Neuregulin-1 attenuates hemolysis- and ischemia induced-cerebrovascular inflammation associated with sickle cell disease

Sickle cell disease (SCD) is a group of inherited red blood cell disorders caused by a mutation in the human beta-globin gene. The most common and severe form, Hemoglobin SS (also known as sickle cell anemia, SCA), results from homozygous inheritance of the hemoglobin S mutation of beta globin ( β 6 (glu -> val)) on chromosome 11. This mutation leads to non-covalent hydrophobic polymerization of hemoglobin molecules into rod-like structures within erythrocytes and the hallmark “sickle” shaped red blood cells under conditions of low oxygen saturation, intracellular dehydration, and/or acidosis.
Source: Journal of Stroke and Cerebrovascular Diseases - Category: Neurology Authors: Source Type: research