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Condition: Anemia
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Total 1392 results found since Jan 2013.
Clinical impact of oral anticoagulation among octogenarians with atrial fibrillation and anaemia
AbstractOur study aimed to describe the efficacy and safety of oral anticoagulation (OAC) use in elderly patients (> or = 80 years-old) with atrial fibrillation (AF) and concomitant anaemia. Data for this study were sourced from AF Research Database (NCT03760874). AF patients aged ≥ 80 who received OAC treatment, both direct oral anticoagulant (DOAC) and vitamin K antagonist (VKA) were selected. Partici pants were categorized as anaemic and non-anaemic. The primary outcome was the occurrence of overall bleeding. The primary effectiveness outcome was the occurrence of thromboembolic events (a composite of isch...
Source: Journal of Thrombosis and Thrombolysis - December 6, 2022 Category: Hematology Source Type: research
Neuregulin-1 attenuates hemolysis- and ischemia induced-cerebrovascular inflammation associated with sickle cell disease
Sickle cell disease (SCD) is a group of inherited red blood cell disorders caused by a mutation in the human beta-globin gene. The most common and severe form, Hemoglobin SS (also known as sickle cell anemia, SCA), results from homozygous inheritance of the hemoglobin S mutation of beta globin ( β 6 (glu -> val)) on chromosome 11. This mutation leads to non-covalent hydrophobic polymerization of hemoglobin molecules into rod-like structures within erythrocytes and the hallmark “sickle” shaped red blood cells under conditions of low oxygen saturation, intracellular dehydration, and/or acidosis.
Source: Journal of Stroke and Cerebrovascular Diseases - December 3, 2022 Category: Neurology Authors: Christopher Chambliss, Jonathan K. Stiles, Beatrice E. Gee Source Type: research
CO147 Comparative Efficacy and Safety of Pharmacological Interventions for Managing Sickle Cell Disease Complications in Children and Adolescents: A Systematic Review With Network Meta-Analyses
Sickle cell disease (SCD), an inherited hemoglobinopathy that causes anemia, severe pain, vaso-occlusive crisis (VOC), is currently recognized as a global public health concern, being the leading cause of pediatric stroke. Our aim was to synthesize the evidence on the efficacy and safety of interventions for managing SCD in this population.
Source: Value in Health - December 1, 2022 Category: International Medicine & Public Health Authors: F Tonin, AC Ginete, J Ferreira, M Delgadinho, F Fernandez-Llimos, M Brito Source Type: research
Charles Bonnet Syndrome Associated With Recurrent Hypertensive Crisis
We describe a patient with episodic CBS triggered by recurrent hypertensive crises, which resolved with blood pressure management in the hospital setting.
Source: Journal of Psychiatric Practice - November 1, 2022 Category: Psychiatry Tags: Clinical Case Discussions Source Type: research
Neurovascular Manifestations of Iron-Deficient Anemia: Narrative Review and Practical Reflections through a Teaching Case
Conclusions: IDA is a common but treatable condition that, independently or synergically, may increase the risk of thrombotic events. The diagnostic and therapeutic approach has not yet been defined, and each case should be individually addressed in a pragmatic clinical road map.PMID:36294407 | DOI:10.3390/jcm11206088
Source: Clinical Lung Cancer - October 27, 2022 Category: Cancer & Oncology Authors: Marialuisa Zedde Giacomo Portaro Laura Ferri Francesco Cavallieri Manuela Napoli Claudio Moratti Fabrizio Piazza Franco Valzania Rosario Pascarella Source Type: research
Monogenic Stroke —Can We Overcome Nature With Nurture?
Although genetic underpinnings of several neurological disorders like epilepsy have been described as early as fourth century bce in the Corpus Hippocraticum, discoveries in stroke have been more recent. One of the first reports demonstrating the importance of heredity in stroke pathogenesis occurred in 1974 with the generation of the stroke-prone spontaneously hypertensive rat. This strain was created using selective breeding and has endured as a valuable asset in contemporary stroke research. Nonetheless, half a century later, the precise genetic determinants even in this single, highly specific rodent stroke phenotype h...
Source: JAMA Neurology - October 27, 2022 Category: Neurology Source Type: research
Combined use of the GRACE ACS risk score and comorbidity indices to increase the effectiveness of hospital mortality risk assessment in patients with acute coronary syndrome
CONCLUSION: CCI and its own comorbidity model, but not CDS and CIRS, are associated with the risk of hospital mortality. The model for assessing comorbidity on a 9-point scale, but not CCI, CDS and CIRS, can significantly improve the predictive value of the GRACE scale.PMID:36286937 | DOI:10.26442/00403660.2022.07.201742
Source: Atherosclerosis - October 26, 2022 Category: Cardiology Authors: M V Zykov N V Dyachenko R M Velieva V V Kashtalap O L Barbarash Source Type: research
Quantitative susceptibility mapping (QSM) and R2* of silent cerebral infarcts in sickle cell anemia
The objective of this work was therefore to investigate the composition of segmented SCI lesions using quantitative MRI for R2* and quantitative magnetic susceptibility mapping (QSM). 211 SCI lesions were segmented from 32 participants with SCA and 6 controls. SCI were segmented according to two definitions (FLAIR+/–T1w-based threshold) using a semi-automated pipeline. Magnetic susceptibility (χ) and R2* maps were calculated from a multi-echo gradient echo sequence and mean SCI values were compared to an equivalent region of interest in normal appearing white matter (NAWM). SCI χ and R2* were investigated as a function...
Source: Frontiers in Neurology - October 20, 2022 Category: Neurology Source Type: research
Characterization of baseline clinical factors associated with incident worsening kidney function in patients with non-valvular atrial fibrillation: the Hokuriku-Plus AF Registry
AbstractEvidence suggests that atrial fibrillation (AF) could increase the risk of worsening kidney function (WKF) which is linked to an increased risk of stroke, bleeding, and death in AF patients. However, limited data exist regarding the factors that could lead to WKF in these patients. Therefore, we sought to identify the potential factors associated with the development of WKF in patients with non-valvular AF (NVAF). We analyzed prospectively recruited 1122 NVAF patients [men 71.9%, median age 73.0 years (interquartile range: 66.0–79.0)] with a baseline estimated glomerular filtration rate (eGFR) ≥ 15 mL/mi...
Source: Heart and Vessels - October 17, 2022 Category: Cardiology Source Type: research
Carvedilol reduces the Neuronal apoptosis after ischemic stroke by modulating ATF3 expression in vitro
In conclusion, Carvedilol may be a key compound targeting ATF3 in OGD/R-PC12 cells.
Source: Developmental Neuroscience - October 11, 2022 Category: Neuroscience Source Type: research
Surveillance for Sickle Cell Disease - Sickle Cell Data Collection Program, Two States, 2004-2018
This report is the first comprehensive description of CDC's efforts in collaboration with participating states to establish, maintain, and expand SCD surveillance through the SCDC program to improve health outcomes for persons living with SCD. Findings from California and Georgia analyses highlighted a need for additional SCD specialty clinics. Despite different approaches, expansion of SCDC to multiple states was possible using standardized, rigorous methods developed across all participating states for reporting on disease prevalence, health care needs and use, and deaths.PUBLIC HEALTH ACTION: Findings from surveillance ...
Source: MMWR Surveill Summ - October 6, 2022 Category: Epidemiology Authors: Angela B Snyder Sangeetha Lakshmanan Mary M Hulihan Susan T Paulukonis Mei Zhou Sophia S Horiuchi Karon Abe Shammara N Pope Laura A Schieve Source Type: research
