Retinal Degeneration After Accidental Intravitreal Injection of Ropivacaine During Strabismus Surgery
No abstract available (Source: RETINA)
Source: RETINA - June 25, 2019 Category: Opthalmology Tags: Photo Essay Source Type: research

QUALITY IMPROVEMENT OF LASER TREATMENT (QUILT)A New Retinal Laser Simulation System for Training in Resource-Poor Countries
No abstract available (Source: RETINA)
Source: RETINA - June 25, 2019 Category: Opthalmology Tags: New Instruments Source Type: research

Diagnostic and Therapeutic Challenges
No abstract available (Source: RETINA)
Source: RETINA - June 25, 2019 Category: Opthalmology Tags: Diagnostic and Therapeutic Challenges Source Type: research

The thicknesses of choroid, macular segments, peripapillary retinal nerve fiber layer, and retinal vascular caliber in hiv-1–infected patients without infectious retinitis
Purpose: To evaluate choroidal, macular, peripapillary retinal nerve fiber layer (RNFL) thicknesses and retinal vascular caliber alterations in HIV-1–infected patients without opportunistic infections. Methods: This cross-sectional study included 45 HIV-1–infected patients and 47 healthy subjects. Spectral domain optical coherence tomography was used for assessment of choroidal, macular, peripapillary RNFL thicknesses and retinal vascular caliber alterations. Results: The mean CD4 count was 426 ± 226 cells per milliliter and the mean HIV-1 RNA level was 1.8 × 105 ± 3.6 × 105 co...
Source: RETINA - June 25, 2019 Category: Opthalmology Tags: Original Study Source Type: research

Differences in refractive outcomes between phacoemulsification for cataract alone and combined phacoemulsification and vitrectomy for epiretinal membrane
Conclusion: Combined phacovitrectomy for concurrent cataract epiretinal membrane by experienced cataract and vitreoretinal surgeons seems to deliver as predictable refractive results as cataract surgery alone. (Source: RETINA)
Source: RETINA - June 25, 2019 Category: Opthalmology Tags: Original Study Source Type: research

ASSOCIATION BETWEEN GENOTYPE AND DISEASE PROGRESSION IN ITALIAN STARGARDT PATIENTS: A Retrospective Natural History Study
Purpose: To investigate the natural history of Stargardt disease over a multiyear follow-up. Methods: We reviewed medical records of Stargardt disease patients, with clinical diagnosis of Stargardt disease at a single institution, which was also supported by molecular diagnosis. All patients underwent best-corrected visual acuity, fundus photography, optical coherence tomography, and full-field electroretinography. Results: The study cohort consisted of 157 Stargardt disease patients aged 30.4 ± 1.1 years. Longitudinal analysis (mean follow-up: 3 years) showed a significant worsening of best-corrected visual...
Source: RETINA - June 25, 2019 Category: Opthalmology Tags: Original Study Source Type: research

Significance of preoperative external limiting membrane height on visual prognosis in patients undergoing macular hole surgery
Conclusion: The ELM height varies widely in idiopathic macular hole. It is higher in eyes where the hole is wider and also when the hole itself is higher. For holes of less than 400 μm in width, a lower ELM height is a strong independent predictor of a good postoperative outcome. (Source: RETINA)
Source: RETINA - June 25, 2019 Category: Opthalmology Tags: Original Study Source Type: research

ACCURACY AND PRECISION OF INTRAVITREAL INJECTIONS OF ANTI–VASCULAR ENDOTHELIAL GROWTH FACTOR AGENTS IN REAL LIFE: What Is Actually in the Syringe?
Purpose: To evaluate the accuracy and precision of anti–vascular endothelial growth factor volume delivery by intravitreal injections in the clinical setup. Methods: Volume output was measured in 669 intravitreal injections administered to patients, calculated from the difference in syringe weight before and after expelling the drug. Three groups were included: prefilled bevacizumab 1.0 mL syringe (Group 1, n = 432), pre-filled ranibizumab in a small-volume syringe with low dead-space plunger design (Group 2, n = 125), and aflibercept drawn and injected using a 1.0-mL syringe (Group 3, n = 112). Accuracy was ana...
Source: RETINA - June 25, 2019 Category: Opthalmology Tags: Original Study Source Type: research

Combination therapy of intravitreal ranibizumab and subthreshold micropulse photocoagulation for macular edema secondary to branch retinal vein occlusion: 6-month result
Conclusion: The combination therapy of IVR and SMLP can treat branch retinal vein occlusion cystoid macular edema effectively, by decreasing the frequency of IVR injections while maintaining good visual acuity. (Source: RETINA)
Source: RETINA - June 25, 2019 Category: Opthalmology Tags: Original Study Source Type: research

INJECTION FREQUENCY OF AFLIBERCEPT VERSUS RANIBIZUMAB IN A TREAT-AND-EXTEND REGIMEN FOR CENTRAL RETINAL VEIN OCCLUSION: A Randomized Clinical Trial
Purpose: To prospectively investigate the injection frequency of aflibercept and ranibizumab in the treatment of macular edema in central retinal vein occlusion. Methods: Patients with treatment-naive central retinal vein occlusion and macular edema were randomized to receive intravitreal injections with aflibercept (n = 22) or ranibizumab (n = 23) in a treat-and-extend regimen with a follow-up time of 18 months. After 3 loading doses, the treatment intervals were extended by 2 weeks to a maximum of 12 weeks. Intervals were shortened by 2 weeks if macular edema recurred. Results: The number of injections was signif...
Source: RETINA - June 25, 2019 Category: Opthalmology Tags: Original Study Source Type: research

Instrumental difference in assessing choroidal hyperpermeability and photodynamic therapy in chronic central serous chorioretinopathy
Purpose: To investigate the difference in choroidal hyperpermeability (CH) assessed using digital fundus camera (DFC) and scanning laser ophthalmoscope (SLO) and its effect on photodynamic therapy (PDT) outcomes in chronic central serous chorioretinopathy. Methods: Midphase indocyanine green angiography (ICGA) images were acquired using both DFC and SLO in 38 consecutive eyes with chronic central serous chorioretinopathy in this retrospective study. Scanning laser ophthalmoscope-ICGA was taken immediately after DFC-ICGA. Photodynamic therapy was applied to the area of CH associated with subretinal fluid (CH-SRF). The ...
Source: RETINA - June 25, 2019 Category: Opthalmology Tags: Original Study Source Type: research

Conbercept in patients with treatment-naive neovascular age-related macular degeneration in real-life setting in china
In this study, we aimed to evaluate the efficacy and safety of intravitreal conbercept in patients with treatment-naive neovascular age-related macular degeneration in real-life setting. Methods: Three consecutive intravitreal injections of conbercept following a pro re nata protocol. The main outcomes were the changes of Early Treatment Diabetic Retinopathy Study best-corrected visual acuity and central retinal thickness between the baseline and the 12th month. Results: Mean best-corrected visual acuity was improved from 39.39 ± 24.91 letters at the baseline to 44.26 ± 22.89 letters at the final follow...
Source: RETINA - June 25, 2019 Category: Opthalmology Tags: Original Study Source Type: research

Sensitivity and specificity of detecting polypoidal choroidal vasculopathy with en face optical coherence tomography and optical coherence tomography angiography
Conclusion: Sensitivity of detecting PCV was low using structural en face OCT and OCTA but specificity was high. Indocyanine green angiography remains the gold standard for PCV detection. (Source: RETINA)
Source: RETINA - June 25, 2019 Category: Opthalmology Tags: Original Study Source Type: research

Comparison of retinal pathology visualization in multispectral scanning laser imaging
Purpose: To compare retinal pathology visualization in multispectral scanning laser ophthalmoscope imaging between the Spectralis and Optos devices. Methods: This retrospective cross-sectional study included 42 eyes from 30 patients with age-related macular degeneration (19 eyes), diabetic retinopathy (10 eyes), and epiretinal membrane (13 eyes). All patients underwent retinal imaging with a color fundus camera (broad-spectrum white light), the Spectralis HRA-2 system (3-color monochromatic lasers), and the Optos P200 system (2-color monochromatic lasers). The Optos image was cropped to a similar size as the Spectrali...
Source: RETINA - June 25, 2019 Category: Opthalmology Tags: Original Study Source Type: research

ROUTINE FUNDUS SCREENING OF FAMILIES OF CHILDREN WITH RETINOBLASTOMA: A Prospective Study of 131 Consecutive Families
Conclusion: Routine fundus screening of siblings allows for early detection of RB in otherwise asymptomatic children. Detection of spontaneously regressed RB in parents may act as a surrogate marker for germline RB1 mutation and is helpful in genetic counseling. (Source: RETINA)
Source: RETINA - June 25, 2019 Category: Opthalmology Tags: Original Study Source Type: research

Photodynamic therapy as primary treatment for small choroidal melanoma
Conclusion: Primary PDT resulted in complete tumor regression of small amelanotic choroidal melanoma in 67% at mean 5 years, with no major effect on visual acuity. (Source: RETINA)
Source: RETINA - June 25, 2019 Category: Opthalmology Tags: Original Study Source Type: research

Morphologic characteristics of macular hole and macular hole retinal detachment associated with extreme myopia
Purpose: To investigate the surgical results and morphologic characteristics of macular hole (MH) and macular hole retinal detachment (MHRD) associated with extreme myopia. Methods: We retrospectively reviewed consecutive cases with axial length ≥28 mm who were treated with pars plana vitrectomy for MH or MHRD. The choroidal and scleral thickness at the fovea, presence of dome-shaped macula, and the height of posterior staphyloma 3 mm from the fovea were measured from postoperative optical coherence tomography images. Results: Significant improvement in visual acuity was obtained postoperatively in both MH (16 e...
Source: RETINA - June 25, 2019 Category: Opthalmology Tags: Original Study Source Type: research

INTRAVITREAL GAS INJECTION WITH LASER PHOTOCOAGULATION FOR HIGHLY MYOPIC FOVEOSCHISIS: Technique and Outcome
Conclusion: C3F8 tamponade combined with laser photocoagulation could be an alternative treatment for highly myopic foveoschisis. (Source: RETINA)
Source: RETINA - June 25, 2019 Category: Opthalmology Tags: Original Study Source Type: research

Posterior staphylomas in eyes with retinitis pigmentosa without high myopia
Purpose: To describe features of posterior staphylomas in nonhighly myopic eyes with retinitis pigmentosa (RP). Methods: The retrospective observational case series study included patients with RP and an axial length of (Source: RETINA)
Source: RETINA - June 25, 2019 Category: Opthalmology Tags: Original Study Source Type: research

Five-year outcomes of intravitreal ranibizumab for choroidal neovascularization in patients with pathologic myopia
Conclusion: Intravitreal ranibizumab provide a 5-year visual benefit in eyes with myopic CNV compared with the natural course. A lack of enlargement of the CNV-related macular atrophy, a better baseline BCVA, and a minimum number of IVR injections were associated with better visual outcomes. (Source: RETINA)
Source: RETINA - June 25, 2019 Category: Opthalmology Tags: Original Study Source Type: research

Rapid progression of foveomacular retinoschisis in young myopics
Conclusion: We report a foveomacular retinoschisis characterized by young age of onset, female predominant, no highly myopia, mostly bilateral involvement, and rapid progression of foveoschisis and visual acuity. Vitrectomy is effective in restoring anatomical structure and stabilize vision. (Source: RETINA)
Source: RETINA - June 25, 2019 Category: Opthalmology Tags: Original Study Source Type: research

Clinical features of lacquer cracks in eyes with pathologic myopia
Conclusion: Lacquer cracks can be detected noninvasively by fundus autofluorescence and optical coherence tomography; however, improvements are necessary to detect all of the lesions. Lacquer cracks frequently progress with time, and an increase in the number of LCs was the most frequent progression pattern. (Source: RETINA)
Source: RETINA - June 25, 2019 Category: Opthalmology Tags: Original Study Source Type: research

Atypical macular holes
Conclusion: With the advancements in retinal imaging, atypical MHs are now more frequently recognized. With increasing understanding of the underlying disease processes, and improvement in investigations and surgical treatment, management of atypical MHs may improve in the future. (Source: RETINA)
Source: RETINA - June 25, 2019 Category: Opthalmology Tags: Review Source Type: research

Understanding Intravitreal Silicone Oil Droplets Due to Intravitreal Injections
No abstract available (Source: RETINA)
Source: RETINA - June 25, 2019 Category: Opthalmology Tags: Editorial Source Type: research

Reply
No abstract available (Source: RETINA)
Source: RETINA - May 24, 2019 Category: Opthalmology Tags: Correspondence Source Type: research

Correspondence
No abstract available (Source: RETINA)
Source: RETINA - May 24, 2019 Category: Opthalmology Tags: Correspondence Source Type: research

Reply
No abstract available (Source: RETINA)
Source: RETINA - May 24, 2019 Category: Opthalmology Tags: Correspondence Source Type: research

Correspondence
No abstract available (Source: RETINA)
Source: RETINA - May 24, 2019 Category: Opthalmology Tags: Correspondence Source Type: research

Reply
No abstract available (Source: RETINA)
Source: RETINA - May 24, 2019 Category: Opthalmology Tags: Correspondence Source Type: research

Correspondence
No abstract available (Source: RETINA)
Source: RETINA - May 24, 2019 Category: Opthalmology Tags: Correspondence Source Type: research

Reply
No abstract available (Source: RETINA)
Source: RETINA - May 24, 2019 Category: Opthalmology Tags: Correspondence Source Type: research

Correspondence
No abstract available (Source: RETINA)
Source: RETINA - May 24, 2019 Category: Opthalmology Tags: Correspondence Source Type: research

Reply
No abstract available (Source: RETINA)
Source: RETINA - May 24, 2019 Category: Opthalmology Tags: Correspondence Source Type: research

Correspondence
No abstract available (Source: RETINA)
Source: RETINA - May 24, 2019 Category: Opthalmology Tags: Correspondence Source Type: research

Choriovitreal Neovascularization After Resolution of Infectious Chorioretinitis
No abstract available (Source: RETINA)
Source: RETINA - May 24, 2019 Category: Opthalmology Tags: Photo Essay Source Type: research

Diagnostic and Therapeutic Challenges
No abstract available (Source: RETINA)
Source: RETINA - May 24, 2019 Category: Opthalmology Tags: Diagnostic and Therapeutic Challenges Source Type: research

Macular microvascular networks in healthy pediatric subjects
Purpose: To report optical coherence tomography angiography (OCTA) values in healthy pediatric eyes and to identify factors that may modify these values. Methods: In this prospective observational cross-sectional study, macular OCTA images were acquired from healthy pediatric patients. Main outcome measures were 1) foveal avascular zone (FAZ) area at the level of the superficial retinal capillary plexus (SCP); 2) SCP and deep retinal capillary plexus (DCP) perfusion density (based on the area of vessels); 3) SCP and DCP vessel density (based on a map with vessels of 1-pixel width); and 4) CC perfusion density. Multipl...
Source: RETINA - May 24, 2019 Category: Opthalmology Tags: Original Study Source Type: research

POSTERIOR FUNDUS HEMORRHAGES: Frequency and Associated Factors: The Beijing Eye Study
Purpose: To examine frequency and associations of retinal hemorrhages. Methods: The population-based Beijing Eye Study included 3,468 individuals. Monoscopic fundus photographs were examined for hemorrhages. Results: Retinal hemorrhages were detected in 515 eyes (429 individuals) (prevalence: 7.6%; 95% confidence interval [CI]: 7.0–8.0 per eye; 12.7%; 95% CI: 11.7–13.7 per person). Higher prevalence of retinal hemorrhages was correlated (multivariate analysis) with higher systolic blood pressure (P (Source: RETINA)
Source: RETINA - May 24, 2019 Category: Opthalmology Tags: Original Study Source Type: research

Vascular alterations revealed with optical coherence tomography angiography in patients with choroideremia
Conclusion: Choroideremia is a disease in which the choriocapillaris maintains a normal structure until the loss of the overlying retinal pigment epithelium. The inner retina also appears not to be affected at the vascular level. Although this study is limited by the small number of patients eligible for inclusion in the study, the observations support the concept of targeting gene therapy to the retinal pigment epithelium and outer retina because there is no evidence of independent degeneration of the choriocapillaris. (Source: RETINA)
Source: RETINA - May 24, 2019 Category: Opthalmology Tags: Original Study Source Type: research

CLINICAL AND GENETIC CHARACTERISTICS OF MALE PATIENTS WITH RPGR-ASSOCIATED RETINAL DYSTROPHIES: A Long-Term Follow-up Study
Purpose: To describe the phenotype and clinical course of patients with RPGR-associated retinal dystrophies, and to identify genotype–phenotype correlations. Methods: A multicenter medical records review of 74 male patients with RPGR-associated retinal dystrophies. Results: Patients had retinitis pigmentosa (RP; n = 52; 70%), cone dystrophy (COD; n = 5; 7%), or cone-rod dystrophy (CORD; n = 17; 23%). The median follow-up time was 11.6 years (range 0–57.1). The median age at symptom onset was 5.0 years (range 0–14 years) for patients with RP and 23.0 years (range 0–60 years) for patients with...
Source: RETINA - May 24, 2019 Category: Opthalmology Tags: Original Study Source Type: research

Spectral domain optical coherence tomography findings in coats disease
Purpose: To evaluate microstructural retinal abnormalities on spectral domain optical coherence tomography (SD-OCT) imaging of eyes with Coats disease. Methods: This is a multicenter, retrospective study in which SD-OCT images of patients with treatment-naive Coats disease were correlated with clinical examination and visual acuity and, when available, followed longitudinally over time. Results: Macular SD-OCT of 27 eyes with Coats disease revealed intraretinal edema (59%), intraretinal exudates (67%), subretinal fluid (37%), subretinal exudate (48%), ellipsoid zone disruption (52%), external limiting membrane disr...
Source: RETINA - May 24, 2019 Category: Opthalmology Tags: Original Study Source Type: research

Differential diagnosis for vitreoretinal lymphoma with vitreoretinal findings, immunoglobulin clonality tests, and interleukin levels
Conclusion: Newly screened immunoglobulin kappa light chain clonality assays may be useful to distinguish VRL from uveitis with high specificity. When sub-retinal pigment epithelium or retinal infiltration is severe and extensive, the IL-10-to-IL-6 ratio may not be typical and should be carefully interpreted. (Source: RETINA)
Source: RETINA - May 24, 2019 Category: Opthalmology Tags: Original Study Source Type: research

RELATIONSHIP OF CLINICAL FEATURES AND BASELINE TUMOR SIZE WITH GENE EXPRESSION PROFILE STATUS IN UVEAL MELANOMA: A Multi-institutional Study
Purpose: To study the relationship between gene expression profile subclass and clinical features in a multicenter cohort of patients with uveal melanoma. Methods: A retrospective, multicenter study was undertaken with patients entered from nine major ocular oncology centers from across the United States. Eligible patients had uveal melanoma and underwent I-125 plaque brachytherapy with concurrent tumor biopsy with gene expression profile testing between January 1, 2010, and October 28, 2014. Data were collected regarding patient demographics, baseline tumor clinical features, and gene expression profile results. Stat...
Source: RETINA - May 24, 2019 Category: Opthalmology Tags: Original Study Source Type: research

Time course of changes in optic disk neovascularization after a single intravitreal bevacizumab injection
Conclusion: In this study, statistically significant regression in the NVD size and flow area was observed as early as 24 hours after a single intravitreal bevacizumab injection, with a continued decreasing trend for at least a 1-month period. (Source: RETINA)
Source: RETINA - May 24, 2019 Category: Opthalmology Tags: Original Study Source Type: research

Outcome of endovascular procedures on ocular findings in takayasu arteritis
Conclusion: Percutaneous endovascular stenting of aortic arch arteries, affected in TA, can lead to reversal of retinopathy changes and restoration of vision if done before neovascular complications set in. (Source: RETINA)
Source: RETINA - May 24, 2019 Category: Opthalmology Tags: Original Study Source Type: research

Intravitreal anti-vascular endothelial growth factor injections for exudative retinal arterial macroaneurysms
Purpose: There is no established therapy for exudative-hemorrhagic complications in primary retinal arteriolar macroaneurysm (RAM). Methods: Retrospective multicenter interventional study of anti-vascular endothelial growth factor in symptomatic RAMs. Central macular thickness in μm and best-corrected visual acuity in logMar were correlated with the RAM size and distance to the macula. Statistical analyses were performed using paired comparisons and Pearson correlation. Results: Thirty-two eyes (32 patients) were treated with a mean of 2.7 injections over a mean follow-up of 16.6 months. Initial best-corrected v...
Source: RETINA - May 24, 2019 Category: Opthalmology Tags: Original Study Source Type: research

Clinical features, imaging, and natural history of myelinated retinal nerve fiber layer
Conclusion: In general, MRNFL is a rare, benign retinal finding with a potential for growth in 10% of cases. This supports previous histopathological reports that MRNFL represents accumulation of both myelin and oligodendrocytes and could be an oligodendrocytic choristoma. (Source: RETINA)
Source: RETINA - May 24, 2019 Category: Opthalmology Tags: Original Study Source Type: research

PHOTODYNAMIC THERAPY FOR SYMPTOMATIC SUBFOVEAL RETINAL PIGMENT EPITHELIAL DETACHMENT IN CENTRAL SEROUS CHORIORETINOPATHY: Outcomes and Prognostic Factors
Conclusion: Subfoveal RPED in central serous chorioretinopathy responded well to reduced-fluence PDT, especially in younger patients with less RPED. Dysmorphopsia, rather than decreased visual acuity, is a main symptomatic presentation in subfoveal RPED. (Source: RETINA)
Source: RETINA - May 24, 2019 Category: Opthalmology Tags: Original Study Source Type: research

Correlations between changes in photoreceptor layer and other clinical characteristics in central serous chorioretinopathy
Conclusion: Morphologic changes in PRL, best-corrected visual acuity, the reduction in foveal outer nuclear layer thickness, and symptom duration correlate closely but may behave asynchronously. These objective parameters, besides symptom duration, could be helpful when considering the timing of central serous chorioretinopathy treatment. (Source: RETINA)
Source: RETINA - May 24, 2019 Category: Opthalmology Tags: Original Study Source Type: research