mice.
CONCLUSION: Pharmacological targeting of FXI reduced atherogenesis in Ldlr-/- mice. Interference with the contact activation system may safely reduce development or progression of atherosclerosis.
PMID: 33421301 [PubMed - as supplied by publisher]
Source: Thrombosis and Haemostasis - January 9, 2021 Category: Hematology Authors: Ngo ATP, Jordan KR, Mueller PA, Hagen MW, Reitsma SE, Puy C, Revenko AS, Lorentz CU, Tucker EI, Cheng Q, Hinds MT, Fazio S, Monia BP, Gailani D, Gruber A, Tavori H, McCarty OJT Tags: J Thromb Haemost Source Type: research
Guillain-Barr é Syndrome Following Novel Coronavirus Disease 2019
: Novel Coronavirus Disease 2019 (COVID-19) has affected more than 89 million people worldwide. As the pandemic rages on, more complications of the disease are recognized including stroke, cardiovascular disease, thromboembolic events, encephalopathy, seizures and more. Peripheral nervous system involvement, particularly Guillain-Barre Syndrome (GBS) are of special interest given the increasing reports of cases related to COVID-19. Because of the potentially delayed onset of symptoms polyradiculoneuropathy and weakness after the traditional COVID-19 symptoms, it is vitally important for emergency physicians to be vigilant ...
Source: The Journal of Emergency Medicine - March 25, 2021 Category: Emergency Medicine Authors: Jordan Yakoby, Ilya Litvak, Edward Yu Tags: Adults Clinical Communications Source Type: research
Adherence to the 2019 AHA/ACC/HRS Focused Update of the 2014 AHA/ACC/HRS Guideline on the Use of Oral Anticoagulant Agents in Middle Eastern Patients with Atrial Fibrillation: The Jordan Atrial Fibrillation (JoFib) Study
CONCLUSIONS: The current status of the utilization of OACs in Middle Eastern AF patients appears to be promising and is consistent with the 2019 focused update of the 2014 AHA/ACC/HRS guideline. This trial is registered with NCT03917992.PMID:33898065 | PMC:PMC8052172 | DOI:10.1155/2021/5515089
Source: International Journal of Vascular Medicine - April 26, 2021 Category: Cardiology Authors: Ayman J Hammoudeh Yousef Khader Nazih Kadri Eyas Al-Mousa Yahya Badaineh Laith Habahbeh Ramzi Tabbalat Hesham Janabi Imad A Alhaddad Source Type: research
