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Contralaterally transplanted human embryonic stem cell-derived neural precursor cells (ENStem-A) migrate and improve brain functions in stroke-damaged rats.
In this study, we investigated the fates of human embryonic stem cell (hESC)-derived NPCs (ENStem-A) for 8 weeks following transplantation into the side contralateral to the infarct region using 7.0T animal magnetic resonance imaging (MRI). T2- and T2*-weighted MRI analyses indicated that the migrating cells were clearly detectable at the infarct boundary zone by 1 week, and the intensity of the MRI signals robustly increased within 4 weeks after transplantation. Afterwards, the signals were slightly increased or unchanged. At 8 weeks, we performed Prussian blue staining and immunohistochemical staining using human-specifi...
Source: exp Mol Med - November 19, 2013 Category: Molecular Biology Authors: Chang DJ, Oh SH, Lee N, Choi C, Jeon I, Kim HS, Shin DA, Lee SE, Kim D, Song J Tags: Exp Mol Med Source Type: research

Transcranial doppler and brain MRI in children with sickle cell disease and high hemoglobin F levels
ConclusionThe mild phenotype among Kuwaiti patients with SCD is reflected in normal TCD velocities and a low prevalence of SBI in children with the disease. Pediatr Blood Cancer © 2013 Wiley Periodicals, Inc.
Source: Pediatric Blood and Cancer - September 11, 2013 Category: Cancer & Oncology Authors: Akram Asbeutah, Renu Gupta, Osama Al‐Saeid, Sam Ashebu, Sundus Al‐Sharida, Ali Mullah‐Ali, Nada Yousef Mustafa, Adekunle Adekile Tags: Research Article Source Type: research

Isolated Shoulder Palsy due to Cortical Infarction: A Case Report and Literature Review of Clinicoradiological Correlations
We report an 80-year-old woman with isolated shoulder palsy because of cortical ischemic infarction in the base of the left precentral gyrus as confirmed by brain magnetic resonance imaging. In our patient, cardiogenic embolism or Trousseau syndrome associated with lung cancer was considered the cause of ischemic infarction. Physicians should consider small cortical infarction, when a patient complains of sudden onset of shoulder weakness without pain. In line with the previous reports, a responsible cortical lesion in our patient corresponded to motor shoulder area in the motor homunculus reported to be located more media...
Source: Journal of Stroke and Cerebrovascular Diseases - September 4, 2013 Category: Neurology Authors: Akiko Kawasaki, Keisuke Suzuki, Hidehiro Takekawa, Norito Kokubun, Masanari Yamamoto, Yohei Asakawa, Madoka Okamura, Koichi Hirata Tags: Case Reports Source Type: research

Potential Misdiagnoses of Bell's Palsy in the Emergency Department
Conclusion: Emergency providers have a very low rate of misdiagnosing Bell's palsy. The association between imaging use and misdiagnosis is likely confounded by patient acuity. Increasing age and diabetes are modest risk factors for misdiagnosis.
Source: Annals of Emergency Medicine - July 29, 2013 Category: Emergency Medicine Authors: Jahan Fahimi, Babak B. Navi, Hooman Kamel Tags: Neurology Source Type: research

MR compatible positioning device for guiding a focused ultrasound system for the treatment of brain deseases
ConclusionA simple, cost effective, portable positioning device has been developed which can be used in virtually any clinical MRI scanner since it can be placed on the table of the MRI scanner. This system can be used to treat in the future patients with brain cancer and ischemic stroke. Copyright © 2013 John Wiley & Sons, Ltd.
Source: The International Journal of Medical Robotics and Computer Assisted Surgery - June 7, 2013 Category: Surgery Authors: N. Mylonas, C. Damianou Tags: Original Article Source Type: research

Biomedical applications of sodium MRI in vivo
In this article we present an up‐to‐date overview of the potential biomedical applications of sodium magnetic resonance imaging (MRI) in vivo. Sodium MRI is a subject of increasing interest in translational imaging research as it can give some direct and quantitative biochemical information on the tissue viability, cell integrity and function, and therefore not only help the diagnosis but also the prognosis of diseases and treatment outcomes. It has already been applied in vivo in most human tissues, such as brain for stroke or tumor detection and therapeutic response, in breast cancer, in articular cartilage, in muscl...
Source: Journal of Magnetic Resonance Imaging - May 30, 2013 Category: Radiology Authors: Guillaume Madelin, Ravinder R. Regatte Tags: Review Source Type: research

Alexia due to ischemic stroke of the visual word form area.
Abstract The visual word form area (VWFA) is a region in the posterior left occipitotemporal cortex adjacent to the fusiform gyrus hypothesized to mediate word recognition. Evidence supporting the role of this area in reading comes from neuroimaging studies of normal subjects, case-controlled lesion studies, and studies of patients with surgical resection of the VWFA for tumors or epilepsy. Based on these prior reports, a small discrete lesion to the VWFA would be expected to cause alexia in a literate person without prior brain process, but such a case has not previously been reported to our knowledge. Here, we r...
Source: Neurocase - March 25, 2013 Category: Neurology Authors: Turkeltaub PE, Goldberg EM, Postman-Caucheteux WA, Palovcak M, Quinn C, Cantor C, Coslett HB Tags: Neurocase Source Type: research

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