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Total 197 results found since Jan 2013.

Disruptions of Anaerobic Gut Bacteria Are Associated with Stroke and Post-stroke Infection: a Prospective Case –Control Study
In conclusion, aberrations in trimethylamine- and butyrate-producing gut bacteria are associated with stroke and stroke-associated infections.
Source: Translational Stroke Research - October 14, 2020 Category: Neurology Source Type: research

Dysbiosis of Gut Microbiota With Reduced Trimethylamine-N-Oxide Level in Patients With Large-Artery Atherosclerotic Stroke or Transient Ischemic Attack Stroke
Conclusions Participants with asymptomatic atherosclerosis did not exhibit an obvious change in gut microbiota and blood TMAO levels; however, stroke and transient ischemic attack patients showed significant dysbiosis of the gut microbiota, and their blood TMAO levels were decreased.
Source: JAHA:Journal of the American Heart Association - November 23, 2015 Category: Cardiology Authors: Yin, J., Liao, S.-X., He, Y., Wang, S., Xia, G.-H., Liu, F.-T., Zhu, J.-J., You, C., Chen, Q., Zhou, L., Pan, S.-Y., Zhou, H.-W. Tags: Stroke Source Type: research

Gut Microbiota in Ischemic Stroke: Role of Gut Bacteria-Derived Metabolites
AbstractIschemic stroke (IS) remains a leading cause of death and long-term disability globally. Several mechanisms including glutamate excitotoxicity, calcium overload, neuroinflammation, oxidative stress, mitochondrial damage, and apoptosis are known to be involved in the pathogenesis of IS, but the underlying pathophysiology mechanisms of IS are not fully clarified. During the past decade, gut microbiota were recognized as a key regulator to affect the health of the host either directly or via their metabolites. Recent studies indicate that gut bacterial dysbiosis is closely related to hypertension, diabetes, obesity, d...
Source: Translational Stroke Research - October 24, 2022 Category: Neurology Source Type: research

Reducing the Risk of Stroke in Patients with Impaired Renal Function: Nutritional Issues
Patients with renal failure have extremely high cardiovascular risk; in dialysis patients the risk of stroke is increased approximately 10-fold over that in the general population. Reasons include not only a high prevalence of traditional risk factors such as diabetes, hypertension and dyslipidemia, but also the accumulation of toxic substances that are eliminated by the kidneys, so have very high levels in patients with renal failure. These include plasma total homocysteine, asymmetric dimethylarginine, thiocyanate, and toxic products of the intestinal microbiome (Gut-Derived Uremic Toxins; GDUT), which include trimethyla...
Source: Journal of Stroke and Cerebrovascular Diseases - November 17, 2020 Category: Neurology Authors: J. David Spence Tags: Review Article Source Type: research

Stroke Dysbiosis Index (SDI) in Gut Microbiome Are Associated With Brain Injury and Prognosis of Stroke
Conclusions: We developed an index to measure gut microbiota dysbiosis in stroke patients; this index was significantly correlated with patients' outcome and was causally related to outcome in a mouse model of stroke. Our model facilitates the potential clinical application of gut microbiota data in stroke and adds quantitative evidence linking the gut microbiota to stroke. Introduction Ischemic stroke imposes a heavy burden on society, with 24.9 million cases worldwide (1). Although intravenous thrombolysis and endovascular treatment greatly improve some patients' prognosis, the prognosis for most pa...
Source: Frontiers in Neurology - April 23, 2019 Category: Neurology Source Type: research

1H NMR-Based Metabolomics Reveals Refined-Huang-Lian-Jie-Du-Decoction (BBG) as a Potential Ischemic Stroke Treatment Drug With Efficacy and a Favorable Therapeutic Window
This study was carried out in accordance with the recommendations of Animal Ethics Committee of China Pharmaceutical University. The protocol was approved by Animal Ethics Committee of China Pharmaceutical University. Author Contributions JW, MY, and LK conceived the experiments and helped to coordinate support and funding. XF performed the research and drafted the manuscript. SL, YL, and DX participated in the experiments. JW analyzed the data and edited the paper. All authors read and approved the final manuscript. Conflict of Interest Statement The authors declare that the research was conducted in the absence of an...
Source: Frontiers in Pharmacology - April 11, 2019 Category: Drugs & Pharmacology Source Type: research

Role of the Gut Microbiota in Stroke Pathogenesis and Potential Therapeutic Implications
Background: Major advances have been made in stroke treatment and prevention in the past decades. However, the burden of stroke remains high. Identification of novel targets and establishment of effective interventions to improve stroke outcomes are, therefore, needed. Recent research highlights the contribution of the gut microbiota to stroke pathogenesis.Summary: Compositional and functional alterations of the gut microbiota, termed dysbiosis, are linked to stroke risk factors, such as obesity, metabolic diseases, and atherosclerosis. In acute cerebral ischemia, the gut microbiota plays a key role in bidirectional intera...
Source: Annals of Nutrition and Metabolism - June 9, 2021 Category: Nutrition Source Type: research

TMAO as a Novel Predictor of Major Adverse Vascular Events and Recurrence in Patients with Large Artery Atherosclerotic Ischemic Stroke
CONCLUSION: Elevated plasma TMAO concentration was independently associated with LAA ischemic stroke. The risk of major vascular event recurrence increased by 2.128 times in the LAA stroke subjects with plasma TMAO level higher than 126.83 pg/mL. Plasma TMAO concentration might be a potential biomarker of major vascular event recurrence.PMID:35345908 | DOI:10.1177/10760296221090503
Source: Atherosclerosis - March 29, 2022 Category: Cardiology Authors: Yan-Yan Chen Zu-Sen Ye Nian-Ge Xia Yun Xu Source Type: research

Association of Gut Microbiota-Dependent Metabolite Trimethylamine N-Oxide with First Ischemic Stroke.
CONCLUSIONS: This study suggested a positive association between plasma TMAO and ischemic stroke. Further studies are required to explore the role of plasma TMAO concentrations in predicting stroke risk. PMID: 32641646 [PubMed - as supplied by publisher]
Source: Journal of Atherosclerosis and Thrombosis - July 10, 2020 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

The Relationship of Large-Artery Atherothrombotic Stroke with Plasma Trimethylamine N-Oxide Level and Blood Lipid-Related Indices: A Cross-Sectional Comparative Study
CONCLUSIONS: The plasma TMAO level, Apo-A1, Apo-B, and HDL-C are important biomarkers for LAA stroke patients.PMID:33977104 | PMC:PMC8087478 | DOI:10.1155/2021/5549796
Source: Biomed Res - May 12, 2021 Category: Research Authors: Dongjuan Xu Wenfeng Zhao Juexian Song Lu Yin Kun Wang Lianyan Wei Yunyun Xu Hongfei Li Baoquan Min Ning Tang Xiaoyan Jiang Hui Liu Shuo Yan Haixia Leng Qing Xue Mao Peng Hongxing Wang Source Type: research

Related factors based on non-targeted metabolomics methods in minor ischaemic stroke
ConclusionIncreased levels of lactic acid, pyruvate, and TMAO may be related to the pathophysiological changes in the minor ischaemic stroke population. High blood pressure, a lack of physical activity, smoking, and increased TMAO level were the influencing factors for the occurrence of minor ischaemic stroke. The serum metabolite TMAO may be associated with MS occurrence
Source: Frontiers in Endocrinology - September 14, 2022 Category: Endocrinology Source Type: research

Trimethyllysine, vascular risk factors and outcome in acute ischemic stroke (MARK-STROKE)
Amino Acids. 2021 Mar 31. doi: 10.1007/s00726-021-02969-x. Online ahead of print.ABSTRACTTrimethyllysine (TML) is involved in the generation of the pro-atherogenic metabolite trimethylamine-N-oxide (TMAO) by gut microbiota. In clinical studies, elevated TML levels predicted major adverse cardiovascular events (MACE) in patients with acute or stable coronary artery disease (CAD). In contrast to cardiovascular patients, the role of TML in patients with acute cerebral ischemia is unknown. Here, we evaluated circulating TML levels in 374 stroke patients from the prospective biomarkers in stroke (MARK-STROKE) study. Compared wi...
Source: Amino Acids - March 31, 2021 Category: Biochemistry Authors: Edzard Schwedhelm Mirjam von Lucadou Sven Peine Susanne Lezius G ötz Thomalla Rainer B öger Christian Gerloff Chi-Un Choe Source Type: research