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Condition: Age-Related Macular Degeneration (AMD)

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Total 77 results found since Jan 2013.

Protective role of the apolipoprotein E2 allele in age-related disease traits and survival: evidence from the Long Life Family Study.
Abstract The apolipoprotein E (apoE) is a classic example of a gene exhibiting pleiotropism. We examine potential pleiotropic associations of the apoE2 allele in three biodemographic cohorts of long-living individuals, offspring, and spouses from the Long Life Family Study, and intermediate mechanisms, which can link this allele with age-related phenotypes. We focused on age-related macular degeneration, bronchitis, asthma, pneumonia, stroke, creatinine, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol, diseases of heart (HD), cancer, and survival. Our analysis detected favorable a...
Source: Biogerontology - July 21, 2016 Category: Geriatrics Authors: Kulminski AM, Raghavachari N, Arbeev KG, Culminskaya I, Arbeeva L, Wu D, Ukraintseva SV, Christensen K, Yashin AI Tags: Biogerontology Source Type: research

Risk of Myocardial Infarction and Stroke With Single or Repeated Doses of Intravitreal Bevacizumab in Age-Related Macular Degeneration
We thank Drs Hanhart and Vinker for their interest in our study. The authors point out to several methodological issues in our paper. First, the difference between the incidence of stroke and myocardial infarction (MI) in the 2 populations (wet age-related macular degeneration [AMD] using intravitreal bevacizumab and those not taking bevacizumab) is expected. As discussed in our paper, control patients who were not taking bevacizumab in the cohort analysis had a higher baseline cardiovascular risk profile than bevacizumab users, which naturally led to different incident rates for MI and stroke.
Source: American Journal of Ophthalmology - April 15, 2016 Category: Opthalmology Authors: Mahyar Etminan, David A. Maberley, David W. Babiuk, Bruce C. Carleton Tags: Correspondence Source Type: research

Systemic safety of intravitreal anti-vascular endothelial growth factor agents in age-related macular degeneration
Purpose of review: The purpose of review is to summarize the literature addressing nonocular adverse events in patients with neovascular age-related macular degeneration treated with intravitreal vascular endothelial growth factor (VEGF) inhibitors and to present possible mechanisms of effect. Recent findings: The incidence of overall nonocular serious adverse events varied from 0 to 39.3% and nonocular adverse events ranged from 0 to 86.9%. Few studies have reported a significant association between use of intravitreal anti-VEGF agents and overall incidence of adverse events, stroke, myocardial infarction, nonocular hemo...
Source: Current Opinion in Ophthalmology - April 8, 2016 Category: Opthalmology Tags: RETINAL, VITREOUS AND MACULAR DISORDERS: Edited by Brandon G. Busbee and John W. Kitchens Source Type: research

Intravitreal Bevacizumab and Cardiovascular Risk in Patients with Age-Related Macular Degeneration: Systematic Review and Meta-Analysis of Randomized Controlled Trials and Observational Studies
Conclusion Published data on IVTB in AMRD provide only a low level of evidence on its cardiovascular safety and do not support any finite conclusions.
Source: Drug Safety - March 7, 2016 Category: Drugs & Pharmacology Source Type: research

Analysis of cardiovascular diseases after the upload phase with intravitreal ranibizumab and bevacizumab in patients with exudative age-related macular degeneration.
CONCLUSION: In this small but prospective clinical study no increased risk for cardiovascular events during the upload phase of the VEGF inhibitors ranibizumab and bevacizumab could be detected when taking the age and pre-existing cardiovascular diseases into consideration. PMID: 26801323 [PubMed - as supplied by publisher]
Source: Der Ophthalmologe - January 22, 2016 Category: Opthalmology Authors: Fischer C, Schäfer K, Dschietzig T, Hoerauf H Tags: Ophthalmologe Source Type: research

Is Alzheimer disease related to age-related macular degeneration?
CONCLUSION: The increased frequency of AD in patients with AMD is significant. This study demonstrated the importance of cognitive assessment in patients with AMD, particularly in the d-AMD type. PMID: 26738356 [PubMed - in process]
Source: Turkish Journal of Medical Sciences - January 12, 2016 Category: Journals (General) Tags: Turk J Med Sci Source Type: research

This Vitamin Can Save Your Brain
Your brain has amazing abilities. And it can heal itself. That’s not something you’re likely to hear from mainstream medicine — especially if you or a loved one suffer from the effects of stroke, Alzheimer’s, Parkinson’s or another form of dementia. Here at the Sears Institute for Anti-Aging Medicine, I’ve seen many people with brain damage. And, sadly, most have been deemed “hopeless” by so-called medical experts. But I can tell you there is nothing hopeless about dementia — no matter what its cause. With the right nutrients, there are times when brain damage can be reversed. And now recent research from...
Source: Al Sears, MD Natural Remedies - December 23, 2015 Category: Complementary Medicine Authors: Al Sears Tags: Brain Health Alzheimer's dementia nutrients tocotrienol vitamin E Source Type: news

Risk of Myocardial Infarction and Stroke with Single or Repeated Doses of Intravitreal Bevacizumab in Age-Related Macular Degeneration
To examine the risk of myocardial infarction and stroke with single and repeated doses of intravitreal bevacizumab in wet age related macular degeneration (AMD).
Source: American Journal of Ophthalmology - December 14, 2015 Category: Opthalmology Authors: Mahyar Etminan, David A. Maberley, David W. Babiuk, Bruce C. Carleton Tags: Original Articles Source Type: research

Pharmacokinetic and Pharmacodynamic Properties of Anti-VEGF Drugs after Intravitreal Injection.
Abstract Subretinal neovascularization and pathologic ocular angiogenesis are common causes of progressive, irreversible impairment of central vision, and dramatically affect quality of life. Anti-vascular endothelial growth factor (anti-VEGF) therapy has improved the quality of life for many patients with age-related macular degeneration, diabetic retinopathy, and other ocular diseases involving neovascularization and edema. In these pathologies, the inhibition of intraocular VEGF is the only therapy that can preserve vision. Four anti-VEGF drugs are currently used to treat ocular neovascularization; pegaptanib, ...
Source: Current Drug Metabolism - October 1, 2015 Category: Drugs & Pharmacology Authors: Semeraro F, Morescalchi F, Duse S, Gambicorti E, Cancarini A, Costagliola C Tags: Curr Drug Metab Source Type: research

Targeted fluorescent probes for detection of oxidative stress in the mitochondria.
Abstract Mitochondrial oxidative stress has been implicated in aging, neurodegenerative diseases, diabetes, stroke, ischemia/reperfusion injury, age-related macular degeneration (AMD) and cancer. Recently, we developed two new mitochondria-targeting fluorescent probes, MitoProbes I/II, which specifically localize in mitochondria and employed both in vivo and in vitro for detection of mitochondrial oxidative stress. Here, we report the design and synthesis of these agents, as well as their utility for real-time imaging of mitochondrial oxidative stress in cells. PMID: 26189896 [PubMed - as supplied by publisher]
Source: Bioorganic and Medicinal Chemistry Letters - July 9, 2015 Category: Chemistry Authors: Yapici NB, Mandalapu S, Michael Gibson K, Bi L Tags: Bioorg Med Chem Lett Source Type: research

Validity of oxygen-ozone therapy as integrated medication form in chronic inflammatory diseases.
VALIDITY OF OXYGEN-OZONE THERAPY AS INTEGRATED MEDICATION FORM IN CHRONIC INFLAMMATORY DISEASES. Cardiovasc Hematol Disord Drug Targets. 2015 Jul 1; Authors: Bocci V, Zanardi I, Valacchi G, Borrelli E, Travagli V Abstract The state-of-the-art of oxygen-ozone therapy is now clarified and all the mechanisms of action of medical ozone are within classical biochemistry and molecular biology. The outcomes of standard treatments in peripheral arterial occlusive disease (PAOD) and dry-form of age-related macular degeneration (AMD) have been compared with the documented therapeutic results achieved with ozonat...
Source: Cardiovascular and Hematological Disorders Drug Targets - July 3, 2015 Category: Drugs & Pharmacology Tags: Cardiovasc Hematol Disord Drug Targets Source Type: research

The effect of blue-blocking intraocular lenses on circadian biological rhythm: protocol for a randomised controlled trial (CLOCK-IOL colour study)
Introduction Blue light information plays an important role in synchronising internal biological rhythm within the external environment. Circadian misalignment is associated with the increased risk of sleep disturbance, obesity, diabetes mellitus, depression, ischaemic heart disease, stroke and cancer. Meanwhile, blue light causes photochemical damage to the retina, and may be associated with age-related macular degeneration (AMD). At present, clear intraocular lenses (IOLs) and blue-blocking IOLs are both widely used for cataract surgery; there is currently a lack of randomised controlled trials to determine whether clear...
Source: BMJ Open - May 12, 2015 Category: Journals (General) Authors: Nishi, T., Saeki, K., Obayashi, K., Miyata, K., Tone, N., Tsujinaka, H., Yamashita, M., Masuda, N., Mizusawa, Y., Okamoto, M., Hasegawa, T., Maruoka, S., Ueda, T., Kojima, M., Matsuura, T., Kurumatani, N., Ogata, N. Tags: Open access, Epidemiology, Ophthalmology Protocol Source Type: research

Key discovery to preventing blindness, stroke devastation
Gene interactions that determine whether cells live or die in such conditions as age-related macular degeneration and ischemic stroke have been discovered by researchers. These common molecular mechanisms in vision and brain integrity can prevent blindness and also promote recovery from a stroke.
Source: ScienceDaily Headlines - January 30, 2015 Category: Science Source Type: news

LSU Health New Orleans makes discovery key to preventing blindness and stroke devastation
(Louisiana State University Health Sciences Center) Research conducted at the LSU Health New Orleans Neuroscience Center of Excellence has discovered gene interactions that determine whether cells live or die in such conditions as age-related macular degeneration and ischemic stroke. These common molecular mechanisms in vision and brain integrity can prevent blindness and also promote recovery from a stroke.
Source: EurekAlert! - Medicine and Health - January 30, 2015 Category: Global & Universal Source Type: news