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Total 202 results found since Jan 2013.

Unusual case of recurrent SMART (stroke-like migraine attacks after radiation therapy) syndrome
Ramnath Santosh Ramanathan, Gayathri Sreedher, Konark Malhotra, Zain Guduru, Deeksha Agarwal, Mary Flaherty, Timothy Leichliter, Sandeep RanaAnnals of Indian Academy of Neurology 2016 19(3):399-401Stroke-like migraine attacks after radiation therapy (SMART) syndrome is a rare delayed complication of cerebral radiation therapy. A 53-year-old female initially presented with headache, confusion and left homonymous hemianopia. Her medical history was notable for cerebellar hemangioblastoma, which was treated with radiation in 1987. Her initial brain MRI (magnetic resonance imaging) revealed cortical enhancement in the right te...
Source: Annals of Indian Academy of Neurology - July 24, 2016 Category: Neurology Authors: Ramnath Santosh Ramanathan Gayathri Sreedher Konark Malhotra Zain Guduru Deeksha Agarwal Mary Flaherty Timothy Leichliter Sandeep Rana Source Type: research

Chapter 56 Diffusion tensor imaging and functional MRI
Publication date: 2016 Source:Handbook of Clinical Neurology, Volume 136 Author(s): Massimo Filippi, Federica Agosta The advances in diffusion-weighted imaging (DWI), diffusion tensor imaging (DTI), and functional magnetic resonance imaging (fMRI) over the last 20 years have vastly contributed to improving the understanding of the brain structure and function in patients with many diseases of the central nervous system (CNS). DWI is commonly used, for instance, in the diagnostic workup of stroke, CNS neoplasia, and rapidly progressive dementia cases. The new DTI methods provide more specific information about the most ...
Source: Handbook of Clinical Neurology - July 16, 2016 Category: Neurology Source Type: research

Optimization of two‐compartment‐exchange‐model analysis for dynamic contrast‐enhanced mri incorporating bolus arrival time
ConclusionThis study proposes an optimized analysis method, ACoPeD, for tissue perfusion and permeability estimation using DCE‐MRI, to be used in clinical settings. J. Magn. Reson. Imaging 2016.
Source: Journal of Magnetic Resonance Imaging - July 6, 2016 Category: Radiology Authors: Guy Nadav, Gilad Liberman, Moran Artzi, Nahum Kiryati, Dafna Ben Bashat Tags: Original Research Source Type: research

Optimization of two ‐compartment‐exchange‐model analysis for dynamic contrast‐enhanced mri incorporating bolus arrival time
ConclusionThis study proposes an optimized analysis method, ACoPeD, for tissue perfusion and permeability estimation using DCE‐MRI, to be used in clinical settings. J. Magn. Reson. Imaging 2016.
Source: Journal of Magnetic Resonance Imaging - July 6, 2016 Category: Radiology Authors: Guy Nadav, Gilad Liberman, Moran Artzi, Nahum Kiryati, Dafna Ben Bashat Tags: Original Research Source Type: research

EPMA-World Congress 2015
Table of contents A1 Predictive and prognostic biomarker panel for targeted application of radioembolisation improving individual outcomes in hepatocellular carcinoma Jella-Andrea Abraham, Olga Golubnitschaja A2 Integrated market access approach amplifying value of “Rx-CDx” Ildar Akhmetov A3 Disaster response: an opportunity to improve global healthcare Russell J. Andrews, Leonidas Quintana A4 USA PPPM: proscriptive, profligate, profiteering medicine-good for 1 % wealthy, not for 99 % unhealthy Russell J. Andrews A5 The role of ...
Source: EPMA Journal - May 8, 2016 Category: Global & Universal Source Type: research

Evidence for cerebellar motor functional reorganization in brain tumor patients: An fMRI study
Publication date: 27 May 2016 Source:Neuroscience Letters, Volume 622 Author(s): Satoshi Kurabe, Kosuke Itoh, Tsutomu Nakada, Yukihiko Fujii Functional reorganization of the motor system following brain damage has been studied extensively in stroke patients, in which not only the cerebrum but also the cerebellum (Cbll) undergoes substantial reorganization. However, the role of Cbll in motor functional reorganization in brain tumor patients remains poorly investigated. Because brain damages in brain tumor patients occur much more slowly than in stroke patients, the neural mechanisms for motor functional reorganization...
Source: Neuroscience Letters - April 26, 2016 Category: Neuroscience Source Type: research

Basic Principle and Image Analysis in the Diffusion Tensor Image.
Abstract The magnetic resonance imaging (MRI) is established as the imaging technique that is essential to the imaging of the central nervous system disease. Above all, the diffusion weighted image (DWI) is known as the tool which can diagnose acute ischemic stroke with high accuracy in a short time. DTI, an applied form of DWI, was devised as a technique to image the structure of the brain white matter. In clinical sites, this technique is used for pathologic elucidation such as the intracerebral tissue injury or mental disorder. Additionally, diffusion tensor tractography (DTT), which is a technique to build thr...
Source: Igaku Butsuri: Japanese Journal of Medical Physics - January 1, 2016 Category: Physics Authors: Sato E, Isobe T, Yamamoto T, Matsumura A Tags: Igaku Butsuri Source Type: research

FDA Approves BIOTRONIK Iperia ICD Systems With Full-Body ProMRI Technology
BIOTRONIK has received FDAapproval for use of its latest family of implantable cardioverter defibrillator (ICD) systems with magnetic resonance imaging (MRI) scans. BIOTRONIK ProMRItechnology allows patients with approved device systems to have 1.5 Tesla MRI scans without an exclusion zone. ICD patients will have expanded access to MRI diagnostic scans, which can be critical for diagnosing conditions such as stroke, brain and cardiac tumors or orthopedic injuries.
Source: Medical Design Online News - December 23, 2015 Category: Medical Equipment Source Type: news

Curcumin pretreatment attenuates inflammation and mitochondrial dysfunction in experimental stroke: the possible role of Sirt1 signaling.
In conclusion, our results demonstrate that CCM treatment attenuates ischemic stroke-induced brain injury via activation of SIRT1. PMID: 26639783 [PubMed - as supplied by publisher]
Source: Brain Research Bulletin - November 27, 2015 Category: Neurology Authors: Miao Y, Zhao S, Gao Y, Wang R, Wu Q, Wu H, Luo T Tags: Brain Res Bull Source Type: research

The 5-lipoxygenase (5-LOX) inhibitor zileuton reduces inflammation and infarct size with improvement in neurological outcome following cerebral ischemia.
The objective of this study was to evaluate the effects of blocking 5-LOX activity in a murine model of transient and global brain ischemia. Zileuton improved neurological deficits and significantly decrease volume and density of lesion, compared to vehicle-ischemic animals measured by magnetic resonance imaging (MRI). In addition, the blockage of 5-LOX reduced infarct area and histopathological changes. Furthermore, by enzyme immunoassay (ELISA) increased brain levels of tumor necrosis factor-alpha (TNF-alpha), interferon-gamma (IFN-gamma), interleukin-1beta (IL-1beta), interleukin-6 (IL-6), chemokine (C-X-C motif) ligand...
Source: Current Neurovascular Research - August 12, 2015 Category: Neurology Authors: Silva BC, de Miranda AS, Rodrigues FG, Silveira AL, de Souza Resende GH, Moraes MF, de Oliveira AC, Parreiras PM, da Silva Barcelos L, Teixeira MM, Machado FS, Teixeira AL, Rachid MA Tags: Curr Neurovasc Res Source Type: research

Therapeutically Targeting Tumor Necrosis Factor-{alpha}/Sphingosine-1-Phosphate Signaling Corrects Myogenic Reactivity in Subarachnoid Hemorrhage Basic Sciences
Conclusions— Vascular smooth muscle cell TNFα and sphingosine-1-phosphate signaling significantly enhance cerebral artery tone in SAH; anti-TNFα and anti–sphingosine-1-phosphate treatment may significantly improve clinical outcome.
Source: Stroke - July 27, 2015 Category: Neurology Authors: Yagi, K., Lidington, D., Wan, H., Fares, J. C., Meissner, A., Sumiyoshi, M., Ai, J., Foltz, W. D., Nedospasov, S. A., Offermanns, S., Nagahiro, S., Macdonald, R. L., Bolz, S.-S. Tags: Animal models of human disease, Acute Cerebral Hemorrhage, Brain Circulation and Metabolism, Other Stroke Treatment - Medical, Other Vascular biology Basic Sciences Source Type: research

Diffusion Magnetic Resonance Imaging: What Water Tells Us about Biological Tissues
by Denis Le Bihan, Mami Iima Since its introduction in the mid-1980s, diffusion magnetic resonance imaging (MRI), which measures the random motion of water molecules in tissues, revealing their microarchitecture, has become a pillar of modern neuroimaging. Its main clinical domain has been the diagnosis of acute brain stroke and neurogical disorders, but it is also used in the body for the detection and management of cancer lesions. It can also produce stunning maps of white matter tracks in the brain, with the potential to aid in the understanding of some psychiatric disorders. However, in order to exploit fully the pote...
Source: PLoS Biology: Archived Table of Contents - July 23, 2015 Category: Biology Authors: Denis Le Bihan et al. Source Type: research

Susceptibility-Weighted Angiography Visualizes Hypoxia in Cerebral Veins
Conclusions: Hypoxia leads to visible and measurable changes in cerebral veins as depicted through SWAN. Possible clinical implications of this finding include stroke and tumor imaging and need further investigation.
Source: Investigative Radiology - May 13, 2015 Category: Radiology Tags: Original Articles Source Type: research

Prevalence of Cerebral Small-Vessel Disease in Long-Term Breast Cancer Survivors Exposed to Both Adjuvant Radiotherapy and Chemotherapy Breast Cancer
Conclusion More CMBs were found in the aRCeBCS group than in the population-based controls. These vascular lesions potentially mark cerebrovascular frailty that could partially explain the well-documented association between chemotherapy and cognitive dysfunction. No support was found for a radiotherapy-related origin of CMBs.
Source: Journal of Clinical Oncology - February 18, 2015 Category: Cancer & Oncology Authors: Koppelmans, Vernooij, Boogerd, Seynaeve, Ikram, Breteler, Schagen Tags: Radiation, Chemotherapy Breast Cancer Source Type: research

Attenuation of acute stroke injury in rat brain by minocycline promotes blood¿brain barrier remodeling and alternative microglia/macrophage activation during recovery
Conclusions: Early minocycline treatment against reperfusion injury significantly promotes neurovascular remodeling during stroke recovery by reducing brain tissue loss, enhancing TJP expression in ischemic brains and facilitating neuroprotective phenotype alternative activation of microglia/macrophages.
Source: Journal of Neuroinflammation - February 10, 2015 Category: Neurology Authors: Yirong YangVictor SalayandiaJeffrey ThompsonLisa YangEduardo EstradaYi Yang Source Type: research