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Early valve repair or replacement is not generally contraindicated in patients with infective endocarditis and stroke with or without intracranial haemorrhage ADULT CARDIAC
Source: European Journal of Cardio-Thoracic Surgery - July 19, 2016 Category: Cardiovascular & Thoracic Surgery Authors: Carrel, T. Tags: Electrophysiology - arrhythmias, Basic research vascular ADULT CARDIAC Source Type: research

Spontaneous subarachnoid haemorrhage
Publication date: Available online 13 September 2016 Source:The Lancet Author(s): R Loch Macdonald, Tom A Schweizer Subarachnoid haemorrhage is an uncommon and severe subtype of stroke affecting patients at a mean age of 55 years, leading to loss of many years of productive life. The rupture of an intracranial aneurysm is the underlining cause in 85% of cases. Survival from aneurysmal subarachnoid haemorrhage has increased by 17% in the past few decades, probably because of better diagnosis, early aneurysm repair, prescription of nimodipine, and advanced intensive care support. Nevertheless, survivors commonly have cognit...
Source: The Lancet - September 13, 2016 Category: Journals (General) Source Type: research

Flow diversion with Pipeline Embolic Device as treatment of subarachnoid hemorrhage secondary to blister aneurysms: dual-center experience and review of the literature
Conclusions Repair of ruptured BA with PED may be a safe and durable option.
Source: Journal of NeuroInterventional Surgery - December 13, 2016 Category: Neurosurgery Authors: Linfante, I., Mayich, M., Sonig, A., Fujimoto, J., Siddiqui, A., Dabus, G. Tags: Hemorrhagic stroke Source Type: research

Clinical Value of Neutrophil to Lymphocyte and Platelet to Lymphocyte Ratio After Aneurysmal Subarachnoid Hemorrhage
ConclusionsNLR and PLR as novel inflammatory biomarkers are independent predictors of DCI development and functional outcome after acute aSAH. When combined together, they may help to identify high-risk patients more powerfully.
Source: Neurocritical Care - December 26, 2016 Category: Neurology Source Type: research

Fatal Neisseria macacae infective endocarditis: first report
We present here the first case ofN. macacae infective endocarditis in a 65-year-old man with a native aortic valve infection complicated by a peri-aortic abscess. N. macacae was isolated from blood culture and was found on the cardiac valve using 16S rDNA detection. Despite an appropriate antibiotic therapy, and aortic homograft replacement, and mitral repair, the patient died 4  days after surgery from a massive hemorrhagic stroke.
Source: Infection - January 27, 2017 Category: Infectious Diseases Source Type: research

Seminar Spontaneous subarachnoid haemorrhage
Subarachnoid haemorrhage is an uncommon and severe subtype of stroke affecting patients at a mean age of 55 years, leading to loss of many years of productive life. The rupture of an intracranial aneurysm is the underlining cause in 85% of cases. Survival from aneurysmal subarachnoid haemorrhage has increased by 17% in the past few decades, probably because of better diagnosis, early aneurysm repair, prescription of nimodipine, and advanced intensive care support. Nevertheless, survivors commonly have cognitive impairments, which in turn affect patients' daily functionality, working capacity, and quality of life.
Source: LANCET - September 12, 2016 Category: Journals (General) Authors: R Loch Macdonald, Tom A Schweizer Tags: Seminar Source Type: research

Femoral Neuropathy Following Spontaneous Retroperitoneal Hemorrhage After Cardiac Surgery: A Case Report
A woman underwent ascending aortic aneurysm repair, aortic root and valve replacement, and coronary artery bypass grafting. Her postoperative course was complicated by stroke and status epilepticus. With supportive care and antiepileptics, her neurologic status improved. Intravenous heparin and aspirin were initiated. On postoperative day 13, she developed a large retroperitoneal hematoma with femoral neuropathy. Because her hematoma was not amenable to percutaneous drainage or surgical evacuation, and considering her comorbidities, a conservative approach was elected. Anticoagulation was held but not reversed, and she was...
Source: A&A Case Reports - April 14, 2017 Category: Anesthesiology Tags: Case Reports: Case Report Source Type: research

White Matter Injury and Recovery after Hypertensive Intracerebral Hemorrhage.
Abstract Hypertensive intracerebral hemorrhage (ICH) could very probably trigger white matter injury in patients. Through the continuous study of white matter injury after hypertensive ICH, we achieve a more profound understanding of the pathophysiological mechanism of its occurrence and development. At the same time, we found a series of drugs and treatment methods for the white matter repair. In the current reality, the research paradigm of white matter injury after hypertensive ICH is relatively obsolete or incomplete, and there are still lots of deficiencies in the research. In the face of the profound changes...
Source: Biomed Res - July 7, 2017 Category: Research Authors: Zuo S, Pan P, Li Q, Chen Y, Feng H Tags: Biomed Res Int Source Type: research

Open Thoracic and Thoraco-abdominal Aortic Repair in Patients with Connective Tissue Disease.
CONCLUSION: Open TAA(A) repair is a durable therapy for patients with CTD. Often being performed as revision surgery, it can be associated with relevant risks and should therefore be reserved for specialised centres. Staged procedures and thus reducing operating time, if applicable, should be preferred. PMID: 28916127 [PubMed - as supplied by publisher]
Source: PubMed: Eur J Vasc Endovasc ... - September 12, 2017 Category: Surgery Authors: Keschenau PR, Kotelis D, Bisschop J, Barbati ME, Grommes J, Mees B, Gombert A, Peppelenbosch AG, Schurink GWH, Kalder J, Jacobs MJ Tags: Eur J Vasc Endovasc Surg Source Type: research

Safety and effectiveness of microsurgical clipping, endovascular coiling, and stent assisted coiling for unruptured anterior communicating artery aneurysms: a systematic analysis of observational studies
Conclusions While there are limitations to the data, EC resulted in a more favorable clinical outcome, and MC resulted in more robust aneurysm repair, for unruptured ACoA aneurysms. SAC had a higher treatment morbidity risk than EC, without reduction in retreatment rate. All treatments were effective in preventing SAH. The current pooled analysis of treatment outcomes provides a useful aid to pretreatment clinical decision making.
Source: Journal of NeuroInterventional Surgery - July 12, 2017 Category: Neurosurgery Authors: O'Neill, A. H., Chandra, R. V., Lai, L. T. Tags: Hemorrhagic stroke Source Type: research

Management of Major Vascular Injuries
Vascular injuries represent a significant burden of mortality and disability. Blunt injuries to the neck vessels can present with signs of stroke either immediately or in a delayed fashion. Most injuries are detected with computed tomography angiography and managed with either antiplatelet medications or anticoagulation. In contrast, patients with penetrating injuries to the neck vessels require airway management, hemorrhage control, and damage control resuscitation before surgical repair. The keys to diagnosis and management of peripheral vascular injury include early recognition of the injury; hemorrhage control with dir...
Source: Emergency Medicine Clinics of North America - November 11, 2017 Category: Emergency Medicine Authors: Chris Evans, Tim Chaplin, David Zelt Source Type: research

Management of Major Vascular Injuries: Neck, Extremities, and Other Things that Bleed.
Abstract Vascular injuries represent a significant burden of mortality and disability. Blunt injuries to the neck vessels can present with signs of stroke either immediately or in a delayed fashion. Most injuries are detected with computed tomography angiography and managed with either antiplatelet medications or anticoagulation. In contrast, patients with penetrating injuries to the neck vessels require airway management, hemorrhage control, and damage control resuscitation before surgical repair. The keys to diagnosis and management of peripheral vascular injury include early recognition of the injury; hemorrhag...
Source: The Medical Clinics of North America - November 15, 2017 Category: General Medicine Authors: Evans C, Chaplin T, Zelt D Tags: Emerg Med Clin North Am Source Type: research

Autophagy after subarachnoid hemorrhage: Can cell death be good?
Abstract Autophagy is a prosurvival, reparative process that maintains cellular homeostasis through lysosomal degradation of selected cytoplasmic components and programmed death of old, dysfunctional, or unnecessary cytoplasmic entities. According to growing evidence, autophagy shows beneficial effects following subarachnoid hemorrhage (SAH). SAH is considered one of the most devastating forms of stroke. Though autophagy is prosurvival and aids in repair, deregulated or excessive autophagy results in increased cell death, more brain injury, and worse outcome. The aim of this review lies in revealing the pathophysi...
Source: Current Neuropharmacology - November 23, 2017 Category: Drugs & Pharmacology Authors: Ho WM, Akyol O, Reis H, Reis C, McBride D, Thome C, Zhang J Tags: Curr Neuropharmacol Source Type: research

Exposure to the ROCK inhibitor fasudil promotes gliogenesis of neural stem cells in vitro
Publication date: April 2018 Source:Stem Cell Research, Volume 28 Author(s): Zubair Ahmed Nizamudeen, Lisa Chakrabarti, Virginie Sottile Fasudil is a clinically approved Rho-associated protein kinase (ROCK) inhibitor that has been used widely to treat cerebral consequences of subarachnoid hemorrhage. It is known to have a positive effect on animal models of neurological disorders including Parkinson's disease and stroke. However, its cellular effect on progenitor populations and differentiation is not clearly understood. While recent studies suggest that fasudil promotes the mobilization of neural stem cells (NSCs) from t...
Source: Stem Cell Research - February 28, 2018 Category: Stem Cells Source Type: research

Acute ischemic dissection of an “S”-shaped carotid artery: The “one-stop” value of using a detachable Solitaire AB stent
This study aimed to evaluate the efficacy and safety of endovascular repair using detachable Solitaire AB stents for acute ischemic dissection of “S”-shaped carotid arteries. From May 2015 to December 2016, a total of 127 patients with acute ischemic stroke (AIS) underwent endovascular treatment in our center. Among them, five AISs were due to acute dissection of an “S”-shaped carotid artery. Coexisting carotid embolism was identified in all five patients, who first underwent successful Solitaire AB stent-based retrieval of the embolism. All patients then underwent Solitaire AB stenting to reopen the occluded carot...
Source: Journal of Clinical Neuroscience - May 9, 2018 Category: Neuroscience Source Type: research

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