Associations and limited shared genetic aetiology between bipolar disorder and cardiometabolic traits in the UK Biobank

CONCLUSIONS: This large study identified increased phenotypic cardiometabolic abnormalities in BPD participants. It is found that the comorbidity of coronary artery disease may be based on shared genetic aetiology. These results motivate hypothesis-driven research to consider individual cardiometabolic traits rather than a composite metabolic syndrome when attempting to disentangle driving mechanisms of cardiometabolic abnormalities in BPD.PMID:33766158 | DOI:10.1017/S0033291721000945
Source: Psychological Medicine - Category: Psychiatry Authors: Source Type: research