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Condition: Aortic Stenosis
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Total 1228 results found since Jan 2013.
Routine cerebral embolic protection in transcatheter aortic valve implantation: rationale and design of the randomised British Heart Foundation PROTECT-TAVI trial
EuroIntervention. 2023 Jan 26:EIJ-D-22-00713. doi: 10.4244/EIJ-D-22-00713. Online ahead of print.ABSTRACTTranscatheter aortic valve implantation (TAVI) is an established treatment for aortic stenosis. Cerebral embolic protection (CEP) devices may impact periprocedural stroke by capturing debris destined for the brain. However, there is a lack of high-quality randomised trial evidence supporting the use of CEP during TAVI. The British Heart Foundation (BHF) PROTECT-TAVI trial will address whether the routine use of CEP reduces the incidence of stroke in patients undergoing TAVI. BHF PROTECT-TAVI is a prospective, open-label...
Source: EuroIntervention - January 27, 2023 Category: Cardiovascular & Thoracic Surgery Authors: Rajesh K Kharbanda Alexander David Perkins James Kennedy Adrian P Banning Andreas Baumbach Daniel J Blackman Matthew Dodd Richard Evans David Hildick-Smith Zahra Jamal Peter Ludman Stephen Palmer Rodney Stables Tim Clayton Source Type: research
Calcified Cerebral Emboli, A "Do Not Miss" Imaging Diagnosis: 22 New Cases and Review of the Literature FELLOWS' JOURNAL CLUB
CONCLUSIONS:
Calcified cerebral emboli are more common than previously assumed, are frequently overlooked or misinterpreted, affect clinical course when diagnosed, and carry substantial risk for recurrent stroke.
Source: American Journal of Neuroradiology - August 14, 2014 Category: Radiology Authors: Walker, B. S., Shah, L. M., Osborn, A. G. Tags: FELLOWS ' JOURNAL CLUB Source Type: research
The Heart and the Head Neurological Implications of Transcatheter Aortic Valve Replacement ∗
In this issue of the Journal, Bosmans et al. (1) report much-awaited stroke outcomes from the ADVANCE study, a multicenter, prospective, nonrandomized cohort of patients undergoing transcatheter aortic valve replacement (TAVR) with the CoreValve prosthesis (Medtronic Inc., Minneapolis, Minnesota) at 44 mostly European sites between March 2010 and July 2011. In this real-world cohort of patients with severe aortic stenosis, the investigators observed stroke rates of 3.0% at 30 days post-TAVR and 5.6% at 2 years. They reported no significant predictors of periprocedural stroke or transient ischemic attack (TIA) occurring ...
Source: Journal of the American College of Cardiology - July 13, 2015 Category: Cardiology Source Type: research
Low-Flow, Low-Gradient Severe Aortic Stenosis in the Setting of Constrictive Pericarditis: Clinical Characteristics, Echocardiographic Features, and Outcomes Valvular Heart Disease
Conclusions—
Our findings highlighted the possibility of CP as a pathophysiological mechanism for low-flow, low-gradient AS. Left ventricular stroke volume index and transaortic gradients were commonly reduced in AS in the setting of CP despite a preserved left ventricular ejection fraction, which may result in underestimation of AS severity. Prior mediastinal radiation, lower left ventricular stroke volume index, and concomitant CP were associated with poorer survival in AS patients.
Source: Circulation: Cardiovascular Imaging - July 14, 2015 Category: Radiology Authors: Tsang, M. Y. C., Choi, J.-O., Borlaug, B. A., Greason, K. L., Cha, S. S., Nishimura, R. A., Oh, J. K. Tags: Pericardial disease, Valvular heart disease, Echocardiography Source Type: research
Clinical outcomes of transcatheter aortic valve implantation in failed bioprosthetic surgical valves vs. native aortic stenosis: insights from a meta-analysis
AbstractThere is no meta-analysis comparing clinical outcomes between valve-in-valve transcatheter aortic valve implantation for failed surgical bioprosthetic valves (ViV-TAVI) and native valve TAVI for aortic stenosis (NV-TAVI). We aimed to investigate clinical outcomes between ViV-TAVI and NV-TAVI using a meta-analysis. EMBASE and MEDLINE were searched through April 2020 to investigate the comparative outcomes between ViV-TAVI and NV-TAVI. The main outcomes were short-term (30-day/in-hospital) mortality, pacemaker implantation (PMI), life threatening and/or major bleeding, stroke, and coronary obstruction, and long-term ...
Source: Cardiovascular Intervention and Therapeutics - November 18, 2020 Category: Cardiology Source Type: research
Treatment of aortic stenosis with a self-expanding transcatheter valve: the International Multi-centre ADVANCE Study
Conclusion
The ADVANCE study demonstrates the safety and effectiveness of the CoreValve System with low mortality and stroke rates in higher risk real-world patients with severe aortic stenosis.
Source: European Heart Journal - October 7, 2014 Category: Cardiology Authors: Linke, A., Wenaweser, P., Gerckens, U., Tamburino, C., Bosmans, J., Bleiziffer, S., Blackman, D., Schafer, U., Muller, R., Sievert, H., Sondergaard, L., Klugmann, S., Hoffmann, R., Tchetche, D., Colombo, A., Legrand, V. M., Bedogni, F., lePrince, P., Schu Tags: TAVI Source Type: research
300 * influence of different pacemaker stimulation modes in patients with ventricular hypertrophy
Conclusion: An increase in the heart rate does not lead to a notable drop in stroke volume postoperatively in left-ventricular hypertrophy; hence a rise in cardiac output can be anticipated up to a rate of 100 bpm. A standardised response in terms of an ideal pacemaker stimulation mode could not be identified.
Source: Interactive CardioVascular and Thoracic Surgery - September 23, 2014 Category: Cardiovascular & Thoracic Surgery Authors: Kiessling, A. H., Elhadouchi, L., Miskovic, A., Reyher, C., Stock, U. A., Moritz, A. Tags: Infective endocarditis and outcomes Source Type: research
2-Year Outcomes After Iliofemoral Self-Expanding Transcatheter Aortic Valve Replacement in Patients With Severe Aortic Stenosis Deemed Extreme Risk for Surgery
ConclusionsPatients with severe AS at extreme surgical risk treated with self-expanding TAVR continued to show good clinical outcomes and hemodynamic valve performance at 2 years. The presence of comorbid conditions rather than valve performance affected 2-year outcomes in these patients. (Safety and Efficacy Study of the Medtronic CoreValve System in the Treatment of Symptomatic Severe Aortic Stenosis in High Risk and Very High Risk Subjects Who Need Aortic Valve Replacement; NCT01240902)
Source: Journal of the American College of Cardiology - September 14, 2015 Category: Cardiology Source Type: research
One-Year Outcomes of Transcatheter Aortic Valve Replacement in Patients With End-Stage Renal Disease
Conclusions Early mortality in patients with ESRD is comparable to previously published data on extreme-risk patients without ESRD, but our data suggest a higher mortality rate at 1 year for ESRD patients, likely due to comorbid conditions. Stroke and major vascular injury are infrequent, and improved valve hemodynamics are maintained at 1 year.
Source: The Annals of Thoracic Surgery - April 18, 2017 Category: Cardiovascular & Thoracic Surgery Source Type: research
Sex-Specific Outcomes of Transcatheter Aortic Valve Replacement With the SAPIEN 3 Valve: Insights From the PARTNER II S3 High-Risk and Intermediate-Risk Cohorts
Conclusions
The study found no apparent sex-specific differences in survival or stroke in this trial of TAVR. This may reflect the changing demographic of patients enrolled, use of newer-generation valves with more sizes available, and more accurate valve sizing techniques.
Source: Journal of the American College of Cardiology: Cardiovascular Interventions - January 1, 2018 Category: Cardiology Authors: Szerlip, M., Gualano, S., Holper, E., Squiers, J. J., White, J. M., Doshi, D., Williams, M. R., Hahn, R. T., Webb, J. G., Svensson, L. G., Kirtane, A. J., Cohen, D. J., Douglas, P. S., Alu, M. C., Crowley, A., Tuzcu, E. M., Makkar, R. R., Herrmann, H. C., Tags: Focus on Cardiovascular Outcomes Among Women Source Type: research
Neuroprotective measures throughout the TAVI pathway.
Authors: Shiyoich A, Kornowski R
Abstract
Aortic stenosis (AS) is the most common clinical valvular heart disorder that warrants active treatment. Symptomatic and severe AS is associated with increased morbidity and mortality if left untouched. Transcatheter aortic valve implantation (TAVI) is an innovative therapeutic modality approved initially for patients with prohibitive surgical risk and subsequently became a mainstream practice and the preferred treatment modality for many patients with severe AS at high and moderate surgical risk. Consistently global TAVI volumes have increased and indications continue to w...
Source: Minerva Cardioangiologica - July 18, 2018 Category: Cardiology Tags: Minerva Cardioangiol Source Type: research
Biomechanics of Human Fetal Hearts with Critical Aortic Stenosis.
Abstract
Critical aortic stenosis (AS) of the fetal heart causes a drastic change in the cardiac biomechanical environment. Consequently, a substantial proportion of such cases will lead to a single-ventricular birth outcome. However, the biomechanics of the disease is not well understood. To address this, we performed Finite Element (FE) modelling of the healthy fetal left ventricle (LV) based on patient-specific 4D ultrasound imaging, and simulated various disease features observed in clinical fetal AS to understand their biomechanical impact. These features included aortic stenosis, mitral regurgitation (MR) an...
Source: Annals of Biomedical Engineering - November 11, 2020 Category: Biomedical Engineering Authors: Ong CW, Ren M, Wiputra H, Mojumder J, Chan WX, Tulzer A, Tulzer G, Buist ML, Mattar CNZ, Lee LC, Yap CH Tags: Ann Biomed Eng Source Type: research
Transcatheter aortic valve implantation versus surgical aortic valve replacement in patients with severe aortic stenosis: a systematic review and meta-analysis
Conclusions
No overall change in the risk of death from any cause or cardiovascular mortality was identified but 95% CIs were often wide, indicating uncertainty. TAVI may reduce the risk of certain side effects while SAVR may reduce the risk of others. Most long-term (5-year) results are limited to older patients at high surgical risk (ie, early trials), therefore more data are required for low risk populations. Ultimately, neither surgical technique was considered dominant, and these results suggest that every patient with SAS should be individually engaged in SDM to make evidence-based, personalised decisions around thei...
Source: BMJ Open - December 6, 2021 Category: General Medicine Authors: Swift, S. L., Puehler, T., Misso, K., Lang, S. H., Forbes, C., Kleijnen, J., Danner, M., Kuhn, C., Haneya, A., Seoudy, H., Cremer, J., Frey, N., Lutter, G., Wolff, R., Scheibler, F., Wehkamp, K., Frank, D. Tags: Open access, Cardiovascular medicine Source Type: research
Association of Mild Valvular Lesions With Long-term Cardiovascular Outcomes Among Black Adults
CONCLUSIONS AND RELEVANCE: Results of this study indicate an association between valvular lesions, even at mild stage, and a long-term risk of cardiovascular events, suggesting the importance of recognizing and monitoring these valvular conditions.PMID:35552723 | DOI:10.1001/jamanetworkopen.2022.11946
Source: Atherosclerosis - May 13, 2022 Category: Cardiology Authors: Kunihiro Matsushita Yumin Gao Jonathan Rubin Ajay J Kirtane Susheel Kodali Elizabeth Selvin Alvaro Alonso Martin B Leon Scott D Solomon Josef Coresh Ervin R Fox Amil M Shah Source Type: research
Clinical implications for diffusion‐weighted MRI brain lesions associated with transcatheter aortic valve replacement
Transcatheter aortic valve replacement (TAVR) is increasingly used to treat patients with aortic stenosis deemed high or extreme surgical risk candidates. Despite improved survival and quality of life following the procedure, TAVR is not without its complications. Stroke is a major source of morbidity and mortality in patients undergoing the procedure, with rates similar to and often higher than those associated with surgery. Most studies show a consistent link between TAVR and embolic lesions visualized on diffusion‐weighted magnetic resonance imaging. The question of whether these lesions lead to long‐term cognitive ...
Source: Catheterization and Cardiovascular Interventions - April 9, 2013 Category: Cardiovascular & Thoracic Surgery Authors: Stephanie M. Meller, Andreas Baumbach, Adam M. Brickman, Alexandra J. Lansky Tags: Valvular and Structural Heart Diseases Source Type: research
