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Total 644 results found since Jan 2013.

Edaravone attenuates H 2 O 2 or glutamate-induced toxicity in hippocampal neurons and improves AlCl 3 /D-galactose induced cognitive impairment in mice
Neurotoxicology. 2021 May 15;85:68-78. doi: 10.1016/j.neuro.2021.05.005. Online ahead of print.ABSTRACTEdaravone (Eda) is a free radical scavenger used in clinical trials for the treatment of ischemic stroke and amyotrophic lateral sclerosis. However, how Eda exerts its neuroprotective effects remains to be elucidated. We investigated the neuroprotective effects of Eda in cultured hippocampal neurons and in a mouse model of AlCl3/D-galactose-induced cognitive impairment. Eda protected hippocampal neurons by eliminating H2O2 or glutamate-induced toxicity, leading to decreased cell viability and neurite shortening. Consisten...
Source: Neurotoxicology - May 18, 2021 Category: Neurology Authors: Huan-Tong Wu Yun Yu Xi-Xi Li Xiu-Yuan Lang Run-Ze Gu Sheng-Rui Fan Xin Fang Jin-Peng Bai Rongfeng Lan Xiao-Yan Qin Source Type: research

Metabolic Aspects of Adenosine Functions in the Brain
Adenosine, acting both through G-protein coupled adenosine receptors and intracellularly, plays a complex role in multiple physiological and pathophysiological processes by modulating neuronal plasticity, astrocytic activity, learning and memory, motor function, feeding, control of sleep and aging. Adenosine is involved in stroke, epilepsy and neurodegenerative pathologies. Extracellular concentration of adenosine in the brain is tightly regulated. Adenosine may be generated intracellularly in the central nervous system from degradation of AMP or from the hydrolysis of S-adenosyl homocysteine, and then exit via bi-directio...
Source: Frontiers in Pharmacology - May 14, 2021 Category: Drugs & Pharmacology Source Type: research

Arachidonic Acid Metabolites in Neurologic Disorders
CONCLUSION: In this review, we discuss experimental and human study results of neurologic disorders related to ARA and its metabolites in line with treatment options.PMID:33982658 | DOI:10.2174/1871527320666210512013648
Source: CNS and Neurological Disorders Drug Targets - May 13, 2021 Category: Drugs & Pharmacology Authors: Oguzhan Kursun Hulya Karatas Hulagu Bariskaner Serefnur Ozturk Source Type: research

Articulatory Correlates of Stress Pattern Disturbances in Talkers With Dysarthria
Conclusions In general, significant stress effects were observed in talkers with dysarthria. However, stress-specific between-group differences in articulatory performance, particularly displacement, may explain the perceptual impression of disturbed stress patterns. Furthermore, similar findings for ALS and MS suggest that articulatory deficits underlying similar stress pattern disturbances are not disease-specific.PMID:33984259 | DOI:10.1044/2021_JSLHR-20-00299
Source: Journal of speech, language, and hearing research : JSLHR - May 13, 2021 Category: Speech-Language Pathology Authors: Daniel Kim Mili Kuruvilla-Dugdale Michael de Riesthal Robin Jones Francesca Bagnato Antje Mefferd Source Type: research

Properties and reactivity of the folic acid and folate photoproduct 6-formylpterin
Free Radic Biol Med. 2021 May 6:S0891-5849(21)00283-5. doi: 10.1016/j.freeradbiomed.2021.05.002. Online ahead of print.ABSTRACTFolates (vitamin B9) are essential components of our diet and our gut microbiota. They are omnipresent in our cells and blood. Folates are necessary for DNA synthesis, methylation, and other vital bioprocesses. Folic acid (FA), as the synthetic form of folates, is largely found in supplements and fortified foods. FA and folate drugs are also extensively used as therapeutics. Therefore, we are continuously exposed to the pterin derivatives, and their photo-degradation products, such as 6-formylpteri...
Source: Free Radical Biology and Medicine - May 9, 2021 Category: Biology Authors: Goossens Jean-Fran çois Xavier Thuru Christian Bailly Source Type: research

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