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Condition: Cardiomyopathy

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Total 1426 results found since Jan 2013.

Peripartum cardiomyopathy: An uncommon cause of ischemic stroke.
Abstract A previously healthy 22-year-old woman with a history with a healthy pregnancy presented 12 weeks after an uneventful delivery with progressive dyspnea and edema. Initial blood workup was relevant for an elevated B-type natriuretic peptide in 1641 pg/mL (reference: 0-100). PMID: 33181805 [PubMed - as supplied by publisher]
Source: Archivos de Cardiologia de Mexico - November 12, 2020 Category: Cardiology Authors: Jiménez-Ruiz A, García-Grimshaw M, Ortega-Márquez J, Moreno-Guillen A, Flores-Silva FD, Cantú-Brito C Tags: Arch Cardiol Mex Source Type: research

Acute Ischemic Stroke in a Young Patient with Left Ventricular Thrombus Attributed to Doxorubicin Cardiomyopathy
We report a case of acute middle cerebral territory ischemic infarction caused by left ventricular thrombus (LVT) in a doxorubicin cardiomyopathy patient. A major adverse effect of doxorubicin is cardiotoxicity. In doxorubicin cardiomyopathy, as the ventricular contractility decreases, LVT can occur and lead to systemic embolic events such as stroke.Case Rep Neurol 2020;12:178 –182
Source: Case Reports in Neurology - December 14, 2020 Category: Neurology Source Type: research

Contribution of nuclear and mitochondrial gene mutations in mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) syndrome
ConclusionIndividuals with MELAS exhibit clinical phenotypes with varying degree of severity affecting multiple systems including auditory, visual, cardiovascular, endocrine, and nervous system. This is the first report to show that nuclear genetic factors influence the clinical outcomes/manifestations of MELAS subjects alone or in combination with m.3243A  >  G mutation.
Source: Journal of Neurology - January 23, 2021 Category: Neurology Source Type: research

Trends, Predictors and Outcomes of Ischemic Stroke Among Patients Hospitalized with Takotsubo Cardiomyopathy
Takotsubo cardiomyopathy (TCM) or stress-induced cardiomyopathy is characterized by transient systolic and diastolic left ventricular dysfunction and evidence of myocardial ischemia with varieties of wall-motion abnormalities.1 –3 It predominantly affects post-menopausal women in the setting of emotional, physical, or medical stress.1–5 TCM has been increasingly recognized in recent years, which could be attributed to better detection from the widespread availability of medical advancements such as early invasive coron ary angiography.
Source: Journal of Stroke and Cerebrovascular Diseases - July 28, 2021 Category: Neurology Authors: Temidayo Abe, Titilope Olanipekun, Joseph Igwe, Mtanis Khoury, Olukayode Busari, Joffi Musonge-Effoe, Effoe Valery, Obiora Egbuche, Paul Mather, Jalal Ghali Source Type: research

Tafamidis Reduces The Decline In Longitudinal Strain And Stroke Volume In Patients With Transthyretin Amyloid Cardiomyopathy
Left ventricular (LV) longitudinal strain and stroke volume are significant predictors of mortality in patients with transthyretin amyloid cardiomyopathy (ATTR-CM). In the Tafamidis in Transthyretin Cardiomyopathy Clinical Trial (ATTR-ACT), tafamidis significantly reduced mortality and CV-related hospitalizations. Further analysis of changes in echocardiographic measures in ATTR-ACT may provide additional insight into the efficacy of tafamidis.
Source: Journal of Cardiac Failure - April 1, 2022 Category: Cardiology Authors: Perry Elliott, Allan L. Klein, Fabio Fernandes, Balarama Gundapaneni, Marla B. Sultan, Sanjiv J. Shah Tags: 256 Source Type: research

NLRP3 Inflammasome Overactivation in Patients with Aneurysmal Subarachnoid Hemorrhage
AbstractAneurysmal subarachnoid hemorrhage (aSAH) is an uncommon and severe subtype of stroke leading to the loss of many years of productive life. We analyzed NLRP3 activity as well as key components of the inflammasome cascade in monocytes and plasma from 28 patients with aSAH and 14 normal controls using flow cytometry, western blot, ELISA, and qPCR technologies. Our data reveal that monocytes from patients with aSAH present an overactivation of the NLRP3 inflammasome, which results in the presence of high plasma levels of interleukin (IL)-1 β, IL-18, gasdermin D, and tissue factor. Although further research is needed,...
Source: Translational Stroke Research - July 11, 2022 Category: Neurology Source Type: research

Dilated Cardiomyopathy With Multiple Left Ventricular Thrombi and Embolic Stroke After Mild COVID-19
We report a case of a 37-year-old man who recovered from mild COVID-19 only to present a few weeks later with devastating cardiovascular involvement that included severe left ventricular impairment resulting from nonischemic cardiomyopathy, multiple left ventricular thrombi, and embolic stroke.PMID:36450145 | DOI:10.14503/THIJ-20-7488
Source: Texas Heart Institute Journal - November 30, 2022 Category: Cardiology Authors: Radhapriya Yalamanchi Madhan Kumar Murugan Krishnaswamy Chandrasekharan Refai Showkathali Source Type: research

3-Year outcomes after left atrial appendage closure in patients with nonvalvular atrial fibrillation: cardiomyopathy related with increased death and stroke rate
Left atrial appendage closure (LAAC) is a novel treatment for stroke prevention in high-risk patients with non-valvular atrial fibrillation (NVAF). However, the long-term outcomes after LAAC in Chinese NVAF pa...
Source: BMC Cardiovascular Disorders - January 17, 2023 Category: Cardiology Authors: Chunyu Chen, Yuyi Chen, Lulu Qu, Xi Su and Yanhong Chen Tags: Research Source Type: research

Mitochondrial encephalopathy with lactic-acidosis and stroke-like episodes syndrome presenting as progressive supranuclear palsy
Clinical manifestations of MELAS are broad and include stroke-like episodes, myopathy, cardiomyopathy, headaches, hearing impairment, dementia, epilepsy, lactic acidemia, cyclic vomiting, diabetes, and short stature. Most cases of MELAS present early in childhood, with only 1 –6% presenting after the age of 40 [1]. Progressive supranuclear palsy (PSP) is a neurodegenerative disorder which can be mimicked by a variety of conditions, such as CADASIL, cerebrovascular disease, and autoimmune encephalitis [2].
Source: Parkinsonism and Related Disorders - July 7, 2023 Category: Neurology Authors: Reece M. Hass, Jennifer L. Whitwell, Elizabeth Y. Coon, Keith A. Josephs, Farwa Ali Tags: Correspondence Source Type: research

Cardiac Preload Responsiveness in Children With Cardiovascular Dysfunction or Dilated Cardiomyopathy: A Multicenter Observational Study*
Conclusions: This study provides “normal” values for global end-diastolic volume index and limits of cardiac preload responsiveness in pediatric patients with cardiovascular dysfunction and dilated cardiomyopathy: 1.33 times normal global end-diastolic volume index represents the upper limit of patent cardiac preload responsiveness, with the highest expected responsiveness being below 0.67 times normal global end-diastolic volume index. The maximum response of the Frank-Starling relationship and therefore the level of no additional preload reserve is 1.33 to 1.51 times normal global end-diastolic volume index. Above 1....
Source: Pediatric Critical Care Medicine - January 1, 2015 Category: Pediatrics Tags: Cardiac Intensive Care Source Type: research

ACC 2019: Medtronic, Edwards low-risk TAVR trial data could pave way to new indications
Results from trials of both Medtronic‘s (NYSE:MDT) and Edwards Lifesciences‘ (NYSE:EW) transcatheter aortic valve replacement systems exploring their use in low-risk patients indicated that the devices were as safe as open surgery, paving the way for possible new indications for TAVR technology. Data from the trials were presented over the weekend at the American College of Cardiology 68th Annual Scientific Session 2019 in New Orleans and simultaneously published in the New England Journal of Medicine. Currently, TAVR devices are only approved by the FDA for treating severe aortic valve stenosis in patients at inte...
Source: Mass Device - March 18, 2019 Category: Medical Devices Authors: Fink Densford Tags: Cardiac Implants Cardiovascular Clinical Trials Featured Replacement Heart Valves Edwards Lifesciences Medtronic Source Type: news

Can I use DOAC in a patient with renal disease?
Case A 76-year-old man is diagnosed with non-valvular atrial fibrillation. His comorbid conditions are hypertension, diabetes complicated by neuropathy, and chronic kidney disease stage 3. His current medications include metformin, lisinopril, gabapentin, and aspirin. His most recent laboratories showed a creatinine 1.8, creatinine clearance (CrCl) 35 mL/min, hemoglobin 11g/dL, and international normalized ratio 1.0. His congestive heart failure, hypertension, age, diabetes, stroke, vascular disease, and sex (CHADSVASc) score is 4. Which medication should we use to prevent stroke in this patient?  Brief overview of the is...
Source: The Hospitalist - February 3, 2022 Category: Hospital Management Authors: Ronda Whitaker Tags: Renal & Genitourinary Source Type: research

The prevalence, predictors, and outcomes of spontaneous echocardiographic contrast or left ventricular thrombus in patients with HFrEF
ConclusionsIn patients with HFrEF, SEC was not uncommon and increased risk of ischaemic stroke as well as LVT. Anticoagulants could play a role in the reduction of stroke risk, suggesting that patients with SEC/LVT, even those in sinus rhythm, would benefit from systemic anticoagulation treatment.
Source: ESC Heart Failure - January 26, 2021 Category: Cardiology Authors: Xiaodong Zhou, Ruiyu Shi, Gaojun Wu, Qianli Zhu, Changzuan Zhou, Liangguo Wang, Chenglong Xue, Yuanyuan Jiang, Xueli Cai, Weijian Huang, Peiren Shan Tags: Original Research Article Source Type: research

From cryptogenic to ESUS: Toward precision medicine?
Rev Neurol (Paris). 2022 May 18:S0035-3787(22)00592-6. doi: 10.1016/j.neurol.2022.01.016. Online ahead of print.ABSTRACTCryptogenic infarctions are infarctions without a defined cause, despite a complete work-up. They differ from infarctions of undetermined causes, which may involve overlapping causes or an incomplete investigation. It is also different from uncommon heritable and non-heritable causes. The term embolic stroke of undetermined source (ESUS) proposed in 2014 is defined as a non-lacunar brain infarct without proximal arterial stenosis or cardioembolic sources. The major advantage of this definition compared to...
Source: Revue Neurologique - May 21, 2022 Category: Neurology Authors: S Timsit Source Type: research