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Condition: Age-Related Macular Degeneration (AMD)

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Total 77 results found since Jan 2013.

Age-related macular degeneration is associated with probable cerebral amyloid angiopathy: A case-control study
Age-related macular degeneration (AMD) is a common retinal degenerative disorder among older individuals. Amyloid deposits, a hallmark of cerebral amyloid angiopathy (CAA), may be involved in the pathogenesis of AMD. Since amyloid deposits may contribute to the development of both AMD and CAA, we hypothesized that patients with AMD have a higher prevalence of CAA.
Source: Journal of Stroke and Cerebrovascular Diseases - July 7, 2023 Category: Neurology Authors: Bhrugun Anisetti, Michael W. Stewart, Eric R. Eggenberger, Md Manjurul I. Shourav, Hossam Youssef, Ahamed Elkhair, Nilufer Ertekin-Taner, James F. Meschia, Michelle P. Lin Source Type: research

Associations of ophthalmic and systemic conditions with incident dementia in the UK Biobank
Conclusions AMD, cataract and DRED but not glaucoma are associated with an increased risk of dementia. Individuals with both ophthalmic and systemic conditions are at higher risk of dementia compared with those with an ophthalmic or systemic condition only.
Source: British Journal of Ophthalmology - January 20, 2023 Category: Opthalmology Authors: Shang, X., Zhu, Z., Huang, Y., Zhang, X., Wang, W., Shi, D., Jiang, Y., Yang, X., He, M. Tags: Press releases Original articles - Clinical science Source Type: research

Effective treatment of intractable diseases using nanoparticles to interfere with vascular supply and angiogenic process
Eur J Med Res. 2022 Nov 4;27(1):232. doi: 10.1186/s40001-022-00833-6.ABSTRACTAngiogenesis is a vital biological process involving blood vessels forming from pre-existing vascular systems. This process contributes to various physiological activities, including embryonic development, hair growth, ovulation, menstruation, and the repair and regeneration of damaged tissue. On the other hand, it is essential in treating a wide range of pathological diseases, such as cardiovascular and ischemic diseases, rheumatoid arthritis, malignancies, ophthalmic and retinal diseases, and other chronic conditions. These diseases and disorder...
Source: Cell Research - November 5, 2022 Category: Cytology Authors: Ahmad Hoseinzadeh Hamed Ghoddusi Johari Mohammad Hossein Anbardar Lobat Tayebi Ehsan Vafa Milad Abbasi Ahmad Vaez Ali Golchin Ali Mohammad Amani Ali Jangjou Source Type: research

Charles Bonnet Syndrome Associated With Recurrent Hypertensive Crisis
We describe a patient with episodic CBS triggered by recurrent hypertensive crises, which resolved with blood pressure management in the hospital setting.
Source: Journal of Psychiatric Practice - November 1, 2022 Category: Psychiatry Tags: Clinical Case Discussions Source Type: research

Joint Genetic Inhibition of PCSK9 and CETP and the Association With Coronary Artery Disease: A Factorial Mendelian Randomization Study
CONCLUSIONS AND RELEVANCE: Our results suggest that joint inhibition of CETP and PCSK9 has additive effects on lipid traits and disease risk, including a lower risk of CAD. Further research may explore whether a combination of CETP- and PCSK9-related therapeutics can benefit high-risk patients who are unable to reach treatment targets with existing options.PMID:35921096 | DOI:10.1001/jamacardio.2022.2333
Source: Atherosclerosis - August 3, 2022 Category: Cardiology Authors: Arjen J Cupido Laurens F Reeskamp Aroon D Hingorani Chris Finan Folkert W Asselbergs G Kees Hovingh Amand F Schmidt Source Type: research

Fish and human health: an umbrella review of observational studies
In conclusion, results from epidemiological studies support the mechanistic effects associated with omega-3 fatty acids from high fish consumption, but evidence needs to be further corroborated with more reliable results.PMID:35758202 | DOI:10.1080/09637486.2022.2090520
Source: International Journal of Food Sciences and Nutrition - June 27, 2022 Category: Nutrition Authors: Joanna Jurek Marcin Owczarek Justyna Godos Sandro La Vignera Rosita A Condorelli Stefano Marventano Maria Tieri Francesca Ghelfi Lucilla Titta Alessandra Lafranconi Angelo Gambera Elena Alonzo Salvatore Sciacca Silvio Buscemi Sumantra Ray Daniele Del Rio Source Type: research

SUBRETINAL DRUSENOID DEPOSITS AND SOFT DRUSEN: Are They Markers for Distinct Retinal Diseases?
Conclusion: Subjects with subretinal drusenoid deposits and non-SDD subjects have distinct systemic associations and serum and genetic risks. Subretinal drusenoid deposits are associated with CVD and stroke, ARMS2 risk, and lower high-density lipoprotein; non-SDDs are associated with higher high-density lipoprotein, CFH risk, and two lipid risk genes. These and other distinct associations suggest that these lesions are markers for distinct diseases.
Source: RETINA - June 26, 2022 Category: Opthalmology Tags: Original Study Source Type: research

Modeling of mitochondrial bioenergetics and autophagy impairment in MELAS-mutant iPSC-derived retinal pigment epithelial cells
CONCLUSIONS: Our studies demonstrate that the MELAS iPSC-derived disease models are powerful tools for dissecting the molecular mechanisms by which mitochondrial DNA alterations influence RPE function in aging and macular degeneration, and for testing novel therapeutics in patients harboring the MELAS genotype.PMID:35715869 | DOI:10.1186/s13287-022-02937-6
Source: Cell Research - June 17, 2022 Category: Cytology Authors: Sujoy Bhattacharya Jinggang Yin Weihong Huo Edward Chaum Source Type: research

Health benefits of astaxanthin against age-related diseases of multiple organs: A comprehensive review
Crit Rev Food Sci Nutr. 2022 Jun 16:1-66. doi: 10.1080/10408398.2022.2084600. Online ahead of print.ABSTRACTAge-related diseases are associated with increased morbidity in the past few decades and the cost associated with the treatment of these age-related diseases exerts a substantial impact on social and health care expenditure. Anti-aging strategies aim to mitigate, delay and reverse aging-associated diseases, thereby improving quality of life and reducing the burden of age-related pathologies. The natural dietary antioxidant supplementation offers substantial pharmacological and therapeutic effects against various dise...
Source: Atherosclerosis - June 16, 2022 Category: Cardiology Authors: Phaniendra Alugoju V K D Krishna Swamy Naga Venkata Anusha Anthikapalli Tewin Tencomnao Source Type: research

What the Science Says About the Health Benefits of Vitamins and Supplements
From multivitamins and melatonin to fiber and fish oil, Americans who are trying to boost their health and immunity have a plethora of supplements to choose from. An estimated 58% of U.S. adults ages 20 and over take dietary supplements, according to the U.S. Centers for Disease Control and Prevention, and the supplement industry is valued at more than $30 billion a year. Supplement use has been growing rapidly over the past few decades along with the wellness industry. “The popular belief is that a supplement is going to be helpful for promoting health,” says Fang Fang Zhang, a professor at Tufts University&rs...
Source: TIME: Health - April 28, 2022 Category: Consumer Health News Authors: Sandeep Ravindran Tags: Uncategorized Diet & Nutrition healthscienceclimate Source Type: news

Deep learning-based simultaneous registration and unsupervised non-correspondence segmentation of medical images with pathologies
ConclusionNCR-Net, a CNN for simultaneous image registration and unsupervised non-correspondence segmentation, is presented. Experimental results show the network ’s ability to segment non-correspondence regions in an unsupervised manner and its robust registration performance even in the presence of large pathologies.
Source: International Journal of Computer Assisted Radiology and Surgery - April 1, 2022 Category: Intensive Care Source Type: research

Effect Modification by Indication to the Risks of Major Thromboembolic Adverse Events in Patients Receiving Intravitreal Anti-Vascular Endothelial Growth Factor Treatment: A Population-Based Retrospective Cohort Study
ConclusionsPatients treated with aflibercept or ranibizumab for different indications may be associated with varying risk of TAEs. The findings provide evidence to support treatment selection, taking indications and TAE risk into consideration.
Source: BioDrugs - March 1, 2022 Category: Drugs & Pharmacology Source Type: research