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Condition: Osteoporosis
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Total 249 results found since Jan 2013.

Association between bisphosphonate use and stroke risk: a meta-analysis
ConclusionOur results suggest that bisphosphonate use is associated with a lower risk of stroke. However, the current evidence does not lead to a definite conclusion due to the borderline statistical significance and high between-study heterogeneity. Future studies, especially RCTs, are necessary to assess causality.
Source: Osteoporosis International - May 30, 2023 Category: Orthopaedics Source Type: research

Efficacy and safety of odanacatib for osteoporosis treatment: a systematic review and meta-analysis
ConclusionODN is an appealing long-term osteoporosis treatment method; however, further research should focus on the potential increased risk of fracture and stroke.
Source: Archives of Orthopaedic and Trauma Surgery - May 11, 2023 Category: Orthopaedics Source Type: research

Quality of life and its associated factors among home-dwelling older people residing in the District of Colombo, Sri Lanka: a community-based cross-sectional study
Conclusion The overall QOL of home-dwelling elders of the Colombo District is moderate, with the lowest score being in social relationships and the highest in the environmental domain. Educational status, engaging in religious activities and financial independence are key factors associated with a better QOL. Limitations in physical activity and chronic diseases are associated with a reduced QOL. Living with the spouse is a key factor associated with the psychological health domain.
Source: BMJ Open - April 12, 2023 Category: General Medicine Authors: Wijesiri, H. S. M. S. K., Wasalathanthri, S., De Silva Weliange, S., Wijeyaratne, C. N. Tags: Open access, Public health Source Type: research

Screening for the primary prevention of fragility fractures among adults aged 40 years and older in primary care: systematic reviews of the effects and acceptability of screening and treatment, and the accuracy of risk prediction tools
ConclusionAn offer of 2-step screening with risk assessment and BMD measurement toselected postmenopausal females with low prevalence of prior fracture probably results in a small reduction in the risk of clinical fragility fracture and hip fracture compared to no screening. These findings were most applicable to the use of clinical FRAX for risk assessment and were not replicated in theoffer-to-screen population where the rate of response to mailed screening questionnaires was low. Limited direct evidence on harms of screening were available; using study data to provide estimates, there may be a moderate degree of overdia...
Source: Systematic Reviews - March 21, 2023 Category: International Medicine & Public Health Source Type: research

Mutations in ARHGEF15 cause autosomal dominant hereditary cerebral small vessel disease and osteoporotic fracture
AbstractCerebral small vessel disease (CSVD) is a prominent cause of ischemic and hemorrhagic stroke and a leading cause of vascular dementia, affecting small penetrating vessels of the brain. Despite current advances in genetic susceptibility studies, challenges remain in defining the causative genes and the underlying pathophysiological mechanisms. Here, we reported that theARHGEF15 gene was a causal gene linked to autosomal dominant inherited CSVD. We identified one heterozygous nonsynonymous mutation of theARHGEF15 gene that cosegregated completely in two families with CSVD, and a heterozygous nonsynonymous mutation an...
Source: Acta Neuropathologica - March 16, 2023 Category: Neurology Source Type: research

Association between serum lipid profile, body mass index and osteoporosis in postmenopausal Sudanese women
CONCLUSIONS: Osteoporotic postmenopausal women had a significant increase in serum lipid profile and BMI. Moreover, we found a positive link between women with cardiovascular diseases and stroke.PMID:36910383 | PMC:PMC9993279 | DOI:10.4314/ahs.v22i3.43
Source: Atherosclerosis - March 13, 2023 Category: Cardiology Authors: Asgad Osman Alfahal Abdalla Eltoum Ali Gadallah Osman Modawe Wael Mohialddin Doush Source Type: research

Reach and Impact of In-Person and Remote Delivery Formats of Walk with Ease
Inquiry. 2023 Jan-Dec;60:469580231152314. doi: 10.1177/00469580231152314.ABSTRACTThis descriptive study retrospectively evaluates the reach and impact of cohorts enrolled in Group (in-person, 2017-2020) and Self-Directed (remote, 2019-2020) delivery formats of the evidenced-based health promotion program, Walk with Ease, implemented statewide in North Carolina. An existing dataset consisting of pre- and post-surveys were analyzed for 1,890 participants; 454 (24%) from the Group format and 1,436 (76%) from Self-Directed. Self-Directed participants were younger, had more years of education, represented more Black/African Ame...
Source: Rural Remote Health - February 21, 2023 Category: Rural Health Authors: Nadia Z Mazza Amy Joy Lanou Serena Weisner Source Type: research

Agreement between self-reported diseases from health surveys and national health registry data: a Danish nationwide study
Conclusion Overall, self-reported data were accurate in identifying individuals without the specific disease (ie, specificity and NPV). However, sensitivity, PPV and kappa varied greatly between diseases. These findings should be considered when interpreting similar results from surveys.
Source: Journal of Epidemiology and Community Health - January 10, 2023 Category: Epidemiology Authors: Jensen, H. A. R., Lau, C. J., Davidsen, M., Ekholm, O., Christensen, A. I. Tags: Original research Source Type: research

Osteoporotic fracture admissions compared to other major medical admissions in Irish public hospitals
ConclusionOsteoporotic fractures represent a large and rapidly increasing illness burden amongst older Irish adults, with substantial care requirements and the resulting onus on our healthcare system. Urgent action is needed to address this public health issue and the services for those at risk of fracture.
Source: Archives of Osteoporosis - December 17, 2022 Category: Orthopaedics Source Type: research

Osteoporosis and cardiovascular disease: a review
CONCLUSION: There is emerging evidence that individuals with osteoporosis are also at an increased risk of coronary artery disease and stroke even after controlling for other factors. The traditional risk factors for cardiovascular disease also predispose people to developing osteoporosis, suggesting that the same mechanism may be causing the two. Moreover, a number of anti-osteoporotic drugs have also been largely linked with cardiovascular disease. This calls for a change in the view of osteoporosis as a metabolic disease but as a cardio-metabolic disorder thereby emphasizing the need for intensified preventive strategie...
Source: Molecular Biology Reports - November 30, 2022 Category: Molecular Biology Authors: Taoreed Adegoke Azeez Source Type: research