Associations of activated coagulation factor VII and factor VIIa-antithrombin levels with genome-wide polymorphisms and cardiovascular disease risk.

CONCLUSIONS: Results support the importance of the F7 and PROCR loci on variation in circulating FVIIa and FVIIa-AT. Findings suggest FVIIa is a risk factor for ischemic stroke in older adults while higher FVIIa-AT may reflect mortality risk. This article is protected by copyright. All rights reserved.
PMID: 29112333 [PubMed - as supplied by publisher]

Source: Thrombosis and Haemostasis - November 7, 2017 Category: Hematology Authors: Olson NC, Raffield LM, Lange LA, Lange EM, Longstreth WT, Chauhan G, Debette S, Seshadri S, Reiner AP, Tracy RP Tags: J Thromb Haemost Source Type: research