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Total 381 results found since Jan 2013.

The relationship of carotid artery disease with mental and neurocognitive disorders
Psychiatriki. 2022 May 26. doi: 10.22365/jpsych.2022.083. Online ahead of print.ABSTRACTCarotid stenosis constitutes a common vascular disease that significantly affects cerebral blood flow and thus is associated with patients' cognitive functions. Carotid revascularization techniques [carotid endarterectomy (CEA) and carotid artery stenting (CAS)] may benefit cognition, though there are opposing findings, reporting an apparent decrement in cognitive function, no effect, or an apparent improvement after revascularization. A great number of studies are trying to evaluate the effect of carotid revascularization (CEA, CAS) on...
Source: Psychiatriki - May 27, 2022 Category: Psychiatry Authors: Christos Ch Liapis Source Type: research

Sensors, Vol. 22, Pages 3674: Linear-Range Extension for Linear Variable Differential Transformer Using Hyperbolic Sine Function
iewruja In this paper, a circuit technique to extend the measuring range of a linear variable differential transformer (LVDT) is proposed. The transfer characteristic of the LVDT contains the odd function form of the cubic polynomial. Therefore, the measuring range of a commercial LVDT is linear in a narrow range compared to its physical dimensions. The wide measuring range of the LVDT requires a large structure of the LVDT, which increases the scale and the cost of the measurement system. The measuring range of the LVDT can be linearly extended to the maximum of the stroke range using the proposed technique. The reali...
Source: Sensors - May 12, 2022 Category: Biotechnology Authors: Apinai Rerkratn Jakkapun Tongcharoen Wandee Petchmaneelumka Vanchai Riewruja Tags: Article Source Type: research

Identifying factors contributing to increased susceptibility to COVID-19 risk: a systematic review of Mendelian randomization studies
ConclusionThis review summarizes modifiable factors for intervention (e.g. smoking, obesity and inflammatory factors) and proteomic signatures (e.g. OAS1 and IL-6) that could help identify drugs for treating COVID-19.
Source: International Journal of Epidemiology - April 20, 2022 Category: Epidemiology Source Type: research

Flinn Foundation commits $5.52M to College of Medicine – Phoenix
The gift will establish two research faculty positions and support training to further translational research in cardiovascular diseases, neurosciences and mental health. April 7, 2022 University Alumni and Development Programflinn-gift-web.jpg Lauren MacDonnell, a research associate in the Translational Cardiovascular Research Center, processes samples in the TCRC lab. Sun Belous/College of Medicine – Phoenix Marketing and CommunicationsHealthCollege of Medicine - PhoenixCollege of PharmacyCompassion Media contact(s)Beth Smith College of Medicine – Phoenixbhsmith1@arizona.edu602-827-2676TheFlinn Foundation has...
Source: The University of Arizona: Health - April 6, 2022 Category: Universities & Medical Training Authors: mittank Source Type: research

Sex differences in the blood-brain barrier: implications for mental health
Front Neuroendocrinol. 2022 Mar 7:100989. doi: 10.1016/j.yfrne.2022.100989. Online ahead of print.ABSTRACTPrevalence of mental disorders, including major depressive disorder (MDD), bipolar disorder (BD) and schizophrenia (SZ) are increasing at alarming rates in our societies. Growing evidence points toward major sex differences in these conditions, and high rates of treatment resistance support the need to consider novel biological mechanisms outside of neuronal function to gain mechanistic insights that could lead to innovative therapies. Blood-brain barrier alterations have been reported in MDD, BD and SZ. Here, we provi...
Source: Frontiers in Neuroendocrinology - March 10, 2022 Category: Endocrinology Authors: Laurence Dion-Albert Luisa Bandeira Binder Beatrice Daigle Amandine Hong-Minh Manon Lebel Caroline Menard Source Type: research

Phosphorylation of PI3K/Akt at Thr308, but not MAPK kinase, mediates lithium-induced neuroprotection against cerebral ischemia in mice
Exp Neurol. 2022 Feb 2:113996. doi: 10.1016/j.expneurol.2022.113996. Online ahead of print.ABSTRACTLithium, in addition to its effect on acute and long-term bipolar disorder, is involved in neuroprotection after ischemic stroke. Yet, its mechanism of action is still poorly understood, which was only limited to its modulatory effect on GSK pathway. Therefore, we initially analyzed the dose-dependent effects of lithium on neurological deficits, infarct volume, brain edema and blood-brain barrier integrity, along with neuronal injury and survival in mice subjected to focal cerebral ischemia. Thereafter, we investigated the in...
Source: Experimental Neurology - February 5, 2022 Category: Neurology Authors: Nilay Ates Aysun Caglayan Zeynep Balcikanli Elif Sertel Mustafa Caglar Beker Pelin Dilsiz Ahmet Burak Caglayan S üleyman Celik Muhammed Furkan Dasdelen Berrak Caglayan T ürkan Yigitbasi Hanefi Ozbek Thorsten Roland Doeppner Dirk Matthias Hermann Ertugru Source Type: research

Functional seizures are associated with cerebrovascular disease and functional stroke is more common in patients with functional seizures than epileptic seizures
CONCLUSION: Our results confirm the initial observation of increased CVD in patients with FSe and further suggest that patients with FSe may be predisposed to developing another functional neurological disorder (FND) (i.e., functional stroke). We speculate that this may be due to shared risk factors and pathophysiological processes that are common to various manifestations of FND.PMID:35123242 | DOI:10.1016/j.yebeh.2022.108582
Source: Epilepsy and Behaviour - February 5, 2022 Category: Neurology Authors: Jonah Fox Slavina B Goleva Kevin F Haas Lea K Davis Source Type: research

Phosphorylation of PI3K/Akt at Thr308, but not MAPK kinase, mediates lithium-induced neuroprotection against cerebral ischemia in mice
Exp Neurol. 2022 Feb 2:113996. doi: 10.1016/j.expneurol.2022.113996. Online ahead of print.ABSTRACTLithium, in addition to its effect on acute and long-term bipolar disorder, is involved in neuroprotection after ischemic stroke. Yet, its mechanism of action is still poorly understood, which was only limited to its modulatory effect on GSK pathway. Therefore, we initially analyzed the dose-dependent effects of lithium on neurological deficits, infarct volume, brain edema and blood-brain barrier integrity, along with neuronal injury and survival in mice subjected to focal cerebral ischemia. Thereafter, we investigated the in...
Source: Experimental Neurology - February 5, 2022 Category: Neurology Authors: Nilay Ates Aysun Caglayan Zeynep Balcikanli Elif Sertel Mustafa Caglar Beker Pelin Dilsiz Ahmet Burak Caglayan S üleyman Celik Muhammed Furkan Dasdelen Berrak Caglayan T ürkan Yigitbasi Hanefi Ozbek Thorsten Roland Doeppner Dirk Matthias Hermann Ertugru Source Type: research