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Protect That Neck! Management of Blunt and Penetrating Neck Trauma
Emerg Med Clin North Am. 2023 Feb;41(1):35-49. doi: 10.1016/j.emc.2022.09.005.ABSTRACTBlunt and penetrating vascular injuries to the neck represent a significant burden of mortality and disability among trauma patients. Blunt cerebrovascular injury can present with signs of stroke either immediately or in a delayed fashion. Most injuries are detected with computed tomography angiogram and managed by antiplatelet agents or unfractionated heparin. In contrast, for patients presenting with penetrating neck injuries, assessment for hard signs of vascular and aerodigestive injury should be done and prompt emergent surgical cons...
Source: The Medical Clinics of North America - November 24, 2022 Category: General Medicine Authors: Matt Piaseczny Julie La Tim Chaplin Chris Evans Source Type: research

Alpha-Asarone Ameliorates Neurological Dysfunction of Subarachnoid Hemorrhagic Rats in Both Acute and Recovery Phases via Regulating the CaMKII-Dependent Pathways
AbstractEarly brain injury (EBI) is the leading cause of poor prognosis for patients suffering from subarachnoid hemorrhage (SAH), particularly learning and memory deficits in the repair phase. A recent report has involved calcium/calmodulin-dependent protein kinase II (CaMKII) in the pathophysiological process underlying SAH-induced EBI. Alpha-asarone (ASA), a major compound isolated from the Chinese medicinal herbAcorus tatarinowii Schott, was proven to reduce secondary brain injury by decreasing CaMKII over-phosphorylation in rats ’ model of intracerebral hemorrhage in our previous report. However, the effect of ASA o...
Source: Translational Stroke Research - February 13, 2023 Category: Neurology Source Type: research

Lumbar Drain Use during Middle Fossa Approaches for Nonneoplastic Pathology of the Skull Base
Conclusion No difference in postoperative outcomes was observed in patients who had an intraoperative LD placed compared to those without LD. Operative times were increased in the LD cohort, but this difference was not statistically significant. Given the similar outcomes, we conclude that LD is not necessary to facilitate safe MCF for nonneoplastic skull base pathologies. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text
Source: Journal of Neurological Surgery Part B: Skull Base - April 21, 2023 Category: Neurosurgery Authors: Dambrino, Robert J. Wong, Gunther W. Tang, Alan R. Jo, Jacob Yengo-Kahn, Aaron M. Lindquist, Nathan R. Freeman, Michael H. Haynes, David S. Tawfik, Kareem O. Chambless, Lola B. Thompson, Reid C. Morone, Peter J. Tags: Original Article Source Type: research

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