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Total 166 results found since Jan 2013.

YiQiFuMai Powder Injection Attenuates Coronary Artery Ligation-Induced Heart Failure Through Improving Mitochondrial Function via Regulating ROS Generation and CaMKII Signaling Pathways
This study was carried out in accordance with the recommendations of “Guide for the Care and Use of Laboratory Animals, National Institutes of Health.” The protocol was approved by the “China Pharmaceutical University.” Surgical Preparation The mice were anesthetized with chloral hydrate (4% chloral hydrate, ip). The HF model was induced by CAL as previously reported (Gao et al., 2010). Successful ligation of the coronary artery was confirmed by the occurrence of ST-segment elevation in electrocardiogram. Sham operated mice were performed the same process except left CAL. After ligation, the h...
Source: Frontiers in Pharmacology - April 9, 2019 Category: Drugs & Pharmacology Source Type: research

The lncRNA MALAT1 rs619586 G Variant Confers Decreased Susceptibility to Recurrent Miscarriage
In conclusion, our study suggests that the rs619586 G variant may have potential protective effects conferring a decreased risk of recurrent miscarriage in the southern Chinese population. Introduction Recurrent miscarriage is defined as the loss of two or more consecutive pregnancies before 20 weeks of gestation (Jaslow et al., 2010; Diejomaoh, 2015). The occurrence of recurrent miscarriage is associated with many factors, including genetic factors, immunological dysfunction, endocrine disorders, unhealthy lifestyles and defects of the reproductive organs (Saravelos and Regan, 2014; Sen et al., 2014; Garrido-Gimen...
Source: Frontiers in Physiology - April 8, 2019 Category: Physiology Source Type: research

Poor Sleep Linked To Dangerous Plaque Buildup In Arteries
By Sandee LaMotte, CNN (CNN) — Here’s another reason why getting a good night’s sleep should be on your must-do list: Sleeping fewer than six hours a night or waking frequently raises your risk of developing damaging plaque in arteries throughout your body, not just your heart. Previous research has shown poor sleep to be strongly associated with coronary heart disease, but “This is the first study to show that objectively measured sleep is independently associated with atherosclerosis throughout the body,” José Ordovás, director of nutrition and genomics at the Jean Mayer USDA Human Nutriti...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - January 14, 2019 Category: Consumer Health News Authors: Health – CBS Boston Tags: Boston News Health CNN Heart Disease Sleep Tufts University Source Type: news

Clinicians cause variation in radiation doses from CT scans
Experts call for more consistency in radiation doses Related items fromOnMedica Radiation exposure may increase risk of stroke and heart disease Breast cancers overdiagnosed Rise in medical radiation incidents Breast screening increases chance of mastectomy Benefits of breast screening are overestimated, research suggests
Source: OnMedica Latest News - January 3, 2019 Category: UK Health Source Type: news

Use of liraglutide and risk of major cardiovascular events: a register-based cohort study in Denmark and Sweden
Publication date: Available online 5 December 2018Source: The Lancet Diabetes & EndocrinologyAuthor(s): Henrik Svanström, Peter Ueda, Mads Melbye, Björn Eliasson, Ann-Marie Svensson, Stefan Franzén, Soffia Gudbjörnsdottir, Kristian Hveem, Christian Jonasson, Björn PasternakSummaryBackgroundTrial evidence shows that the glucagon-like peptide-1 receptor agonist liraglutide significantly reduces the risk of major cardiovascular events among patients with type 2 diabetes who have established cardiovascular disease or are at high cardiovascular risk. We aimed to assess the cardiovascular effectiveness of liraglutide in rou...
Source: The Lancet Diabetes and Endocrinology - December 6, 2018 Category: Endocrinology Source Type: research

Atherosclerosis in systemic lupus erythematosus
Publication date: June 2017Source: Best Practice & Research Clinical Rheumatology, Volume 31, Issue 3Author(s): Sara Croca, Anisur RahmanAbstractCardiovascular disease (CVD), comprising coronary heart disease and stroke, is one of the most important causes of death in patients with systemic lupus erythematosus (SLE). The risks of developing both clinical CVD and sub-clinical atherosclerosis are increased in patients with SLE. This increase is not fully explained by traditional cardiovascular risk factors such as smoking, hypertension and elevated cholesterol, and it is believed that immune dysfunction also contributes to C...
Source: Best Practice and Research Clinical Rheumatology - July 10, 2018 Category: Rheumatology Source Type: research

The Relationship Between Bone Mineral Density and Cardiovascular Function in Duchenne Muscular Dystrophy: A Retrospective Cohort Study
In this study, we explored the relationship between BMD and cardiovascular health, and observed no association between BMD and LVEF. The primary results were in the opposite direction than the hypothesized direction, with the model beta coefficient for BMD indicating a negative relationship with LVEF; however, the size of the effect BMD had on LVEF was very small and not statistically significant. The secondary linear regression analyses provided consistent results with the primary linear regression, indicating that the primary results are sensitive to a variety of slightly modified conditions. It is possible that the nul...
Source: PLOS Currents Muscular Dystrophy - March 22, 2018 Category: Neurology Authors: Tara Anne Kervin Source Type: research

Burden of cardiovascular disease across 29 countries and GPs' decision to treat hypertension in oldest-old.
CONCLUSIONS: GPs' choice to treat/not treat hypertension in oldest-old was explained by differences in country-specific health characteristics. GPs in countries with high CVD burden and low life expectancy at age 60 were most likely to treat hypertension in oldest-old. Key Points  • General practitioners (GPs) are in a clinical dilemma when deciding whether (or not) to treat hypertension in the oldest-old (>80 years of age).  • In this study including 1947 GPs from 29 countries, we found that a high country-specific cardiovascular disease (CVD) burden (i.e. myocardial infarction and/or stroke) was associated...
Source: Primary Care - January 25, 2018 Category: Primary Care Authors: Streit S, Gussekloo J, Burman RA, Collins C, Kitanovska BG, Gintere S, Gómez Bravo R, Hoffmann K, Iftode C, Johansen KL, Kerse N, Koskela TH, Peštić SK, Kurpas D, Mallen CD, Maisonneuve H, Merlo C, Mueller Y, Muth C, Ornelas RH, Šter MP, Petrazzuoli F Tags: Scand J Prim Health Care Source Type: research

Atherosclerosis and cardiovascular involvement in celiac disease: the role of autoimmunity and inflammation.
CONCLUSIONS: On the basis of the reported association among CD, AS and CV diseases, we suggest to perform a more detailed CV risk assessment in all CD patients than what is currently being achieved in clinical practice, in order to scan and treat modifiable CV risk factors in these patients. In particular, we suggest to resort to instrumental techniques to detect AS in the subclinical stage, in order to prevent AS development and CV diseases in CD patients. PMID: 29243787 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - December 17, 2017 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

Atherosclerosis in systemic lupus erythematosus
Publication date: Available online 16 October 2017 Source:Best Practice & Research Clinical Rheumatology Author(s): Sara Croca, Anisur Rahman Cardiovascular disease (CVD), comprising coronary heart disease and stroke, is one of the most important causes of death in patients with systemic lupus erythematosus (SLE). The risks of developing both clinical CVD and sub-clinical atherosclerosis are increased in patients with SLE. This increase is not fully explained by traditional cardiovascular risk factors such as smoking, hypertension and elevated cholesterol, and it is believed that immune dysfunction also contribute...
Source: Best Practice and Research Clinical Rheumatology - December 5, 2017 Category: Rheumatology Source Type: research

Associations of activated coagulation factor VII and factor VIIa-antithrombin levels with genome-wide polymorphisms and cardiovascular disease risk.
CONCLUSIONS: Results support the importance of the F7 and PROCR loci on variation in circulating FVIIa and FVIIa-AT. Findings suggest FVIIa is a risk factor for ischemic stroke in older adults while higher FVIIa-AT may reflect mortality risk. This article is protected by copyright. All rights reserved. PMID: 29112333 [PubMed - as supplied by publisher]
Source: Thrombosis and Haemostasis - November 7, 2017 Category: Hematology Authors: Olson NC, Raffield LM, Lange LA, Lange EM, Longstreth WT, Chauhan G, Debette S, Seshadri S, Reiner AP, Tracy RP Tags: J Thromb Haemost Source Type: research

Associations of activated coagulation factor VII and factor VIIa ‐antithrombin levels with genome‐wide polymorphisms and cardiovascular disease risk
ConclusionsResults support the importance of the F7 and PROCR loci on variation in circulating FVIIa and FVIIa‐AT. Findings suggest FVIIa is a risk factor for ischemic stroke in older adults while higher FVIIa‐AT may reflect mortality risk.This article is protected by copyright. All rights reserved.
Source: Journal of Thrombosis and Haemostasis - November 1, 2017 Category: Hematology Authors: N. C Olson, L. M Raffield, L. A Lange, E.M. Lange, W. T Longstreth, G. Chauhan, S. Debette, S. Seshadri, A. P Reiner, R. P Tracy Tags: Original Article ‐ Coagulation Source Type: research

Educational inequality in cardiovascular diseases: a sibling approach.
CONCLUSIONS: Confounding from factors shared by siblings explained the associations between education and the cardiovascular disease outcomes but to varying degrees. This should be taken into account when planning interventions aimed at reducing educational inequalities in the development of cardiovascular disease, ischaemic heart disease and stroke. PMID: 28992724 [PubMed - as supplied by publisher]
Source: Scandinavian Journal of Public Health - October 1, 2017 Category: International Medicine & Public Health Authors: Søndergaard G, Dalton SO, Mortensen LH, Osler M Tags: Scand J Public Health Source Type: research

Metoprolol Reduces Hemodynamic and Metabolic Overload in Asymptomatic Aortic Valve Stenosis Patients: A Randomized Trial Ventricular Structure and Function
Conclusions— In patients with asymptomatic AS, metoprolol increases systolic ejection time and reduces aortic valve gradients, global afterload, and myocardial oxygen requirements. Thus, metoprolol displays favorable hemodynamic and metabolic effects and could improve outcome in patients with asymptomatic AS. Clinical Trial Registration— URL: http://www.clinicaltrials.gov. Unique identifier: NCT02076711.
Source: Circulation: Cardiovascular Imaging - September 27, 2017 Category: Radiology Authors: Hansson, N. H., Sorensen, J., Harms, H. J., Kim, W. Y., Nielsen, R., Tolbod, L. P., Frokiaer, J., Bouchelouche, K., Dodt, K. K., Sihm, I., Poulsen, S. H., Wiggers, H. Tags: Clinical Studies, Metabolism, Valvular Heart Disease, Imaging, Nuclear Cardiology and PET Ventricular Structure and Function Source Type: research