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Condition: Alzheimer's
Therapy: Statin Therapy

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Total 22 results found since Jan 2013.

The effect of statins on the differentiation and function of central nervous system cells
Curr Med Chem. 2023 Mar 8. doi: 10.2174/0929867330666230308121645. Online ahead of print.ABSTRACTStatins (3-hydroxy-3-methylglutaryl-CoA reductase inhibitors) reduce plasma cholesterol and improve endothelium-dependent vasodilation, inflammation, and oxidative stress. The effect of statins on the central nervous system (CNS), particularly on cognition and neurological disorders such as cerebral ischemic stroke, multiple sclerosis (MS), and Alzheimer's disease (AD), has received increasing attention in recent years, both within the scientific community and in the media. This review aims to provide an updated discussion on t...
Source: Current Medicinal Chemistry - March 9, 2023 Category: Chemistry Authors: Sajjad Chamani Leila Mobasheri Shadi Zerehpoosh Ali Naghizadeh Alice P McCloskey Manfredi Rizzo Tannaz Jamialahmadi Amirhossein Sahebkar Source Type: research

Statins, Risk of Death and Ischemic Stroke in Patients with Dementia: A Registry-Based Observational Cohort Study.
CONCLUSION: The use of statins might be beneficial for the survival and ischemic stroke risk in patients with dementia in a dose-dependent manner. PMID: 33327915 [PubMed - as supplied by publisher]
Source: Current Alzheimer Research - December 15, 2020 Category: Neurology Authors: Bojana P, Hong X, Marta VL, Bengt W, Milica GK, Maria E, Sara GP Tags: Curr Alzheimer Res Source Type: research

The effects of statins on microglial cells to protect against neurodegenerative disorders: A mechanistic review
AbstractMicroglia are the primary innate immune system cells in the central nervous system (CNS). They are crucial for the immunity, neurogenesis, synaptogenesis, neurotrophic support, phagocytosis of cellular debris, and maintaining the CNS integrity and homeostasis. Invasion by pathogens as well as in CNS injuries and damages results in activation of microglia known as microgliosis. The activated microglia have the capacity to release proinflammatory mediators leading to neuroinflammation. However, uncontrolled neuroinflammation can give rise to various neurological disorders (NDs), especially the neurodegenerative disea...
Source: BioFactors - December 16, 2019 Category: Biochemistry Authors: Hossein Bagheri, Faezeh Ghasemi, George E. Barreto, Thozhukat Sathyapalan, Tannaz Jamialahmadi, Amirhossein Sahebkar Tags: Review Article Source Type: research

Men ’s dementia risk higher after androgen deprivation therapy
Carefully weigh benefits of hormone suppression against risks for men with prolonged life expectancy Related items fromOnMedica Fund specialist dementia training to improve care and save money New evidence on benzodiazepine link to Alzheimer ’s Statin use after stroke not linked to bleeds Some antipsychotics linked to raised mortality in dementia One in 10 children in phase I cancer trials respond to drugs
Source: OnMedica Latest News - July 3, 2019 Category: UK Health Source Type: news

Apelin-13 Suppresses Neuroinflammation Against Cognitive Deficit in a Streptozotocin-Induced Rat Model of Alzheimer ’s Disease Through Activation of BDNF-TrkB Signaling Pathway
Conclusion The data in this manuscript demonstrates that apelin-13 upregulates BDNF against STZ-induced congnitive impairment by suppressing glial cell activity and inflammatory factors release. This suggests apelin signaling may be a new target in the treatment of AD. Ethics Statement All experimental protocols were carried out according to the National Institutes of Health Guide for the Care and Use of Laboratory Animals approved by the Central South University at XiangYa Animal Care and Use Committee. Author Contributions XqQ and LH conceived the study and contributed to its experimental design. HqL carried out the...
Source: Frontiers in Pharmacology - April 15, 2019 Category: Drugs & Pharmacology Source Type: research

Effect of Inflammation on the Process of Stroke Rehabilitation and Poststroke Depression
Conclusions Stroke comprises ischemic stroke and ICH. The immuno-inflammatory process is involved in neural plasticity following events such as a hemorrhage or ischemic stroke. After ischemia, astrocytes, microglia, and MDMs play important roles during rehabilitation with the modulation of cytokines or chemokines, such as TNF-α and IL-1. Moreover, MiRNAs are also important posttranscriptional regulators in these glial mitochondrial responses to cerebral ischemia. ICH involves processes similar and different to those seen in ischemia, including neuronal injury, astrocytic and microglial/macrophage activation, and n...
Source: Frontiers in Psychiatry - April 10, 2019 Category: Psychiatry Source Type: research

Consecutive Slides on Axial View Is More Effective Than Transversal Diameter to Differentiate Mechanisms of Single Subcortical Infarctions in the Lenticulostriate Artery Territory
Conclusion: Consecutive slides on axial view (≥4 consecutive slices) might be more effective than transversal diameter to identify the atherosclerotic mechanisms of SSIs in the lenticulostriate artery territory. Clinical Trial Registration: http://www.clinicaltrials.gov. Unique identifier: NCT00664846 Introduction Single subcortical infarctions (SSIs) have been considered to be caused by lipohyalinosis degeneration in small artery disease, traditionally called lacunar infarct (1). However, atherosclerosis occurring in the parental artery blocking the orifice of the branch artery or atherosclerosis in the p...
Source: Frontiers in Neurology - April 8, 2019 Category: Neurology Source Type: research

Mortality and Associated Morbidities Following Traumatic Brain Injury in Older Medicare Statin Users
Conclusion: These findings provide valuable information for clinicians treating older adults with TBI as clinicians can consider, when appropriate, atorvastatin and simvastatin to older adults with TBI in order to decrease mortality and associated morbidities.
Source: The Journal of Head Trauma Rehabilitation - November 1, 2018 Category: Neurology Tags: Focus on Clinical Research and Practice Source Type: research

Pharmacologic Interventions to Prevent Cognitive Decline, Mild Cognitive Impairment, and Clinical Alzheimer-Type Dementia: A Systematic Review.
Conclusion: Evidence does not support use of the studied pharmacologic treatments for cognitive protection in persons with normal cognition or MCI. Primary Funding Source: Agency for Healthcare Research and Quality. PMID: 29255847 [PubMed - as supplied by publisher]
Source: Annals of Internal Medicine - December 19, 2017 Category: Internal Medicine Authors: Fink HA, Jutkowitz E, McCarten JR, Hemmy LS, Butler M, Davila H, Ratner E, Calvert C, Barclay TR, Brasure M, Nelson VA, Kane RL Tags: Ann Intern Med Source Type: research

Statins vs Alzheimer ' s; Marriage vs Fatal Stroke; Study by App
(MedPage Today) -- Cardiovascular Daily wraps up the top cardiology news of the week
Source: MedPage Today Psychiatry - December 16, 2016 Category: Psychiatry Source Type: news

Does statin use cause memory decline in the elderly?
Statin therapy has strong evidence supporting health benefits and mortality reduction in cardiovascular disease, stroke, diabetes, renal disease, and genetic lipid disorders. Further, reports that statin therapy might be protective against Alzheimer ’s disease have subsequently been refuted in randomized trials. Low-level evidence based on case reports suggests that statins may adversely affect memory, a significant consumer concern. In this review, the published evidence on statins and memory in the elderly in randomized controlled trials an d prospective observational cohort studies was examined in detail.
Source: Trends in Cardiovascular Medicine - March 27, 2016 Category: Cardiology Authors: Katherine Samaras, Henry Brodaty, Perminder S. Sachdev Source Type: research

A twist on the genetic link between Alzheimer’s and heart disease
Alzheimer’s disease often strikes fear in people’s hearts because it gradually erodes a person’s ability to remember, think, and learn. There is no cure, and available treatments alleviate symptoms only temporarily. An estimated 5.3 million Americans currently have Alzheimer’s disease, yet this brain disorder is far less common than heart disease. More than 85 million people in the United States are living with some form of cardiovascular disease or the after-effects of stroke, which also affects brain function. Many people don’t realize that Alzheimer’s and heart disease share a genetic link: the apolipoprotei...
Source: New Harvard Health Information - March 25, 2016 Category: Consumer Health News Authors: Julie Corliss Tags: Alzheimer's Disease Behavioral Health Brain and cognitive health Genes Healthy Aging Heart Health Memory Mental Health Source Type: news