Retinal Pigment Epithelium Atrophy After Subretinal Voretigene Neparvovec-rzyl for RPE65-Related Disease: A 6-Month Follow-Up
No abstract available (Source: RETINA)
Source: RETINA - November 24, 2022 Category: Opthalmology Tags: Photo Essay Source Type: research

Mystery of changing choroidal thickness
No abstract available (Source: RETINA)
Source: RETINA - November 24, 2022 Category: Opthalmology Tags: Diagnostic and Therapeutic Challenges Source Type: research

Microscope-Integrated Optical Coherence Tomography–Guided Autologous Full-Thickness Neurosensory Retinal Autograft for Large Macular Hole–Related Total Retinal Detachment
Conclusion: Microscope-integrated optical coherence tomography provides intraoperative visualization of MHs and provides real-time feedback regarding dimensions of the retinal autograft, thus aiding in accurate sizing of the graft. This ensures that the autograft fits snugly in the MH, thereby restoring macular structure and improving visual acuity. (Source: RETINA)
Source: RETINA - November 24, 2022 Category: Opthalmology Tags: Surgical Technique Source Type: research

Intrascleral hydration for 23-Gauge Pars Plana Vitrectomy Sclerotomy Closure
Conclusion: The intrascleral stroma hydration is a simple and fast technique that does not require extra surgical materials. (Source: RETINA)
Source: RETINA - November 24, 2022 Category: Opthalmology Tags: Surgical Technique Source Type: research

Limited Vitrectomy for Pseudophakic Rhegmatogenous Retinal Detachment
No abstract available (Source: RETINA)
Source: RETINA - November 24, 2022 Category: Opthalmology Tags: Surgical Technique Source Type: research

PROGRESSIVE PERIPAPILLARY CHOROID THINNING AND RETINAL NEURODEGENERATION IN PATIENTS WITH DIABETES: A 3-Year Cohort Study
Purpose: To investigate longitudinal changes in peripapillary choroidal thickness (pCT) and retinal nerve fiber thickness (pRNFLT) in patients with Type 2 diabetes mellitus. Methods: This was a prospective observational cohort study. Patients with Type 2 diabetes mellitus without diabetic retinopathy (DR) at baseline were recruited, followed up for three years, and further divided into an incident DR group and a non-DR group according to the outcome. The pCT and pRNFLT were measured through swept-source optical coherence tomography at 1-year interval, and the mean rates of pCT and pRNFLT thinning were compared b...
Source: RETINA - November 24, 2022 Category: Opthalmology Tags: Original Study Source Type: research

Intraoperative optical coherence tomography for real-time visualization of the positional relationship between buckling material and retinal breaks during scleral buckling for rhegmatogenous retinal detachment
Conclusion: This procedure is a novel approach that enables safer and more accurate placement of the buckling material and may contribute to improving the outcomes of scleral buckling in the future. (Source: RETINA)
Source: RETINA - November 24, 2022 Category: Opthalmology Tags: Original Study Source Type: research

Fluorescence lifetime imaging ophthalmoscopy as predictor of long-term functional outcome in macula-off rhegmatogenous retinal detachment
Purpose: To assess whether macular fluorescence lifetimes may serve as a predictor for long-term outcomes in macula-off rhegmatogenous retinal detachment. Methods: A single-center observational study was conducted. Patients with pseudophakic macula-off rhegmatogenous retinal detachment were included and evaluated 1 and 6 months after successful reattachment surgery. Fluorescence lifetime imaging ophthalmoscopy lifetimes in the central Early Treatment Diabetic Retinopathy Study grid subfield, in two distinct channels (short spectral channel and long spectral channel) were analyzed. Best-corrected visual acuity op...
Source: RETINA - November 24, 2022 Category: Opthalmology Tags: Original Study Source Type: research

CONGENITAL POSTERIOR POLAR CHORIORETINAL HYPOPLASIA: Expansion of the Clinical Spectrum, Mutation, and Its Association With PRDM13
Conclusion: The phenotype of this disease falls between the spectrum of progressive bifocal chorioretinal atrophy and NCMD. The findings are most consistent with progressive bifocal chorioretinal atrophy with the exception that there is no bifocal nature to the appearance nor is it progressive. Another view is that the phenotype seems to be an extremely severe form of NCMD. Given that this disease falls in between progressive bifocal chorioretinal atrophy and NCMD, we propose calling it congenital posterior polar chorioretinal hypoplasia. (Source: RETINA)
Source: RETINA - November 24, 2022 Category: Opthalmology Tags: Original Study Source Type: research

Comparison of primary and secondary forms of multiple evanescent white dot syndrome
Conclusion: In secondary MEWDS, outer retinal lesions are less extensive and located close to preexisting chorioretinal lesions. Mild signs of intraocular inflammation on multimodal imaging are more frequent in secondary MEWDS during recovery. These findings suggest that chorioretinal inflammation may trigger secondary MEWDS. (Source: RETINA)
Source: RETINA - November 24, 2022 Category: Opthalmology Tags: Original Study Source Type: research

Efficacy of combined systemic corticosteroid and early immunomodulatory therapy within three months of onset in vogt–koyanagi–harada disease
Purpose: To evaluate the clinical outcomes of combined systemic corticosteroid and early immunomodulatory therapy (IMT) within 3 months of onset in Vogt–Koyanagi–Harada (VKH) disease compared with conventional therapy. Methods: This retrospective observational case series included 73 eyes of 38 patients with VKH, categorized into the conventional (n = 41) and the early IMT (n = 32) groups. Clinical information was gathered from patients' medical records. Primary outcome measures were visual acuity, subfoveal choroidal thickness, and uveitis outcome including occurrence of sunset glow fundus. Results: ...
Source: RETINA - November 24, 2022 Category: Opthalmology Tags: Original Study Source Type: research

Optical coherence tomography angiography findings in patients with chronic thromboembolic pulmonary hypertension
Conclusion: Measurements of the foveal avascular zone and vessel density of the DVC and subfoveal choroidal thickness may be useful and sensitive predictors of retinal and choroidal circulation impairment in CTEPH patients without systemic disease. (Source: RETINA)
Source: RETINA - November 24, 2022 Category: Opthalmology Tags: Original Study Source Type: research

Effects of half-dose photodynamic therapy on chronic central serous chorioretinopathy with or without macular neovascularization assessed using optical coherence tomography angiography
Purpose: To assess the effects of half-dose photodynamic therapy on subretinal fluid and macular neovascularization (MNV) using optical coherence tomography angiography in patients with chronic central serous chorioretinopathy. Methods: Clinical information on 168 patients (168 eyes) with chronic central serous chorioretinopathy obtained before and 6 months after treatment with half-dose photodynamic therapy was retrospectively analyzed. Patients were categorized into a success (145 eyes) or failure (23 eyes) group based on the absence or presence of subretinal fluid, respectively, and clinical data were compare...
Source: RETINA - November 24, 2022 Category: Opthalmology Tags: Original Study Source Type: research

Parafoveal inner retinal thinning as the biomarker predicting less recurrence of macular edema in central retinal vein occlusion after discontinuing antivascular endothelial growth factor
Conclusion: Parafoveal inner retinal thinning and intact ellipsoid zone after resolution of macular edema by antivascular endothelial growth factor treatment were predictive of a lower risk of recurrence of macular edema in CRVO. These intuitive biomarkers may help predict future disease courses and design optimal treatment strategies. (Source: RETINA)
Source: RETINA - November 24, 2022 Category: Opthalmology Tags: Original Study Source Type: research

Multimodal imaging features and treatment responses of choroidal neovascularization secondary to central serous chorioretinopathy
Purpose: To investigate features of central serous chorioretinopathy with choroidal neovascularization (CNV) on multimodal imaging and analyze their association with treatment response. Methods: A total of 37 patients with chronic central serous chorioretinopathy complicated by CNV were divided into bevacizumab and photodynamic therapy groups, and each group was subdivided into responders and nonresponders according to subretinal fluid status at 3 months. We assessed multimodal imaging parameters (subfoveal choroidal thickness; vortex vein engorgement; choroidal vascular hyperpermeability; and CNV morphologic pa...
Source: RETINA - November 24, 2022 Category: Opthalmology Tags: Original Study Source Type: research