The Endocannabinoid System and its Modulation by Cannabidiol (CBD).

The Endocannabinoid System and its Modulation by Cannabidiol (CBD). Altern Ther Health Med. 2019 Jun;25(S2):6-14 Authors: Corroon J, Felice JF Abstract The endocannabinoid system (ECS) is an extensive endogenous signaling system with multiple elements, the number of which may be increasing as scientists continue to elucidate its role in human health and disease. The ECS is seemingly ubiquitous in animal species and is modulated by diet, sleep, exercise, stress, and a multitude of other factors, including exposure to phytocannabinoids, like Cannabidiol (CBD). Modulating the activity of this system may offer tremendous therapeutic promise for a diverse scope of diseases, ranging from mental health disorders, neurological and movement disorders, pain, autoimmune disease, spinal cord injury, cancer, cardiometabolic disease, stroke, TBI, osteoporosis, and others. PMID: 31202198 [PubMed - in process]
Source: Alternative Therapies in Health and Medicine - Category: Complementary Medicine Authors: Tags: Altern Ther Health Med Source Type: research

Related Links:

Although sleep is ubiquitous, its evolutionary purpose remains elusive. Though every species of animal, as well as many plants sleep, theories of its origin are purely physiological, e.g. to conserve energy, make repairs or to consolidate learning. An evolutionary reason for sleep would answer one of biology ’s fundamental unanswered questions. When environmental conditions change on a periodic basis (winter/summer, day/night) organisms must somehow confront the change or else be less able to compete in either niche. Seasonal adaptation includes the migration of birds, changes in honeybee physiology a nd winter absci...
Source: Journal of Circadian Rhythms - Category: Biology Source Type: research
Publication date: 1 June 2020Source: Carbohydrate Polymers, Volume 237Author(s): Chayanaphat Chokradjaroen, Ratana Rujiravanit, Sewan Theeramunkong, Nagahiro Saito
Source: Carbohydrate Polymers - Category: Biomedical Science Source Type: research
Publication date: Available online 30 March 2020Source: Biochimica et Biophysica Acta (BBA) - BiomembranesAuthor(s): Lorenza González-Mariscal, Jael Miranda, Helios Gallego-Gutiérrez, Misael Cano-Cortina, Elida Amaya
Source: Biochimica et Biophysica Acta (BBA) Biomembranes - Category: Biochemistry Source Type: research
This article is protected by copyright. All rights reserved
Source: Proteomics - Category: Biochemistry Authors: Tags: Review Source Type: research
New J. Chem., 2020, Accepted Manuscript DOI: 10.1039/C9NJ05449A, PaperYang Lei, Haixia Ye, Siqing Xiang, Yuan Huang, Chao Zhu, Weiying Zhang, Yong Chen, Qing Liang You Achieving dynamic regulation of cell-surface interactions is especially attractive for tissue engineering and cell-based treatment. Herein, we report a bottom-up approach for the generation of near-infrared (NIR)-controlled supramolecular “Pipette Device”... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - New J. Chem. latest articles - Category: Chemistry Authors: Source Type: research
ABSTRACTGermicidal lamps that emit primarily 254 nm ultraviolet radiation (UV) are routinely utilized for surface sterilization but cannot be used for human skin because they cause genotoxicity. As an alternative, 222 nm ‐UVC have been reported to exert sterilizing ability comparable to that of 254 nm‐UVC without producing cyclobutane pyrimidine dimers (CPDs), the major DNA lesions caused by UV. However, there has been no clear evidence for safety in chronic exposure to skin, particularly with respect to carcino genesis. We therefore investigated the long‐term effects of 222 nm‐UVC on skin using a highly photocarci...
Source: Photochemistry and Photobiology - Category: Science Authors: Tags: RESEARCH ARTICLE Source Type: research
In this study the EGFR over‐expressing human head/neck OSC‐19‐luc2‐cGFP tumour with transfected GFP gen e was used in a skin‐fold window‐chamber model in BALB/c nude mice. The uptake and localization of the conjugate in the tumour and its surrounding normal tissues were studied by an intravital confocal laser scanning microscopy with image analyses. The tumour was also irradiated with 690 nm las er light 24 hours after conjugate administration. The vascular and tumour responses were examined by morphological evaluation and immunohistochemistry (IHC). The amount of conjugate in the tumour peaked at 24‐4...
Source: Photochemistry and Photobiology - Category: Science Authors: Tags: SPECIAL ISSUE RESEARCH ARTICLE Source Type: research
Contributors : Ivan Martinez ; Tayvia BrownmillerSeries Type : Expression profiling by arrayOrganism : Homo sapiensNumerous studies have implicated changes in the Y chromosome in male cancers, however few have investigated the biological importance of Y chromosome non-coding RNAs. Here, we demonstrate a group of Y chromosome-expressed long non-coding RNAs (lncRNAs) involved in male non-small cell lung cancer (NSCLC) radiation sensitivity. Radiosensitive male NSCLC cell lines demonstrated a dose-dependent induction of linc-SPRY3-2/3/4 following irradiation, not observed in radioresistant male NSCLC cell lines. Cytogenetics ...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research
Authors: Angarita-Sierra T, Montañez-Méndez A, Toro-Sánchez T, Rodríguez-Vargas A Abstract Envenomations by colubrid snakes in Colombia are poorly known, consequently, the clinical relevance of these species in snakebite accidents has been historically underestimated. Herein, we report the first case of envenomation by opisthoglyphous snakes in Colombia occurred under fieldwork conditions at the municipality of Distracción, in the department of La Guajira. A female biologist was bitten on the index finger knuckle of her right hand when she tried to handle a false fer-de-lance snak...
Source: Biomedica : Revista del Instituto Nacional de Salud - Category: International Medicine & Public Health Tags: Biomedica Source Type: research
ConclusionsThe findings suggest children with 22q11DS may have a higher risk of experiencing clinical sleep problems, compared to typically developing children. Consideration of additional screening and treatment of sleep disorders in children with 22q11DS is warranted.
Source: Molecular Genetics & Genomic Medicine - Category: Genetics & Stem Cells Authors: Tags: ORIGINAL ARTICLE Source Type: research
More News: Alternative and Complementary Therapies | Autoimmune Disease | Back Pain | Brain | Cancer | Cancer & Oncology | Cardiology | Complementary Medicine | Diets | Heart | Men | Neurology | Nutrition | Orthopaedics | Osteoporosis | Pain | Sleep Disorders | Sleep Medicine | Spinal Cord Injury | Sports Medicine | Stroke