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Total 24 results found since Jan 2013.

Effect of Inflammation on the Process of Stroke Rehabilitation and Poststroke Depression
Conclusions Stroke comprises ischemic stroke and ICH. The immuno-inflammatory process is involved in neural plasticity following events such as a hemorrhage or ischemic stroke. After ischemia, astrocytes, microglia, and MDMs play important roles during rehabilitation with the modulation of cytokines or chemokines, such as TNF-α and IL-1. Moreover, MiRNAs are also important posttranscriptional regulators in these glial mitochondrial responses to cerebral ischemia. ICH involves processes similar and different to those seen in ischemia, including neuronal injury, astrocytic and microglial/macrophage activation, and n...
Source: Frontiers in Psychiatry - April 10, 2019 Category: Psychiatry Source Type: research

Anxiety in Patients With Acute Ischemic Stroke: Risk Factors and Effects on Functional Status
Conclusion: Depressive symptoms are the major correlates of PSA while more severe PSA is associated with poorer ADL and health-related QOL. Acute lesions involving CHWM may correlate with PSA in ischemic stroke patients with mild-to-moderate neurologic deficits, supporting a lesion-location hypothesis in PSA.IntroductionAnxiety is prevalent after stroke and occurs in about one-quarter of stroke survivors (1, 2). Poststroke anxiety (PSA) may have a negative impact on quality of life (QOL) of stroke survivors, affecting their rehabilitation (3). Furthermore, one prospective study found that severe anxiety symptoms were assoc...
Source: Frontiers in Psychiatry - April 16, 2019 Category: Psychiatry Source Type: research

A cross-sectional study to assess the association between major depression and inflammatory markers in patients with acute ischemic stroke.
Conclusion: This study suggests that in patients who have experienced AIS, there is no significant relationship between major depression and basal proinflammatory cytokines (TNF-α, IL-1 β, IL-18), BDNF, and NSE. PMID: 31142907 [PubMed]
Source: Indian Journal of Psychiatry - June 1, 2019 Category: Psychiatry Tags: Indian J Psychiatry Source Type: research

Mania secondary to focal brain lesions: implications for understanding the functional neuroanatomy of bipolar disorder
ConclusionsSecondary mania should be suspected in patients with neurological deficits, histories atypical for classic bipolar disorder, and first manic episodes after the age of 40 years. Treatment with antimanic medications, along with specific treatment for the underlying neurologic condition, is typically required. Typical lesion locations fit with current models of bipolar disorder, which implicate hyperactivity of left‐hemisphere reward‐processing brain areas and hypoactivity of bilateral prefrontal emotion‐modulating regions. Lesion studies complement these models by suggesting that right‐hemisphere limbic‐...
Source: Bipolar Disorders - April 25, 2016 Category: Psychiatry Authors: David Satzer, David J Bond Tags: Review Article Source Type: research

Harnessing the Four Elements for Mental Health
DiscussionAs detailed above, the “elements” in both a classical and a contemporary sense have effects on our mental health and are potentially modifiable aspects that can be harnessed as therapeutic interventions. The most robust interventional evidence currently available shows tentative support for several use of the elements via horticultural and nature-exposure therapy, green exercise/physical activity, sauna and heat therapy, balneotherapy, and breathing exercises. It should be noted that, in many cases, these interventions were not studied in definitive diagnosed psychiatric disorders and thus it is pre...
Source: Frontiers in Psychiatry - April 23, 2019 Category: Psychiatry Source Type: research

Alexithymia in Neurological Disease: A Review.
Conclusions: Identification of alexithymia could be relevant for prognosis and therapeutic decisions in patients with neurological disease and is certainly worthy of further study. Tools with which to measure alexithymia and delineation from affective disorders and apathy are important methodological issues for future work. PMID: 25658681 [PubMed - as supplied by publisher]
Source: Journal of Neuropsychiatry and Clinical Neurosciences - February 8, 2015 Category: Psychiatry Tags: J Neuropsychiatry Clin Neurosci Source Type: research

Transcriptomic Analysis of Mecp2 Mutant Mice Reveals Differentially Expressed Genes and Altered Mechanisms in Both Blood and Brain
This study was carried out in accordance with the recommendations of National Animal Welfare Authority, Ireland. The protocol was approved by the Animal Ethical Committee Trinity College Dublin and HPRA.Author ContributionsAS performed the experiments and wrote the paper; KH provided assistance in the design and analysis of the RNAseq experiment; DT contributed to sample extraction and establishment of the colony; and DT and MG designed and supervised all the parts of the research and the writing of the manuscript.FundingThe study was funded by the Wellcome Trust Grant WT079408/C/06/Z issued to MG, and by an SFI FN Funded ...
Source: Frontiers in Psychiatry - April 29, 2019 Category: Psychiatry Source Type: research

Could Antibodies or Hormones Slow Brain Damage from Alzheimer’s?
Scientists have discovered that certain antibodies may help slow the progression of Alzheimer’s disease. Dr. Patricia Salinas of University College London, UK, and her team focused on a protein called Dkk1, present in raised levels in the brains of people with Alzheimer’s disease. Using brain samples from mice, the team looked at the progressive disintegration of synapses in the hippocampus when exposed to a protein called amyloid-beta, thought to be central to the development of Alzheimer’s disease. “Synaptic loss mediated by amyloid-beta in early stages of the disease might contribute to cognitive...
Source: Psych Central - June 1, 2013 Category: Psychiatry Authors: Jane Collingwood Tags: Aging Alzheimer's Disorders General Seniors Abnormal Deposits Alzheimer S Disease Antibodies Brain Area Brain Damage Cognitive Decline Cognitive Impairments Disintegration Dr Patricia Dr Simon Hippocampus Journal Of Neurosc Source Type: news

Sudden unexpected death in schizophrenia: Autopsy findings in psychiatric inpatients
In conclusion, sudden cardiac death occurs at a 0.8% rate in a psychiatric hospital, well above general population rates. Autopsy findings indicate that sudden death in schizophrenia is caused by structural cardiovascular, respiratory and neurological abnormalities, with most cases due to acute myocardial infarction. Early recognition and treatment of coronary artery disease must become a clinical priority for all adults with schizophrenia.
Source: Schizophrenia Research - April 7, 2014 Category: Psychiatry Authors: Petru Ifteni, Christoph U. Correll, Victoria Burtea, John M. Kane, Peter Manu Tags: Clinical Studies Source Type: research

The Dementia Caregiver: A Guide to Caring for Someone with Alzheimer’s Disease
After caring for a parent with deadly Alzheimer’s disease, I found Marc Agronin’s new book matched my observations and experience. In The Dementia Caregiver, Agronin, an adult and geriatric psychiatrist with significant credentials, shares what he’s learned from patients and their families, providing a valuable guide. Really, the book should be required reading for everyone over the age of sixty-five because of the likelihood of having to deal with Alzheimer’s firsthand — although the book is aimed more at those younger adults who will have to contend with the disease in their parents or grandparents. But, t...
Source: Psych Central - January 30, 2016 Category: Psychiatry Authors: Dave Schultz Tags: Aging Alzheimer's Book Reviews Caregivers Family General Holiday Coping Self-Help Seniors books on alzheimers books on neurocognitive disorders caring for aging parents caring for dementia guide to caring for someone with alzheim Source Type: news

The State of Our Understanding of the Pathophysiology and Optimal Treatment of Depression: Glass Half Full or Half Empty?
Abstract Major depressive disorder is a remarkably common and often severe psychiatric disorder associated with high levels of morbidity and mortality. Patients with major depression are prone to several comorbid psychiatric conditions, including posttraumatic stress disorder, anxiety disorders, obsessive-compulsive disorder, and substance use disorders, and medical conditions, including cardiovascular disease, diabetes, stroke, cancer, which, coupled with the risk of suicide, result in a shortened life expectancy. The goal of this review is to provide an overview of our current understanding of major depression, ...
Source: The American Journal of Psychiatry - July 31, 2020 Category: Psychiatry Authors: Nemeroff CB Tags: Am J Psychiatry Source Type: research

Differential Regulation of Angiogenic Gene Networks in Postmortem Brains of Opioid Use Disorder Subjects
This study comprehensively interrogated the transcriptomic and proteomic profiles of the dorsolateral prefrontal cortex (BA9) in subjects with opioid use disorder (OUD), to investigate the molecular effects of opioid abuse in the human brain.
Source: Biological Psychiatry - April 27, 2021 Category: Psychiatry Authors: Emily Mendez, Haichao Wei, Laura Stertz, Gabriel Fries, Ruifeng Hu, Xizi Wu, Katherine Najera, Karla Moriel, Thomas Meyer, Zhongming Zhao, Jiaqian Wu, Consuelo Walss-Bass Source Type: research

Tube feeding in patients with dementia is associated with a longer palliative care unit stay
CONCLUSION: The present study showed that, in patients with an established diagnosis of dementia, TF is common and independently associated with a longer length of PCU stay. Nevertheless, the study was underpowered and the results deserve confirmation in larger studies.PMID:34971282 | DOI:10.1002/alz.052919
Source: The Journal of Alzheimers Association - December 31, 2021 Category: Psychiatry Authors: Hilal Zengin Ilker Tasci Source Type: research