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Hospitalizations in OSA patients
Obstructive sleep apnea (OSA) is associated with cardiovascular comorbidities and other chronic diseases, accounting for long-term morbidity, with elevated symptomatic burden and hospitalizations. We aim to study the hospitalizations' causes in OSA patients and its relation to OSA severity and PAP therapy adhesion.This is a retrospective study including 281 hospitalizations corresponding to 200 OSA patients during 2019. Mean age 65 years, 67% were males, and 43,5% (n=87) had severe OSA; 85% patients under PAP; 60,4% (n=102) good adherent patients. Overlap with obesity hypoventilation syndrome (n=7) and COPD (n=48) was noti...
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Cancela da Fonseca Ferreira Santos, G. S., Van Zeller, M., Carrico, F., Rodrigues, D., Torres Redondo, M., Drummond, M. Tags: 04.02 - Clinical and epidemiological respiratory sleep medicine Source Type: research

What is Ondine ’ s Curse?
Discussion Congenital central hypoventilation syndrome (CCHS) is an autosomal dominant with variable inheritance genetic disease caused by mutation in the Paired Like Homeobox B2 (PHOX2B) gene on chromosome 4. There are two other genes which may also cause CCHS. CCHS affects the chemoreceptor afferent ventilation pathways and is a neural crest migration problem of the autonomic nervous system. The incidence is unknown but a prevalence of 1 in 200,000 live births has been reported. Obviously it is a rarer phenomenon because of the general lethality of the syndrome. Patients usually present at birth or soon afterwards, but o...
Source: PediatricEducation.org - August 15, 2022 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news

Sleep Apnea Linked to Lower Stroke Mortality After Thrombectomy Sleep Apnea Linked to Lower Stroke Mortality After Thrombectomy
Obstructive sleep apnea is paradoxically associated with lower risk for mortality and in-hospital complications after thrombectomy for acute ischemic stroke, new research suggests.Medscape Medical News
Source: Medscape Neurology and Neurosurgery Headlines - October 21, 2021 Category: Neurology Tags: Neurology & Neurosurgery News Source Type: news

Anesthetic management for robotic hysterectomy in obese women
Purpose of review Obesity is a major health epidemic, with the prevalence reaching ∼40% in the United States in recent years. It is associated with increased risk of hypertension, diabetes, heart disease, stroke, obstructive sleep apnea (OSA), and gynecologic conditions requiring surgery. Those comorbidities, in addition to the physiologic changes associated with obesity, lead to increased risk of perioperative complications. The purpose of this review is to highlight the anesthetic considerations for robotic assisted hysterectomy in obese patients. Recent findings In the general gynecologic population, minima...
Source: Current Opinion in Anaesthesiology - May 12, 2021 Category: Anesthesiology Tags: OBSTETRIC AND GYNECOLOGICAL ANESTHESIA: Edited by Jill Mhyre Source Type: research

How demographic and clinical characteristics contribute to the recovery of post-stroke dysphagia?
According to the analysis to find out how demographic and clinical characteristics influent the dysphagia outcome after stroke, furthermore, giving some insights to clinical treatment. One hundred eighty post-stroke dysphagia (PSD) patients were enrolled in this retrospective study at the stroke rehabilitation department. The outcome measurements are beside water swallow test at discharge and length of stay at hospital. Twenty-five demographic and clinical variables were collected for this study. Logistic regression and multilinear regression were utilized to estimate models to identify the risk and protect predictors o...
Source: Medicine - January 29, 2021 Category: Internal Medicine Tags: Research Article: Diagnostic Accuracy Study Source Type: research

Central sleep apnea predicts pulmonary complications after cardiac surgery.
The objectives of the present study were to determine the incidence of the composite endpoint postoperative MPCs and to identify predictors for postoperative MPCs in patients without SDB, with obstructive sleep apnea (OSA) and with central sleep apnea (CSA) undergoing cardiac surgery. STUDY DESIGN: and methods: In this sub-analysis of the ongoing prospective observational study CONSIDER AF, preoperative risk factors for postoperative MPCs were examined in 250 patients undergoing cardiac surgery. Postoperative MPCs, including respiratory failure, acute respiratory distress syndrome, pneumonia, or pulmonary embolism, we...
Source: Chest - August 12, 2020 Category: Respiratory Medicine Authors: Tafelmeier M, Luft L, Zistler E, Floerchinger B, Camboni D, Creutzenberg M, Zeman F, Schmid C, Maier LS, Wagner S, Arzt M Tags: Chest Source Type: research

Association between obstructive sleep apnea and risk of post-stroke depression: A hospital-based study in ischemic stroke patients
This study aimed to detect the correlation between OSA severity and post-stroke depression (PSD) in ischemic stroke patients.
Source: Journal of Stroke and Cerebrovascular Diseases - May 13, 2020 Category: Neurology Authors: Chuanyou Li, Yuanyue Liu, Pengfei Xu, Qiqi Fan, Pengyu Gong, Caixia Ding, Lei Sheng, Xiaohao Zhang Source Type: research

Integrating the STOP-BANG score and clinical data to predict cardiovascular events after infarction: A machine learning study.
Abstract BACKGROUND: Obstructive sleep apnea (OSA) conveys worse clinical outcomes in coronary artery disease patients. The STOP-BANG score is a simple tool that evaluates the risk of OSA and can be added to the large number of clinical variables and scores obtained during the management of myocardial infarction (MI) patients. Currently, machine learning (ML) is able to select and integrate numerous variables to optimize prediction tasks. RESEARCH QUESTION: Can the integration of STOP-BANG score with clinical data and scores through ML better identify patients who suffered an in-hospital cardiovascular event ...
Source: Chest - April 24, 2020 Category: Respiratory Medicine Authors: Calvillo-Argüelles O, Sierra-Fernández CR, Padilla-Ibarra J, Rodriguez-Zanella H, Balderas-Muñoz K, Arias-Mendoza MA, Martínez-Sánchez C, Selmen-Chattaj S, Dominguez-Mendez BE, van der Harst P, Juarez-Orozco LE Tags: Chest Source Type: research

MicroRNAs in Venous Thrombo-Embolism
Publication date: Available online 1 February 2020Source: Clinica Chimica ActaAuthor(s): Anju Angelina Hembrom, Swati Srivastava, Iti Garg, Bhuvnesh KumarAbstractBackgroundVenous Thrombo-embolism (VTE) is the major preventable cause of death and disability worldwide. It has the third highest incidence rate of hospital death after coronary artery disease (CAD) and stroke. With the establishment of Virchow’s triad stating the major factors responsible for VTE including stasis, hypercoagulability and endothelial dysfunction, the last decade reported number of studies regarding its diagnosis and prophylaxis. Till date the mo...
Source: Clinica Chimica Acta - February 1, 2020 Category: Laboratory Medicine Source Type: research

MicroRNAs in Venous Thrombo-Embolism.
Abstract BACKGROUND: Venous Thrombo-embolism (VTE) is the major preventable cause of death and disability worldwide. It has the third highest incidence rate of hospital death after coronary artery disease (CAD) and stroke. With the establishment of Virchow's triad stating the major factors responsible for VTE including stasis, hypercoagulability and endothelial dysfunction, the last decade reported number of studies regarding its diagnosis and prophylaxis. Till date the most commonly used clinical marker for its diagnosis is the D-dimer test, detecting endogenous fibrinolysis. This test often gives false positive ...
Source: International Journal of Clinical Chemistry - January 31, 2020 Category: Chemistry Authors: Angelina Hembrom A, Srivastava S, Garg I, Kumar B Tags: Clin Chim Acta Source Type: research

Effect of obstructive sleep apnoea and its treatment with continuous positive airway pressure on the prevalence of cardiovascular events in patients with acute coronary syndrome (ISAACC study): a randomised controlled trial
This study is registered with Clinicaltrials.gov, NCT01335087 and is now closed.FindingsBetween April 25, 2011, and Feb 2, 2018, a total of 2834 patients with ACS had respiratory polygraphy, of whom 2551 (90·01%) were recruited. 1264 (49·55%) patients had OSA and were randomly assigned to the CPAP group (n=633) or the UC group (n=631). 1287 (50·45%) patients did not have OSA, of whom 603 (46·85%) were randomly assigned to the reference group. Patients were followed up for a median of 3·35 years (IQR 1·50–5·31). The prevalence of cardiovascular events was similar in the CPAP and UC groups (98 events [16%] vs 108 ev...
Source: The Lancet Respiratory Medicine - December 14, 2019 Category: Respiratory Medicine Source Type: research

Obstructive Sleep Apnea before Ischemic Stroke: Clinical Relevance to Infarction Volume and Neurological Recovery
Background: Obstructive sleep apnea (OSA) is a probable risk factor with speculative roles in the induction or aggravation of acute ischemic stroke (AIS). Methods: The association between OSA and AIS severity was retrospectively analyzed using clinical data of first-onset AIS patients, admitted to our hospital between January 2013 and September 2016. Eligible patients were categorized based on the presence of OSA prior to stroke. Stroke severity and functional outcomes were evaluated using the National Institute of Health Stroke Severity Scale (NIHSS) and the modified Rankin scale (mRS), respectively.
Source: Journal of Stroke and Cerebrovascular Diseases - May 20, 2019 Category: Neurology Authors: Li Zhang, Ran Meng, Shuling Shang, Chuanjie Wu, Di Wu, Shuyi Shang, Lifeng Chen, Yunshu Zhang, Xunming Ji Source Type: research

Extended Risk Factors for Stroke Prevention.
Authors: Zhang S, Zhang W, Zhou G Abstract Stroke causes disability and high mortality, while it can be prevented by increasing public awareness of risk factors. The common known risk factors are hypertension, atrial fibrillation, heart failure, smoking, alcohol consumption, low physical activity, overweight and hypercholesterolemia. However, the deep understanding of risk factors is limited. Moreover, more risk factor emerges in recent years. To further increase the awareness of risk factors for stroke prevention, this review indicates the reasonable application of antihypertensive agents according to the age-depe...
Source: Journal of the National Medical Association - March 18, 2019 Category: General Medicine Tags: J Natl Med Assoc Source Type: research

Poor Sleep Linked To Dangerous Plaque Buildup In Arteries
By Sandee LaMotte, CNN (CNN) — Here’s another reason why getting a good night’s sleep should be on your must-do list: Sleeping fewer than six hours a night or waking frequently raises your risk of developing damaging plaque in arteries throughout your body, not just your heart. Previous research has shown poor sleep to be strongly associated with coronary heart disease, but “This is the first study to show that objectively measured sleep is independently associated with atherosclerosis throughout the body,” José Ordovás, director of nutrition and genomics at the Jean Mayer USDA Human Nutriti...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - January 14, 2019 Category: Consumer Health News Authors: Health – CBS Boston Tags: Boston News Health CNN Heart Disease Sleep Tufts University Source Type: news

High-Resolution Pulse Oximetry (HRPO): A Cost-Effective Tool in Screening for Obstructive Sleep Apnea (OSA) in Acute Stroke and Predicting Outcome
Obstructive sleep apnea (OSA) is a well-known risk factor for stroke. This is attributed to multiple mechanisms such as endothelial dysfunction, atrial fibrillation, hypertension, and comorbid obesity. STOP questionnaire alone is unreliable to diagnose OSA and in-hospital sleep study is costly and can be technically challenging. We used high-resolution pulse oximetry (HRPO) to test the feasibility of screening for OSA and predicting outcome.
Source: Journal of Stroke and Cerebrovascular Diseases - August 7, 2018 Category: Neurology Authors: Sridhara Sastry Yaddanapudi, Maria Carissa Pineda, David W. Boorman, Richard E. Bryne, Krista Lim Hing, Sunil Sharma Source Type: research

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