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Total 19 results found since Jan 2013.

Predictors of stroke favorable functional outcome in guinea, results from the conakry stroke registry
Stroke epidemiology and health care systems are different in Low to middle income countries (LMIC) than in high income countries (HIC) failing HIC based predictive model.    We aimed at identifying the impact of modifiable variables in acute stroke management in Conakry, Guinea as potential predictors of favorable stroke outcome.
Source: Journal of Stroke and Cerebrovascular Diseases - March 20, 2022 Category: Neurology Authors: Cisse Abass Fode, Ligot No émie, Conde Kaba, Barry Souleymane Djigué, Toure Mohamed Lamine, Konate Mamadi, Soumah Fode Mohamed, Diawara Karinka, Traore Mohamed, Naeije Gilles Source Type: research

Minimal Setting Stroke Unit in a Sub-Saharan African Public Hospital
Introduction: Sub-Saharan Africa (SSA) has the highest stroke prevalence along with a case fatality that amounts to 40%. We aimed to assess the effect of a minimal setting stroke unit in SSA Public hospital on stroke mortality and main medical complications. Materials and Methods: The study was set in Conakry, Guinea, Ignace Deen public referral hospital. Clinical characteristics, hospital mortality and main medical stroke complications rates (pneumonia, urinary tract infections, sores and venous thromboembolism) of admitted stroke patients after the installation of a minimal stroke unit equipped with heart rate, bloo...
Source: Frontiers in Neurology - August 6, 2019 Category: Neurology Source Type: research

Translation into Spanish and a preliminary analysis of the psychometric properties of the Newcastle Stroke-Specific Quality of Life Measure (NEWSQOL) questionnaire for rating the quality of life among post-stroke patients.
CONCLUSION: The Spanish version of the NEWSQOL questionnaire is reliable for evaluating the quality of life in post-stroke patients, as well as being well accepted. The questionnaire must be used in more broader samples in order to evaluate its validity and sensitivity. PMID: 29178105 [PubMed - in process]
Source: Revista de Neurologia - November 29, 2017 Category: Neurology Authors: Soto-Vidal C, Pacheco-da-Costa S, Fernandez-Guinea S, Gallego-Izquierdo T Tags: Rev Neurol Source Type: research

IJERPH, Vol. 17, Pages 4237: Validation of the Spanish Version of Newcastle Stroke-Specific Quality of Life Measure (NEWSQOL)
Conclusion: The Spanish version of the NEWSQOL questionnaire is reliable, valid, and feasible to evaluate quality of life in the Spanish population.
Source: International Journal of Environmental Research and Public Health - June 13, 2020 Category: Environmental Health Authors: Concepci ón Soto-Vidal Soraya Pacheco-da-Costa Victoria Calvo-Fuente Sara Fern ández-Guinea Carlos Gonz ález-Alted Tom ás Gallego-Izquierdo Tags: Article Source Type: research

Cardiovascular Programming During and After Diabetic Pregnancy: Role of Placental Dysfunction and IUGR
This study demonstrated that the incidence of ischemic heart disease and death were three times higher among men with low birth weight compared to men with high birth weight (5). Epidemiological investigations of adults born at the time of the Dutch famine between 1944 and 1945 revealed an association between maternal starvation and a low infant birth weight with a high incidence of hypertension and coronary heart disease in these adults (23). Furthermore, Painter et al. reported the incidence of early onset coronary heart disease among persons conceived during the Dutch famine (24). In that regard, Barker's findin...
Source: Frontiers in Endocrinology - April 8, 2019 Category: Endocrinology Source Type: research

Is Aberrant Reno-Renal Reflex Control of Blood Pressure a Contributor to Chronic Intermittent Hypoxia-Induced Hypertension?
This study demonstrated unaltered vascular conductance in response to lumbar sympathetic stimulation in CIH-exposed rats. Aortic compliance was increased and estimated blood volume was unchanged in CIH-exposed rats. Increased blood pressure was related to an increase in cardiac output, which was confirmed by echocardiography (Lucking et al., 2014). It is suggested therefore that hypertension in the CIH model can be evoked by over-excitation of the cardiac arm of sympathetic nervous system (SNS), even before mechanisms of enhanced peripheral vasoconstriction and endothelial dysfunction are initiated (Naghshin et al., 2009)....
Source: Frontiers in Physiology - April 23, 2019 Category: Physiology Source Type: research

Reperfusion of cerebral artery thrombosis by the GPIb-VWF blockade with the Nanobody ALX-0081 reduces brain infarct size in guinea pigs
Thrombolytic therapy is the cornerstone of treatment of acute atherothrombotic ischemic stroke but is associated with brain hemorrhage; antiplatelet therapy has limited efficacy and is still associated with intracranial bleeding. Therefore, new antithrombotic approaches with a better efficacy/safety ratio are required. We have assessed the effect of ALX-0081, a Nanobody against the A1 domain of von Willebrand factor (VWF) that blocks VWF binding to GPIb, of the thrombolytic agent recombinant tissue plasminogen activator (rtPA), and of the GPIIb/IIIa antagonist tirofiban, in a middle cerebral artery (MCA) thrombosis model i...
Source: Blood - June 20, 2013 Category: Hematology Authors: Momi, S., Tantucci, M., Van Roy, M., Ulrichts, H., Ricci, G., Gresele, P. Tags: Platelets and Thrombopoiesis, Thrombosis and Hemostasis Source Type: research

Test of the Usefulness of a Paradigm to Identify Potential Cardiovascular Liabilities of Four Test Articles With Varying Pharmacological Properties in Anesthetized Guinea Pigs
This study aimed to establish the feasibility of an anesthetized guinea pig preparation to assess functional liabilities in the setting of simultaneous drug-induced electrocardiographic/hemodynamic changes, by evaluating the effects of various compounds with known cardiovascular properties on direct and indirect indices of left ventricular function. In short, twenty nine male guinea pigs were instrumented to measure electrocardiograms, systemic arterial pressure, and left ventricular pressure-volume relationships. After baseline measurement, all animals were given intravenous infusions of vehicle and two escalating concent...
Source: Toxicological Sciences - January 31, 2014 Category: Toxicology Authors: Kijtawornrat, A., Ueyama, Y., del Rio, C., Sawangkoon, S., Buranakarl, C., Chaiyabutr, N., Hamlin, R. L. Tags: Research Article Source Type: research

Citicoline retards myopia progression following form deprivation in guinea pigs
The retinal dopaminergic system is involved in the myopic shift following form deprivation. Citicoline has been demonstrated to stimulate the dopaminergic system in the brain and retina. Furthermore, citicoline has been used in many neurogenic diseases, such as senile cognitive impairment, stroke and Parkinson's disease as well as in amblyopia and glaucoma. Our aim was to investigate the effect of citicoline on the refractive state and retinal dopamine level in form deprivation myopia of guinea pigs. Guinea pigs, at an age of four weeks, were randomly divided into normal control, deprivation, deprived + citicoline and depr...
Source: Experimental Biology and Medicine - May 31, 2016 Category: Research Authors: Mao, J., Liu, S., Fu, C. Tags: Pharmacology/Toxicology Source Type: research

For Humanitarian Workers, Mental Health Needs Are Often Overlooked
July 19, 2017It ' s time to take mental well-being during complex emergencies seriously.In my family there was always a strong culture of suffering in silence. We were encouraged as children to ignore small injuries and illnesses, and to soldier on without complaint.I only realized the full extent of this embedded behavior when my elderly mother dislocated her shoulder and refused to go to the hospital for 24 hours, somehow believing that it would get better on its own.It has always been difficult to shake off this deeply ingrained sense that to ask for help is somehow weak. When, in a one year period, my son had a serious...
Source: IntraHealth International - July 19, 2017 Category: International Medicine & Public Health Authors: mnathe Source Type: news

Omecamtiv Mecarbil Abolishes Length-Mediated Increase in Guinea Pig Cardiac Myofiber Ca(2+) Sensitivity.
Abstract Omecamtiv mecarbil (OM) is a pharmacological agent that augments cardiac contractile function by enhancing myofilament Ca(2+) sensitivity. Given that interventions that increase myofilament Ca(2+) sensitivity have the potential to alter length-dependent activation (LDA) of cardiac myofilaments, we tested the influence of OM on this fundamental property of the heart. This is significant not only because LDA is prominent in cardiac muscle but also because it contributes to the Frank-Starling law, a mechanism by which the heart increases stroke volume in response to an increase in venous return. We measured ...
Source: Biophysical Journal - August 22, 2017 Category: Physics Authors: Gollapudi SK, Reda SM, Chandra M Tags: Biophys J Source Type: research

Prenatal hypoxia impairs cardiac mitochondrial and ventricular function in guinea pig offspring in a sex-related manner.
CONCLUSION: Prenatal HPX is a programming stimulus that increases MAP and decreases cardiac and mitochondrial function in male offspring. Sex-related differences in the contractile and mitochondrial responses suggest female GPs are protected against cardiovascular programming of prenatal HPX. PMID: 30365351 [PubMed - as supplied by publisher]
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - October 26, 2018 Category: Physiology Authors: Thompson LP, Chen L, Polster BM, Pinkas G, Song H Tags: Am J Physiol Regul Integr Comp Physiol Source Type: research

Stroking GUINEA PIGS helps people recover from catastrophic brain injuries
A study by the University of Basel found allowing traumatic brain injury patients to stroke 'cute animals' during rehabilitation sessions nearly doubled how chatty and positive they were.
Source: the Mail online | Health - April 9, 2019 Category: Consumer Health News Source Type: news

Isolation of Antimicrobial Compounds From Cnestis ferruginea Vahl ex. DC (Connaraceae) Leaves Through Bioassay-Guided Fractionation
Conclusion In conclusion, aqueous extracts of C. ferruginea leaves showed antimicrobial activity due to the presence of hydroquinone and caffeic acid methyl ester. This supports its traditional use for infections and confirmed that the active molecules are water-soluble. Author Contributions KK, SP, LVP, and WL conceived and designed the experiments. SP, KK, M-RY, and J-GL performed the experiments. SP, LVP, WL, M-RY, J-GL, and Z-HJ analyzed the data. WL and Z-HJ contributed reagents, materials, and analysis tools. KK, SP, WL, M-RY, Z-HJ, and LVP contributed to the writing of the manuscript. All authors contributed to m...
Source: Frontiers in Microbiology - April 10, 2019 Category: Microbiology Source Type: research

Introduction to Purinergic Signaling.
Abstract Purinergic signaling was proposed in 1972, after it was demonstrated that adenosine 5'-triphosphate (ATP) was a transmitter in nonadrenergic, noncholinergic inhibitory nerves supplying the guinea-pig taenia coli. Later, ATP was identified as an excitatory cotransmitter in sympathetic and parasympathetic nerves, and it is now apparent that ATP acts as a cotransmitter in most, if not all, nerves in both the peripheral nervous system and central nervous system (CNS). ATP acts as a short-term signaling molecule in neurotransmission, neuromodulation, and neurosecretion. It also has potent, long-term (trophic) ...
Source: Mol Biol Cell - October 27, 2019 Category: Molecular Biology Authors: Burnstock G Tags: Methods Mol Biol Source Type: research