Autophagy after subarachnoid hemorrhage: Can cell death be good?

Autophagy after subarachnoid hemorrhage: Can cell death be good? Curr Neuropharmacol. 2017 Nov 23;: Authors: Ho WM, Akyol O, Reis H, Reis C, McBride D, Thome C, Zhang J Abstract Autophagy is a prosurvival, reparative process that maintains cellular homeostasis through lysosomal degradation of selected cytoplasmic components and programmed death of old, dysfunctional, or unnecessary cytoplasmic entities. According to growing evidence, autophagy shows beneficial effects following subarachnoid hemorrhage (SAH). SAH is considered one of the most devastating forms of stroke. Though autophagy is prosurvival and aids in repair, deregulated or excessive autophagy results in increased cell death, more brain injury, and worse outcome. The aim of this review lies in revealing the pathophysiological pathways and the effects of autophagy on the neurovascular unit following SAH. Current results from animal studies will be discussed focusing on the effects of inhibitors and inducers of autophagy. In addition, this review discusses the clinical translation of potential neuropharmacological targets that can help prevent early brain injury (EBI) following SAH by incorporating programmed cell death into clinical management. PMID: 29173174 [PubMed - as supplied by publisher]
Source: Current Neuropharmacology - Category: Drugs & Pharmacology Authors: Tags: Curr Neuropharmacol Source Type: research