Filtered By:
Condition: Huntington's Disease

This page shows you your search results in order of date. This is page number 17.

Order by Relevance | Date

Total 289 results found since Jan 2013.

Precision medicine is coming, but not anytime soon
President Obama’s announcement of a Precision Medicine Initiative was one of the few items in this year’s State of the Union address to garner bipartisan support. And for good reason. Precision medicine, also known as personalized medicine, offers the promise of health care — from prevention to diagnosis to treatment — based on your unique DNA profile. Who wouldn’t want that? We’ve already had a taste of precision medicine. Relatively low-tech therapies like eyeglasses, orthotic devices, allergy treatments, and blood transfusions have long been personalized for the individual. Genetic analysis o...
Source: New Harvard Health Information - March 26, 2015 Category: Consumer Health News Authors: Beverly Merz Tags: Health care personalized health care precision medicine Source Type: news

Individuals with neurological diseases are at increased risk of fractures within 180 days of admission to long-term care in Ontario
Conclusion: LTC residents with ADRD, epilepsy and traumatic brain injury are at a higher risk for sustaining an incident fracture in the first 180 days of admission and should be considered for fracture prevention strategies.
Source: Age and Ageing - February 23, 2015 Category: Geriatrics Authors: Jantzi, M., Maher, A. C., Ioannidis, G., Hirdes, J. P., Giangregorio, L. M., Papaioannou, A. Tags: Research Papers Source Type: research

Alexithymia in Neurological Disease: A Review.
Conclusions: Identification of alexithymia could be relevant for prognosis and therapeutic decisions in patients with neurological disease and is certainly worthy of further study. Tools with which to measure alexithymia and delineation from affective disorders and apathy are important methodological issues for future work. PMID: 25658681 [PubMed - as supplied by publisher]
Source: Journal of Neuropsychiatry and Clinical Neurosciences - February 8, 2015 Category: Psychiatry Tags: J Neuropsychiatry Clin Neurosci Source Type: research

Adipose Tissue Derived Stem Cells in Neural Regenerative Medicine.
In this study, several human clinical trials using ADSCs for neuronal disorders were investigated. It is suggested that ADSCs are one of the choices among various stem cells for translating into clinical application in the near future. PMID: 25647067 [PubMed - as supplied by publisher]
Source: Cell Transplantation - February 2, 2015 Category: Cytology Authors: Yeh DC, Chan TM, Harn HJ, Chiou TW, Chen HS, Lin ZS, Lin SZ Tags: Cell Transplant Source Type: research

Zinc: indications in brain disorders
This article is protected by copyright. All rights reserved.
Source: Fundamental and Clinical Pharmacology - February 1, 2015 Category: Drugs & Pharmacology Authors: Atish Prakash, Kanchan Bharti, Abu Bakar Abdul Majeed Tags: Review Article Source Type: research

Linking Genes to Neurological Clinical Practice: The Genomic Basis for Neurorehabilitation
Large-scale genomics projects such as the Human Genome Project and the International HapMap Project promise significant advances in the ability to diagnose and treat many conditions, including those with a neurological basis. A major focus of research has emerged in the neurological sciences to elucidate the molecular and genetic basis of various neurological diseases. Indeed, genetic factors are implicated in susceptibility for many neurological disorders, with family history studies providing strong evidence of familial risk for conditions such as stroke, Parkinson's, Alzheimer's, and Huntington's diseases. Heritability ...
Source: Journal of Neurologic Physical Therapy - January 1, 2015 Category: Physiotherapy Tags: Special Interest Articles Source Type: research

Linking Genes to Neurological Clinical Practice: The Genomic Basis for Neurorehabilitation
Large-scale genomics projects such as the Human Genome Project and the International HapMap Project promise significant advances in the ability to diagnose and treat many conditions, including those with a neurological basis. A major focus of research has emerged in the neurological sciences to elucidate the molecular and genetic basis of various neurological diseases. Indeed, genetic factors are implicated in susceptibility for many neurological disorders, with family history studies providing strong evidence of familial risk for conditions such as stroke, Parkinson's, Alzheimer's, and Huntington's diseases. Heritability ...
Source: Journal of Neurologic Physical Therapy - December 23, 2014 Category: Physiotherapy Tags: Special Interest Articles Source Type: research

Prediction of manifest Huntington's disease with clinical and imaging measures: a prospective observational study
Publication date: December 2014 Source:The Lancet Neurology, Volume 13, Issue 12 Author(s): Jane S Paulsen , Jeffrey D Long , Christopher A Ross , Deborah L Harrington , Cheryl J Erwin , Janet K Williams , Holly James Westervelt , Hans J Johnson , Elizabeth H Aylward , Ying Zhang , H Jeremy Bockholt , Roger A Barker Background Although the association between cytosine-adenine-guanine (CAG) repeat length and age at onset of Huntington's disease is well known, improved prediction of onset would be advantageous for clinical trial design and prognostic counselling. We compared various measures for tracking progression and pr...
Source: The Lancet Neurology - December 8, 2014 Category: Neurology Source Type: research

Protocol for REducing Anti-Psychotic use in residential care-Huntington Disease (REAP-HD): a pilot cluster randomised controlled trial of a multifaceted intervention for health professionals
This study aims to test the hypothesis that the multifaceted REducing Anti-Psychotic use in residential care-Huntington Disease (REAP-HD) programme is more effective than standard staff education (SSE) in reducing antipsychotic use for people with HD in residential care facilities (RCF). Methods and analysis this is a cluster randomised controlled trial with blinded outcome assessment. The study population is healthcare professionals looking after people with HD in individual RCF, in the state of New South Wales. Each RCF will be centrally randomised to the REAP-HD programme or the comparator, SSE. Blinded outcome assessm...
Source: BMJ Open - December 2, 2014 Category: Journals (General) Authors: Loy, C. T., Hayen, A., McKinnon, C. Tags: Open access, Mental health, Neurology Protocol Source Type: research

Linking Genes to Neurological Clinical Practice: The Genomic Basis for Neurorehabilitation.
Abstract Large-scale genomics projects such as the Human Genome Project and the International HapMap Project promise significant advances in the ability to diagnose and treat many conditions, including those with a neurological basis. A major focus of research has emerged in the neurological sciences to elucidate the molecular and genetic basis of various neurological diseases. Indeed, genetic factors are implicated in susceptibility for many neurological disorders, with family history studies providing strong evidence of familial risk for conditions such as stroke, Parkinson's, Alzheimer's, and Huntington's disea...
Source: Physical Therapy - November 20, 2014 Category: Physiotherapy Authors: Goldberg A, Curtis CL, Kleim JA Tags: J Neurol Phys Ther Source Type: research

Neuroprotection by Saponins
Saponins, an important group of bioactive plant natural products, are glycosides of triterpenoid or steroidal aglycones. Their diverse biological activities are ascribed to their different structures. Saponins have long been recognized as key ingredients in traditional Chinese medicine. Accumulated evidence suggests that saponins have significant neuroprotective effects on attenuation of central nervous system disorders, such as stroke, Alzheimer's disease, Parkinson's disease, and Huntington's disease. However, our understanding of the mechanisms underlying the observed effects remains incomplete. Based on recently report...
Source: Phytotherapy Research - November 19, 2014 Category: Biochemistry Authors: Aijing Sun, Xianxiang Xu, Junsheng Lin, Xiuling Cui, Ruian Xu Tags: Review Source Type: research

Disruption of striatal-enriched protein tyrosine phosphatase (STEP) function in neuropsychiatric disorders
Publication date: Available online 10 September 2014 Source:Neuroscience Research Author(s): Takatoshi Karasawa , Paul J. Lombroso Striatal-enriched protein tyrosine phosphatase (STEP) is a brain-specific tyrosine phosphatase that plays a major role in the development of synaptic plasticity. Recent findings have implicated STEP in several psychiatric and neurological disorders, including Alzheimer's disease, schizophrenia, fragile X syndrome, Huntington's disease, stroke/ischemia, and stress-related psychiatric disorders. In these disorders, STEP protein expression levels and activity are dysregulated, contributing to th...
Source: Neuroscience Research - November 18, 2014 Category: Neuroscience Source Type: research

Into the groove: Can rhythm influence Parkinson's disease?
Publication date: December 2013 Source:Neuroscience & Biobehavioral Reviews, Volume 37, Issue 10, Part 2 Author(s): Cristina Nombela , Laura E. Hughes , Adrian M. Owen , Jessica A. Grahn Previous research has noted that music can improve gait in several pathological conditions, including Parkinson's disease, Huntington's disease and stroke. Current research into auditory-motor interactions and the neural bases of musical rhythm perception has provided important insights for developing potential movement therapies. Specifically, neuroimaging studies show that rhythm perception activates structures within key motor...
Source: Neuroscience and Biobehavioral Reviews - November 9, 2014 Category: Neuroscience Source Type: research

P2X7 receptor: an emerging target in central nervous system diseases
Publication date: October 2014 Source:Trends in Pharmacological Sciences, Volume 35, Issue 10 Author(s): Beáta Sperlágh , Peter Illes The ATP-sensitive homomeric P2X7 receptor (P2X7R) has received particular attention as a potential drug target because of its widespread involvement in inflammatory diseases as a key regulatory element of the inflammasome complex. However, it has only recently become evident that P2X7Rs also play a pivotal role in central nervous system (CNS) pathology. There is an explosion of data indicating that genetic deletion and pharmacological blockade of P2X7Rs alter responsiveness in animal mod...
Source: Trends in Pharmacological Sciences - November 6, 2014 Category: Drugs & Pharmacology Source Type: research

Huntington's Disease
information sheet compiled by the National Institute of Neurological Disorders and Stroke (NINDS).
Source: NINDS Disorders: National Institute of Neurological Disorders and Stroke - October 26, 2014 Category: Neurology Source Type: research