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Condition: Septic Shock

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Total 242 results found since Jan 2013.

High Serum sTREM-1 Correlates With Myocardial Dysfunction and Predicts Prognosis in Septic Patients.
CONCLUSIONS: Myocardial dysfunction is common in patients with severe sepsis and septic shock and high serum levels of sTREM-1 correlates with myocardial dysfunction to some extent but is not an independent predictor, which more importantly showed prognostic value for septic shock outcome. PMID: 27238916 [PubMed - in process]
Source: The American Journal of the Medical Sciences - May 31, 2016 Category: Journals (General) Authors: Li Z, Zhang E, Hu Y, Liu Y, Chen B Tags: Am J Med Sci Source Type: research

Muhammed Ali's Death Underscores Importance of Prehospital Sepsis Detection
Muhammad Ali, one of the greatest athletes of all times and a world-class treasure, passed away on Friday, June 3, 2016, as result of sepsis. Imagine if an EMS crew could have detected that he was becoming septic and was able to treat him in the field, helping the hospital attack this deadly condition before it attacked his vital organs? Soon, crews all over the world will be capable of doing so. Severe sepsis is caused by overwhelming infection, and is responsible for significant morbidity and mortality among hospitalized patients. Clinical identification of sepsis includes two or more of the systemic inflammatory respons...
Source: JEMS Patient Care - June 6, 2016 Category: Emergency Medicine Authors: A.J. Heightman, MPA, EMT-P Tags: Patient Care Source Type: news

French Intensive Care Society, International congress - Réanimation 2016.
C, Sauneuf B, Verrier P, Pottier V, Orabona M, Samba D, Viquesnel G, Lermuzeaux M, Hazera P, Hanouz JL, Parienti JJ, Du Cheyron D, Demoule A, Clavel M, Rolland-Debord C, Perbet S, Terzi N, Kouatchet A, Wallet F, Roze H, Vargas F, Guérin C, Dellamonica J, Jaber S, Similowski T, Quenot JP, Binquet C, Vinsonneau C, Barbar SD, Vinault S, Deckert V, Lemaire S, Hssain AA, Bruyère R, Souweine B, Lagrost L, Adrie C, Jung B, Daurat A, De Jong A, Chanques G, Mahul M, Monnin M, Molinari N, Lheureux O, Trepo E, Hites M, Cotton F, Wolff F, Surin R, Créteur J, Vincent JL, Gustot T, Jacobs F, Taccone FS, Neuville M, Timsit JF, El-Hel...
Source: Australian Family Physician - May 31, 2016 Category: Primary Care Authors: Jaillette E, Girault C, Brunin G, Zerimech F, Chiche A, Broucqsault-Dedrie C, Fayolle C, Minacori F, Alves I, Barrailler S, Robriquet L, Delaporte E, Thellier D, Delcourte C, Duhamel A, Nseir S, Valette X, Desmeulles I, Savary B, Masson R, Seguin A, Daubi Tags: Ann Intensive Care Source Type: research

Longitudinal Study of the Effects of Bacteremia and Sepsis on 5-year Risk of Cardiovascular Events
Conclusions. Prior instances of bacteremia and sepsis substantially increase the 5-year risk of CV events.
Source: Clinical Infectious Diseases - July 30, 2016 Category: Infectious Diseases Authors: Jafarzadeh, S. R., Thomas, B. S., Warren, D. K., Gill, J., Fraser, V. J. Tags: ARTICLES AND COMMENTARIES Source Type: research

Predictors of 30-day mortality following hip/pelvis fractures
Discussion Several preoperative patient risk factors and postoperative complications greatly increased the odds for patient mortality following 30-days after initial surgery. Orthopaedic surgeons can utilize these predictive risk factors to better improve patient care. Level of evidence Retrospective study. Level IV.
Source: Orthopaedics and Traumatology: Surgery and Research - August 3, 2016 Category: Orthopaedics Source Type: research

Muhammed Ali's Death Underscores Importance of Prehospital Sepsis Detection
Muhammad Ali, one of the greatest athletes of all times and a world-class treasure, passed away on Friday, June 3, 2016, as result of sepsis. Imagine if an EMS crew could have detected that he was becoming septic and was able to treat him in the field, helping the hospital attack this deadly condition before it attacked his vital organs? Soon, crews all over the world will be capable of doing so. Severe sepsis is caused by overwhelming infection, and is responsible for significant morbidity and mortality among hospitalized patients. Clinical identification of sepsis includes two or more of the systemic inflammatory respons...
Source: JEMS Patient Care - June 6, 2016 Category: Emergency Medicine Authors: A.J. Heightman, MPA, EMT-P Tags: Patient Care Source Type: news

South Carolina EMS Integrates In-Hospital Sepsis Care into Protocols
Medic 29 is dispatched to a college dorm for a female with chief complaint of lower abdominal and flank pain for the past five days. The dorm room appears clean and well kept. The patient appears to be a typical 18-year-old college student. She's lying on her bed and is responsive to verbal stimuli, hot to touch, and tachycardic with weak and thready radial pulses at 128. She reports painful urinating for the past 48 hours, general malaise, weakness and nausea. She appears to have labored respirations with a room air SpO2 reading of 95% and is hypotensive with a systolic blood pressure of 88 mmHg that remains low during tr...
Source: JEMS Patient Care - September 1, 2016 Category: Emergency Medicine Authors: Jason G. Walchok, NRP, FP-C Tags: Patient Care Source Type: news

Challenges in Sepsis Care
There are 2 important recent changes in sepsis care. The first key change is the 2016 Sepsis-3 definitions from the recent consensus workgroup with new sepsis and septic shock definitions. Useful tools for assessing patients that have a greater risk of mortality include Sequential Organ Failure Assessment (SOFA) in intensive care units and quick SOFA outside intensive care units. The second change involves management of fluid resuscitation and measures of volume responsiveness. Measures such as blood pressure and central venous pressure are not reliable. Fluid challenges and responsiveness should be based on stroke volume ...
Source: Critical Care Nursing Clinics of North America - September 25, 2016 Category: Nursing Authors: Maureen A. Seckel, Thomas Ahrens Source Type: research

The effects of neoadjuvant therapy on morbidity and mortality of esophagectomy for esophageal cancer: American college of surgeons national surgical quality improvement program (ACS –NSQIP) 2005–2012
ConclusionsWe conclude that neoadjuvant therapy followed by esophagectomy for esophageal cancer does not have a negative impact on 30‐day mortality. Neoadjuvant therapy is associated with increased odds of PE. J. Surg. Oncol. © 2016 Wiley Periodicals, Inc.
Source: Journal of Surgical Oncology - November 3, 2016 Category: Cancer & Oncology Authors: Michel J. Sabra, Carmen Smotherman, Dale F. Kraemer, Michael S. Nussbaum, Joseph J. Tepas, Ziad T. Awad Tags: Research Article Source Type: research

Time interval between infective endocarditis first symptoms and diagnosis: relationship to infective endocarditis characteristics, microorganisms and prognosis.
CONCLUSIONS: The time interval between IE first symptoms and diagnosis is closely related to the IE clinical presentation, patient characteristics and causative microorganism. Better prognosis reported in late-diagnosed IE may be related to a higher rate of valvular surgery. KEY MESSAGES Infective endocarditis, which time interval between first symptoms and diagnosis was less than one month, were mainly due to Staphylococcus aureus in France. Staphylococcus aureus infective endocarditis were associated with septic shock, transient ischemic attack or stroke and higher mortality rates than infective endocarditis due to other...
Source: Annals of Medicine - November 5, 2016 Category: Internal Medicine Tags: Ann Med Source Type: research

A Rational Approach to Fluid Therapy in Sepsis
(Abstracted from Br J Anaesth, 116:339–349, 2016) The current standard of care for managing patients with severe sepsis and septic shock is aggressive fluid resuscitation, until a central venous pressure of greater than 8 mm Hg is achieved. The rationale behind this approach is to increase a patient’s stroke volume, which in turn improves cardiac output and organ perfusion.
Source: Survey of Anesthesiology - November 19, 2016 Category: Anesthesiology Tags: Critical Care Source Type: research

Major publications in the critical care pharmacotherapy literature in 2015.
CONCLUSION: Important recent additions to the critical care pharmacy literature include updated joint clinical practice guidelines on the management of spontaneous ICH, ACLS, and SVT. PMID: 28122702 [PubMed - as supplied by publisher]
Source: American Journal of Health-System Pharmacy : AJHP - January 24, 2017 Category: Drugs & Pharmacology Authors: Wong A, Erdman M, Hammond DA, Holt T, Holzhausen JM, Horng M, Huang LL, Jarvis J, Kram B, Kram S, Lesch C, Mercer J, Rech MA, Rivosecchi R, Stump B, Teevan C, Day S Tags: Am J Health Syst Pharm Source Type: research

Changes in B-type natriuretic peptide and related hemodynamic parameters following a fluid challenge in critically ill patients with severe sepsis or septic shock
Conclusions: An increase in BNP soon after a fluid challenge may have some predictive utility of a large LVEDd, which in turn can be used to independently predict the SV response to a fluid challenge.
Source: Indian Journal of Critical Care Medicine - March 8, 2017 Category: Intensive Care Authors: Shahed Omar Ahmad Ali Yahya Atiya Rudo Lufuno Mathivha Joel M Dulhunty Source Type: research

Opportunities for the repurposing of PARP inhibitors for the therapy of non ‐oncological diseases
We present a preclinical and clinical action plan for the repurposing of PARP inhibitors.
Source: British Journal of Pharmacology - March 26, 2017 Category: Drugs & Pharmacology Authors: Nathan A Berger, Valerie C Besson, A Hamid Boulares, Alexander B ürkle, Alberto Chiarugi, Robert S Clark, Nicola J Curtin, Salvatore Cuzzocrea, Ted M Dawson, Valina L Dawson, György Haskó, Lucas Liaudet, Flavio Moroni, Pál Pacher, Peter Radermacher, A Tags: REVIEW ARTICLE THEMED ISSUE Source Type: research

Extracorporeal membrane oxygenation in critically ill neonates and children.
Abstract Extracorporeal membrane oxygenation is used as a last resort during neonatal and pediatric resuscitation in case of refractory circulatory or respiratory failure under maximum conventional therapies. Different types of ECMO can be used depending on the initial failure. The main indications for ECMO are refractory respiratory failure (acute respiratory distress syndrome, status asthmaticus, severe pneumonia, meconium aspiration syndrome, pulmonary hypertension) and refractory circulatory failure (cardiogenic shock, septic shock, refractory cardiac arrest). The main contraindications are a gestational age u...
Source: Archives de Pediatrie - April 14, 2017 Category: Pediatrics Authors: Rambaud J, Guilbert J, Guellec I, Jean S, Durandy A, Demoulin M, Amblard A, Carbajal R, Leger PL Tags: Arch Pediatr Source Type: research