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Condition: Huntington's Disease
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Total 289 results found since Jan 2013.
Whole genome transcriptomic reveals heat stroke molecular signatures in humans
This article is protected by copyright. All rights reserved.PMID:36951421 | DOI:10.1113/JP284031
Source: The Journal of Physiology - March 23, 2023 Category: Physiology Authors: Abderrezak Bouchama Mamoon Rashid Shuja Shafi Malik Saeed Almahri Yara Yassin Mashan Abdullah Nour Abdulmalek Fuad Maashi Abdulaziz Mashi Altaf Khan Badriah Alotaibi Cynthia Lehe Sameer Mohammad Haitham Alkadi Deemah Al Waadani Saber Yezli Source Type: research
An analysis of neurovascular disease markers in the hippocampus of Tupaia chinensis at different growth stages
DiscussionIt was suggested that when the hippocampus of T. chinensis developed from day 15 to 3 months, the expression of oxidatively phosphorylated proteins and RPs would vary over time. Meanwhile, the hippocamppal protein expression profile of T. chinensis after 3 months had become stable. Moreover, the study underlines that, during the early development of the hippocampus of T. chinensis, energy demand increases while protein synthesis decreases. The mitochondria of T. chinensis changes with age, and the oxidative phosphorylation metabolic pathway of mitochondria is closely related to neurovascular diseases, such as str...
Source: Frontiers in Neurology - January 17, 2023 Category: Neurology Source Type: research
Measurement properties of outcome measures used in neurological telerehabilitation: A systematic review using COSMIN checklist
CONCLUSION: The present results can be used to assist in choosing appropriate measurement tools, both in research and clinical practice, during telerehabilitation in individuals with neurological conditions. Measurement error, content validity, structural validity, and responsiveness need to be further investigated. In addition, the measurement properties of tools used in telerehabilitation in other neurological conditions, such as Huntington's disease, should also be investigated.REGISTRATION NUMBER: CRD42021257662.PMID:36448251 | DOI:10.1177/02692155221129834
Source: Clinical Rehabilitation - November 30, 2022 Category: Rehabilitation Authors: Sherindan Ayessa Ferreira de Brito Aline Alvim Scianni Paula da Cruz Peniche Christina Danielli Coelho de Morais Faria Source Type: research
Modulators of ASIC1a and its potential as a therapeutic target for age-related diseases
Ageing Res Rev. 2022 Nov 9:101785. doi: 10.1016/j.arr.2022.101785. Online ahead of print.ABSTRACTAge-related diseases have become more common with the advancing age of the worldwide population. Such diseases involve multiple organs, with tissue degeneration and cellular apoptosis. To date, there is a general lack of effective drugs for treatment of most age-related diseases and there is therefore an urgent need to identify novel drug targets for improved treatment. Acid-sensing ion channel 1a (ASIC1a) is a degenerin/epithelial sodium channel family member, which is activated in an acidic environment to regulate pathophysio...
Source: Ageing Research Reviews - November 12, 2022 Category: Genetics & Stem Cells Authors: Ren-Peng Zhou Hong-Yu Liang Wei-Rong Hu Jie Ding Shu-Fang Li Yong Chen Ying-Jie Zhao Chao Lu Fei-Hu Chen Wei Hu Source Type: research
Role of Nrf2 in Aging, Alzheimer's and Other Neurodegenerative Diseases
This article also highlights the Nrf2 structural and functional activities in healthy and disease states, and also discusses the current status of Nrf2 research and therapeutic strategies to treat aging and neurodegenerative diseases.PMID:36243357 | DOI:10.1016/j.arr.2022.101756
Source: Ageing Research Reviews - October 15, 2022 Category: Genetics & Stem Cells Authors: Mathew George Matthan Tharakan John Culberson Arubala P Reddy P Hemachandra Reddy Source Type: research
Molecules, Vol. 27, Pages 6804: Alzheimer & rsquo;s Disease as a Major Public Health Concern: Role of Dietary Saponins in Mitigating Neurodegenerative Disorders and Their Underlying Mechanisms
This study highlights various neuroprotective mechanisms of saponins including free radical scavenging, modulation of neuroprotective signaling pathways, activation of neurotrophic factors, modulation of neurotransmitters, inhibition of BACE1 enzyme and tau hyper-phosphorylation. The study concludes that saponins have considerable efficacy against various pathological targets of neurological disorders, especially AD, and might be an important source of leads against neurodegenerative disorders.
Source: Molecules - October 11, 2022 Category: Chemistry Authors: Abduljawad Elawad Elkhalifa Ahmed Hamdoon Salim Ashraf Ayaz Hassan Bungau Tags: Review Source Type: research
Tracers progress for positron emission tomography imaging of glial-related disease
J Biomed Res. 2022 Jun 28:1-15. doi: 10.7555/JBR.36.20220017. Online ahead of print.ABSTRACTGlial cells play an essential part in the neuron system. They can not only serve as structural blocks in the human brain but also participate in many biological processes. Extensive studies have shown that astrocytes and microglia play an important role in neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, Huntington's disease, as well as glioma, epilepsy, ischemic stroke, and infections. Positron emission tomography is a functional imaging technique providing molecular-level information before anatomic ch...
Source: Biomed Res - September 22, 2022 Category: Research Authors: Haoran Jia Tianwu Xie Source Type: research
Integrated Microarray Analysis to Identify Genes and Small-Molecule Drugs Associated with Stroke Progression
Evid Based Complement Alternat Med. 2022 Sep 1;2022:7634509. doi: 10.1155/2022/7634509. eCollection 2022.ABSTRACTSeveral blood biomarkers are now considered increasingly important for stratifying risk, monitoring disease progression, and evaluating the response to therapy in ischemic stroke. The purpose of the present study was to identify the key genes associated with ischemic stroke progression and elucidate the potential therapeutic small molecules. Microarray datasets related to stroke for GSE58294, GSE22255, and GSE16561 were obtained from the Gene Expression Omnibus (GEO) database. Differentially expressed genes (DEG...
Source: Evidence-based Complementary and Alternative Medicine - September 12, 2022 Category: Complementary Medicine Authors: Shasha Cui Yunfeng Zhao Menghui Huang Huan Zhang Wei Zhao Zhenhua Chen Source Type: research
Protective effect of 3-n-butylphthalide against intrastriatal injection of malonic acid-induced neurotoxicity and biochemical alteration in rats
In this study, we used intrastriatal injections of malonic acid in rats to mimic mitochondrial abnormalities and the other HD like symptoms. We found that treatment with NBP significantly attenuated malonic acid-induced motor and cognitive dysfunction in locomotor behaviour test, rotarod test, novel object recognition test and morris water maze test, prevented neurotoxicity and mitochondrial damage, activated TGF-β1/Akt/Wnt/β-Catenin pathway in striatum, but didn't regulate mitochondrial fusion and fission. The above effect was partly reversed by a PI3K/Akt inhibitor. Our data support NBP as a potential candidate for the...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 12, 2022 Category: Drugs & Pharmacology Authors: Chunling Yuan Li Zheng Yingdai Zhao Source Type: research
Cytokine storm and neuropathological alterations in patients with neurological manifestations of COVID-19
Curr Alzheimer Res. 2022 Sep 8. doi: 10.2174/1567205019666220908084559. Online ahead of print.ABSTRACTThe COVID-19 pandemic is caused by the severe acute respiratory syndrome coronavirus (SARS-CoV-2), a respiratory pathogen with neuroinvasive potential. Neurological COVID-19 manifestations include loss of smell and taste, headache, dizziness, stroke, and potentially fatal encephalitis. Several studies found elevated proinflammatory cytokines such as TNF-α, IFN-γ, IL-6 IL-8, IL-10 IL-16, IL-17A, and IL-18 in severely and critically ill COVID-19 patients, which may persist even after apparent recovery from infection. Bioma...
Source: Current Alzheimer Research - September 12, 2022 Category: Neurology Authors: Christos Tsagkaris Muhammad Bilal Irem Aktar Youssef Aboufandi Ahmet Tas Abdullahi Tunde Aborode Tarun Kumar Suvvari Shoaib Ahmad Anastasiia Shkodina Rachana Phadke Marwa S Emhamed Atif Amin Baig Athanasios Alexiou Ghulam Md Ashraf Mohammad Amjad Kamal Source Type: research
Integrated Microarray Analysis to Identify Genes and Small-Molecule Drugs Associated with Stroke Progression
Evid Based Complement Alternat Med. 2022 Sep 1;2022:7634509. doi: 10.1155/2022/7634509. eCollection 2022.ABSTRACTSeveral blood biomarkers are now considered increasingly important for stratifying risk, monitoring disease progression, and evaluating the response to therapy in ischemic stroke. The purpose of the present study was to identify the key genes associated with ischemic stroke progression and elucidate the potential therapeutic small molecules. Microarray datasets related to stroke for GSE58294, GSE22255, and GSE16561 were obtained from the Gene Expression Omnibus (GEO) database. Differentially expressed genes (DEG...
Source: Evidence-based Complementary and Alternative Medicine - September 12, 2022 Category: Complementary Medicine Authors: Shasha Cui Yunfeng Zhao Menghui Huang Huan Zhang Wei Zhao Zhenhua Chen Source Type: research
Cytokine storm and neuropathological alterations in patients with neurological manifestations of COVID-19
Curr Alzheimer Res. 2022 Sep 8. doi: 10.2174/1567205019666220908084559. Online ahead of print.ABSTRACTThe COVID-19 pandemic is caused by the severe acute respiratory syndrome coronavirus (SARS-CoV-2), a respiratory pathogen with neuroinvasive potential. Neurological COVID-19 manifestations include loss of smell and taste, headache, dizziness, stroke, and potentially fatal encephalitis. Several studies found elevated proinflammatory cytokines such as TNF-α, IFN-γ, IL-6 IL-8, IL-10 IL-16, IL-17A, and IL-18 in severely and critically ill COVID-19 patients, which may persist even after apparent recovery from infection. Bioma...
Source: Current Alzheimer Research - September 12, 2022 Category: Neurology Authors: Christos Tsagkaris Muhammad Bilal Irem Aktar Youssef Aboufandi Ahmet Tas Abdullahi Tunde Aborode Tarun Kumar Suvvari Shoaib Ahmad Anastasiia Shkodina Rachana Phadke Marwa S Emhamed Atif Amin Baig Athanasios Alexiou Ghulam Md Ashraf Mohammad Amjad Kamal Source Type: research
