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Condition: Subarachnoid Hemorrhage
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Total 3336 results found since Jan 2013.
Risk and population attributable fraction of stroke subtypes in Japan
CONCLUSION: Although there are differences according to the subtypes, hypertension could be regarded as the most crucial target for preventing strokes in Japan.PMID:37460296 | DOI:10.2188/jea.JE20220364
Source: Journal of Epidemiology - July 17, 2023 Category: Epidemiology Authors: Hiroshi Yatsuya Kazumasa Yamagishi Yuanying Li Isao Saito Yoshihiro Kokubo Isao Muraki Manami Inoue Shoichiro Tsugane Hiroyasu Iso Norie Sawada Source Type: research
Association between baseline pulse pressure and hospital mortality in non-traumatic subarachnoid hemorrhage patients: a retrospective cohort study
ConclusionFor patients with non-traumatic SAH, the association between baseline PP and risk of hospital mortality was non-linear, with an inflection point at 60 mmHg and a minimal risk at 57 to 68 mmHg (Q2) of baseline PP level.
Source: Frontiers in Neurology - July 17, 2023 Category: Neurology Source Type: research
Lifelong cerebrovascular disease burden among CADASIL patients: analysis from a global health research network
DiscussionEarly screening and targeted treatment strategies are warranted to help CADASIL patients with symptom management and risk mitigation.
Source: Frontiers in Neurology - July 14, 2023 Category: Neurology Source Type: research
Altered levels of transthyretin in human cerebral microdialysate after subarachnoid haemorrhage using proteomics; a descriptive pilot study
Subarachnoid haemorrhage (SAH) is one of the most severe forms of stroke in which delayed cerebral ischemia is one of the major complications. Neurointensive care aims at preventing and treating such complicat...
Source: Proteome Science - July 7, 2023 Category: Bioinformatics Authors: Fredrik Ginstman, Bijar Ghafouri and Peter Zsigmond Tags: Research Source Type: research
Connection between oxidative stress and subcellular organelle in subarachnoid hemorrhage: Novel mechanisms and therapeutic implications
CNS Neurosci Ther. 2023 Jul 5. doi: 10.1111/cns.14348. Online ahead of print.ABSTRACTSpontaneous subarachnoid hemorrhage (SAH) is one of the most devastating forms of stroke, with limited treatment modalities and poor patient outcomes. Previous studies have proposed multiple prognostic factors; however, relative research on treatment has not yet yielded favorable clinical outcomes. Moreover, recent studies have suggested that early brain injury (EBI) occurring within 72 h after SAH may contribute to its poor clinical outcomes. Oxidative stress is recognized as one of the main mechanisms of EBI, which causes damage to vario...
Source: CNS Neuroscience and Therapeutics - July 6, 2023 Category: Neuroscience Authors: Jiahao Zhang Zeyu Zhang Xiaoyu Wang Yibo Liu Qian Yu Kaikai Wang Yuanjian Fang Cameron Lenahan Maohua Chen Sheng Chen Source Type: research
Neuroinflammation in Acute Ischemic and Hemorrhagic Stroke
AbstractPurpose of ReviewThis review aims to provide an overview of neuroinflammation in ischemic and hemorrhagic stroke, including recent findings on the mechanisms and cellular players involved in the inflammatory response to brain injury.Recent FindingsNeuroinflammation is a crucial process following acute ischemic stroke (AIS) and hemorrhagic stroke (HS). In AIS, neuroinflammation is initiated within minutes of the ischemia onset and continues for several days. In HS, neuroinflammation is initiated by blood byproducts in the subarachnoid space and/or brain parenchyma. In both cases, neuroinflammation is characterized b...
Source: Current Neurology and Neuroscience Reports - July 3, 2023 Category: Neuroscience Source Type: research
Comparative efficacy and safety of various mechanical thrombectomy strategies for patients with acute ischemic stroke: a Bayesian network meta-analysis
CONCLUSION: Our results indicated that, with the exception of functional outcome, combined treatment might be the outstanding strategy. Apart from subarachnoid hemorrhage, all three mechanical thrombectomy strategies proved better strategies than standard medical treatment.REGISTRATION: PROSPERO (CRD42022351878).PMID:37384114 | PMC:PMC10293521 | DOI:10.1177/17562864231181180
Source: Adv Data - June 29, 2023 Category: Epidemiology Authors: Jiahao Meng Zeya Yan Jie Zhang Wei Wang Xinyu Tao Feng Gu Xingyu Yang Tao Xue Wanchun You Zhouqing Chen Zhong Wang Gang Chen Source Type: research
Dynamic Measurements of Cerebral Blood Flow Responses to Cortical Spreading Depolarization in the Murine Endovascular Perforation Subarachnoid Hemorrhage Model
AbstractDelayed cerebral ischemia (DCI) is the most severe complication after subarachnoid hemorrhage (SAH), and cortical spreading depolarization (CSD) is believed to play a vital role in it. However, the dynamic changes in cerebral blood flow (CBF) in response to CSD in typical SAH models have not been well investigated. Here, SAH was established in mice with endovascular perforation. Subsequently, the spontaneous CBF dropped instantly and then returned to baseline rapidly. After KCl application to the cortex, subsequent hypoperfusion waves occurred across the groups, while a lower average perfusion level was found in th...
Source: Translational Stroke Research - June 29, 2023 Category: Neurology Source Type: research
Aspirin and Subarachnoid Haemorrhage in the UK Biobank
In this study, we aimed to clarify the association between aspirin and SAH in the general population. The UK Biobank is a prospective population-based cohort study. Sex, age, smoking, alcohol, medication use, hypertension, blood pressure, ischaemic heart disease and stroke were recorded at baseline assessments. Follow-up is conducted through linkages to National Health Service data including electronic, coded death certificate, hospital and primary care data. Cox proportional hazards modelling was used to analyse the association between aspirin use and SAH. Of the 501,060 participants included in the analysis, a total of 5...
Source: Translational Stroke Research - June 29, 2023 Category: Neurology Source Type: research
The clinical utility of dual-energy CT in post-thrombectomy care: Part 1, predictors and outcomes of subarachnoid and intraparenchymal hemorrhage
Dual-energy CT allows differentiation between blood and iodinated contrast. We aimed to determine predictors of subarachnoid and intraparenchymal hemorrhage on dual-energy CT performed immediately post-thrombectomy and the impact of these hemorrhages on 90-day outcomes.
Source: Journal of Stroke and Cerebrovascular Diseases - June 29, 2023 Category: Neurology Authors: Seoiyoung Ahn, Nishit Mummareddy, Steven G. Roth, Jacob Jo, Akshay Bhamidipati, Yeji Ko, Julie DiNitto, Rohan V. Chitale, Matthew R. Fusco, Michael T. Froehler Source Type: research
Hospital Discharge and Readmissions Before and During the COVID-19 Pandemic for California Acute Stroke Inpatients
Stroke is a leading cause of death and disability in the United States, with approximately 795,000 new strokes occurring annually, including acute ischemic stroke (AIS), intracerebral hemorrhage (ICH), and subarachnoid hemorrhage (SAH).1 The Coronavirus Disease 2019 (COVID-19) pandemic has impacted all levels of care for stroke patients, such as delays in initial presentation, reduction in acute therapies, limitations of in-patient resources, delays or lack of initiation of secondary stroke prevention therapy, and limitations in rehabilitation services after hospital discharge.
Source: Journal of Stroke and Cerebrovascular Diseases - June 23, 2023 Category: Neurology Authors: George P. Albert, Daryl C. McHugh, Debra E. Roberts, Adam G. Kelly, Remi Okwechime, Robert G. Holloway, Benjamin P. George Source Type: research
Resolution of Cerebral Inflammation Following Subarachnoid Hemorrhage
ConclusionsBy the herein presented molecular and histological data we provide an important indication for an incomplete resolution of inflammation within the brain parenchyma after SAH. Inflammatory resolution and the return to tissue homeostasis represent an important contribution to the disease ’s pathology influencing the impact on brain damage and outcome after SAH. Therefore, we consider a novel complementary or even superior therapeutic approach that should be carefully rethought in the management of cerebral inflammation after SAH. An acceleration of the resolution phase at the cell ular and molecular levels could...
Source: Neurocritical Care - June 22, 2023 Category: Neurology Source Type: research
