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Ultrasound Deep Brain Stimulation Modulates Body Temperature in Mice
Body temperature plays a critical role in rehabilitation, and numerous studies proved that the regulation of body temperature contributes to the sensorimotor recovery of patients with brain diseases such as stroke. The hypothalamus plays a key role in thermoregulation. Ultrasound deep brain stimulation (UDBS) can noninvasively modulate deep brain nuclei and have potential applications in the treatment of Parkinson’s disease, Alzheimer’s disease, and depression, among others. The purpose of this study was to investigate whether ultrasound stimulation of the hypothalamus could regulate body temperature in free-...
Source: IEE Transactions on Neural Systems and Rehabilitation Engineering - July 15, 2022 Category: Neuroscience Source Type: research

Association of Carotid Intima-Media Thickness with Brain MRI Markers in the Atherosclerosis Risk in Communities Neurocognitive Study (ARIC-NCS)
CONCLUSION: Over a median follow-up of 21 years, greater midlife cIMT and presence of carotid plaque were associated with smaller deep gray matter volume and cortical volume in a meta ROI involving temporal and parietal lobe regions typically involved in neurodegeneration, including Alzheimer's disease, in later life. Contrary to our hypothesis, associations between measures of arterial injury and markers of vascular brain injury were null.PMID:35193028 | DOI:10.1016/j.jstrokecerebrovasdis.2022.106388
Source: Atherosclerosis - February 22, 2022 Category: Cardiology Authors: Wendy Wang Faye L Norby Alvaro Alonso Rebecca F Gottesman Clifford R Jack Michelle L Meyer David S Knopman Kevin J Sullivan Timothy M Hughes Kamakshi Lakshminarayan Pamela L Lutsey Source Type: research

Focused ultrasound opening brain to previously impossible treatments
(University of Virginia Health System) Focused ultrasound, the researchers hope, could revolutionize treatment for conditions from Alzheimer's to epilepsy to brain tumors -- and even help repair the devastating damage caused by stroke.
Source: EurekAlert! - Medicine and Health - May 6, 2020 Category: International Medicine & Public Health Source Type: news

Glutamate Transport and Preterm Brain Injury
Silvia Pregnolato1*, Elavazhagan Chakkarapani1, Anthony R. Isles2 and Karen Luyt1 1Department of Neonatal Neurology, Translational Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom 2Behavioural Genetics Group, MRC Centre for Neuropsychiatric Genetics and Genomics, School of Medicine, Cardiff University, Cardiff, United Kingdom Preterm birth complications are the leading cause of child death worldwide and a top global health priority. Among the survivors, the risk of life-long disabilities is high, including cerebral palsy and impairment of movement, cognition, and beh...
Source: Frontiers in Physiology - April 23, 2019 Category: Physiology Source Type: research

Cardiovascular Programming During and After Diabetic Pregnancy: Role of Placental Dysfunction and IUGR
This study demonstrated that the incidence of ischemic heart disease and death were three times higher among men with low birth weight compared to men with high birth weight (5). Epidemiological investigations of adults born at the time of the Dutch famine between 1944 and 1945 revealed an association between maternal starvation and a low infant birth weight with a high incidence of hypertension and coronary heart disease in these adults (23). Furthermore, Painter et al. reported the incidence of early onset coronary heart disease among persons conceived during the Dutch famine (24). In that regard, Barker's findin...
Source: Frontiers in Endocrinology - April 8, 2019 Category: Endocrinology Source Type: research

Exploiting BBB disruption for the delivery of nanocarriers to the diseased CNS.
Abstract The blood-brain barrier (BBB) segregates the central nervous system from the systemic circulation. As such, the BBB not only prevents toxins and pathogens from entering the brain, but also limits the brain uptake of therapeutic molecules. However, under certain pathological conditions, the BBB is disrupted, allowing direct interaction between blood components and the diseased site. Moreover, techniques such as focused ultrasound can further disrupt the BBB in diseased regions. This review focuses on strategies that leverage such BBB disruption for delivering nanocarriers to the central nervous system (CNS...
Source: Current Opinion in Biotechnology - March 4, 2019 Category: Biotechnology Authors: Umlauf BJ, Shusta EV Tags: Curr Opin Biotechnol Source Type: research

Poor Sleep Linked To Dangerous Plaque Buildup In Arteries
By Sandee LaMotte, CNN (CNN) — Here’s another reason why getting a good night’s sleep should be on your must-do list: Sleeping fewer than six hours a night or waking frequently raises your risk of developing damaging plaque in arteries throughout your body, not just your heart. Previous research has shown poor sleep to be strongly associated with coronary heart disease, but “This is the first study to show that objectively measured sleep is independently associated with atherosclerosis throughout the body,” José Ordovás, director of nutrition and genomics at the Jean Mayer USDA Human Nutriti...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - January 14, 2019 Category: Consumer Health News Authors: Health – CBS Boston Tags: Boston News Health CNN Heart Disease Sleep Tufts University Source Type: news

Ultrasound helps identify dementia risk factor
Ultrasound can help researchers identify a dementia risk factor among older...Read more on AuntMinnie.comRelated Reading: AI helps uncover clues for Alzheimer's disease in MRI data Flortaucipir-PET targets tau for Alzheimer's diagnoses MRI links lifestyle factors to stroke, dementia risk PET could make synaptic density an Alzheimer's biomarker MRI links inflammation to cognitive decline
Source: AuntMinnie.com Headlines - October 17, 2018 Category: Radiology Source Type: news

Current and future uses of transcranial focused ultrasound in neurosurgery.
Authors: Hersh DS, Eisenberg HM Abstract Focused ultrasound (FUS) produces a region of high intensity at the focal zone of the beam but with minimal effects at adjacent areas, allowing the sonication of deep targets throughout the body. Despite early obstacles to transmitting ultrasound energy through the skull, recent advances in ultrasound technology, software, and real-time monitoring have resulted in a renewed interest in the clinical applications of transcranial FUS. Following extensive pre- clinical studies, ultrasound-induced thermal ablation has been approved by several countries for the treatment of essent...
Source: Journal of Neurosurgical Sciences - November 8, 2017 Category: Neurosurgery Tags: J Neurosurg Sci Source Type: research

Ultrasound Markers of Carotid Atherosclerosis and Cognition Clinical Sciences
Conclusions—Subclinical carotid atherosclerosis was associated with worse cognition among those at higher risk for Alzheimer disease. Interventions targeting early stages of atherosclerosis may modify cognitive aging.
Source: Stroke - June 26, 2017 Category: Neurology Authors: Hannah Gardener, Michelle R. Caunca, Chuanhui Dong, Ying Kuen Cheung, Mitchell S.V. Elkind, Ralph L. Sacco, Tatjana Rundek, Clinton B. Wright Tags: Ultrasound, Cognitive Impairment, Atherosclerosis Original Contributions Source Type: research

The neuroprotective effect of focused ultrasound: new perspectives on an old tool.
CONCLUSION: Future well-conducted human studies are emergently needed to assess the neuroprotective effects of FUS. PMID: 28458041 [PubMed - as supplied by publisher]
Source: Brain Research Bulletin - April 27, 2017 Category: Neurology Authors: Yulug B, Hanoglu L, Kilic E Tags: Brain Res Bull Source Type: research