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Condition: Septic Shock

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Total 242 results found since Jan 2013.

A Blood Filter Fights Deadly Inflammatory Response
A new blood filtration technology may prove to be life-saving for patients whose normally healthy inflammatory response to injury or illness has gone into overdrive, resulting in fatally high levels of cytokines in their blood. In an interview with MD+DI, Dr. Phillip Chan, MD, PhD, CEO of CytoSorbents Corp., explained that inflammation, and the production of substances called cytokines that drive inflammation, are the body’s natural response to heal injury or infection. But sometimes, the inflammatory response is so severe in such conditions as sepsis and infection, burn injuries, trauma, pancreatitis, li...
Source: MDDI - October 9, 2019 Category: Medical Devices Authors: Susan Shepard Tags: Cardiovascular Source Type: news

Pneumocephalus and pneumorachis after blunt chest trauma without spinal fractures: a case report
ConclusionsThis is the first case report to describe pneumorachis and pneumocephalus following blunt trauma with pneumothorax, but no spinal or skull fractures. The mechanism that is probably involved here is a migration of air with subcutaneous emphysema and a pleural hernia into the spinal canal. However, in cases of pneumorachis or pneumocephalus, skull fractures need to be investigated as these require surgery and appropriate vaccination to prevent meningitis.
Source: Journal of Medical Case Reports - October 24, 2019 Category: General Medicine Source Type: research

An antibody against HK blocks Alzheimer’s disease peptide {beta}-amyloid-induced bradykinin release in human plasma Immunology and Inflammation
Bradykinin is a proinflammatory factor that mediates angioedema and inflammation in many diseases. It is a key player in some types of hereditary angioedema and is involved in septic shock, traumatic injury, Alzheimer’s disease (AD), and stroke, among others. Activation of the plasma contact system leads to elevated levels of...
Source: Proceedings of the National Academy of Sciences - November 11, 2019 Category: Science Authors: Zu-Lin Chen, Pradeep Singh, Jyen Wong, Katharina Horn, Sidney Strickland, Erin H. Norris Tags: Brief Reports Biological Sciences Source Type: research

Reaction in oral mucosa due to intensive therapy polypharmacy: case report
A 51-year-old white female patient hospitalized in the intensive care unit because of acute ischemic stroke who needed tracheostomy and vasoactive drugs in high dosage evolved with aspiration pneumonia and septic shock. At 30 days of hospitalization, intraoral examination revealed multiple superficial ulcers on the lips, buccal mucosa, tongue, and mouth floor, circumscribed by erythematous halo and covered by pseudomembrane with severe pain symptomatology and evolution of 15 days. Concomitantly, the patient presented bilateral conjunctivitis with erythema in the sclera and periocular region.
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - December 15, 2019 Category: ENT & OMF Authors: ANDRESSA COUTINHO RIBEIRO, CLAUDIA CRISTIANE BAISEREDO DE CARVALHO, ANA FL ÁVIA SCHUELER DE ASSUMPÇÃO LEITE, ADRIANA TEREZINHA NEVES NOVELLINO ALVES, SIMONE DE QUEIROZ CHAVES LOURENÇO, JOSIANE COSTA RODRIGUES DE SÁ Source Type: research

A Simple Risk Score to Predict Clavien-Dindo Grade IV and V Complications After Non-elective Cholecystectomy
ConclusionA simple risk-score model predicts severe complications in patients undergoing unplanned cholecystectomy for common indications encountered in an acute care surgery service and identifies high-risk patients.
Source: Journal of Gastrointestinal Surgery - February 5, 2020 Category: Surgery Source Type: research

Respiratory Variations in Aortic Blood Flow to Predict Volume Responsiveness in Ventilated Children With Leukemia and Neutropenic Septic Shock*
Conclusions: Respiratory variation in velocity time integral of aortic blood flow and respiratory variation in peak velocity of aortic blood flow derived from transthoracic echocardiography showed only a fair reliability in predicting volume responsiveness in ventilated children with leukemia and neutropenic septic shock.
Source: Pediatric Critical Care Medicine - May 1, 2020 Category: Pediatrics Tags: Online Clinical Investigations Source Type: research

Studying the Clinical Data of COVID Positive patients admitted to a tertiary care academic hospital
Conclusion: The most common presenting symptoms included fever, cough, and shortness of breath. Patients who required ICU admission at presentation had a worse prognosis. Those with greater severity of symptoms were mainly elderly patients among which the most common comorbidity was hypertention followed by cardiac disease.
Source: Journal of Emergencies, Trauma and Shock - June 9, 2020 Category: Emergency Medicine Authors: Julio Arrieta Sagar Galwankar Natalia Lattanzio Darrel Ray Amit Agrawal Source Type: research

Idarucizumab for dabigatran reversal in daily clinical practice: A case series
CONCLUSION Our first experiences with idarucizumab use in daily-care settings support a rapid and efficient decrease in the anticoagulant effect of dabigatran in emergency situations. Late re-occurrence of dabigatran effect was noted in a subset of patients with severe renal failure.
Source: European Journal of Anaesthesiology - September 12, 2020 Category: Anesthesiology Tags: Coagulation Source Type: research

Dynamic Arterial Elastance During Experimental Endotoxic Septic Shock: A Potential Marker of Cardiovascular Efficiency
Dynamic arterial elastance (Eadyn), the ratio between pulse pressure variation (PPV) and stroke volume variation (SVV), has been suggested as a dynamic parameter relating pressure and flow. We aimed to determine the effects of endotoxic septic shock and hemodynamic resuscitation on Eadyn in an experimental study in 18 New Zealand rabbits. Animals received placebo (SHAM, n = 6) or intravenous lipopolysaccharide (E. Coli 055:B5, 1 mg⋅kg–1) with or without (EDX-R, n = 6; EDX, n = 6) hemodynamic resuscitation (fluid bolus of 20 ml⋅kg–1 and norepinephrine for restoring mean arterial pressure). Continuous arterial pressu...
Source: Frontiers in Physiology - October 1, 2020 Category: Physiology Source Type: research

Effect of VTILVOT variation rate on the assessment of fluid responsiveness in septic shock patients
This study aimed to assess the predictive value of velocity time integral (VTI) of the left ventricular outflow tract (LVOT) on volume expansion test (VET) as an indicator of volume responsiveness in septic shock patients. Septic shock patients undergoing mechanical ventilation were recruited. The hemodynamic parameters before and after VE were monitored by pulse indicated continuous cardiac output (PiCCO) and echocardiography. Heart rate, cardiac index (CI), mean arterial pressure (MAP), central venous pressure, stroke volume variation (SVV), CI and variation of pulse pressure (PPV), and the changes in cardiac parameters ...
Source: Medicine - November 20, 2020 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research

Fluid Response Evaluation in Sepsis Hypotension and Shock
Patients in septic shock routinely receive large volumes of intravenous fluids as part of their initial resuscitation. However, hypervolemia secondary to aggressive fluid administration is associated with increased morbidity and mortality including renal failure, respiratory failure, or death. Dynamic approaches to hemodynamic monitoring for fluid responsiveness (FR) including measurement of stroke volume (SV) following increased fluid volume through IV fluids during passive leg raise (PLR) may have a role in guiding resuscitative efforts, although the benefits in an emergency department or ICU setting are unclear.
Source: The Journal of Emergency Medicine - January 1, 2021 Category: Emergency Medicine Authors: Benjamin Robert Wagner, Zachary B. Lewis Tags: Abstract Source Type: research

Clinical Features and Outcome of Infective Endocarditis in a University Hospital in Romania.
Conclusions: Staphylococcus aureus IE was associated with the presence of large vegetations, prosthetic valve endocarditis and intracardiac abscess. Coagulase negative Staphylococcus (CoNS) infection was associated with prosthetic valve dysfunction. Streptococcus gallolyticus etiology correlated with ischemic embolic stroke and the presence of large vegetations. Cardiovascular surgery was recommended in 67.4% of patients but was performed only on half of them. In hospital death occurred in 33.7% of patients and independent predictors of mortality were congestive heart failure and septic shock. PMID: 33578787 [PubMed -...
Source: Medicina (Kaunas) - February 10, 2021 Category: Universities & Medical Training Authors: Babeș EE, Lucuța DA, Petcheși CD, Zaha AA, Ilyes C, Jurca AD, Vesa CM, Zaha DC, Babeș VV Tags: Medicina (Kaunas) Source Type: research

Left ventricular-arterial coupling as a predictor of stroke volume response to norepinephrine in septic shock – a prospective cohort study
This study aims t...
Source: BMC Anesthesiology - February 17, 2021 Category: Anesthesiology Authors: Xiaoyang Zhou, Jianneng Pan, Yang Wang, Hua Wang, Zhaojun Xu and Weibo Zhuo Tags: Research article Source Type: research

Established evidence-based treatment guidelines help mitigate disparities in quality of emergency care.
CONCLUSIONS: Long-standing, nationally reported evidence-based guidelines can help eliminate sex and race/ethnicity disparities in quality of care. When providers know their care is being monitored and reported, their implicit biases may be less likely to impact care. PMID: 33599040 [PubMed - as supplied by publisher]
Source: Accident and Emergency Nursing - February 18, 2021 Category: Emergency Medicine Authors: Trent SA, George N, Havranek EP, Ginde AA, Haukoos JS Tags: Acad Emerg Med Source Type: research

Clinical Features and Outcome of Infective Endocarditis in a University Hospital in Romania
Conclusions: Staphylococcus aureus IE was associated with the presence of large vegetations, prosthetic valve endocarditis and intracardiac abscess. Coagulase negative Staphylococcus (CoNS) infection was associated with prosthetic valve dysfunction. Streptococcus gallolyticus etiology correlated with ischemic embolic stroke and the presence of large vegetations. Cardiovascular surgery was recommended in 67.4% of patients but was performed only on half of them. In hospital death occurred in 33.7% of patients and independent predictors of mortality were congestive heart failure and septic shock.PMID:33578787 | DOI:10.3390/medicina57020158
Source: Medicina (Kaunas) - February 13, 2021 Category: Universities & Medical Training Authors: Emilia Elena Babe ș Diana Anca Lucu ța Codru ța Diana Petcheși Andreea Atena Zaha Cristian Ilyes Alexandru Daniel Jurca Cosmin Mihai Vesa Dana Carmen Zaha Vlad Victor Babe ș Source Type: research