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Specialty: Neurology
Condition: Hemorrhagic Stroke

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Total 7056 results found since Jan 2013.

Cerebrolysin as an Early Add-on to Reperfusion Therapy: Risk of Hemorrhagic Transformation after Ischemic Stroke (CEREHETIS), a prospective, randomized, multicenter pilot study
Cerebrolysin could mitigate reperfusion injury and hemorrhagic transformation (HT) in animal models of acute ischemic stroke.
Source: BMC Neurology - March 27, 2023 Category: Neurology Authors: Dina R. Khasanova and Mikhail N. Kalinin Tags: Research Source Type: research

Neutrophil to lymphocyte ratio is associated with the epilepsy after primary intracerebral hemorrhage
CONCLUSION: High NLR at admission is associated with an increased risk of PSE, which suggests that NLR may play a role in risk stratification in patients with ICH.PMID:36963316 | DOI:10.1016/j.yebeh.2023.109177
Source: Epilepsy and Behaviour - March 24, 2023 Category: Neurology Authors: Mengqi Lin Ru Lin Dongqin Zhu Yuhuan Wu Lufei Feng Weizeng Su Weilei He Source Type: research

Risk factors for intracerebral hemorrhage in patients undergoing maintenance hemodialysis
ConclusionHigher systolic BP and abnormal iPTH metabolism might be associated with ICH in patients undergoing hemodialysis. Comprehensive control of hypertension and iPTH may be a fundamental preventive strategy for ICH in these patients.
Source: Frontiers in Neurology - March 22, 2023 Category: Neurology Source Type: research

Characteristics of stroke after liver and kidney transplantation
ConclusionsIn-hospital, perioperative, and hemorrhagic strokes were more common in the LT group than in the KT group. Ischemic stroke subtypes did not differ significantly between the two groups and undetermined etiology was the most common cause of ischemic stroke in both groups. High mortality after stroke was noted in transplantation patients and was associated with in-hospital stroke.
Source: Frontiers in Neurology - March 22, 2023 Category: Neurology Source Type: research

Stellate ganglion block ameliorated central post-stroke pain with comorbid anxiety and depression through inhibiting HIF-1 α/NLRP3 signaling following thalamic hemorrhagic stroke
Central post-stroke pain (CPSP) is an intractable and disabling central neuropathic pain that severely affects patients ’ lives, well-being, and socialization abilities. However, CPSP has been poorly studied me...
Source: Journal of Neuroinflammation - March 21, 2023 Category: Neurology Authors: Zhong-Mou Shi, Jun-Jie Jing, Zheng-Jie Xue, Wen-Jun Chen, Yan-Bin Tang, Du-Juan Chen, Xin-Yi Qi, Li Huang, Yi-Qing Zou, Xiao-Zhi Wu and Fei Yang Tags: Research Source Type: research

TNF-Blockade for Primary Stroke Prevention in Adenosine Deaminase 2 Deficiency: A Case Series
We present a family with multiple affected children to highlight the importance of TNF blockade not just as secondary stroke prevention but also as primary stroke prevention in genetically affected but clinically asymptomatic patients. Methods A proband with recurrent cryptogenic strokes was referred for evaluation at the NIH CC. The parents and 3 clinically asymptomatic siblings were also evaluated. Results The proband was diagnosed with DADA2 based on biochemical testing; her antiplatelet therapies were discontinued, and she was started on TNF blockade for secondary stroke prevention. Her 3 asymptomatic siblings were s...
Source: Neurology Neuroimmunology and Neuroinflammation - March 20, 2023 Category: Neurology Authors: Soldatos, A., Toro, C., Hoffmann, P., Romeo, T., Deuitch, N., Brofferio, A., Aksentijevich, I., Kastner, D. L., Ombrello, A. K. Tags: Childhood stroke, Stroke in young adults, Stroke prevention, Vasculitis, All Genetics Clinical/Scientific Note Source Type: research

The Role of Oxidative Stress in the Progression of Secondary Brain Injury Following Germinal Matrix Hemorrhage
AbstractGerminal matrix hemorrhage (GMH) can be a fatal condition responsible for the death of 1.7% of all neonates in the USA. The majority of GMH survivors develop long-term sequalae with debilitating comorbidities. Higher grade GMH is associated with higher mortality rates and higher prevalence of comorbidities. The pathophysiology of GMH can be broken down into two main titles: faulty hemodynamic autoregulation and structural weakness at the level of tissues and cells. Prematurity is the most significant risk factor for GMH, and it predisposes to both major pathophysiological mechanisms of the condition. Secondary brai...
Source: Translational Stroke Research - March 17, 2023 Category: Neurology Source Type: research

Impact of hypertensive disorders of pregnancy on short- and long-term outcomes of pregnancy-associated hemorrhagic stroke
ConclusionsIn this retrospective study, women with hypertension disorders of pregnancy did not show worse short-term outcomes of pregnancy-associated hemorrhagic stroke compared to those without but had poorer long-term functional outcomes. This underlines the importance of prevention, recognition, and treatment of hypertension disorders in these women.
Source: Frontiers in Neurology - March 16, 2023 Category: Neurology Source Type: research

Mutations in ARHGEF15 cause autosomal dominant hereditary cerebral small vessel disease and osteoporotic fracture
AbstractCerebral small vessel disease (CSVD) is a prominent cause of ischemic and hemorrhagic stroke and a leading cause of vascular dementia, affecting small penetrating vessels of the brain. Despite current advances in genetic susceptibility studies, challenges remain in defining the causative genes and the underlying pathophysiological mechanisms. Here, we reported that theARHGEF15 gene was a causal gene linked to autosomal dominant inherited CSVD. We identified one heterozygous nonsynonymous mutation of theARHGEF15 gene that cosegregated completely in two families with CSVD, and a heterozygous nonsynonymous mutation an...
Source: Acta Neuropathologica - March 16, 2023 Category: Neurology Source Type: research

The effects of aneurysmal subarachnoid hemorrhage on cerebral vessel diameter and flow velocity
Transcranial Doppler flow velocity is used to monitor for cerebral vasospasm following aneurysmal subarachnoid hemorrhage. Generally, blood flow velocities appear inversely related to the square of vessel diameter representing local fluid dynamics. However, studies of flow velocity-diameter relationships are few, and may identify vessels for which diameter changes are better correlated with Doppler velocity. We therefore studied a large retrospective cohort with concurrent transcranial Doppler velocities and angiographic vessel diameters.
Source: Journal of Stroke and Cerebrovascular Diseases - March 16, 2023 Category: Neurology Authors: Richard L. Wang, Kevin J. Gingrich, Awais Vance, Mark D. Johnson, Babu G. Welch, David L. McDonagh Source Type: research

Necessity and timing of angioplasty in acute large-vessel occlusion strokes due to intracranial atherosclerotic disease: A cohort analysis with data from the angel-ACT registry
ConclusionsAngioplasty and/or stenting should be performed at an early stage for ICAD-related acute LVOS.RegistrationURL: https://www.clinicaltrials.gov; Unique identifier: NCT03370939.
Source: Frontiers in Neurology - March 16, 2023 Category: Neurology Source Type: research

Mutations in ARHGEF15 cause autosomal dominant hereditary cerebral small vessel disease and osteoporotic fracture
AbstractCerebral small vessel disease (CSVD) is a prominent cause of ischemic and hemorrhagic stroke and a leading cause of vascular dementia, affecting small penetrating vessels of the brain. Despite current advances in genetic susceptibility studies, challenges remain in defining the causative genes and the underlying pathophysiological mechanisms. Here, we reported that theARHGEF15 gene was a causal gene linked to autosomal dominant inherited CSVD. We identified one heterozygous nonsynonymous mutation of theARHGEF15 gene that cosegregated completely in two families with CSVD, and a heterozygous nonsynonymous mutation an...
Source: Acta Neuropathologica - March 16, 2023 Category: Neurology Source Type: research

The NG2-glia is a potential target to maintain the integrity of neurovascular unit after acute ischemic stroke
Neurobiol Dis. 2023 Mar 13:106076. doi: 10.1016/j.nbd.2023.106076. Online ahead of print.ABSTRACTThe neurovascular unit (NVU) plays a critical role in health and disease. In the current review, we discuss the critical role of a class of neural/glial antigen 2 (NG2)-expressing glial cells (NG2-glia) in regulating NVU after acute ischemic stroke (AIS). We first introduce the role of NG2-glia in the formation of NVU during development as well as aging-induced damage to NVU and accompanying NG2-glia change. We then discuss the reciprocal interactions between NG2-glia and the other component cells of NVU, emphasizing the factor...
Source: Neurobiology of Disease - March 15, 2023 Category: Neurology Authors: Xiaoyan Hu Panpan Geng Xiaoyun Zhao Qian Wang Changqing Liu Chun Guo Wen Dong Xinchun Jin Source Type: research