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Total 381 results found since Jan 2013.

N-Acetylcysteine: A Review of Clinical Usefulness (an Old Drug with New Tricks)
CONCLUSION: The use of N-acetylcysteine should be considered in a number of conditions as our population ages and levels of glutathione drop. Supplementation may contribute to reducing morbidity and mortality in some chronic conditions as outlined in the article.PMID:34221501 | PMC:PMC8211525 | DOI:10.1155/2021/9949453
Source: Journal of Nutrition and Metabolism - July 5, 2021 Category: Nutrition Authors: Gerry K Schwalfenberg Source Type: research

Potential Disease-Modifying Effects of Lithium Carbonate in Niemann-Pick Disease, Type C1
Conclusion: Lithium is a potential therapeutic option for NP-C1 patients. Larger randomized and double-blind clinical trials are needed to further support this finding.Clinical Trial Registration:ClinicalTrials.gov, NCT03201627.
Source: Frontiers in Pharmacology - June 9, 2021 Category: Drugs & Pharmacology Source Type: research

Depression and anxiety symptoms are related to pain and frailty but not cognition or delirium in older surgical patients
ConclusionIn our cohort, we did not detect an association between preoperative depression and anxiety symptoms and neurocognitive disorders. Preoperative depression and anxiety symptoms were related to physical pain and frailty. Taken together, these suggest that in patients without a formal psychiatric diagnosis, preoperative depression and anxiety symptoms are related to physical state rather than a harbinger of early cognitive decline. Future studies are needed to understand the nature of the relationship between depression and anxiety symptoms and physical state in surgical patients.
Source: Brain and Behavior - May 5, 2021 Category: Neurology Authors: Sophia Wang, Brielle Cardieri, Hung Mo Lin, Xiaoyu Liu, Mary Sano, Stacie G. Deiner Tags: ORIGINAL RESEARCH Source Type: research

Evidence to Support the Use of S-Adenosylmethionine for Treatment of Post-Concussive Sequelae in the Military
CONCLUSION: There is evidence of a potential benefit of SAMe as an intervention to help with symptoms across the range of post-concussive sequelae and syndromes commonly seen in military mTBI. Since the discovery of SAMe in 1952, this pleiotropic molecule has shown the significance of its involvement in several metabolic cascades in such disparate systems as epigenetics, bioenergetics, DNA methylation, neurotransmitter systems, and potential usefulness in military TBI. Significant limitations include disparate presentations seen in patients with mild TBI, those with post-concussive syndrome, as well as those with comorbid ...
Source: Pain Physician - April 26, 2021 Category: Anesthesiology Authors: Danny A Schieffler Sofia E Matta Source Type: research

Suicide Following Stroke in the United States Veterans Health Administration Population
In the United States (US), suicide is a leading cause of death, and most of these suicides involve firearms, highlighting the importance of lethal means safety in suicide prevention.(1, 2) US Veterans experience a suicide rate 1.5 times higher than US civilian adults and are more likely to use firearms as the means of suicide.(3) Risk factors for suicide within this population include demographic factors such as sex, age, race, and level of education, as well as health factors such as smoking status, psychiatric conditions (e.g., posttraumatic stress disorder [PTSD], depression, bipolar and anxiety disorders, schizophrenia...
Source: Archives of Physical Medicine and Rehabilitation - March 31, 2021 Category: Rehabilitation Authors: Jordan M. Wyrwa, Tyler M. Shirel, Trisha A. Hostetter, Alexandra L. Schneider, Claire A. Hoffmire, Kelly A. Stearns-Yoder, Jeri E. Forster, Nathan E. Odom, Lisa A. Brenner Tags: Original Research Source Type: research

Suicide After Stroke in the United States Veteran Health Administration Population
In the United States (US), suicide is a leading cause of death, and most of these suicides involve firearms, highlighting the importance of lethal means safety in suicide prevention.1,2 US veterans experience a suicide rate 1.5 times higher than US civilian adults and are more likely to use firearms as the means of suicide.3 Risk factors for suicide within this population include demographic factors such as sex, age, race, and level of education, as well as health factors such as smoking status, psychiatric conditions (eg, posttraumatic stress disorder, depression, bipolar and anxiety disorders, schizophrenia, alcohol or o...
Source: Archives of Physical Medicine and Rehabilitation - March 31, 2021 Category: Rehabilitation Authors: Jordan M. Wyrwa, Tyler M. Shirel, Trisha A. Hostetter, Alexandra L. Schneider, Claire A. Hoffmire, Kelly A. Stearns-Yoder, Jeri E. Forster, Nathan E. Odom, Lisa A. Brenner Tags: ORIGINAL RESEARCH Source Type: research

Associations and limited shared genetic aetiology between bipolar disorder and cardiometabolic traits in the UK Biobank
CONCLUSIONS: This large study identified increased phenotypic cardiometabolic abnormalities in BPD participants. It is found that the comorbidity of coronary artery disease may be based on shared genetic aetiology. These results motivate hypothesis-driven research to consider individual cardiometabolic traits rather than a composite metabolic syndrome when attempting to disentangle driving mechanisms of cardiometabolic abnormalities in BPD.PMID:33766158 | DOI:10.1017/S0033291721000945
Source: Psychological Medicine - March 26, 2021 Category: Psychiatry Authors: Anna E F ürtjes Jonathan R I Coleman Jess Tyrrell Cathryn M Lewis Saskia P Hagenaars Source Type: research

Lithium alleviates blood-brain barrier breakdown after cerebral ischemia and reperfusion by upregulating endothelial Wnt/ β-catenin signaling in mice.
Lithium alleviates blood-brain barrier breakdown after cerebral ischemia and reperfusion by upregulating endothelial Wnt/β-catenin signaling in mice. Neuropharmacology. 2021 Jan 29;:108474 Authors: Ji YB, Gao Q, Tan XX, Huang XW, Ma YZ, Fang C, Wang SN, Qiu LH, Cheng YX, Guo FY, Chang J Abstract Although upregulation of endothelial Wnt/β-catenin signaling may be used to treat blood-brain barrier (BBB) breakdown caused by cerebral ischemia/reperfusion injury, no agents based on this mechanism are available clinically. Lithium, a medication used for treating bipolar mood disorders, upregulates Wnt/β-...
Source: Neuropharmacology - January 29, 2021 Category: Drugs & Pharmacology Authors: Ji YB, Gao Q, Tan XX, Huang XW, Ma YZ, Fang C, Wang SN, Qiu LH, Cheng YX, Guo FY, Chang J Tags: Neuropharmacology Source Type: research

Unipolar stroke, electroosmotic pump carbon nanotube yarn muscles
Success in making artificial muscles that are faster and more powerful and that provide larger strokes would expand their applications. Electrochemical carbon nanotube yarn muscles are of special interest because of their relatively high energy conversion efficiencies. However, they are bipolar, meaning that they do not monotonically expand or contract over the available potential range. This limits muscle stroke and work capacity. Here, we describe unipolar stroke carbon nanotube yarn muscles in which muscle stroke changes between extreme potentials are additive and muscle stroke substantially increases with increasing po...
Source: ScienceNOW - January 28, 2021 Category: Science Authors: Chu, H., Hu, X., Wang, Z., Mu, J., Li, N., Zhou, X., Fang, S., Haines, C. S., Park, J. W., Qin, S., Yuan, N., Xu, J., Tawfick, S., Kim, H., Conlin, P., Cho, M., Cho, K., Oh, J., Nielsen, S., Alberto, K. A., Razal, J. M., Foroughi, J., Spinks, G. M., Kim, Tags: Materials Science reports Source Type: news

Burst Motor Cortex Stimulation Evokes Sustained Suppression of Thalamic Stroke Pain: A Narrative Review and Single-Case Overview
AbstractChronic refractory central post-stroke pain (CPSP), one of the most disabling consequences of cerebral stroke, occurs in up to 10% of patients with CPSP. Because a considerable proportion of these patients with chronic pain remain resistant to pharmacological and behavioral therapies, adjunctive invasive and non-invasive brain stimulation therapies are needed. We performed a review of human studies applying burst and conventional motor cortex stimulation (burstMCS and cMCS, respectively) for chronic pain states, on the basis of data sources identified through searches of PubMed, MEDLINE/OVID, and SCOPUS, as well as...
Source: Pain and Therapy - December 16, 2020 Category: Anesthesiology Source Type: research