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Condition: Hemorrhagic Stroke
Procedure: Gastroschisis Repair

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Total 192 results found since Jan 2013.

Pretreatment of Mouse Neural Stem Cells with Carbon Monoxide-Releasing Molecule-2 Interferes with NF-κB p65 Signaling and Suppresses Iron Overload-Induced Apoptosis.
Abstract Neural stem cell (NSC) transplantation is a promising approach to repair the damaged brain after hemorrhagic stroke; however, it is largely limited by the poor survival of donor cells. Breakdown products of the hematoma and subsequent iron overload contribute to the impairment of survival of neural cells. There is little information regarding the mechanism involved in the death of grafted cells. Furthermore, therapeutic research targeted to improving the survival of grafted neural stem cells (NSCs) is strikingly lacking. Here, we showed that iron overload induced apoptosis of C17.2 cells, a cell line orig...
Source: Cellular and Molecular Neurobiology - March 10, 2016 Category: Cytology Authors: Xie Z, Han P, Cui Z, Wang B, Zhong Z, Sun Y, Yang G, Sun Q, Bian L Tags: Cell Mol Neurobiol Source Type: research

Sterile Neuroinflammation and Strategies for Therapeutic Intervention.
Authors: Banjara M, Ghosh C Abstract Sterile neuroinflammation is essential for the proper brain development and tissue repair. However, uncontrolled neuroinflammation plays a major role in the pathogenesis of various disease processes. The endogenous intracellular molecules so called damage-associated molecular patterns or alarmins or damage signals that are released by activated or necrotic cells are thought to play a crucial role in initiating an immune response. Sterile inflammatory response that occurs in Alzheimer's disease (AD), Parkinson's disease (PD), stroke, hemorrhage, epilepsy, or traumatic brain injur...
Source: International Journal of Inflammation - January 28, 2017 Category: Allergy & Immunology Tags: Int J Inflam Source Type: research

Early Prophylactic Hypothermia for Patients With Severe Traumatic Injury: Premature to Close the Case
This study demonstrates that there is no role for the initiation of hypothermia during the acute phase of TBI (1, 2). However, it would be damaging to abandon the concept prematurely. Inflammation Also Paves the Way to Tissue Repair As soon as trauma occurs, the inflammatory cascade begins to take place. The deleterious role of inflammation in the secondary injury response is well-documented, hence the rationale to attempt early prophylactic hypothermia in TBI. However, inflammation also initiates tissue repair and regeneration (3–6). We now know that the secondary injury response accompanies the regenerating and...
Source: Frontiers in Neurology - April 8, 2019 Category: Neurology Source Type: research

Canagliflozin Inhibits Human Endothelial Cell Proliferation and Tube Formation
In conclusion, the present study identified canagliflozin as a potent inhibitor of human EC proliferation. The anti-proliferative action of canagliflozin is observed in ECs isolated from both the venous and arterial circulation, and is partly due to the blockade of cyclin A expression. In addition, this study found that canagliflozin inhibits tube formation in cultured ECs and mouse aortic rings. Notably, these actions are specific for canagliflozin and not seen with other SGLT2 inhibitors. The ability of canagliflozin to exert these pleiotropic effects on EC function may contribute to both the adverse and salutary actions...
Source: Frontiers in Pharmacology - April 15, 2019 Category: Drugs & Pharmacology Source Type: research

Iron Metabolism and Brain Development in Premature Infants
Yafeng Wang1,2,3, Yanan Wu2, Tao Li1,2,3, Xiaoyang Wang2,4 and Changlian Zhu2,3* 1Department of Neonatology (NICU), Children’s Hospital Affiliated Zhengzhou University, Zhengzhou, China 2Henan Key Laboratory of Child Brain Injury, Institute of Neuroscience and Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China 3Department of Clinical Neuroscience, Center for Brain Repair and Rehabilitation, Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden 4Department of Physiology, Sahlgrenska Academy, Institute of Neuroscience and Physiology, University of Got...
Source: Frontiers in Physiology - April 24, 2019 Category: Physiology Source Type: research

Retrograde arterial perfusion and its outcome in robotic mitral valve surgery
CONCLUSION: Retrograde arterial perfusion is a safe method for minimally invasive cardiac surgery less than 3.5 hours under mild hypothermic status.PMID:34840044 | DOI:10.1016/j.asjsur.2021.10.013
Source: Asian Journal of Surgery - November 29, 2021 Category: Surgery Authors: Yi-Chia Wang Nai-Hsin Chi Ya-Chen Wang Yih-Sharng Chen Chi-Hsiang Huang Source Type: research

E-108 Ruptured intracranial aneurysm presenting as isolated acute subdural hemorrhage
ConclusionIn rare cases, ruptured intracranial aneurysms can be associated with isolated subdural hemorrhage. Common treatment options include endovascular coiling and microsurgical clipping. However, endovascular repair is often preferred especially when the patient may not be able to tolerate a surgical procedure, as was the case with this patient. In this case, the patient presented with stroke-like symptoms and was found to have a subdural hemorrhage. After emergent craniotomy to evacuate the hematoma, successful endovascular coiling was performed, and the patient was stabilized for further management>Disclosures D....
Source: Journal of NeuroInterventional Surgery - July 23, 2022 Category: Neurosurgery Authors: Babici, D., Johansen, P., Newman, S., Packer, E., Snelling, B. Tags: SNIS 19th annual meeting electronic poster abstracts Source Type: research

Midterm Results of David Reimplantation in Patients With Connective Tissue Disorder ORIGINAL ARTICLES: ADULT CARDIAC
Conclusions Prophylactic root and valve preservation using David reimplantation is safe and provides excellent midterm effectiveness and low risk of late events except for endocarditis.
Source: The Annals of Thoracic Surgery - January 30, 2013 Category: Cardiovascular & Thoracic Surgery Authors: Svensson, L. G., Blackstone, E. H., Alsalihi, M., Batizy, L. H., Roselli, E. E., McCullough, R., Vivacqua, A., Moran, R. T., Gillinov, A. M., Thamilarasan, M., Griffin, B., Hammer, D. F., Stewart, W. J., Sabik, J. F., Lytle, B. W. Tags: Valve disease ORIGINAL ARTICLES: ADULT CARDIAC Source Type: research

Minimally invasive approach provides at least equivalent results for surgical correction of mitral regurgitation: A propensity-matched comparison
Conclusions: In appropriate patients with isolated mitral valve disease of any cause, a right minithoracotomy approach may be used without compromising clinical outcome.
Source: The Journal of Thoracic and Cardiovascular Surgery - February 16, 2013 Category: Cardiovascular & Thoracic Surgery Authors: Andrew B. Goldstone, Pavan Atluri, Wilson Y. Szeto, Alen Trubelja, Jessica L. Howard, John W. MacArthur, Craig Newcomb, Joseph P. Donnelly, Dale M. Kobrin, Mary A. Sheridan, Christiana Powers, Robert C. Gorman, Joseph H. Gorman, Alberto Pochettino, Joseph Tags: Acquired Cardiovascular Disease Source Type: research

Inhospital Complications Associated with Catheter Ablation of Atrial Fibrillation in the United States between 2000-2010: Analysis of 93,801 Procedures.
CONCLUSIONS: The overall complication rate was 6.29% in patients undergoing AF ablation. There was a significant association between operator and hospital volume on adverse outcomes. This suggests a need for future research into identifying the safety measures in AF ablations and instituting appropriate interventions to improve overall AF ablation outcomes. PMID: 24061087 [PubMed - as supplied by publisher]
Source: Circulation - September 23, 2013 Category: Cardiology Authors: Deshmukh A, Patel NJ, Pant S, Shah N, Chothani A, Mehta K, Grover P, Singh V, Vallurupalli S, Savani GT, Badheka A, Tuliani T, Dabhadkar K, Dibu G, Reddy YM, Sewani A, Kowalski M, Mitrani R, Paydak H, Viles-Gonzalez JF Tags: Circulation Source Type: research

Rehabilitation Improves Behavioral Recovery and Lessens Cell Death Without Affecting Iron, Ferritin, Transferrin, or Inflammation After Intracerebral Hemorrhage in Rats
Conclusions. Rehabilitation is an effective behavioral and neuroprotective strategy for ICH. Neither effect appears to stem from influencing iron toxicity or inflammation. Thus, additional work must identify underlying mechanisms to help further therapeutic gains.
Source: Neurorehabilitation and Neural Repair - April 14, 2014 Category: Neurology Authors: Caliaperumal, J., Colbourne, F. Tags: Basic Research Article Source Type: research

126 * extra-anatomic revascularisation for distal occlusion of the left or right common carotid artery in acute type a aortic dissection with cerebral malperfusion
Conclusion: Extra-anatomic bypass for distal LCCA or RCCA occlusion presents a valuable bail-out technique to restore cerebral perfusion during AADA repair, potentially reducing the increased incidence of neurological complications in patients with cerebral malperfusion.
Source: Interactive CardioVascular and Thoracic Surgery - September 23, 2014 Category: Cardiovascular & Thoracic Surgery Authors: Luehr, M., Etz, C. D., Lehmkuhl, L., Misfeld, M., Bakhtiary, F., Borger, M., Mohr, F. Tags: Complicated type A aortic dissection: Malperfusion and outcome Source Type: research

Is aneurysm repair justified for the patients aged 80 or older after aneurysmal subarachnoid hemorrhage?
Conclusions Better prognosis was obtained when ruptured aneurysm was repaired in the elderly than it was treated conservatively. From the results of this study, we should not hesitate to offer the definitive surgery for the elderly with aSAH.
Source: Journal of NeuroInterventional Surgery - October 7, 2014 Category: Neurosurgery Authors: Sadamasa, N., Koyanagi, M., Fukuda, H., Chin, M., Handa, A., Yamagata, S. Tags: Hemorrhagic stroke Source Type: research

Early results of the Axium MicroFX for Endovascular Repair of IntraCranial Aneurysm (AMERICA) study: a multicenter prospective observational registry
Conclusions This prospective study of Axium MicroFX coils demonstrates excellent aneurysm occlusion rates. 52% of aneurysms were completely occluded post-procedure. Within the ruptured aneurysm group, post-procedure occlusion rates were 63.6%. Major AE rates were consistent with historical data.
Source: Journal of NeuroInterventional Surgery - August 6, 2014 Category: Neurosurgery Authors: Fargen, K. M., Blackburn, S., Carpenter, J. S., Jabbour, P., Mack, W. J., Rai, A. T., Siddiqui, A. H., Turner, R. D., Mocco, J. Tags: Hemorrhagic stroke Source Type: research