Index
Publication date: April 2018Source: Best Practice & Research Clinical Rheumatology, Volume 32, Issue 2Author(s): (Source: Best Practice and Research Clinical Rheumatology)
Source: Best Practice and Research Clinical Rheumatology - December 7, 2018 Category: Rheumatology Source Type: research

Editorial Board
Publication date: April 2018Source: Best Practice & Research Clinical Rheumatology, Volume 32, Issue 2Author(s): (Source: Best Practice and Research Clinical Rheumatology)
Source: Best Practice and Research Clinical Rheumatology - December 7, 2018 Category: Rheumatology Source Type: research

Epidemiology of rheumatic and musculoskeletal diseases
Publication date: April 2018Source: Best Practice & Research Clinical Rheumatology, Volume 32, Issue 2Author(s): Suzanne M.M. Verstappen, Loreto Carmona (Source: Best Practice and Research Clinical Rheumatology)
Source: Best Practice and Research Clinical Rheumatology - December 7, 2018 Category: Rheumatology Source Type: research

Uveitis in the Spondyloarthopathies
Publication date: December 2017Source: Best Practice & Research Clinical Rheumatology, Volume 31, Issue 6Author(s): Srilakshmi M. Sharma, Daniel JacksonAbstractUveitis is a frequently occurring extra-articular manifestation of spondyloarthropathies (SpAs), ankylosing spondylitis (AS), reactive arthritis (ReA), psoriatic arthritis (PsA) and inflammatory bowel disease (IBD), occurring in both adults and children with SpA. Uveitis occurs with varying frequency according to the SpA subtype (33% in AS, 6–9% in PsA, 25% in ReA, 13% in undifferentiated SpA and 2–5% in IBD), the presence of HLA-B27 and with increas...
Source: Best Practice and Research Clinical Rheumatology - December 6, 2018 Category: Rheumatology Source Type: research

Index
Publication date: February 2018Source: Best Practice & Research Clinical Rheumatology, Volume 32, Issue 1Author(s): (Source: Best Practice and Research Clinical Rheumatology)
Source: Best Practice and Research Clinical Rheumatology - December 5, 2018 Category: Rheumatology Source Type: research

Editorial Board
Publication date: February 2018Source: Best Practice & Research Clinical Rheumatology, Volume 32, Issue 1Author(s): (Source: Best Practice and Research Clinical Rheumatology)
Source: Best Practice and Research Clinical Rheumatology - December 5, 2018 Category: Rheumatology Source Type: research

Preface
Publication date: February 2018Source: Best Practice & Research Clinical Rheumatology, Volume 32, Issue 1Author(s): Raashid Ahmed Luqmani, David Jayne (Source: Best Practice and Research Clinical Rheumatology)
Source: Best Practice and Research Clinical Rheumatology - December 5, 2018 Category: Rheumatology Source Type: research

Index
Publication date: October 2017Source: Best Practice & Research Clinical Rheumatology, Volume 31, Issue 5Author(s): (Source: Best Practice and Research Clinical Rheumatology)
Source: Best Practice and Research Clinical Rheumatology - December 1, 2018 Category: Rheumatology Source Type: research

Involvement of epigenetics in osteoarthritis
Publication date: October 2017Source: Best Practice & Research Clinical Rheumatology, Volume 31, Issue 5Author(s): Rodrigo Coutinho de Almeida, Yolande F.M. Ramos, Ingrid MeulenbeltAbstractOsteoarthritis (OA) is the most prevalent chronic age-related arthritic disease that mainly affects the diarthrodial joints. Nevertheless, there is no treatment currently available that can effectively reduce symptoms or slow down or stop disease progression. The lack of disease-modifying therapies could be explained by the complex pathogenesis of OA, which is still not completely understood. Intertwined epigenetic mechanisms such as...
Source: Best Practice and Research Clinical Rheumatology - December 1, 2018 Category: Rheumatology Source Type: research

Role of the autonomic nervous system in osteoarthritis
Publication date: October 2017Source: Best Practice & Research Clinical Rheumatology, Volume 31, Issue 5Author(s): Alice Courties, Jérémie Sellam, Francis BerenbaumAbstractJoint homeostasis is affected by local and systemic processes. Catecholaminergic and cholinergic fibers innervate the synovium, trabecular bone, and periosteum. Several studies have investigated the involvement of the autonomic nervous system (ANS) in joint homeostasis and the pathophysiology of osteoarthritis (OA). Various resident cells of osteoarticular tissues express receptors for sympathetic and parasympathetic neurotransmitters (...
Source: Best Practice and Research Clinical Rheumatology - December 1, 2018 Category: Rheumatology Source Type: research

Editorial Board
Publication date: October 2017Source: Best Practice & Research Clinical Rheumatology, Volume 31, Issue 5Author(s): (Source: Best Practice and Research Clinical Rheumatology)
Source: Best Practice and Research Clinical Rheumatology - December 1, 2018 Category: Rheumatology Source Type: research

Editorial Board
Publication date: December 2017Source: Best Practice & Research Clinical Rheumatology, Volume 31, Issue 6Author(s): (Source: Best Practice and Research Clinical Rheumatology)
Source: Best Practice and Research Clinical Rheumatology - December 1, 2018 Category: Rheumatology Source Type: research

Index
Publication date: December 2017Source: Best Practice & Research Clinical Rheumatology, Volume 31, Issue 6Author(s): (Source: Best Practice and Research Clinical Rheumatology)
Source: Best Practice and Research Clinical Rheumatology - December 1, 2018 Category: Rheumatology Source Type: research

Clinical features and structured clinical evaluation of vasculitis
Publication date: Available online 22 November 2018Source: Best Practice & Research Clinical RheumatologyAuthor(s): C. Ponte, A.F. Águeda, R.A. LuqmaniAbstractSystemic vasculitides are a group of heterogeneous conditions with overlapping patterns of clinical and laboratory manifestations. Moreover, clinical features can be non-specific and seemingly disparate. A major factor in defining optimal therapy and measuring treatment response is careful disease assessment targeting four main domains: activity, damage, prognosis and quality of life/function. Assessment tools such as the Birmingham Activity Score and the ...
Source: Best Practice and Research Clinical Rheumatology - November 23, 2018 Category: Rheumatology Source Type: research

Update on the epidemiology, risk factors and disease outcomes of osteoarthritis
Publication date: Available online 22 November 2018Source: Best Practice & Research Clinical RheumatologyAuthor(s): Terence W. O'Neill, Paul S. McCabe, John McBethAbstractOsteoarthritis (OA) is the most frequent form of arthritis and a leading cause of pain and disability worldwide. OA can affect any synovial joint, although the hip, knee, hand, foot and spine are the most commonly affected sites. Knowledge about the occurrence and risk factors for OA is important to define the clinical and public health burden of the disease to understand mechanisms of disease occurrence and may also help to inform the development of ...
Source: Best Practice and Research Clinical Rheumatology - November 23, 2018 Category: Rheumatology Source Type: research

Update on the epidemiology, risk factors and disease outcomes of Juvenile idiopathic arthritis
Publication date: Available online 19 November 2018Source: Best Practice & Research Clinical RheumatologyAuthor(s): Jason Palman, Stephanie Shoop-Worrall, Kimme Hyrich, Janet E. McDonaghAbstractJuvenile idiopathic arthritis (JIA) is the most common inflammatory joint condition of childhood and represents seven JIA subtypes characterised by distinct clinical and laboratory variables. Genetic and environmental factors are known to influence JIA, although many unanswered questions remain. Measurement of health outcomes in JIA is imperative for both clinical practice and research. Patient-reported outcomes present particul...
Source: Best Practice and Research Clinical Rheumatology - November 21, 2018 Category: Rheumatology Source Type: research

Genetics and pathogenesis of small-vessel vasculitis
Publication date: Available online 17 November 2018Source: Best Practice & Research Clinical RheumatologyAuthor(s): Alan D. SalamaAbstractSmall-vessel vasculitides are uncommon autoimmune diseases characterised by inflammation and necrosis of arterioles, capillaries and venules, frequently described as various (previously eponymous) clinical syndromes. Some are associated with vessel wall immune complex deposition, whereas others are pauci-immune but paradoxically often associated with circulating anti-neutrophil cytoplasmic antibodies (ANCA). Most is known about the pathogenesis of the pauci-immune ANCA-associated syn...
Source: Best Practice and Research Clinical Rheumatology - November 18, 2018 Category: Rheumatology Source Type: research

Overview of changes in RMD epidemiology and outcome development in the last 10 years
Publication date: Available online 17 November 2018Source: Best Practice & Research Clinical RheumatologyAuthor(s): Suzanne M.M. Verstappen, Loreto CarmonaAbstractEpidemiological studies have been affected by environmental (or technological and societal) changes in the last 10 years, such as the emergence of registries, big data and machine learning algorithms, epigenetics, data protection regulations or a more solid presence of the patient perspective in outcomes research. As a consequence we, epidemiologists, are facing challenges in the design, conduct, and analysis of the studies, as well as on the interpretation o...
Source: Best Practice and Research Clinical Rheumatology - November 18, 2018 Category: Rheumatology Source Type: research

Imaging in axial spondyloarthritis: Changing concepts and thresholds
Publication date: Available online 17 November 2018Source: Best Practice & Research Clinical RheumatologyAuthor(s): Ulrich Weber, Xenofon BaraliakosAbstractImaging is key to recognition of axial spondyloarthritis (SpA) because clinical and laboratory examinations have limited diagnostic utility. Only MRI can capture both inflammation and bone remodeling by simultaneous depiction of active and structural lesions and their anatomic location. Bone marrow edema of limited extent on the sacroiliac joint (SIJ) MRI is often nonspecific and should be interpreted along with the clinical context. Contextual interpretation of the...
Source: Best Practice and Research Clinical Rheumatology - November 18, 2018 Category: Rheumatology Source Type: research

Investigations in systemic vasculitis – The role of renal pathology
Publication date: Available online 17 November 2018Source: Best Practice & Research Clinical RheumatologyAuthor(s): Annelies E. Berden, Maria A.C. Wester Trejo, Ingeborg M. BajemaAbstractANCA-associated vasculitis (AAV) describes a group of small-vessel vasculitides with frequent renal involvement. The first description of these conditions can be traced back to the 19th-century paper on necrotizing vasculitis by Kussmaul and Maier. Since then, our understanding of the pathogenesis has improved and the histopathological lesions have been described in detail. Characteristic histologic lesions in ANCA-associated glomerulo...
Source: Best Practice and Research Clinical Rheumatology - November 18, 2018 Category: Rheumatology Source Type: research

Update on the epidemiology, risk factors, and disease outcomes of axial spondyloarthritis
Publication date: Available online 16 November 2018Source: Best Practice & Research Clinical RheumatologyAuthor(s): Clementina López-Medina, Anna MoltóAbstractAxial spondyloarthritis (axSpA) is the prototype of a class of a rheumatic chronic inflammatory disease named spondyloarthritis (SpA).The prevalence of axSpA ranges between 0.1% and 1.4% globally, hence showing geographic differences that can be explained mostly by the prevalence of the HLA-B27 antigen. However, not many studies have evaluated the incidence of this disease.Inflammation may be initiated in the enthesis as a consequence of the action ...
Source: Best Practice and Research Clinical Rheumatology - November 17, 2018 Category: Rheumatology Source Type: research

Update on the epidemiology, risk factors, and disease outcomes of rheumatoid arthritis
This article reviews the new developments in RA research and discusses the latest insights into epidemiology, risk factors, predisease states, and outcomes. (Source: Best Practice and Research Clinical Rheumatology)
Source: Best Practice and Research Clinical Rheumatology - November 17, 2018 Category: Rheumatology Source Type: research

Comorbidities in spondyloarthritis including psoriatic arthritis
Publication date: Available online 15 November 2018Source: Best Practice & Research Clinical RheumatologyAuthor(s): Anna Moltó, Maxime DougadosAbstractComorbidities in spondyloarthritis (SpA) including psoriatic arthritis have to be differentiated to the concept of clinical features of SpA (e.g., uveitis, psoriasis, and inflammatory bowel disease). In addition to atherosclerosis-related cardiovascular diseases, the most frequent comorbidities in SpA are osteoporosis, fibromyalgia, and depression.Moreover, the current available drug therapies (e.g., NSAIDs, corticosteroids, and biologics) might increase the risk ...
Source: Best Practice and Research Clinical Rheumatology - November 16, 2018 Category: Rheumatology Source Type: research

Introduction, epidemiology and classification of vasculitis
Publication date: Available online 16 November 2018Source: Best Practice & Research Clinical RheumatologyAuthor(s): Richard A. Watts, Joanna RobsonAbstractClassification of the vasculitides has been traditionally based on vessel size. The American College of Rheumatology (ACR) criteria were developed in the 1980s and published in 1990 before the development of ANCA testing and modern imaging techniques such as MRI and PET scanning, and therefore, these criteria are not fit for use in 2010s. The Chapel Hill Consensus Conference provided a framework for defining various types of vasculitis. In the next two years, new cla...
Source: Best Practice and Research Clinical Rheumatology - November 16, 2018 Category: Rheumatology Source Type: research

Update on the epidemiology, risk factors, and outcomes of systemic vasculitides
Publication date: Available online 2 November 2018Source: Best Practice & Research Clinical RheumatologyAuthor(s): Alvise Berti, Christian DejacoAbstractAntineutrophil cytoplasmic antibody (ANCA)–associated vasculitis (AAV) and giant cell arteritis (GCA) are the most common primary systemic vasculitides of the adult population, while polymyalgia rheumatica (PMR) is a clinical syndrome often associated with GCA.Incidence and prevalence rates of AAV have been increasing in the last decades, whereas those of GCA and PMR have remained stable. The mutual interplay between environmental and genetic risk factors leading...
Source: Best Practice and Research Clinical Rheumatology - November 3, 2018 Category: Rheumatology Source Type: research

Nonradiographic axial spondyloarthritis
This article reviews the current state of the literature as the understanding of this disease spectrum expands. The conceptual history and terminology, genetics, and epidemiology are reviewed. The clinical manifestations, diagnostic approach, and measures of disease activity are examined. Finally the current treatment modalities and recommendations and the research agenda for nr-axSpA are reviewed. With the advent of new criteria, the disease spectrum can be studied in a systematic manner. These data have enriched our knowledge that reflects an earlier or milder form of disease on a spectrum same as that of ankylosing spon...
Source: Best Practice and Research Clinical Rheumatology - November 3, 2018 Category: Rheumatology Source Type: research

Uveitis and spondyloarthropathies
Publication date: Available online 25 October 2018Source: Best Practice & Research Clinical RheumatologyAuthor(s): Srilakshmi M. Sharma, Daniel JacksonAbstractUveitis is a frequently occurring extra-articular manifestation of spondyloarthropathies (SpAs), ankylosing spondylitis (AS), reactive arthritis (ReA), psoriatic arthritis (PsA) and inflammatory bowel disease (IBD), occurring in both adults and children with SpA. Uveitis occurs with varying frequency according to the SpA subtype (33% in AS, 6–9% in PsA, 25% in ReA, 13% in undifferentiated SpA and 2–5% in IBD), the presence of HLA-B27 and with increasi...
Source: Best Practice and Research Clinical Rheumatology - October 26, 2018 Category: Rheumatology Source Type: research

Disease activity assessment in patients with psoriatic arthritis
Publication date: Available online 11 October 2018Source: Best Practice & Research Clinical RheumatologyAuthor(s): Andreas Kerschbaumer, Josef S. Smolen, Daniel AletahaAbstractPsoriatic arthritis (PsA) is an inflammatory disease in patients with a personal or family history of psoriasis. While synovitis is the major hallmark, enthesitis, dactylitis, axial inflammation, and skin and nail involvement are variable in prevalence and severity. The assessment of disease activity is important to determine the treatment target (“Treat-to-Target”) as well as early response to therapy, because a prolonged ineffective...
Source: Best Practice and Research Clinical Rheumatology - October 11, 2018 Category: Rheumatology Source Type: research

Pediatric forms of vasculitis
Publication date: Available online 10 October 2018Source: Best Practice & Research Clinical RheumatologyAuthor(s): Seza Özen, Hafize Emine Sönmez, Selcan DemirAbstractPrimary vasculitides that affect children are a challenging and complex group of disorders that may involve any system of the body and lead to significant morbidity and mortality. In recent years, there have been significant advances in the field of childhood vasculitides, including the development of classification criteria and outcome assessment. Although some forms of vasculitis occur in both children and adults, considerable differences exis...
Source: Best Practice and Research Clinical Rheumatology - October 10, 2018 Category: Rheumatology Source Type: research

Update on the epidemiology, risk factors, and disease outcomes of psoriatic arthritis
Publication date: Available online 5 October 2018Source: Best Practice & Research Clinical RheumatologyAuthor(s): Dilek Solmaz, Lihi Eder, Sibel Zehra AydinAbstractPsoriatic arthritis (PsA) is a chronic inflammatory disease that affects different structures of the musculoskeletal system in addition to the skin and the nail. The complexity of the disease had been a barrier to understand the pathogenesis and define valid outcome tools; however, our understanding about the disease has considerably increased with time mainly because of the advances in imaging, new discoveries in genetics and underlying inflammatory pathway...
Source: Best Practice and Research Clinical Rheumatology - October 6, 2018 Category: Rheumatology Source Type: research

Investigations in systemic vasculitis – The role of imaging
Publication date: Available online 25 September 2018Source: Best Practice & Research Clinical RheumatologyAuthor(s): Wolfgang A. Schmidt, Daniel BlockmansAbstractImaging plays an increasing role for confirming a suspected diagnosis of giant cell arteritis (GCA) or Takayasu arteritis (TAK). Ultrasound, magnetic resonance imaging (MRI), and computed tomography demonstrate a homogeneous, most commonly concentric, arterial wall thickening. 18F-Fluorodeoxyglucose (FDG) positron emission tomography (PET) displays increased FDG uptake of inflamed artery walls delineating increased metabolism. Ultrasound and MRI are recommende...
Source: Best Practice and Research Clinical Rheumatology - October 5, 2018 Category: Rheumatology Source Type: research

Thumb base osteoarthritis: A hand osteoarthritis subset requiring a distinct approach
Publication date: Available online 26 September 2018Source: Best Practice & Research Clinical RheumatologyAuthor(s): Margreet Kloppenburg, Sjoerd van Beest, Féline P.B. KroonAbstractHand osteoarthritis (OA) is usually a polyarticular disease, preferentially affecting the thumb base (TB) and interphalangeal joints. TB OA alone is generally not addressed separately, but as a part of hand OA. Studies have shown that OA in the TB joints clusters together, as does OA in the interphalangeal joints, supporting it as a distinct subset. Further support for this view comes from a specific risk profile, influence on clinic...
Source: Best Practice and Research Clinical Rheumatology - October 5, 2018 Category: Rheumatology Source Type: research

Gut inflammation in spondyloarthritis
Publication date: Available online 27 September 2018Source: Best Practice & Research Clinical RheumatologyAuthor(s): Aroldo Rizzo, Angelo Ferrante, Giuliana Guggino, Francesco CicciaAbstractSpondyloarthritis (SpA) is a group of related diseases sharing common etiopathogenic mechanisms and clinical manifestations supported by a complex genetic predisposition. Gut inflammation is present in patients with SpA including patients showing clinically evident intestinal inflammation in the form of Crohn's disease or ulcerative colitis and patients who despite the absence of signs and symptoms of intestinal inflammation display...
Source: Best Practice and Research Clinical Rheumatology - October 5, 2018 Category: Rheumatology Source Type: research

Update on the epidemiology, risk factors, and disease outcomes of systemic lupus erythematosus
Publication date: Available online 27 September 2018Source: Best Practice & Research Clinical RheumatologyAuthor(s): Irini Gergianaki, Alessandra Bortoluzzi, George BertsiasAbstractObtaining an updated view of the epidemiology, risk factors, and prognosis of systemic lupus erythematosus (SLE) is pivotal to our understanding of the disease burden. Recent community-based studies with comprehensive methodology provided more accurate disease occurrence estimates and suggested that SLE may be more frequent than previously thought. Gender, race, and socioeconomic status are important disease determinants, and there is increa...
Source: Best Practice and Research Clinical Rheumatology - October 5, 2018 Category: Rheumatology Source Type: research

Update on the epidemiology and disease outcome of Familial Mediterranean fever
Publication date: Available online 29 September 2018Source: Best Practice & Research Clinical RheumatologyAuthor(s): Seza ÖzenAbstractAutoinflammatory diseases (AIDs) are diseases of the innate immune system, with clinical and laboratory evidence of attacks of inflammation. The more common AIDs are those associated with periodic fevers: Familial Mediterranean fever (FMF); Mevalonate Kinase Deficiency (MKD)/Hyperimmunoglobulin D Syndrome (HIDS); Cryopyrin-associated Autoinflammatory Syndrome (CAPS); and Tumor Necrosis Factor Receptor-Associated Periodic Syndrome (TRAPS). Classification criteria have been developed ...
Source: Best Practice and Research Clinical Rheumatology - October 5, 2018 Category: Rheumatology Source Type: research

Genetics in ankylosing spondylitis – Current state of the art and translation into clinical outcomes
Publication date: Available online 3 October 2018Source: Best Practice & Research Clinical RheumatologyAuthor(s): Matthew A. Brown, B. Paul WordsworthAbstractAnkylosing spondylitis (AS) is the prototypic form of axial spondyloarthritis (axSpA). It is highly heritable, with studies conducted in twins and in unrelated cases and controls showing that the heritability for AS is much higher than those for inflammatory bowel disease or rheumatoid arthritis. To date, 116 loci have been identified, contributing to 28% of the genetic variation in the disease. These loci provide important clues into pathogenic pathways in the di...
Source: Best Practice and Research Clinical Rheumatology - October 5, 2018 Category: Rheumatology Source Type: research

Update on the epidemiology, risk factors and disease outcomes of Behçet's disease
Publication date: Available online 21 September 2018Source: Best Practice & Research Clinical RheumatologyAuthor(s): Nurullah AkkoçAbstractBehçet's disease (BD) may be regarded as a polygenic autoinflammatory disease although adaptive immune system has also been implicated in pathogenesis. Different classification criteria sets exist for BD, including the new “International Criteria for BD.” The pooled prevalence of BD was calculated as 10.3 per 100,000 population globally. BD is common along the Silk Road, including Turkey. Male sex and early onset are associated with a more severe disease co...
Source: Best Practice and Research Clinical Rheumatology - September 22, 2018 Category: Rheumatology Source Type: research

Prognosis and future developments in vasculitis
Publication date: Available online 22 September 2018Source: Best Practice & Research Clinical RheumatologyAuthor(s): N. Basu, M. Karabayas, C. PuseyAbstractThe prognosis of ANCA-associated vasculitis has been transformed in recent years. Once it was a set of invariably acute and fatal conditions, but these disorders are currently considered to be chronic diseases. This change is largely attributable to earlier diagnosis and the careful application of immunotherapeutics. However, patients still experience premature mortality, relapse, comorbid ill health and poor quality of life. Mortality rates in large-vessel vasculit...
Source: Best Practice and Research Clinical Rheumatology - September 22, 2018 Category: Rheumatology Source Type: research

Oral treatment options for AS and PsA: DMARDs and small-molecule inhibitors
Publication date: Available online 20 September 2018Source: Best Practice & Research Clinical RheumatologyAuthor(s): Jonathan Chan, Dafna GladmanAbstractSpondyloarthritis (SpA) represents a group of common diseases that share a number of characteristic clinical manifestations including peripheral arthritis, spondylitis, enthesitis, and dactylitis. Additionally, they can often be associated with extra-articular manifestations including psoriasis, anterior uveitis, and inflammatory bowel disease. The two most widely studied clinical phenotypes are ankylosing spondylitis and psoriatic arthritis.Although a number of biolog...
Source: Best Practice and Research Clinical Rheumatology - September 20, 2018 Category: Rheumatology Source Type: research

Evolving concepts of new bone formation in axial spondyloarthritis: Insights from animal models and human studies
Publication date: Available online 20 September 2018Source: Best Practice & Research Clinical RheumatologyAuthor(s): Rik J. Lories, Nigil HaroonAbstractNew bone formation potentially leading to ankylosis of the sacroiliac joints and the spine is the main type of structural damage to the skeleton that characterizes axial spondyloarthritis. New data from animal models, imaging, and patient cohort studies support the view that sustained suppression of inflammation by therapeutic interventions can slow down the ankylosing process, at least in a large proportion of the patients. Although specific growth factor molecular sig...
Source: Best Practice and Research Clinical Rheumatology - September 20, 2018 Category: Rheumatology Source Type: research

The role of atherosclerosis in osteoarthritis
Publication date: Available online 14 September 2018Source: Best Practice & Research Clinical RheumatologyAuthor(s): S.M.A. Bierma-Zeinstra, J.H. WaarsingAbstractIn recent years, several papers that report an association between atherosclerosis (AS) and osteoarthritis (OA) have been published. Studying this relation is, however, not a sinecure owing to the multifactorial nature of these diseases and their long lead-in times. In this review, we discuss the evidence that is currently available for the association between OA and both subclinical AS and AS-related cardiovascular disease (CVD) events. We found that evidence...
Source: Best Practice and Research Clinical Rheumatology - September 15, 2018 Category: Rheumatology Source Type: research

Update on the epidemiology, risk factors, and disease outcomes of systemic sclerosis
Publication date: Available online 14 September 2018Source: Best Practice & Research Clinical RheumatologyAuthor(s): Francesca Ingegnoli, Nicola Ughi, Carina MihaiAbstractSystemic sclerosis (SSc) is a chronic immune-mediated connective tissue disease with heterogeneous organ involvement. New classification criteria were developed allowing disease identification even before the onset of its hallmark, skin fibrosis. Incidence and prevalence vary among reports and are influenced by methodology. Despite earlier diagnosis, mortality of SSc is still considerable, mainly because of cardiopulmonary causes. Genetic predispositi...
Source: Best Practice and Research Clinical Rheumatology - September 14, 2018 Category: Rheumatology Source Type: research

Soluble biochemical markers of osteoarthritis: Are we close to using them in clinical practice?
Publication date: Available online 11 September 2018Source: Best Practice & Research Clinical RheumatologyAuthor(s): Ali Mobasheri, Anne-Christine Bay-Jensen, Oreste Gualillo, Jonanthan Larkin, Marc C. Levesque, Yves HenrotinAbstractOsteoarthritis (OA) is the most common form of arthritis and a major cause of pain and disability. Recent work suggests that the global burden of OA is increasing, and costs associated with treatment are expected to increase dramatically as the aging human population expands. OA is currently diagnosed using radiography, but this technique is an indirect and insensitive measure of alteration...
Source: Best Practice and Research Clinical Rheumatology - September 12, 2018 Category: Rheumatology Source Type: research

Osteoarthritis: Research in motion
Publication date: Available online 7 September 2018Source: Best Practice & Research Clinical RheumatologyAuthor(s): Francis Berenbaum, Margreet Kloppenburg (Source: Best Practice and Research Clinical Rheumatology)
Source: Best Practice and Research Clinical Rheumatology - September 8, 2018 Category: Rheumatology Source Type: research

Preface: Future trends in the field of spondyloarthritis
Publication date: Available online 6 September 2018Source: Best Practice & Research Clinical RheumatologyAuthor(s): Jonathan Sherlock, Peter C. Taylor (Source: Best Practice and Research Clinical Rheumatology)
Source: Best Practice and Research Clinical Rheumatology - September 7, 2018 Category: Rheumatology Source Type: research

Born to run: The paradox of biomechanical force in spondyloarthritis from an evolutionary perspective
Publication date: Available online 1 September 2018Source: Best Practice & Research Clinical RheumatologyAuthor(s): Karlijn Debusschere, Isabelle Cambré, Eric Gracey, Dirk ElewautAbstractSpondyloarthritis (SpA) refers to a group of chronic inflammatory arthritic diseases that can be severely debilitating. The most common form of SpA affecting the peripheral skeleton is psoriatic arthritis, while that affecting the axial skeleton is ankylosing spondylitis. SpA has a multifactorial nature, with both genetic and environmental factors initiating and maintaining the disease. Recently, the role of biomechanical stress...
Source: Best Practice and Research Clinical Rheumatology - September 1, 2018 Category: Rheumatology Source Type: research

Th17 cell responses in spondyloarthritis
Publication date: Available online 30 August 2018Source: Best Practice & Research Clinical RheumatologyAuthor(s): J.S.H. Gaston, D.R. JadonAbstractTargeting IL-17 has become an important option in the current treatment of spondyloarthritis (SpA). To place this therapeutic advancement in context, we review the discovery and properties of this cytokine, noting those which predispose to inflammation and led to it being considered as an attractive target for the treatment of arthritis, especially SpA. The processes that regulate the differentiation of IL-17-producing cells, particularly Th17 CD4+ T cells, have been investi...
Source: Best Practice and Research Clinical Rheumatology - August 31, 2018 Category: Rheumatology Source Type: research

The complications of vasculitis and its treatment
Publication date: Available online 28 August 2018Source: Best Practice & Research Clinical RheumatologyAuthor(s): Catherine King, Lorraine Harper, Mark LittleAbstractSurvival following a diagnosis of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) has improved since the introduction of cyclophosphamide-based immunosuppressive regimens and is now almost 80% at 5 years. However, mortality remains 2.6 times greater in the population with AAV than in an age- and sex-matched general population. The greatest risk of harm for patients with AAV is during the first year of diagnosis and from the adverse ...
Source: Best Practice and Research Clinical Rheumatology - August 29, 2018 Category: Rheumatology Source Type: research

Conventional and biological immunosuppressants in vasculitis
Publication date: Available online 22 August 2018Source: Best Practice & Research Clinical RheumatologyAuthor(s): Loic Guillevin, Chetan Mukhtyar, Christian Pagnoux, Max YatesAbstractThe following chapter outlines the main findings from clinical trials, which provide information on the current best evidence-based management of the myriad of conditions that comprise vasculitis.Glucocorticoids (GCs) have been the mainstay of treatment of large-vessel vasculitis since Birkhead et al. used intramuscular cortisone daily and obtained good results in patients with giant cell arteritis. Recent trial data offer the hope th...
Source: Best Practice and Research Clinical Rheumatology - August 23, 2018 Category: Rheumatology Source Type: research

The role of HLA-B*27 in spondyloarthritis
Publication date: Available online 23 August 2018Source: Best Practice & Research Clinical RheumatologyAuthor(s): Robert A. Colbert, Fatemeh Navid, Tejpal GillAbstractThe mechanism by which HLA-B*27 predisposes to spondyloarthritis remains unresolved. Arthritogenic peptides have not been defined in humans and are not involved in experimental models of spondyloarthritis. Aberrant properties of HLA-B*27 can activate the IL-23/IL-17 axis in HLA-B*27 transgenic rats and humans. In HLA-B*27-independent rodent models, spondyloarthritis can be driven by IL-23 triggering entheseal-resident CD4-/CD8- T cells or CD4+ Th17 T...
Source: Best Practice and Research Clinical Rheumatology - August 23, 2018 Category: Rheumatology Source Type: research