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Total 644 results found since Jan 2013.

The Role of Mitochondrial Genes in Neurodegenerative Disorders
Curr Neuropharmacol. 2021 Sep 8. doi: 10.2174/1570159X19666210908163839. Online ahead of print.ABSTRACTMitochondrial disorders are clinically heterogeneous, resulting from nuclear gene and mitochondrial mutations that disturb the mitochondrial functions and dynamics. There is a lack of evidence linking mtDNA mutations to neurodegenerative disorders, mainly due to the absence of noticeable neuropathological lesions in postmortem samples. This review describes various gene mutations in Alzheimer's disease, Parkinson's disease, Amyotrophic Lateral Sclerosis, Multiple Sclerosis, and Stroke. These abnormalities, including PINK1...
Source: Current Neuropharmacology - September 10, 2021 Category: Drugs & Pharmacology Authors: Rajesh Kumar Seetha Harilal Della Grace Thomas Parambi S K Kanthlal Md Atiar Rahman Athanasios Alexiou Gaber El-Saber Batiha Bijo Mathew Source Type: research

Molecules, Vol. 26, Pages 4700: The Therapeutic Potential of Celastrol in Central Nervous System Disorders: Highlights from In Vitro and In Vivo Approaches
Trabace Celastrol, the most abundant compound derived from the root of Tripterygium wilfordii, largely used in traditional Chinese medicine, has shown preclinical and clinical efficacy for a broad range of disorders, acting via numerous mechanisms, including the induction of the expression of several neuroprotective factors, the inhibition of cellular apoptosis, and the decrease of reactive oxygen species (ROS). Given the crucial implication of these pathways in the pathogenesis of Central Nervous System disorders, both in vitro and in vivo studies have focused their attention on the possible use of this compound in th...
Source: Molecules - August 3, 2021 Category: Chemistry Authors: Stefania Schiavone Maria Grazia Morgese Paolo Tucci Luigia Trabace Tags: Review Source Type: research

Efficient Roles of miR-146a in Cellular and Molecular Mechanisms of Neuroinflammatory Disorders: An Effectual Review in Neuroimmunology
This study aims to provide a meticulous review regarding the roles of miR-146a in the pathogenesis and progression of several neuroinflammatory disorders such as multiple sclerosis, amyotrophic lateral sclerosis, Alzheimer's disease, temporal lobe epilepsy, and ischemic stroke, etc. The study also considers its eligibility for use as an ideal biomarker and therapeutic target in these diseases. The awareness of these mechanisms can facilitate the disease management/treatment, lead to patients' amelioration, improve the quality of life, and mitigate the risk of death.PMID:34293378 | DOI:10.1016/j.imlet.2021.07.004
Source: Immunology Letters - July 22, 2021 Category: Allergy & Immunology Authors: Mona Aslani Seyed Shahabeddin Mortazavi-Jahromi Abbas Mirshafiey Source Type: research

Efficient roles of miR-146a in cellular and molecular mechanisms of neuroinflammatory disorders: An effectual review in neuroimmunology
This study aims to provide a meticulous review regarding the roles of miR-146a in the pathogenesis and progression of several neuroinflammatory disorders such as multiple sclerosis, amyotrophic lateral sclerosis, Alzheimer's disease, temporal lobe epilepsy, ischemic stroke, etc. The study also considers its eligibility for use as an ideal biomarker and therapeutic target in these diseases. The awareness of these mechanisms can facilitate the disease management/treatment, lead to patients' amelioration, improve the quality of life, and mitigate the risk of death.PMID:34293378 | DOI:10.1016/j.imlet.2021.07.004
Source: Immunology Letters - July 22, 2021 Category: Allergy & Immunology Authors: Mona Aslani Seyed Shahabeddin Mortazavi-Jahromi Abbas Mirshafiey Source Type: research

Efficient Roles of miR-146a in Cellular and Molecular Mechanisms of Neuroinflammatory Disorders: An Effectual Review in Neuroimmunology
This study aims to provide a meticulous review regarding the roles of miR-146a in the pathogenesis and progression of several neuroinflammatory disorders such as multiple sclerosis, amyotrophic lateral sclerosis, Alzheimer's disease, temporal lobe epilepsy, and ischemic stroke, etc. The study also considers its eligibility for use as an ideal biomarker and therapeutic target in these diseases. The awareness of these mechanisms can facilitate the disease management/treatment, lead to patients' amelioration, improve the quality of life, and mitigate the risk of death.PMID:34293378 | DOI:10.1016/j.imlet.2021.07.004
Source: Immunology Letters - July 22, 2021 Category: Allergy & Immunology Authors: Mona Aslani Seyed Shahabeddin Mortazavi-Jahromi Abbas Mirshafiey Source Type: research

Role of microbiota-derived short-chain fatty acids in nervous system disorders
Biomed Pharmacother. 2021 Jul;139:111661. doi: 10.1016/j.biopha.2021.111661. Epub 2021 May 8.ABSTRACTDuring the past decade, accumulating evidence from the research highlights the suggested effects of bacterial communities of the human gut microbiota and their metabolites on health and disease. In this regard, microbiota-derived metabolites and their receptors, beyond the immune system, maintain metabolism homeostasis, which is essential to maintain the host's health by balancing the utilization and intake of nutrients. It has been shown that gut bacterial dysbiosis can cause pathology and altered bacterial metabolites' fo...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 10, 2021 Category: Drugs & Pharmacology Authors: Rasoul Mirzaei Behnaz Bouzari Seyed Reza Hosseini-Fard Maryam Mazaheri Yaghoub Ahmadyousefi Milad Abdi Saba Jalalifar Zahra Karimitabar Ali Teimoori Hossein Keyvani Farhad Zamani Rasoul Yousefimashouf Sajad Karampoor Source Type: research

Novel Drug Delivery System for Curcumin: Implementation to Improve Therapeutic Efficacy against Neurological Disorders
Conclusion: The review also summarises the numerous toxicological studies and the role of curcumin in CNS disorders.PMID:34225614 | DOI:10.2174/1386207324666210705114058
Source: Combinatorial Chemistry and High Throughput Screening - July 6, 2021 Category: Chemistry Authors: Roohi Mohi-Ud-Din Reyaz Hassan Mir Taha Umair Wani Abdul Jalil Shah Ishtiyaq Mohi-Ud-Din Mudasir Ahmad Dar Faheem Hyder Pottoo Source Type: research

Dynamic nanoassemblies for imaging and therapy of neurological disorders
Adv Drug Deliv Rev. 2021 Jun 16:113832. doi: 10.1016/j.addr.2021.113832. Online ahead of print.ABSTRACTThe past decades have witnessed an increased incidence of neurological disorders (NDs) such as Alzheimer's disease, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, ischemic stroke, and epilepsy, which significantly lower patients' life quality and increase the economic and social burden. Recently, nanomedicines composed of imaging and/or therapeutic agents have been explored to diagnose and/or treat NDs due to their enhanced bioavailability, blood-brain barrier (BBB) permeability, and targeting c...
Source: Advanced Drug Delivery Reviews - June 19, 2021 Category: Drugs & Pharmacology Authors: Lingxiao Zhang Heng Sun Jing Zhao Jiyoung Lee Liang Ee Low Linji Gong Ying Chen Nan Wang Chaojie Zhu Peihua Lin Zeyu Liang Min Wei Daishun Ling Fangyuan Li Source Type: research