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Total 204 results found since Jan 2013.

Helping to End Addiction Long-term Initiative, or NIH HEAL Initiative, and NINDS (National Institute of Neurological Disorders and Stroke) Early Phase Pain Investigation Clinical Network (EPPIC-Net) Provides Robust Infrastructure for Clinical Trials of Non-addictive Pain Therapeutics
We present EPPIC-Net's accomplishments since opening in Q4 of 2019. In its first year, EPPIC-Net established a robust infrastructure including a Clinical Coordinating Center, Data Coordinating Center, and 12 Specialized Clinical Centers across th e US, providing broad outreach to diverse pain populations.
Source: The Journal of Pain - May 1, 2022 Category: Materials Science Authors: Barbara Karp, Rebecca Hommer, Marlene Peters Lawrence, Jennifer H. Barnes, Clinton B. Wright Tags: Clinical Trials for Pain Research121 Source Type: research

NIH HEAL Initiative: National Institute of Neurological Disorders and Stroke Preclinical Program for Non-Addictive Pain Therapeutic Development
The National Institutes of Health Helping to End Addiction Long-term, or NIH HEAL Initiative aims to focus efforts on advancing scientific solutions to stem the opioid crisis, improving prevention and treatment of opioid misuse/addiction, and enhancing pain management. NINDS is charged with accelerating the discovery and development of new non-addictive pharmacologic and non-pharmacologic pain therapeutics as part of the HEAL Initiative. PSPP provides researchers from academia and industry, within the US and internationally, an efficient, rigorous, one-stop in vivo resource to screen and profile therapeutic candidates incl...
Source: The Journal of Pain - May 1, 2022 Category: Materials Science Authors: Sarah Woller, Smriti Iyengar Tags: 107 Source Type: research

Why Acupuncture Is Going Mainstream in Medicine
When the opioid addiction crisis began to surge in the U.S. about a decade ago, Dr. Medhat Mikhael spent a lot of time talking to his patients about other ways to heal pain besides opioids, from other types of medications to alternative treatments. As a pain management specialist at MemorialCare Orange Coast Medical Center in Fountain Valley, Calif., he didn’t anticipate leaving behind the short-term use of opioids altogether, since they work so well for post-surgical pain. But he wanted to recommend a remedy that was safer and still effective. That turned out to be acupuncture. “Like any treatment, acupuncture...
Source: TIME: Health - April 29, 2022 Category: Consumer Health News Authors: Elizabeth Millard Tags: Uncategorized healthscienceclimate medicine Source Type: news

Impact of Electronic Cigarette Vaping on Cerebral Ischemia: What We Know So Far
AbstractElectronic cigarettes (ECs) are battery-powered nicotine delivery devices that have rapidly gained popularity and attention globally. ECs work by heating a liquid to produce an aerosol that usually contains nicotine, flavoring compounds, and other chemicals, which are inhaled during vaping. EC aerosols are depicted to contain a lower number and overall quantity of harmful toxicants than conventional cigarettes (CCs). However, emerging research indicates that EC aerosols contain harmful ingredients including ultrafine particles, volatile organic compounds, and heavy metals. One common ingredient found in both CCs an...
Source: Translational Stroke Research - April 18, 2022 Category: Neurology Source Type: research

Pharmaceutical perspective of neuropathic pain management for primary care providers
Inflammopharmacology. 2022 Mar 28. doi: 10.1007/s10787-022-00963-7. Online ahead of print.ABSTRACTNeuropathic pain (NP) is a chronic condition that affects ~ 1% of the general population globally. Several conditions such as chronic diabetes, herpes zoster (HZ), cancer, HIV, stroke, multiple sclerosis, physical compression or damage of nerves and certain surgical procedures can lead to neuropathy and related pain. The condition is difficult to treat with traditional analgesic drugs. Typically, non-traditional analgesics are used in treating pain in this condition such as antidepressants and antiepileptic drugs. Opioids are ...
Source: Herpes - March 29, 2022 Category: Infectious Diseases Authors: Sandhya Jinesh Justin Kullgren Gollapudi S Shankar Rajan Radhakrishnan Source Type: research

Neuropsychological Outcomes in Individuals With Type 1 and Type 2 Diabetes
ConclusionMicrovascular/macrovascular complications are associated with a high risk of neuropsychological outcomes regardless of diabetes status. Therefore, preventing microvascular and macrovascular complications will likely help reduce the likelihood of neuropsychological outcomes either as the result of similar pathophysiologic processes or by preventing the direct and indirect consequences of these complications. For individuals with type 2 diabetes, risk factors beyond complications (such as obesity) likely contribute to neuropsychological outcomes.
Source: Frontiers in Endocrinology - March 4, 2022 Category: Endocrinology Source Type: research

Cannabis Use and Stroke: Does a Risk Exist?
Conclusions: In people with cannabis use, the prevalence of ischemic stroke and hemorrhagic stroke was 1.2% and 0.3%, respectively, higher than the prevalence of people without use (0.8% and 0.2%). There is insufficient information on timing, exposure, duration, and dose-responsive relationship.
Source: Journal of Addiction Medicine - March 1, 2022 Category: Addiction Tags: Original Research Source Type: research

Epidemiology of young stroke in the ludhiana population-based stroke registry
Conclusion: Hypertension, diabetes mellitus, drug addiction, and tobacco intake were significantly associated with young stroke. Outcome was also better in younger people.
Source: Annals of Indian Academy of Neurology - February 22, 2022 Category: Neurology Authors: Monika Singla Gagandeep Singh Paramdeep Kaur Jeyaraj D Pandian Source Type: research

Stroke survivors 50% more likely to suffer another if they are heavy cannabis smokers, study finds
Cannabis addicts who have survived a stroke could have a nearly 50 per cent greater risk of repeated stroke events than people who don't use the drug, new US research has suggests.
Source: the Mail online | Health - February 3, 2022 Category: Consumer Health News Source Type: news

Neurological toll of COVID-19
AbstractThe first case of coronavirus illness was discovered in Wuhan, China, in January 2020 and quickly spread worldwide within the next couple of months. The condition was initially only linked with respiratory disorders. After the evolution of various variants of the SARS-CoV-2, the critical impact of the virus spread to multiple organs and soon, neurological disorder manifestations started to appear in the infected patients. The review is focused on the manifestation of various neurological disorders linked with both the central nervous system and peripheral nervous system. Disorders such as cytokine release syndrome,...
Source: Neurological Sciences - January 16, 2022 Category: Neurology Source Type: research

Ditching cigarettes for smokeless tobacco can help cut cardiovascular risks, study finds
Regular smokers are at heightened risk of developing cardiovascular disease, but crushing the butts in favor of a “smokeless” alternative like chewing tobacco, snuff or tobacco lozenges may go a long way toward bringing the danger down to a more normal level, a new UCLA-led study shows.The findings also indicate that the primary culprit in smokers ’ increased risk is not nicotine but other chemicals found in tobacco smoke. Both cigarettes and smokeless tobacco products contain large quantities of nicotine.The study,published today in the journal Nicotine and Tobacco Research, involved a team of researchers from UCLA...
Source: UCLA Newsroom: Health Sciences - January 6, 2022 Category: Universities & Medical Training Source Type: news

Anxiety, Depression, Psychological Symptoms, Negative Effects, and Other Symptoms of Nicotine Withdrawal
This case occurred in a 33-year-old man who has been smoking for 19 years. He had a pattern of consuming 14 cigarettes per day with 30 mg of nicotine intake and high tar levels. The level of tolerance for consumption of nicotine and tar per day is 10 to 15 mg. High cigarette consumption correlates with high nicotine consumption as well. Excessive nicotine consumption over a long period can lead to lung cancer, stroke, heart disease, chronic obstructive pulmonary disease, and psychological disorders.
Source: Addictive Disorders and Their Treatment - November 25, 2021 Category: Addiction Tags: Case Reports Source Type: research

Compound Developed at UArizona Health Sciences Provides Innovative Pain Relief
Digital media& downloads Compound Developed at UArizona Health Sciences Provides Innovative Pain Relief Researchers targeted a common sodium ion channel to reverse pain and saw positive results that could lead to a nonaddictive solution to treat pain. Today University of Arizona Health Sciencespain-relief-web.jpgHealthBIO5College of Medicine - TucsonExpertsResearch Media contact(s)Stacy Pigott University of Arizona Health Sciencesspigott@arizona.edu520-539-4152Researchers at the  University of Arizona Health Sciences are closer to developing a safe and effective non-opioid pain reliever after a study showed that...
Source: The University of Arizona: Health - November 15, 2021 Category: Universities & Medical Training Authors: mittank Source Type: research

Hospital-based Buprenorphine/Naloxone Initiation in a Patient With Limited Communication Abilities: A Case Report
North America's opioid crisis highlights the profound need for low-barrier access to opioid agonist therapy (OAT) for the treatment of opioid use disorder (OUD). This case describes a 33-year-old female with a history of opioid and stimulant use disorder admitted to hospital after a left middle cerebral artery ischemic stroke with resulting aphasia. After medical stabilization, she consented to buprenorphine/naloxone through limited verbal and written communication. After 14 days of titration, she was stabilized on 14 to 3.5 milligrams of buprenorphine/naloxone daily. Buprenorphine/naloxone initiation and titration is pati...
Source: Journal of Addiction Medicine - November 1, 2021 Category: Addiction Tags: Case Reports Source Type: research