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Total 644 results found since Jan 2013.

Poloxamer 188 (P188), A Potential Polymeric Protective Agent for Central Nervous System Disorders: A Systematic Review
Curr Neuropharmacol. 2021 May 28. doi: 10.2174/1570159X19666210528155801. Online ahead of print.ABSTRACTPoloxamer 188 (P188) is an FDA-approved biocompatible block copolymer composed of repeating units of poly(ethylene oxide) (PEO) and poly(propylene oxide) (PPO). Due to its amphiphilic nature and high hydrophile-lipophile balance (HLB) value of 29, P188 is used as a stabilizer/emulsifier in many cosmetics and pharmaceuticals preparations. While the applications of P188 as an excipient are widely explored, the data on the pharmacological activity of P188 are scarce. Notably, the neuroprotective potential of P188 has gained...
Source: Current Neuropharmacology - June 2, 2021 Category: Drugs & Pharmacology Authors: Win Ning Chen Mohd Farooq Shaikh Saatheeyavaane Bhuvanendran Abhijit Date Mohammad Tahir Ansari Ammu Kutty Radhakrishnan Iekhsan Othman Source Type: research

Scientists discover a new genetic form of ALS in children
(NIH/National Institute of Neurological Disorders and Stroke) In a study of 11 medical-mystery patients, an international team of researchers led by scientists at the National Institutes of Health and the Uniformed Services University (USU) discovered a new and unique form of amyotrophic lateral sclerosis (ALS). Unlike most cases of ALS, the disease began attacking these patients during childhood, worsened more slowly than usual, and was linked to a gene, called SPTLC1, that is part of the body's fat production system.
Source: EurekAlert! - Medicine and Health - May 31, 2021 Category: International Medicine & Public Health Source Type: news

Molecules, Vol. 26, Pages 3208: Progress in PET Imaging of Neuroinflammation Targeting COX-2 Enzyme
hn Mann Neuroinflammation and cyclooxygenase-2 (COX-2) upregulation are associated with the pathogenesis of degenerative brain diseases such as Alzheimer’s disease (AD), Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS), epilepsy, and a response to traumatic brain injury (TBI) or stroke. COX-2 is also induced in acute pain, depression, schizophrenia, various cancers, arthritis and in acute allograft rejection. Positron emission tomography (PET) imaging allows for the direct measurement of in vivo COX-2 upregulation and thereby enables disease staging, therapy evaluation and aid quantifying target occupa...
Source: Molecules - May 27, 2021 Category: Chemistry Authors: Jaya Prabhakaran Andrei Molotkov Akiva Mintz J. John Mann Tags: Review Source Type: research

Toll ‐like receptors in neuroinflammation, neurodegeneration and alcohol‐induced brain damage
This article is protected by copyright. All rights reserved.
Source: IUBMB Life - May 26, 2021 Category: Research Authors: Mar ía Pascual, Maria Calvo‐Rodriguez, Lucía Núñez, Carlos Villalobos, Juan Ureña, Consuelo Guerri Tags: CRITICAL REVIEW Source Type: research

A Study to Decipher the Potential Effects of Butylphthalide against Central Nervous System Diseases Based on Network Pharmacology and Molecular Docking Integration Strategy
CONCLUSIONS: Our study proposed a drug-target-disease integrated method to predict the drug repurposing potentials to associated diseases by application of NP and MD, which could be an attractive alternative to facilitate the development of CNS disease therapies. NBP may be promising and showed potentials to be repurposed for treatments for AD, epilepsy, ALS, and depression, and further investigations are warranted to be carefully designed and conducted.PMID:34035826 | PMC:PMC8116153 | DOI:10.1155/2021/6694698
Source: Molecular Medicine - May 26, 2021 Category: Molecular Biology Authors: Qinqin Zhao Bei Zheng Pinpin Feng Xiang Li Source Type: research

Edaravone attenuates H 2 O 2 or glutamate-induced toxicity in hippocampal neurons and improves AlCl 3 /D-galactose induced cognitive impairment in mice
Neurotoxicology. 2021 May 15:S0161-813X(21)00050-4. doi: 10.1016/j.neuro.2021.05.005. Online ahead of print.ABSTRACTEdaravone (Eda) is a radical scavenger used in clinical trials for the treatment of ischemic stroke and amyotrophic lateral sclerosis. However, how Eda exerts its neuroprotective effects remains to be elucidated. We investigated the neuroprotective effects of Eda in cultured hippocampal neurons and in a mouse model of AlCl3/D-galactose-induced cognitive impairment. Eda protected hippocampal neurons by eliminating H2O2 or glutamate-induced toxicity, leading to decreased cell viability and neurite shortening. C...
Source: Neurotoxicology - May 18, 2021 Category: Neurology Authors: Huan-Tong Wu Yun Yu Xi-Xi Li Xiu-Yuan Lang Run-Ze Gu Sheng-Rui Fan Xin Fang Jin-Peng Bai Rongfeng Lan Xiao-Yan Qin Source Type: research

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