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Condition: Osteoporosis

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Total 356 results found since Jan 2013.

817 Ethanol induces skin hyperpigmentation in mice with aldehyde dehydrogenase 2 deficiency
Excessive alcohol consumption leads to alcohol use disorder. Alcohol is metabolized to acetaldehyde, which is then oxidized to acetic acid by aldehyde dehydrogenases (ALDH), a class of enzymes that facilitate the conversion of aldehydes to their corresponding acids. Among ALDHs, mitochondrial ALDH2 is the primary enzyme involved in the metabolism of acetaldehyde. In addition to its well-known role in ethanol metabolism, recent studies have suggested that ALDH2 dysfunction is associated with a variety of human diseases including cardiovascular diseases, diabetes, neurodegenerative diseases, stroke, cancer, anemia, pain, osteoporosis and aging.
Source: Journal of Investigative Dermatology - April 19, 2019 Category: Dermatology Authors: T. Yamauchi, A. Matsumoto, S. Ito, K. Wakamatsu, T. Suzuki, M. Fujita Tags: Pigmentation and Melanoma Source Type: research

Exercise as a Prescription for Patients with Various Diseases
Publication date: Available online 18 April 2019Source: Journal of Sport and Health ScienceAuthor(s): Xin Luan, Xiangyang Tian, Haixin Zhang, Rui Huang, Na Li, Peijie Chen, Ru WangAbstractA growing understanding of the benefits of exercise over the past few decades has prompted researchers to take an interest in the possibilities of exercise therapy. Because each sport has its own set of characteristics and physiological complications that tend to appear during exercise training, the effects and underlying mechanisms of exercise remain unclear. Thus, the first step in probing exercise effects on different diseases is the s...
Source: Journal of Sport and Health Science - April 20, 2019 Category: Sports Medicine Source Type: research

Osteoporosis and Sarcopenia Increase Frailty Syndrome in the Elderly
Conclusions World population is aging and the increase in life expectancy is often unhealthy. In particular, musculoskeletal aging, which leads to sarcopenia and osteoporosis, has several causes such as changes in body composition, inflammation, and hormonal imbalance. Sarcopenia, osteoporosis, and more frequently, sarcopenic obesity are commonly associated with aging and frequently closely linked each other, often leading to the development of a frailty syndrome. Frailty syndrome favors an increased risk of loss function in daily activities, for cardiovascular diseases, cancers, falls, and mortality. As the number of eld...
Source: Frontiers in Endocrinology - April 23, 2019 Category: Endocrinology Source Type: research

Prevent Osteoporotic Fractures With a Fracture Liaison Service
Imagine leaving the hospital after suffering a heart attack without being treated for hypertension or being started on a beta blocker. What would we think of the hospital where patients are never educated about the relationship between treating hypertension and reducing myocardial infarction and stroke risk? Unfortunately, this happens every day with osteoporosis and fractures... [Read More]
Source: The Rheumatologist - May 18, 2019 Category: Rheumatology Authors: Micah Yu, MD, Anna Lafian, DO, & Christina Downey, MD Tags: Conditions Osteoporosis osteoporotic fracture rates Source Type: research

The Design and Validation of a New Algorithm to Identify Incident Fractures in Administrative Claims Data
This article is protected by copyright. All rights reserved.
Source: Journal of Bone and Mineral Research - June 5, 2019 Category: Orthopaedics Authors: Nicole C. Wright, Shanette G. Daigle, Mary E. Melton, Elizabeth S. Delzell, Akhila Balasubramanian, Jeffrey R. Curtis Tags: ORIGINAL ARTICLE Source Type: research

The Endocannabinoid System and its Modulation by Cannabidiol (CBD).
Abstract The endocannabinoid system (ECS) is an extensive endogenous signaling system with multiple elements, the number of which may be increasing as scientists continue to elucidate its role in human health and disease. The ECS is seemingly ubiquitous in animal species and is modulated by diet, sleep, exercise, stress, and a multitude of other factors, including exposure to phytocannabinoids, like Cannabidiol (CBD). Modulating the activity of this system may offer tremendous therapeutic promise for a diverse scope of diseases, ranging from mental health disorders, neurological and movement disorders, pain, autoi...
Source: Alternative Therapies in Health and Medicine - May 31, 2019 Category: Complementary Medicine Authors: Corroon J, Felice JF Tags: Altern Ther Health Med Source Type: research

The Design and Validation of a New Algorithm to Identify Incident Fractures in Administrative Claims Data
This article is protected by copyright. All rights reserved.
Source: Journal of Bone and Mineral Research - June 5, 2019 Category: Orthopaedics Authors: Nicole C. Wright, Shanette G. Daigle, Mary E. Melton, Elizabeth S. Delzell, Akhila Balasubramanian, Jeffrey R. Curtis Tags: ORIGINAL ARTICLE Source Type: research

Decreased physical health-related quality of life —a persisting state for older women with clinical vertebral fracture
ConclusionsClinical vertebral fracture was associated with lower self-rated physical HRQoL, for up to 18.9  years after time of fracture.
Source: Osteoporosis International - June 20, 2019 Category: Orthopaedics Source Type: research

Characteristics of arterial hypertension in menopausal diabetic women
ConclusionHigh blood pressure is a public health problem most often associated with other cardiovascular risk factors. An evaluation of cardiovascular risk is necessary in postmenopausal hypertensive diabetic women and effective management of risk factors is recommended.
Source: Archives of Cardiovascular Diseases Supplements - July 24, 2019 Category: Cardiology Source Type: research

The Design and Validation of a New Algorithm to Identify Incident Fractures in Administrative Claims Data
This article is protected by copyright. All rights reserved.
Source: Journal of Bone and Mineral Research - June 5, 2019 Category: Orthopaedics Authors: Nicole C. Wright, Shanette G. Daigle, Mary E. Melton, Elizabeth S. Delzell, Akhila Balasubramanian, Jeffrey R. Curtis Tags: ORIGINAL ARTICLE Source Type: research

Increased Risk of Musculoskeletal Disorders and Mental Health Problems in Retired Professional Jockeys: A Cross-Sectional Study
Int J Sports Med DOI: 10.1055/a-0902-8601To examine the prevalence of chronic disease and mental health problems in retired professional, male jockeys compared to an age-matched reference population. A cross-sectional study comparing data from a cohort of retired professional jockeys with an age-matched general population sample. Male participants (age range: 50–89 years old) were used to compare health outcomes of self-reported physician-diagnosed conditions: heart disease, stroke, diabetes, hypertension, osteoporosis, osteoarthritis, depression and anxiety between study populations. Conditional logistic regression mode...
Source: International Journal of Sports Medicine - August 6, 2019 Category: Sports Medicine Authors: Mackinnon, Anna-Louise Jackson, Kate Kuznik, Kerry Turner, Alison Hill, Jerry Davies, Madeleine A. M. Jones, Mary Elizabeth Delmestri, Antonella Sanchez-Santos, Maria T. Newton, Julia Tags: Clinical Sciences Source Type: research

Vitamin D and cardiovascular disorders
In conclusion, preclinical data generated a plausible hypothesis of a link between vitamin D status and extra-skeletal events, including cardiovascular endpoints. Whether the vitamin D endocrine system is redundant for the human vascular system or whether the RCTs have not been optimally designed to answer the research question is thus not yet settled.
Source: Osteoporosis International - August 10, 2019 Category: Orthopaedics Source Type: research

Practical tips for prescribing exercise for fall prevention
ConclusionDepending on the population, exercise as a single or as part of a multifactorial intervention may be beneficial in reducing falls.
Source: Osteoporosis International - September 30, 2019 Category: Orthopaedics Source Type: research

Introduction to Purinergic Signaling.
Abstract Purinergic signaling was proposed in 1972, after it was demonstrated that adenosine 5'-triphosphate (ATP) was a transmitter in nonadrenergic, noncholinergic inhibitory nerves supplying the guinea-pig taenia coli. Later, ATP was identified as an excitatory cotransmitter in sympathetic and parasympathetic nerves, and it is now apparent that ATP acts as a cotransmitter in most, if not all, nerves in both the peripheral nervous system and central nervous system (CNS). ATP acts as a short-term signaling molecule in neurotransmission, neuromodulation, and neurosecretion. It also has potent, long-term (trophic) ...
Source: Mol Biol Cell - October 27, 2019 Category: Molecular Biology Authors: Burnstock G Tags: Methods Mol Biol Source Type: research

Potassium binding for conservative and preservative management of chronic kidney disease
In conclusion, there are new well tolerated and effective K+-binding agents for acutely and chronically managing hyperkalemia.
Source: Current Opinion in Nephrology and Hypertension - November 29, 2019 Category: Urology & Nephrology Tags: NOVEL THERAPEUTIC APPROACHES IN NEPHROLOGY AND HYPERTENSION: Edited by Kamyar Kalantar-Zadeh and Ekamol Tantisattamo Source Type: research