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Total 1318 results found since Jan 2013.

An Association Study of CASQ1 Gene Polymorphisms and Heat Stroke
Publication date: June 2014 Source:Genomics, Proteomics & Bioinformatics, Volume 12, Issue 3 Author(s): Ying Li , Yu Wang , Lin Ma Although molecular mechanisms of heat stroke under physiological and pathological conditions have not yet been elucidated, a novel disease-associated gene encoding a calcium-binding protein, calsequestrin-1 (CASQ1), was suggested relevant based on results from a transgenic murine model. Here, we show the association between single nucleotide polymorphisms (SNPs) of CASQ1 and physiological parameters for heat stroke from a study involving 150 patients. Pooled DNA from heat stroke patie...
Source: Genomics, Proteomics and Bioinformatics - November 1, 2014 Category: Bioinformatics Source Type: research

Exertional heat stroke in a young military trainee: is it preventable?
Conclusion It is clear that heat stroke does occur in military trainees while preventive strategies are being practiced. It is important for those who provide healthcare to soldiers to provide proper advice on how to identify impending heat stroke prior to any exercises resulting in severe physical exertion. Further, treating physicians should educate all military trainees about preventive strategies.
Source: Military Medical Research - March 30, 2016 Category: Global & Universal Source Type: research

Mesenchymal stem cell ‐based treatments for stroke, neural trauma, and heat stroke
ConclusionThis review offers a testable platform for targeting microglial‐mediated cytokines in clinical trials based upon the rational design of MSC therapy in the future. MSCs that are derived from the placenta provide a great choice for stem cell therapy. Although targeting the microglial activation is an important approach to reduce the burden of the injury, it is not the only one. This review focuses on this specific aspect. Ischemic stroke, neural trauma, and heatstroke all cause cerebral ischemia‐related deficits. Exogenous MSC therapy is promising as a means of augmenting brain ischemia‐induced deficits. MSC...
Source: Brain and Behavior - August 2, 2016 Category: Neurology Authors: Yogi Chang ‐Yo Hsuan, Cheng‐Hsien Lin, Ching‐Ping Chang, Mao‐Tsun Lin Tags: Review Source Type: research

Quercetin protects against heat stroke-induced myocardial injury in male rats: Antioxidative and antiinflammatory mechanisms
Publication date: Available online 16 January 2017 Source:Chemico-Biological Interactions Author(s): Xiaojing Lin, Cheng-Hsien Lin, Tingbao Zhao, Dan Zuo, Zhujun Ye, Lin Liu, Mao-Tsun Lin Heat stroke is characterilized by hyperthermia, systemic inflammation, and multiple organ failure including arterial hypotension. This definition can be fulfilled by a rat model of heat stroke used in the present study. Anesthetized animals were exposed to heat exposure (43 °C for 70 min) and then returned to room temperature (26 °C) for recovery. One hour before heat exposure, an intraperitoneal dose of quercetin (30 mg/kg) or veh...
Source: Chemico Biological Interactions - January 16, 2017 Category: Biochemistry Source Type: research

Adjuvant rhubarb alleviates organs dysfunction and inhibits inflammation in heat stroke.
In conclusion, rhubarb intake provided a significant benefit for patients with heat stroke by inhibiting systemic inflammation and mitigating liver and kidney injury. PMID: 30116399 [PubMed]
Source: Experimental and Therapeutic Medicine - August 19, 2018 Category: General Medicine Tags: Exp Ther Med Source Type: research

Calycosin-7-O- β-D-glucoside reduces myocardial injury in heat stroke rats.
CONCLUSION: We thus conclude that myocardial injury can be a pressing need for the design of diagnostic and therapeutic modalities for heat stroke. In particular, our data indicate that CG protects against heat stroke in rats by mitigating myocardial injury. PMID: 30245143 [PubMed - as supplied by publisher]
Source: J Formos Med Assoc - September 20, 2018 Category: General Medicine Authors: Tsai CC, Wu HH, Chang CP, Lin CH, Yang HH Tags: J Formos Med Assoc Source Type: research

Dysfunction of Iron Metabolism and Iron-Regulatory Proteins in the Rat Hippocampus After Heat Stroke
Heat stroke, the most serious type of heat illness, refers to the presence of hyperthermia (core temperature>40°C), accompanied by central nervous system dysfunction. The hippocampus is a particularly vulnerable region in the early stage of heat stroke. Increasing evidence suggests that dysregulation of brain iron metabolism is involved in many neurodegenerative diseases. However, whether heat stroke causes dysfunction of iron metabolism, as well as iron-regulatory proteins, in the hippocampus remains unknown. The present study was conducted to explore the effects on spatial learning and memory, as well as iron content, f...
Source: Shock - May 15, 2019 Category: Emergency Medicine Tags: Basic Science Aspects Source Type: research

A survey of solitary death by heat stroke in Yokohama City
ConclusionsThe time from the occurrence of heat stroke death to the discovery of death tended to be longer in unmarried, non-elderly persons.
Source: Journal of Public Health - February 9, 2020 Category: Health Management Source Type: research

The Role of Skeletal Muscles in Exertional Heat Stroke Pathophysiology
Int J Sports Med DOI: 10.1055/a-1400-9754The active participation of skeletal muscles is a unique characteristic of exertional heat stroke. Nevertheless, the only well-documented link between skeletal muscle activities and exertional heat stroke pathophysiology is the extensive muscle damage (e. g., rhabdomyolysis) and subsequent leakage of intramuscular content into the circulation of exertional heat stroke victims. Here, we will present and discuss rarely explored roles of skeletal muscles in the context of exertional heat stroke pathophysiology and recovery. This includes an overview of heat production that contribute...
Source: International Journal of Sports Medicine - March 26, 2021 Category: Sports Medicine Authors: Laitano, Orlando Oki, Kentaro Leon, Lisa R. Tags: Review Source Type: research

Out-of-Hospital Cold Water Immersion for Classic (Non-Exertional) Heat Stroke Guided by Real-time Core Temperature Monitoring: A Case Series
Prehosp Emerg Care. 2022 Nov 15:1-11. doi: 10.1080/10903127.2022.2148795. Online ahead of print.ABSTRACTHeat stroke is a problem that occurs primarily in the out-of-hospital environment. "Cool first, transport second" has been emphasized in consensus statements and systematic reviews regarding the treatment of exertional heat stroke by both EMS and the sports medicine/athletic training communities. However, there remains little guidance on cooling recommendations for the out-of-hospital care of non-exertional heat stroke or classic heat stroke. There is no consensus on the safety or feasibility of cooling classic heat stro...
Source: Prehospital Emergency Care - November 15, 2022 Category: Endocrinology Authors: Ryan C Jacobsen Bryan Beaver Benjamin Abo Source Type: research