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Condition: Obesity
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Total 40 results found since Jan 2013.

Cell-Based Therapies for Stroke: Promising Solution or Dead End? Mesenchymal Stem Cells and Comorbidities in Preclinical Stroke Research
Conclusion The high prevalence of comorbidities in patients with stroke indicates the need for therapies in preclinical studies that take into account these comorbidities in order to avoid failures in translation to the patient. Preclinical studies are beginning to evaluate the efficacy of MSC treatment in stroke associated with comorbidities, especially hypertension, for ischemic and hemorrhagic stroke. Regarding aging and diabetes, only ischemic stroke studies have been performed. For the moment, few studies have been performed and contradictory results are being reported. These contradictory results may be due to the u...
Source: Frontiers in Neurology - April 8, 2019 Category: Neurology Source Type: research

Age- and Sex-Associated Impacts of Body Mass Index on Stroke Type Risk: A 27-Year Prospective Cohort Study in a Low-Income Population in China
Conclusions Being overweight increased the risk of both ischemic and hemorrhagic strokes; obesity was only associated with an increased risk of IS. Additionally, the positive association between BMI and stroke risk was only observed in participants aged <65 years and the associations differed between men and women. Being overweight increased the risk of both ischemic and hemorrhagic strokes in men and being underweight increased their risk of hemorrhagic stroke. In women, being overweight increased the hemorrhagic stroke risk, whereas obesity increased their IS risks. The high prevalence of hypertension and elevat...
Source: Frontiers in Neurology - April 30, 2019 Category: Neurology Source Type: research

Shengui Sansheng San Ameliorates Cerebral Energy Deficiency via Citrate Cycle After Ischemic Stroke
Conclusion In summary, SSS extraction significantly ameliorates cerebral energy metabolism via boosting citrate cycle, which mainly embodies the enhancements of blood glucose concentration, glucose and lactate transportation and glucose utilization, as well as the regulations of relative enzymes activities in citrate cycle. These ameliorations ultimately resulted in numerous ATP yield after stroke, which improved neurological function and infarcted volume. Collectively, it suggests that SSS extraction has exerted advantageous effect in the treatment of cerebral ischemia. Ethics Statement All animal operations were accor...
Source: Frontiers in Pharmacology - April 22, 2019 Category: Drugs & Pharmacology Source Type: research

A Serious Diagnosis Lacking Common Symptoms
​BY JENNIFER TUONG; IVAN KHARCHENKO; JEAN LUC AGARD; & AHMED RAZIUDDIN, MDA 65-year-old man who had HIV well-controlled with highly active antiretroviral therapy, hypertension, sciatica, and restless leg syndrome presented to the emergency department with left leg pain. He also had had chemotherapy and radiation for anal cancer. The patient said the pain had started 45 minutes earlier when he was sitting on the toilet.He described the pain as sore in quality and 10/10 on the pain scale. He reported that it had started in his lower back and radiated to his left leg. He said he had had no trauma or weakness to the regi...
Source: The Case Files - May 28, 2019 Category: Emergency Medicine Tags: Blog Posts Source Type: research

Impact of intraoperative neurologic deficits in carotid endarterectomy under regional anesthesia.
Conclusions. Neurologic deficits during carotid clamping are a predictor of perioperative stroke. Body mass index > 30 kg/m2, a lower degree of ipsilateral stenosis, and a higher degree of contralateral stenosis are independent predictors of neurologic deficits and, therefore, might play a role in the prevention of procedure-related stroke. PMID: 33487041 [PubMed - as supplied by publisher]
Source: Scandinavian Cardiovascular Journal - January 27, 2021 Category: Cardiology Tags: Scand Cardiovasc J Source Type: research

Effects of Body Surface Area-Indexed Calculations in the Morbidly Obese: A Mathematical Analysis
Conclusion: In morbidly obese patients, cardiac and stroke indices can be misleading relative to the underlying raw values (CO and SV) as a result of distortion by widely used BSA formulae. The authors caution against relying on threshold cardiac and stroke indices as triggers for the initiation of hemodynamic therapies in the morbidly obese. Further research on what BSA formula should be used on patients with very extreme body types is warranted.
Source: Journal of Cardiothoracic and Vascular Anesthesia - October 2, 2013 Category: Anesthesiology Authors: Adam C. Adler, Brian H. Nathanson, Karthik Raghunathan, William T. McGee Tags: Original Article Source Type: research

Cardiac Structure and Function in Morbidly Obese Parturients: An Echocardiographic Study.
CONCLUSIONS: Cardiac index did not differ between obese pregnant women and those with normal BMI. Their increased left ventricular mass and lower stroke volume index could indicate a limited adaptive reserve. Obese women had minor decreases in septal left ventricular tissue Doppler velocity, but the E/E' average values did not suggest clinically significant diastolic dysfunction. PMID: 29878938 [PubMed - as supplied by publisher]
Source: Anesthesia and Analgesia - June 5, 2018 Category: Anesthesiology Authors: Buddeberg BS, Fernandes NL, Vorster A, Cupido BJ, Lombard CJ, Swanevelder JL, Girard T, Dyer RA Tags: Anesth Analg Source Type: research

Ability of mini fluid challenge to predict fluid responsiveness in obese patients undergoing surgery in the prone position.
CONCLUSIONS: The increase in SVI after a rapid infusion of 100 ml crystalloid could predict fluid responsiveness in patients with BMI ≥30 kg/m2 in the prone position. PMID: 30994311 [PubMed - as supplied by publisher]
Source: Minerva Anestesiologica - April 19, 2019 Category: Anesthesiology Tags: Minerva Anestesiol Source Type: research

Hacking The Nervous System
(Photo: © Job Boot) One nerve connects your vital organs, sensing and shaping your health. If we learn to control it, the future of medicine will be electric.When Maria Vrind, a former gymnast from Volendam in the Netherlands, found that the only way she could put her socks on in the morning was to lie on her back with her feet in the air, she had to accept that things had reached a crisis point. “I had become so stiff I couldn’t stand up,” she says. “It was a great shock because I’m such an active person.”It was 1993. Vrind was in her late 40s and working two jobs, athletics coach and a carer for disabled ...
Source: Science - The Huffington Post - May 30, 2015 Category: Science Source Type: news

Unmasking of estrogen dependent changes in left ventricular structure-function in aged female rats: A potential model for pre-HFpEF.
This article is protected by copyright. All rights reserved. PMID: 30681142 [PubMed - as supplied by publisher]
Source: The Journal of Physiology - January 25, 2019 Category: Physiology Authors: Bustamante M, Garate-Carrillo A, Ito B, Garcia R, Carson N, Ceballos G, Ramirez-Sanchez I, Omens J, Villarreal F Tags: J Physiol Source Type: research

Is Aberrant Reno-Renal Reflex Control of Blood Pressure a Contributor to Chronic Intermittent Hypoxia-Induced Hypertension?
This study demonstrated unaltered vascular conductance in response to lumbar sympathetic stimulation in CIH-exposed rats. Aortic compliance was increased and estimated blood volume was unchanged in CIH-exposed rats. Increased blood pressure was related to an increase in cardiac output, which was confirmed by echocardiography (Lucking et al., 2014). It is suggested therefore that hypertension in the CIH model can be evoked by over-excitation of the cardiac arm of sympathetic nervous system (SNS), even before mechanisms of enhanced peripheral vasoconstriction and endothelial dysfunction are initiated (Naghshin et al., 2009)....
Source: Frontiers in Physiology - April 23, 2019 Category: Physiology Source Type: research

Follow-up to ‘Cholecystectomy in the presence of a large patent foramen ovale: laparoscopic or open?’
We previously reported an obese patient with cholelithiasis and acute cholecystitis, who was scheduled to undergo an emergency laparoscopic cholecystectomy, but was recognized preoperatively to have a large patent foramen ovale (PFO) with a right-to-left shunt that was open at rest . She also had concomitant choledocholithiasis, and she underwent an endoscopic sphincterotomy with prompt resolution of her fever and abdominal pain. At the time, the benefits of laparoscopy were weighed against the risk of paradoxical emboli and stroke, and the choice of either a laparoscopic or open cholecystectomy was discussed carefully wit...
Source: Journal of Clinical Anesthesia - April 22, 2013 Category: Anesthesiology Authors: Pringl L. Miller, Larry Litt, Nelson Schiller, John Maa Tags: Correspondence Source Type: research

EEG as a Surrogate to Brain Imaging for Diagnosing Stroke in Morbidly Obese Patients
No abstract available
Source: Journal of Neurosurgical Anesthesiology - December 5, 2014 Category: Anesthesiology Tags: Departments: Correspondence Source Type: research

Perianesthesia Implications of Obstructive Sleep Apnea
Obstructive sleep apnea (OSA) is a complex medical condition that affects not only the airway but also the cardiopulmonary, endocrine, and central nervous systems. Obstructive sleep apnea can usually be identified with a focused history and physical examination and is commonly associated with obese, middle-aged men with hypertension and glucose intolerance. A high index of suspicion for OSA should arise when reports of loud snoring, nighttime arousal, and acid reflux accompanied by a history of stroke, atrial fibrillation, or congestive heart failure are elicited during a perianesthesia evaluation. Perianesthesia risk in O...
Source: Critical Care Nursing Quarterly - December 11, 2014 Category: Nursing Tags: Original Articles Source Type: research