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Condition: Huntington's Disease

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Total 289 results found since Jan 2013.

The microRNAs (miRs) overexpressing mesenchymal stem cells (MSCs) therapy in neurological disorders; hope or hype
AbstractAltered expression of multiple miRNAs was found to be extensively involved in the pathogenesis of different neurological disorders including Alzheimer's disease, Parkinson's disease, stroke, epilepsy, multiple sclerosis, amyotrophic lateral sclerosis, and Huntington's disease. One of the biggest concerns within gene-based therapy is the delivery of the therapeutic microRNAs to the intended place, which is obligated to surpass the biological barriers without undergoing degradation in the bloodstream or renal excretion. Hence, the delivery of modified and unmodified miRNA molecules using excellent vehicles is require...
Source: Biotechnology Progress - September 6, 2023 Category: Biotechnology Authors: Sulieman Ibraheem Shelash Al ‐Hawary, Anas Yahya Ali, Yasser Fakri Mustafa, Ria Margiana, Shamsutdinova Maksuda Ilyasovna, Montather F. Ramadan, Sami G. Almalki, Marim Alwave, Safa Alkhayyat, Ali Alsalamy Tags: REVIEW Source Type: research

Detection of Ferroptosis in Models of Brain Diseases
Methods Mol Biol. 2023;2712:233-251. doi: 10.1007/978-1-0716-3433-2_21.ABSTRACTFerroptosis is a regulated form of non-apoptotic cell death driven by iron-dependent lipid peroxidation. In the past decade, ferroptosis has been reported to be involved in the pathological role in the central nervous system degenerative diseases (e.g., Alzheimer's disease, Huntington's disease, and Parkinson's disease), stroke, traumatic brain injury, and brain tumor. However, how to reliably detect and classify ferroptosis from other cell death in pathological conditions remains a great challenge, especially in primary brain cells and brain ti...
Source: Mol Biol Cell - August 14, 2023 Category: Molecular Biology Authors: Danmin Shen Fei Yang Qian Li Source Type: research

The key roles of reactive oxygen species in microglial inflammatory activation: Regulation by endogenous antioxidant system and exogenous sulfur-containing compounds
Eur J Pharmacol. 2023 Aug 5:175966. doi: 10.1016/j.ejphar.2023.175966. Online ahead of print.ABSTRACTAberrant innate immunity in the brain has been implicated in the pathogenesis of several central nervous system (CNS) disorders, including Alzheimer's disease, Huntington's disease, Parkinson's disease, stroke, amyotrophic lateral sclerosis, and depression. Except for extraparenchymal CNS-associated macrophages, which predominantly afford protection against peripheral invading pathogens, it has been reported that microglia, a population of macrophage-like cells governing CNS immune defense in nearly all neurological disease...
Source: European Journal of Pharmacology - August 7, 2023 Category: Drugs & Pharmacology Authors: Hua Fan Qianqian Bai Yang Yang Xiaofei Shi Ganqin Du Junqiang Yan Jian Shi Dongmei Wang Source Type: research

Ataxia and hyperkinetic movement disorders
Hyperkinetic movement disorders comprise excessive involuntary movements, the different types of movement having characteristic clinical features. Ataxia is a disorder of impaired coordination and balance, most commonly caused by cerebellar pathology. Sensory ataxia occurs when the pathways conveying proprioceptive sensory information are impaired. Chorea is a random writhing involuntary movement that can be caused by acute medical causes such as stroke and hyperglycaemia. Huntington disease is the most common cause of progressive chorea.
Source: Medicine - July 24, 2023 Category: Internal Medicine Authors: Christopher Kobylecki Tags: Movement disorders Source Type: research

Perspectives and new aspects of histone deacetylase inhibitors in the therapy of CNS diseases
Eur J Med Chem. 2023 Jun 29;258:115613. doi: 10.1016/j.ejmech.2023.115613. Online ahead of print.ABSTRACTMany populations worldwide are suffering from central nervous system (CNS) diseases such as brain tumors, neurodegenerative diseases (Alzheimer's disease, Parkinson's disease and Huntington's disease) and stroke. There is a shortage of effective drugs for most CNS diseases. As one of the regulatory mechanisms of epigenetics, the particular role and therapeutic benefits of histone deacetylases (HDACs) in the CNS have been extensively studied. In recent years, HDACs have attracted increasing attention as potential drug ta...
Source: European Journal of Medicinal Chemistry - July 3, 2023 Category: Chemistry Authors: Bo Han Mengfei Wang Jiayi Li Qiushi Chen Niubing Sun Xuezhi Yang Qingwei Zhang Source Type: research

Is exercise actually good for the brain?
There are plenty of reasons to get off your duff and exercise—but is improving your brain one of them? The U.S. Centers for Disease Control and Prevention touts exercise as a way to “ boost brain health , ” while the World Health Organization suggests that about 2 hours of moderate activity or 75 minutes of vigorous activity per week can help improve thinking and memory skills . But new research reveals a more complex picture. One recent review of the literature suggests the studies tying exercise to brain health may have important limitations , including small sample sizes. Othe...
Source: ScienceNOW - June 30, 2023 Category: Science Source Type: news

Neuroprotective effect of aloe emodin against Huntington's disease-like symptoms in R6/1 transgenic mice
Food Funct. 2023 May 16. doi: 10.1039/d3fo00156c. Online ahead of print.ABSTRACTAloe emodin is a natural anthraquinone derived from aloe or rhubarb, showing anti-renal fibrosis, anti-atherosclerosis and anti-cancer effects. Aloe emodin also shows neuroprotective effects in ischemic stroke rats. Naturally, anthraquinone derivatives generally have the effect of inhibiting the transforming growth factor-β1 (TGF-β1) pathway. There is an increase in the calcium/calmodulin-dependent protein kinase II (CaMKII) and TGF-β1 levels in both Huntington's disease (HD) patients' brains and HD transgenic mice. Thus, we hypothesized tha...
Source: Atherosclerosis - May 16, 2023 Category: Cardiology Authors: Nan Yan Shuai Wang Haotian Gao Jiaqi Chen Jiahui Cao Pengsheng Wei Xue Li Ying Yu Yan Wang Yalin Niu Yijie Wang Shuyuan Liu Ge Jin Source Type: research

Whole genome transcriptomic reveals heat stroke molecular signatures in humans
This article is protected by copyright. All rights reserved.PMID:36951421 | DOI:10.1113/JP284031
Source: The Journal of Physiology - March 23, 2023 Category: Physiology Authors: Abderrezak Bouchama Mamoon Rashid Shuja Shafi Malik Saeed Almahri Yara Yassin Mashan Abdullah Nour Abdulmalek Fuad Maashi Abdulaziz Mashi Altaf Khan Badriah Alotaibi Cynthia Lehe Sameer Mohammad Haitham Alkadi Deemah Al Waadani Saber Yezli Source Type: research